Exercise PhysiologyNCT07268976
Jackfruit Effects on Adipokines and Cognition in Boxers
A study testing Jackfruit Supplement in people with Exercise Physiology and Cognitive Function, run by Bayburt University at 1 site in Turkey (Türkiye).
Trial summary
This study investigates the effects of jackfruit oil extract on adipokine levels (Irisin, Omentin-1), brain-derived neurotrophic factor (BDNF), cognitive performance, and body measurements in healthy young boxers aged 18-25. Read more about this study
- Who is it for?
- Ages 18 to 25 yearsHealthy volunteers can take part
- Conditions the study is for
- Exercise Physiology, Cognitive Function, Adipokine Response
- What is being tested?
- Jackfruit Supplement
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 7 Jan 2025to 10 Jun 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 25 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male boxers aged 18-25 years
- Healthy individuals without any diagnosed chronic disease
- Participating in regular weekly boxing training
- Able to continue training throughout the study period
- Willing to voluntarily participate in the study
- Able to provide written and/or verbal informed consent
Who cannot join
- Presence of chronic diseases (e.g., diabetes, cardiovascular disorders)
- Any injury or musculoskeletal condition preventing continuation of training
- Known allergy or hypersensitivity to jackfruit or its components
- Use of medications or supplements that could interfere with study outcomes
- Individuals who refuse to provide informed consent
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Bayburt Gençlik Merkezi Kapali Spor Salonu
Bayburt, Merkez, 69000
About this study
Official title: Effect of Jackfruit Consumption on Adipokine, Cerebral Response, Cognitive Performance and Anthropometric Parameters in Boxers
This study investigates the effects of jackfruit oil extract on adipokine levels (Irisin, Omentin-1), brain-derived neurotrophic factor (BDNF), cognitive performance, and body measurements in healthy young boxers aged 18-25. Participants were randomly assigned to four groups receiving different doses of jackfruit oil extract (0, 100, 200, 300 mg/kg) or no supplement. Saliva samples, cognitive tests, and body measurements were collected at the start of the study and after 30 days to evaluate the outcomes.
Read the detailed description
This interventional study evaluates the effects of different doses of jackfruit oil extract on healthy young boxers aged 18-25. Participants were randomly assigned to four groups and followed for 30 days.
Saliva samples were collected to measure irisin, omentin-1, and BDNF levels. Cognitive performance was assessed using the Wisconsin Card Sorting Test and the Trail Making Test. Anthropometric parameters including weight, BMI, waist, hip, chest, limb circumferences, and body composition were measured at baseline and on day 30.
Statistical analyses were performed using SPSS version 26. ANOVA, Duncan, and Pearson correlation tests were used to determine significant differences and relationships between variables.
This study is randomized and controlled. Participants receive either one of three doses of jackfruit oil extract or no supplement. The follow-up period is 30 days.
- Conditions
- Exercise Physiology, Cognitive Function, Adipokine Response, Brain-Derived Neurotrophic Factor (BDNF), Irisin, Omentin-1
- Being tested
- Jackfruit Supplement
- Keywords
- Boxer, Athletes, Jackfruit, Irisin, Omentin-1, BDNF, Cognitive Performance, Anthropometric Measurements, Adipokines, Trail Making Test, Wisconsin Card Sorting Test (WCST), Body Composition
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Jackfruit SupplementDietary supplement
Participants in the experimental group will receive a daily dose of jackfruit supplement during the study period. The supplement is administered orally and standardized for bioactive components. Participants in the control group will not receive any jackfruit supplement.
| Study group | Role | What they receive |
|---|---|---|
| J0 - Kontrol Grubu | No intervention | Katılımcılar hiçbir jackfruit yağı ekstresi almadı. Sadece normal diyet ve antrenman programlarını sürdürdüler. |
| J100 | Experimental | Katılımcılara 100 mg/kg jackfruit yağı ekstresi oral olarak 500 ml su içinde verildi. Müdahale 30 gün boyunca günlük olarak uygulandı. Receives: Dietary Supplement: Jackfruit Supplement |
| J200 | Experimental | Katılımcılara 200 mg/kg jackfruit yağı ekstresi oral olarak 500 ml su içinde verildi. Müdahale 30 gün boyunca günlük olarak uygulandı. Receives: Dietary Supplement: Jackfruit Supplement |
| J300 | Experimental | Katılımcılara 300 mg/kg jackfruit yağı ekstresi oral olarak 500 ml su içinde verildi. Müdahale 30 gün boyunca günlük olarak uygulandı. Receives: Dietary Supplement: Jackfruit Supplement |
What is being measured
The primary outcome is the main question the study is designed to answer.
