Microdissection Testicular Sperm ExtractionNCT07268235

Timing of Oocyte Retrieval and Micro Testicular Sperm Extraction

An observational study of Microdissection Testicular Sperm Extraction, run by Clinique Ovo at 1 site in Canada.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Trial summary

This is a retrospective study to assess outcomes of micro-TESE performed 24 or 48 hours before oocyte retrieval and ICSI. Read more about this study

Who is it for?: Ages 18 years and older, men only
Conditions the study is for: Microdissection Testicular Sperm Extraction
How many people: 129 participants
Where: 1 siteCanada
Study dates: 15 Nov 2025to 30 Nov 2025
Phase: Observational
Are there results?: None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 years and older
Men only
No healthy volunteers
Adult, Older adult

Study population: Men who underwent a micro-TESE for IVF treatment

Who may be able to join

Men who underwent a micro-TESE at the OVO clinic from June 2015 to January 2025.
Patients with non-obstructive azoospermia (NOA), (absence of spermatozoa in multiple semen analyses)
Patients with cryptozoospermia, (presence of a small number of spermatozoa detectable only after semen centrifugation)
Patients with oligoasthenoteratozoospermia (OAT), (sperm concentration of less than 15 million/mL, reduced motility and abnormal morphology)

Who cannot join

Patients who did not have any sperm noted following micro-TESE
Use of donor sperm or oocytes
Frozen sperm or oocytes
Same day oocyte retrieval and sperm extraction
Reversible cause of cryptozoospermia (i.e presence of a varicocele, febrile illness, or recent toxin exposure) Partial genital tract obstruction (i.e post-vaso-vasostomy, post-vasoepididymostomy, and low volume cryptozoospermia with ejaculatory duct obstruction)

Trial locations and contacts

1 site in 1 country.

Canada1 site

Clinique ovo
Montreal, Quebec, H4P 2S4

Other trials in Canada

About this study

Official title: Timing of Oocyte Retrieval and Micro Testicular Sperm Extraction: Does it Make a Difference? A Single-center Retrospective Cohort

This is a retrospective study to assess outcomes of micro-TESE performed 24 or 48 hours before oocyte retrieval and ICSI.

Read the detailed description

This retrospective study evaluates patients undergoing ICSI following micro-TESE. Participants are assigned to two groups based on the interval between sperm extraction and oocyte retrieval (24 vs. 48 hours). Clinical and embryological outcomes from the first embryo transfer will be assessed.

Conditions: Microdissection Testicular Sperm Extraction
Keywords: Nonobstructive Azoospermia, oligoasthenoteratozoospermia, intracytoplasmic sperm injection, In vitro fertilization, cryptozoospermia
Medical subject headings: Azoospermia, Nonobstructive, Oligospermia

What is being measured

The primary outcome is the main question the study is designed to answer.

Number of live births following ICSI with micro-TESE either 24 or 48 hours prior to oocyte retrieval
Measured: For IVF performed from June 2015 to January 2025

Secondary outcomes (3)

Percentage of fertilized oocytes with two pronuclei (2PN)
Measured: For IVF performed from June 2015 to January 2025
Percentage of usable blastocyst (defined as frozen and transferred blastocysts)
Measured: For IVF performed from June 2015 to January 2025
Pregnancy rate based on positive β-hCG
Measured: For IVF performed from June 2015 to January 2025

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

15 Nov 202530 Nov 2025

First posted5 Dec 2025
Study start15 Nov 2025
Primary completion30 Nov 2025
Study completion30 Nov 2025

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for Microdissection Testicular Sperm ExtractionStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Observational
Observational model: Cohort
Time perspective: Retrospective
Enrolment: 129 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07268235
Sponsor's protocol ID: Micro-TESE
Status last verified: Dec 2025
First submitted: 17 Nov 2025
Last updated: 5 Dec 2025
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No

Study at a glance

From the registry record, last updated by the sponsor on 5 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Timing of Oocyte Retrieval and Micro Testicular Sperm Extraction: Does it Make a Difference? A Single-center Retrospective Cohort
ClinicalTrials.gov ID: NCT07268235
Acronym / sponsor ID: Micro-TESE
Conditions: Microdissection Testicular Sperm Extraction
Keywords: Nonobstructive Azoospermia, oligoasthenoteratozoospermia, intracytoplasmic sperm injection, In vitro fertilization, cryptozoospermia
Study type: Observational
Recruitment status: Completed
Enrolment: 129 participants (actual)
Lead sponsor: Clinique OvoIndustry (pharma, biotech, devices)
Study start: 15 Nov 2025 (actual)
Primary completion: 30 Nov 2025 (actual)
Study completion: 30 Nov 2025 (actual)
First posted: 5 Dec 2025 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

This is a retrospective study to assess outcomes of micro-TESE performed 24 or 48 hours before oocyte retrieval and ICSI.

Detailed description

Study design

Observational model: Cohort
Time perspective: Retrospective

Who may qualify

Ages: 18 years and older
Sex: Male only
Healthy volunteers: Not accepted
Age groups: Adult, Older adult
Study population: Men who underwent a micro-TESE for IVF treatment

Key inclusion criteria (4 listed)

Men who underwent a micro-TESE at the OVO clinic from June 2015 to January 2025.
Patients with non-obstructive azoospermia (NOA), (absence of spermatozoa in multiple semen analyses)
Patients with cryptozoospermia, (presence of a small number of spermatozoa detectable only after semen centrifugation)
Patients with oligoasthenoteratozoospermia (OAT), (sperm concentration of less than 15 million/mL, reduced motility and abnormal morphology)

Key exclusion criteria (5 listed)

Patients who did not have any sperm noted following micro-TESE
Use of donor sperm or oocytes
Frozen sperm or oocytes
Same day oocyte retrieval and sperm extraction
Reversible cause of cryptozoospermia (i.e presence of a varicocele, febrile illness, or recent toxin exposure) Partial genital tract obstruction (i.e post-vaso-vasostomy, post-vasoepididymostomy, and low volume cryptozoospermia with ejaculatory duct obstruction)

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Primary outcome

Number of live births following ICSI with micro-TESE either 24 or 48 hours prior to oocyte retrieval
Time frame: For IVF performed from June 2015 to January 2025

3 secondary outcomes

Percentage of fertilized oocytes with two pronuclei (2PN)
Time frame: For IVF performed from June 2015 to January 2025
Percentage of usable blastocyst (defined as frozen and transferred blastocysts)
Time frame: For IVF performed from June 2015 to January 2025
Pregnancy rate based on positive β-hCG
Time frame: For IVF performed from June 2015 to January 2025

Results and safety

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 5 Dec 2025.
Individual participant dataSharing planned: No

Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

Isaac-Jacques Kadoch, MD principal investigator

Clinique Ovo

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

An observational study of Microdissection Testicular Sperm Extraction, run by Clinique Ovo at 1 site in Canada.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 5 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Number of live births following ICSI with micro-TESE either 24 or 48 hours prior to oocyte retrieval (time frame: For IVF performed from June 2015 to January 2025). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07268235.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Dec 2025.