ST Elevation (STEMI) Myocardial InfarctionNCT07263282
LA Strain in Predicting Early Complication in STEMI After PPCI
An observational study of ST Elevation (STEMI) Myocardial Infarction, run by Assiut University at 1 site in Egypt.
Trial summary
The goal of this observational study To evaluate the predictive value of left atrial strain for in-hospital outcomes in patients with ST-segment elevation myocardial infarction undergoing PPCI. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- ST Elevation (STEMI) Myocardial Infarction
- What is being tested?
- 2D echocardiography
- How many people
- 135 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Dec 2025to 1 Feb 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: patients diagnosed with ST-segment elevation myocardial infarction and Underwent successful primary percutaneous coronary intervention and control group to provide baseline parameters for comparing LA strain and other echocardiographic parameters
Who may be able to join
- Adults aged ≥18 years.
- Diagnosed with ST-segment elevation myocardial infarction (STEMI) according to current ESC/AHA criteria
- Underwent successful primary percutaneous coronary intervention (PPCI) within 12 hours of symptom onset.
- Sinus rhythm on admission .
- Trans thoracic echocardiography (TTE) performed within 48 hours of admission with adequate image quality for speckle-tracking analysis.
Who cannot join
- Previous myocardial infarction or prior PCI/CABG.
- Patients known to have atrial fibrillation or other sustained supraventricular arrhythmias.
- Significant valvular heart disease (severe stenosis or regurgitation).
- Congenital heart disease or cardiomyopathy (hypertrophic, dilated, restrictive).
- Poor echocardiographic window preventing LA strain analysis .
- Mechanical complications (e.g., papillary muscle rupture, VSD, free wall rupture).
- Prior cardiac surgery or known structural lesions that preventing reliable LA measurement.
- patient presenting with killip class III or IV from the start
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Left Atrium Strain as a Predictor of In-Hospital Outcomes in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
The goal of this observational study To evaluate the predictive value of left atrial strain for in-hospital outcomes in patients with ST-segment elevation myocardial infarction undergoing PPCI. The main questions it aims to answer are:
Is low parameters of left atrial strain associated early complication ? What is the correlation between LA strain parameters and conventional echocardiographic indices of left ventricular systolic and diastolic function ? Is there more affection to LA strain in certain territory over the others ? What is the correlation between LA strain and LA volume index across infarct territories ? Does LA strain Correlate with TAPSE and PASP to evaluate right-heart interactions ?
Read the detailed description
The overall trend of ST-segment elevated myocardial infarction has shown an annual increase. Post-infarction heart failure is one of the major adverse cardiovascular events in patients with post-percutaneous coronary intervention.
Therefore, the prediction and accurate assessment of in-hospital outcomes in patients have gained more research and clinical attention.
Left ventricular ejection fraction may no longer be the sole and most reliable predictor of events after a STEMI. Left atrial function may be a comprehensive marker of left-sided cardiac function, as it reflects both diastolic and systolic properties of overall cardiac function.
LA function influences left ventricular filling and cardiac output. Compromised LV function leads to reduced passive LA stretch and filling, contributing to increased LV filling pressures and a subsequent decline in LA function and compliance.
. LA strain is a measurement of atrial myocardial deformation, which is less influenced by cardiac preload and less angle-dependent compared to volumetric indices, such as the left atrial volume index and E/e' ratio.
LA strain is useful in various clinical scenarios, as predicting atrial fibrillation, diastolic dysfunction, and as a measure of LV filling pressure .
LA strain by echocardiographic speckle tracking analysis, is relatively inexpensive, non-invasive and easy to perform, so may be useful as a predictor of in-hospital outcomes.
Previous studies have demonstrated that reduced LA function is linked to clinical outcomes including all-cause mortality.
- Being tested
- 2D echocardiography
- Keywords
- strain in STEMI
- Medical subject headings
- ST Elevation Myocardial Infarction, Myocardial Infarction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
2D echocardiographyOther
LA strain by 2D echocardiographic speckle tracking analysis
| Study group | Role | What they receive |
|---|---|---|
| group normal strain | group normal parameters of LA strain by 2D echocardiography Receives: Other: 2D echocardiography | |
| group low strain | group low parameters of LA strain by 2D echocardiography Receives: Other: 2D echocardiography | |
| group control | control group to provide reference for normal parameters of LA strain for age by 2D echocardiography Receives: Other: 2D echocardiography |
What is being measured
The primary outcome is the main question the study is designed to answer.
the predictive value of left atrial strain for detecting incidence of in-hospital outcomes in patients with ST-segment elevation myocardial infarction undergoing primary PCI.