Salivary Irisin Level
Irisin levels measured from saliva samples collected from participants using the ELISA method.
Measured: Day 0 and Day 30
Salivary Omentin-1 Level
Omentin-1 levels measured from saliva samples collected from participants using the ELISA method.
Measured: Day 0 and Day 30.
Salivary BDNF Level
BDNF levels measured from saliva samples collected from participants using the ELISA method.
Measured: Day 0 and Day 30.
Secondary outcomes (28)
Body Weight (kg)
Body weight measured using Tanita BC-418 bioimpedance device.
Measured: Day 0 and Day 30
Height (cm)
Height measured using a standard stadiometer.
Measured: Day 0 and Day 30
Body Mass Index (kg/m²)
BMI calculated using the formula weight (kg)/height (m²).
Measured: Day 0 and Day 30
Waist Circumference (cm)
Waist circumference measured with a flexible tape measure.
Measured: Day 0 and Day 30
Hip Circumference (cm)
Hip circumference measured with a flexible tape measure.
Measured: Day 0 and Day 30
Chest Circumference (cm)
Chest circumference measured using a flexible tape measure.
Measured: Day 0 and Day 30
Upper Arm Circumference (Right/Left, cm)
Right and left upper arm circumferences measured with a flexible tape measure.
Measured: Day 0 and Day 30
Wrist Circumference (Right/Left, cm)
Right and left wrist circumferences measured with a flexible tape measure.
Measured: Day 0 and Day 30
Thigh Circumference (Right/Left, cm)
Right and left thigh circumferences measured with a flexible tape measure.
Measured: Day 0 and Day 30
Calf Circumference (Right/Left, cm)
Right and left calf circumferences measured with a flexible tape measure.
Measured: Day 0 and Day 30
Total Body Fat Mass (kg)
Total body fat mass measured using Tanita BC-418.
Measured: Day 0 and Day 30
Total Body Fat Percentage (%)
Total body fat percentage measured using Tanita BC-418.
Measured: Day 0 and Day 30
Abdominal Fat Mass (kg)
Abdominal fat mass measured using Tanita BC-418.
Measured: Day 0 and Day 30
Regional Fat Percentages (Right/Left Arm & Leg)
Regional fat percentages for arms and legs measured by Tanita BC-418.
Measured: Day 0 and Day 30
Total Muscle Mass (kg)
Total muscle mass assessed using Tanita BC-418.
Measured: Day 0 and Day 30
Regional Muscle Mass (Right/Left Arm & Leg, kg)
Regional muscle mass of arms and legs measured by Tanita BC-418.
Measured: Day 0 and Day 30
Basal Metabolic Rate (BMR)
Basal metabolic rate calculated by Tanita BC-418.
Measured: Day 0 and Day 30
Metabolic Age
Metabolic age estimated using Tanita BC-418 device.
Measured: Day 0 and Day 30
Total Body Water (kg)
Total body water measured via bioimpedance analysis.
Measured: Day 0 and Day 30
Total Body Water Percentage (%)
Total Body Water Percentage (%)
Measured: Day 0 and Day 30
WCST Total Correct Responses
Total correct responses obtained from the Wisconsin Card Sorting Test.
Measured: Day 0 and Day 30
WCST Total Incorrect Responses
Total incorrect responses measured using the Wisconsin Card Sorting Test.
Measured: Day 0 and Day 30
WCST Perseverative Error Count
Perseverative errors recorded during the Wisconsin Card Sorting Test.
Measured: Day 0 and Day 30
WCST Total Time (seconds)
Total time required to complete the Wisconsin Card Sorting Test.
Measured: Day 0 and Day 30
Trail Making Test A Completion Time (seconds)
Completion time for Trail Making Test Part A.
Measured: Day 0 and Day 30
Trail Making Test B Completion Time (seconds)
Completion time for Trail Making Test Part B.