To evaluate the predictive value of left atrial strain for hospitalized patients with ST-segment elevation myocardial infarction undergoing primary PCI as regarding
- All-cause in-hospital mortality
- New/worsening heart failure requiring IV therapy or ICU care
- Cardiogenic shock (requiring inotropes or mechanical support)
- Sustained ventricular arrhythmia (VT/VF)
Measured: up to one week
Secondary outcomes (4)
correlation with other parameters
Correlation between LA strain parameters (reservoir, conduit, and contractile strain) by speckle tracking echocardiography and conventional echocardiographic indices of left ventricular (LV) systolic and diastolic function (LVEF, LVGLS , E/e', LAVI).
Measured: up to one week
LA strain across different territories
Compare LA strain (reservoir, conduit, contractile) by speckle tracking echocardiography between anterior (LAD-territory) vs inferior (RCA/LCx-territory) STEMI as which territory would have more affection to LA strain
Measured: up to one week
LA stain vs LAVI
Correlation between LA strain and LA volume index (LAVI) across infarct territories
Measured: up to one week
LA strain and right side
Correlate LA strain with TAPSE and PASP to evaluate right-heart interactions
Measured: up to one week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Dec 2025
- Study start1 Dec 2025 (estimated)
- Primary completion1 Dec 2026 (estimated)
- Study completion1 Feb 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (14)Papers the sponsor has linked to this study.
- Other trials for ST Elevation (STEMI) Myocardial InfarctionStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 135 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmed Youssef Dandrawy, Assiut University
- Investigators
- Doaa A Fouad, Professor, Principal investigator, Assiut UniversityMagdy I Algowhary, Assistant Professor, Principal investigator, Assiut UniversityAhmed G Bakry, Assistant Professor, Principal investigator, South Valley University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07263282
- Sponsor's protocol ID
- left atrial strain in STEMI
- Status last verified
- Dec 2025
- First submitted
- 16 Nov 2025
- Last updated
- 12 Dec 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Badano LP, Kolias TJ, Muraru D, Abraham TP, Aurigemma G, Edvardsen T, D'Hooge J, Donal E, Fraser AG, Marwick T, Mertens L, Popescu BA, Sengupta PP, Lancellotti P, Thomas JD, Voigt JU; Industry representatives; Reviewers: This document was reviewed by members of the 2016-2018 EACVI Scientific Documents Committee. Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging. Eur Heart J Cardiovasc Imaging. 2018 Jun 1;19(6):591-600. doi: 10.1093/ehjci/jey042.
PubMed 29596561Nagueh SF, Smiseth OA, Appleton CP, Byrd BF 3rd, Dokainish H, Edvardsen T, Flachskampf FA, Gillebert TC, Klein AL, Lancellotti P, Marino P, Oh JK, Popescu BA, Waggoner AD. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016 Apr;29(4):277-314. doi: 10.1016/j.echo.2016.01.011. No abstract available.
PubMed 27037982Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015 Jan;28(1):1-39.e14. doi: 10.1016/j.echo.2014.10.003.
PubMed 25559473Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, Caforio ALP, Crea F, Goudevenos JA, Halvorsen S, Hindricks G, Kastrati A, Lenzen MJ, Prescott E, Roffi M, Valgimigli M, Varenhorst C, Vranckx P, Widimsky P; ESC Scientific Document Group. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018 Jan 7;39(2):119-177. doi: 10.1093/eurheartj/ehx393. No abstract available.
PubMed 28886621Ahmeti A, Bytyci FS, Bielecka-Dabrowa A, Bytyci I, Henein MY. Prognostic value of left atrial volume index in acute coronary syndrome: A systematic review and meta-analysis. Clin Physiol Funct Imaging. 2021 Mar;41(2):128-135. doi: 10.1111/cpf.12689. Epub 2021 Jan 12.
PubMed 33372377Wu H, Wang H, Wang X, Xu L, Wu J. Myocardial strain combined with clinical risk factors in the prediction of in-hospital heart failure among patients with ST-segment elevation myocardial infarction. Clin Radiol. 2024 Nov;79(11):e1304-e1311. doi: 10.1016/j.crad.2024.07.016. Epub 2024 Jul 26.
PubMed 39191561Chu AA, Wu TT, Zhang L, Zhang Z. The prognostic value of left atrial and left ventricular strain in patients after ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. Cardiol J. 2021;28(5):678-689. doi: 10.5603/CJ.a2020.0010. Epub 2020 Feb 10.
PubMed 32037499Svartstein AW, Lassen MH, Skaarup KG, Grove GL, Vyff F, Ravnkilde K, Pedersen S, Galatius S, Modin D, Biering-Sorensen T. Predictive value of left atrial strain in relation to atrial fibrillation following acute myocardial infarction. Int J Cardiol. 2022 Oct 1;364:52-59. doi: 10.1016/j.ijcard.2022.05.026. Epub 2022 May 14.
PubMed 35577164Nagueh SF, Khan SU. Left Atrial Strain for Assessment of Left Ventricular Diastolic Function: Focus on Populations With Normal LVEF. JACC Cardiovasc Imaging. 2023 May;16(5):691-707. doi: 10.1016/j.jcmg.2022.10.011. Epub 2023 Jan 11.
PubMed 36752445Robinson S, Ring L, Oxborough D, Harkness A, Bennett S, Rana B, Sutaria N, Lo Giudice F, Shun-Shin M, Paton M, Duncan R, Willis J, Colebourn C, Bassindale G, Gatenby K, Belham M, Cole G, Augustine D, Smiseth OA. The assessment of left ventricular diastolic function: guidance and recommendations from the British Society of Echocardiography. Echo Res Pract. 2024 Jun 3;11(1):16. doi: 10.1186/s44156-024-00051-2.
PubMed 38825710Li R, Sun F, Piao S, He X, Li R, Xu L, Song G, Cong J. Left Atrial Strain and Compliance Correlate with Diastolic Dysfunction Grades and Complications during Pre-eclampsia: A Speckle-Tracking Echocardiography Study. Ultrasound Med Biol. 2021 Dec;47(12):3411-3419. doi: 10.1016/j.ultrasmedbio.2021.08.003. Epub 2021 Aug 27.
PubMed 34456083Lenselink C, Ricken KWLM, Groot HE, de Bruijne TJ, Hendriks T, van der Harst P, Voors AA, Lipsic E. Incidence and predictors of heart failure with reduced and preserved ejection fraction after ST-elevation myocardial infarction in the contemporary era of early percutaneous coronary intervention. Eur J Heart Fail. 2024 May;26(5):1142-1149. doi: 10.1002/ejhf.3225. Epub 2024 Apr 4.
PubMed 38576163Zhang L, Liu Z, Zhu Y, Wu M, Huang H, Yang W, Peng K, Zeng J. Development and validation of a prognostic model for predicting post-discharge mortality risk in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). J Cardiothorac Surg. 2024 Mar 30;19(1):163. doi: 10.1186/s13019-024-02665-3.
PubMed 38555468Abe T, Olanipekun T, Adedinsewo D, Ogunmoroti O, Udongwo N, Effoe V, Rice B, Onuorah I, Ghali JK, Mehta PK, Michos ED. Trends and Outcomes of ST-Segment-Elevation Myocardial Infarction Among Young Women in the United States. J Am Heart Assoc. 2023 Mar 7;12(5):e026811. doi: 10.1161/JAHA.122.026811. Epub 2023 Feb 27.
PubMed 36847058
Study at a glance
From the registry record, last updated by the sponsor on 12 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Left Atrium Strain as a Predictor of In-Hospital Outcomes in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
- ClinicalTrials.gov ID
- NCT07263282
- Acronym / sponsor ID
- left atrial strain in STEMI
- Keywords
- strain in STEMI
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 135 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 1 Dec 2025 (estimated)
- Primary completion
- 1 Dec 2026 (estimated)
- Study completion
- 1 Feb 2027 (estimated)
- First posted
- 4 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational study To evaluate the predictive value of left atrial strain for in-hospital outcomes in patients with ST-segment elevation myocardial infarction undergoing PPCI. The main questions it aims to answer are:
Is low parameters of left atrial strain associated early complication ? What is the correlation between LA strain parameters and conventional echocardiographic indices of left ventricular systolic and diastolic function ? Is there more affection to LA strain in certain territory over the others ? What is the correlation between LA strain and LA volume index across infarct territories ? Does LA strain Correlate with TAPSE and PASP to evaluate right-heart interactions ?
Detailed description
The overall trend of ST-segment elevated myocardial infarction has shown an annual increase. Post-infarction heart failure is one of the major adverse cardiovascular events in patients with post-percutaneous coronary intervention.
Therefore, the prediction and accurate assessment of in-hospital outcomes in patients have gained more research and clinical attention.