Measured: Day 0 and Day 30
Biomarker Correlations (Irisin-Omentin-BDNF vs. Dose/Day)
Pearson correlation analysis examining relationships between biomarkers and intervention dose/day.
Measured: Based on Day 30 measurements
Safety Outcomes (Adverse Event Monitoring)
Monitoring of potential adverse events related to 300 mg/kg JOE administration.
Measured: Continuous monitoring throughout 30 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Dec 2025
- Study start7 Jan 2025
- Primary completion10 Feb 2025
- Study completion10 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Exercise PhysiologyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants were randomly assigned to four parallel groups (J0, J100, J200, J300) receiving different doses of jackfruit oil extract (0, 100, 200, 300 mg/kg). Each group received the assigned intervention for 30 days, and outcomes including salivary irisin, omentin-1, BDNF levels, cognitive performance, and anthropometric measurements were assessed at baseline and at the end of the intervention.
- Masking
- None (open label)
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Bayburt University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, HATİCE BUDAK, Bayburt University
- Investigators
- BÜLENT BAYRAKTAR, Principal investigator, BAYBURT ÜNİVERSİTESİ
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07268976
- Sponsor's protocol ID
- BU-2025-01
- Status last verified
- Dec 2025
- First submitted
- 26 Aug 2025
- Last updated
- 8 Dec 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified participant-level data including salivary irisin, omentin-1, BDNF levels, anthropometric measurements, and cognitive test results will be shared with other researchers upon reasonable request after publication of the main study results. Access will require approval from the institutional ethics committee and signing a data use agreement.
Study at a glance
From the registry record, last updated by the sponsor on 8 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Jackfruit Consumption on Adipokine, Cerebral Response, Cognitive Performance and Anthropometric Parameters in Boxers
- ClinicalTrials.gov ID
- NCT07268976
- Acronym / sponsor ID
- BU-2025-01
- Conditions
- Exercise Physiology, Cognitive Function, Adipokine Response, Brain-Derived Neurotrophic Factor (BDNF), Irisin, Omentin-1
- Keywords
- Boxer, Athletes, Jackfruit, Irisin, Omentin-1, BDNF, Cognitive Performance, Anthropometric Measurements
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Bayburt UniversityUniversity, hospital or other
- Study start
- 7 Jan 2025 (actual)
- Primary completion
- 10 Feb 2025 (actual)
- Study completion
- 10 Jun 2025 (actual)
- First posted
- 8 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigates the effects of jackfruit oil extract on adipokine levels (Irisin, Omentin-1), brain-derived neurotrophic factor (BDNF), cognitive performance, and body measurements in healthy young boxers aged 18-25. Participants were randomly assigned to four groups receiving different doses of jackfruit oil extract (0, 100, 200, 300 mg/kg) or no supplement. Saliva samples, cognitive tests, and body measurements were collected at the start of the study and after 30 days to evaluate the outcomes.
Detailed description
This interventional study evaluates the effects of different doses of jackfruit oil extract on healthy young boxers aged 18-25. Participants were randomly assigned to four groups and followed for 30 days.
Saliva samples were collected to measure irisin, omentin-1, and BDNF levels. Cognitive performance was assessed using the Wisconsin Card Sorting Test and the Trail Making Test. Anthropometric parameters including weight, BMI, waist, hip, chest, limb circumferences, and body composition were measured at baseline and on day 30.
Statistical analyses were performed using SPSS version 26. ANOVA, Duncan, and Pearson correlation tests were used to determine significant differences and relationships between variables.
This study is randomized and controlled. Participants receive either one of three doses of jackfruit oil extract or no supplement. The follow-up period is 30 days.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
- Model description
- Participants were randomly assigned to four parallel groups (J0, J100, J200, J300) receiving different doses of jackfruit oil extract (0, 100, 200, 300 mg/kg). Each group received the assigned intervention for 30 days, and outcomes including salivary irisin, omentin-1, BDNF levels, cognitive performance, and anthropometric measurements were assessed at baseline and at the end of the intervention.