Left ventricular ejection fraction may no longer be the sole and most reliable predictor of events after a STEMI. Left atrial function may be a comprehensive marker of left-sided cardiac function, as it reflects both diastolic and systolic properties of overall cardiac function.
LA function influences left ventricular filling and cardiac output. Compromised LV function leads to reduced passive LA stretch and filling, contributing to increased LV filling pressures and a subsequent decline in LA function and compliance.
. LA strain is a measurement of atrial myocardial deformation, which is less influenced by cardiac preload and less angle-dependent compared to volumetric indices, such as the left atrial volume index and E/e' ratio.
LA strain is useful in various clinical scenarios, as predicting atrial fibrillation, diastolic dysfunction, and as a measure of LV filling pressure .
LA strain by echocardiographic speckle tracking analysis, is relatively inexpensive, non-invasive and easy to perform, so may be useful as a predictor of in-hospital outcomes.
Previous studies have demonstrated that reduced LA function is linked to clinical outcomes including all-cause mortality.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| group normal strain | – | Other: 2D echocardiographygroup normal parameters of LA strain by 2D echocardiography |
| group low strain | – | Other: 2D echocardiographygroup low parameters of LA strain by 2D echocardiography |
| group control | – | Other: 2D echocardiographycontrol group to provide reference for normal parameters of LA strain for age by 2D echocardiography |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- patients diagnosed with ST-segment elevation myocardial infarction and Underwent successful primary percutaneous coronary intervention and control group to provide baseline parameters for comparing LA strain and other echocardiographic parameters
Key inclusion criteria (5 listed)
- Adults aged ≥18 years.
- Diagnosed with ST-segment elevation myocardial infarction (STEMI) according to current ESC/AHA criteria
- Underwent successful primary percutaneous coronary intervention (PPCI) within 12 hours of symptom onset.
- Sinus rhythm on admission .
- Trans thoracic echocardiography (TTE) performed within 48 hours of admission with adequate image quality for speckle-tracking analysis.
Key exclusion criteria (8 listed)
- Previous myocardial infarction or prior PCI/CABG.
- Patients known to have atrial fibrillation or other sustained supraventricular arrhythmias.
- Significant valvular heart disease (severe stenosis or regurgitation).
- Congenital heart disease or cardiomyopathy (hypertrophic, dilated, restrictive).
- Poor echocardiographic window preventing LA strain analysis .
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| 2D echocardiographyLA strain by 2D echocardiographic speckle tracking analysis | Other | group control, group low strain, group normal strain |
Primary outcome
the predictive value of left atrial strain for detecting incidence of in-hospital outcomes in patients with ST-segment elevation myocardial infarction undergoing primary PCI.
Time frame: up to one week
To evaluate the predictive value of left atrial strain for hospitalized patients with ST-segment elevation myocardial infarction undergoing primary PCI as regarding * All-cause in-hospital mortality * New/worsening heart failure requiring IV therapy or ICU care * Cardiogenic shock (requiring inotropes or mechanical support) * Sustained ventricular arrhythmia (VT/VF)
4 secondary outcomes
correlation with other parameters
Time frame: up to one week
LA strain across different territories
Time frame: up to one week
LA stain vs LAVI
Time frame: up to one week
LA strain and right side
Time frame: up to one week
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Dec 2025.
- Results publication: PubMed 29596561Badano LP, Kolias TJ, Muraru D, Abraham TP, Aurigemma G, Edvardsen T, D'Hooge J, Donal E, Fraser AG, Marwick T, Mertens L, Popescu BA, Sengupta PP, Lancellotti P, Thomas JD, Voigt JU; Industry representatives; Reviewers: This document was reviewed by members of the 2016-2018 EACVI Scientific Documents Committee. Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging. Eur Heart J Cardiovasc Imaging. 2018 Jun 1;19(6):591-600. doi: 10.1093/ehjci/jey042.
- Results publication: PubMed 27037982Nagueh SF, Smiseth OA, Appleton CP, Byrd BF 3rd, Dokainish H, Edvardsen T, Flachskampf FA, Gillebert TC, Klein AL, Lancellotti P, Marino P, Oh JK, Popescu BA, Waggoner AD. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016 Apr;29(4):277-314. doi: 10.1016/j.echo.2016.01.011. No abstract available.
- Results publication: PubMed 25559473Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015 Jan;28(1):1-39.e14. doi: 10.1016/j.echo.2014.10.003.
- Results publication: PubMed 28886621Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, Caforio ALP, Crea F, Goudevenos JA, Halvorsen S, Hindricks G, Kastrati A, Lenzen MJ, Prescott E, Roffi M, Valgimigli M, Varenhorst C, Vranckx P, Widimsky P; ESC Scientific Document Group. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018 Jan 7;39(2):119-177. doi: 10.1093/eurheartj/ehx393. No abstract available.
- Results publication: PubMed 33372377Ahmeti A, Bytyci FS, Bielecka-Dabrowa A, Bytyci I, Henein MY. Prognostic value of left atrial volume index in acute coronary syndrome: A systematic review and meta-analysis. Clin Physiol Funct Imaging. 2021 Mar;41(2):128-135. doi: 10.1111/cpf.12689. Epub 2021 Jan 12.
- Results publication: PubMed 39191561Wu H, Wang H, Wang X, Xu L, Wu J. Myocardial strain combined with clinical risk factors in the prediction of in-hospital heart failure among patients with ST-segment elevation myocardial infarction. Clin Radiol. 2024 Nov;79(11):e1304-e1311. doi: 10.1016/j.crad.2024.07.016. Epub 2024 Jul 26.
- Results publication: PubMed 32037499Chu AA, Wu TT, Zhang L, Zhang Z. The prognostic value of left atrial and left ventricular strain in patients after ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. Cardiol J. 2021;28(5):678-689. doi: 10.5603/CJ.a2020.0010. Epub 2020 Feb 10.
- Results publication: PubMed 35577164Svartstein AW, Lassen MH, Skaarup KG, Grove GL, Vyff F, Ravnkilde K, Pedersen S, Galatius S, Modin D, Biering-Sorensen T. Predictive value of left atrial strain in relation to atrial fibrillation following acute myocardial infarction. Int J Cardiol. 2022 Oct 1;364:52-59. doi: 10.1016/j.ijcard.2022.05.026. Epub 2022 May 14.
- Results publication: PubMed 36752445Nagueh SF, Khan SU. Left Atrial Strain for Assessment of Left Ventricular Diastolic Function: Focus on Populations With Normal LVEF. JACC Cardiovasc Imaging. 2023 May;16(5):691-707. doi: 10.1016/j.jcmg.2022.10.011. Epub 2023 Jan 11.
- Results publication: PubMed 38825710Robinson S, Ring L, Oxborough D, Harkness A, Bennett S, Rana B, Sutaria N, Lo Giudice F, Shun-Shin M, Paton M, Duncan R, Willis J, Colebourn C, Bassindale G, Gatenby K, Belham M, Cole G, Augustine D, Smiseth OA. The assessment of left ventricular diastolic function: guidance and recommendations from the British Society of Echocardiography. Echo Res Pract. 2024 Jun 3;11(1):16. doi: 10.1186/s44156-024-00051-2.
- Results publication: PubMed 34456083Li R, Sun F, Piao S, He X, Li R, Xu L, Song G, Cong J. Left Atrial Strain and Compliance Correlate with Diastolic Dysfunction Grades and Complications during Pre-eclampsia: A Speckle-Tracking Echocardiography Study. Ultrasound Med Biol. 2021 Dec;47(12):3411-3419. doi: 10.1016/j.ultrasmedbio.2021.08.003. Epub 2021 Aug 27.
- Results publication: PubMed 38576163Lenselink C, Ricken KWLM, Groot HE, de Bruijne TJ, Hendriks T, van der Harst P, Voors AA, Lipsic E. Incidence and predictors of heart failure with reduced and preserved ejection fraction after ST-elevation myocardial infarction in the contemporary era of early percutaneous coronary intervention. Eur J Heart Fail. 2024 May;26(5):1142-1149. doi: 10.1002/ejhf.3225. Epub 2024 Apr 4.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Doaa A Fouad, Professor principal investigator
Assiut University
Magdy I Algowhary, Assistant Professor principal investigator
Assiut University
Ahmed G Bakry, Assistant Professor principal investigator
South Valley University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of ST Elevation (STEMI) Myocardial Infarction, run by Assiut University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 12 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ahmed Y Dandrawy, medical doctor (+201013086863, ahmed_youssef200@yahoo.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
the predictive value of left atrial strain for detecting incidence of in-hospital outcomes in patients with ST-segment elevation myocardial infarction undergoing primary PCI. (time frame: up to one week). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07263282, which also lists 14 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Dec 2025; AzTrials last refreshed its copy on 26 Oct 2026.