| Arm | Type | Receives |
|---|---|---|
| J0 - Kontrol Grubu | No intervention | –Katılımcılar hiçbir jackfruit yağı ekstresi almadı. Sadece normal diyet ve antrenman programlarını sürdürdüler. |
| J100 | Experimental | Dietary Supplement: Jackfruit SupplementKatılımcılara 100 mg/kg jackfruit yağı ekstresi oral olarak 500 ml su içinde verildi. Müdahale 30 gün boyunca günlük olarak uygulandı. |
| J200 | Experimental | Dietary Supplement: Jackfruit SupplementKatılımcılara 200 mg/kg jackfruit yağı ekstresi oral olarak 500 ml su içinde verildi. Müdahale 30 gün boyunca günlük olarak uygulandı. |
| J300 | Experimental | Dietary Supplement: Jackfruit SupplementKatılımcılara 300 mg/kg jackfruit yağı ekstresi oral olarak 500 ml su içinde verildi. Müdahale 30 gün boyunca günlük olarak uygulandı. |
Who may qualify
- Ages
- 18 to 25 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Male boxers aged 18-25 years
- Healthy individuals without any diagnosed chronic disease
- Participating in regular weekly boxing training
- Able to continue training throughout the study period
- Willing to voluntarily participate in the study
Key exclusion criteria (5 listed)
- Presence of chronic diseases (e.g., diabetes, cardiovascular disorders)
- Any injury or musculoskeletal condition preventing continuation of training
- Known allergy or hypersensitivity to jackfruit or its components
- Use of medications or supplements that could interfere with study outcomes
- Individuals who refuse to provide informed consent
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Jackfruit SupplementParticipants in the experimental group will receive a daily dose of jackfruit supplement during the study period. The supplement is administered orally and standardized for bioactive components. Participants in the control group will not receive any jackfruit supplement. | Dietary supplement | J100, J200, J300 |
Primary outcome
Salivary Irisin Level
Time frame: Day 0 and Day 30
Irisin levels measured from saliva samples collected from participants using the ELISA method.
Salivary Omentin-1 Level
Time frame: Day 0 and Day 30.
Omentin-1 levels measured from saliva samples collected from participants using the ELISA method.
Salivary BDNF Level
Time frame: Day 0 and Day 30.
BDNF levels measured from saliva samples collected from participants using the ELISA method.
28 secondary outcomes
Body Weight (kg)
Time frame: Day 0 and Day 30
Height (cm)
Time frame: Day 0 and Day 30
Body Mass Index (kg/m²)
Time frame: Day 0 and Day 30
Waist Circumference (cm)
Time frame: Day 0 and Day 30
Hip Circumference (cm)
Time frame: Day 0 and Day 30
Chest Circumference (cm)
Time frame: Day 0 and Day 30
Upper Arm Circumference (Right/Left, cm)
Time frame: Day 0 and Day 30
Wrist Circumference (Right/Left, cm)
Time frame: Day 0 and Day 30
Thigh Circumference (Right/Left, cm)
Time frame: Day 0 and Day 30
Calf Circumference (Right/Left, cm)
Time frame: Day 0 and Day 30
Total Body Fat Mass (kg)
Time frame: Day 0 and Day 30
Total Body Fat Percentage (%)
Time frame: Day 0 and Day 30
Abdominal Fat Mass (kg)
Time frame: Day 0 and Day 30
Regional Fat Percentages (Right/Left Arm & Leg)
Time frame: Day 0 and Day 30
Total Muscle Mass (kg)
Time frame: Day 0 and Day 30
Regional Muscle Mass (Right/Left Arm & Leg, kg)
Time frame: Day 0 and Day 30
Basal Metabolic Rate (BMR)
Time frame: Day 0 and Day 30
Metabolic Age
Time frame: Day 0 and Day 30
Total Body Water (kg)
Time frame: Day 0 and Day 30
Total Body Water Percentage (%)
Time frame: Day 0 and Day 30
WCST Total Correct Responses
Time frame: Day 0 and Day 30
WCST Total Incorrect Responses
Time frame: Day 0 and Day 30
WCST Perseverative Error Count
Time frame: Day 0 and Day 30
WCST Total Time (seconds)
Time frame: Day 0 and Day 30
Trail Making Test A Completion Time (seconds)
Time frame: Day 0 and Day 30
Trail Making Test B Completion Time (seconds)
Time frame: Day 0 and Day 30
Biomarker Correlations (Irisin-Omentin-BDNF vs. Dose/Day)
Time frame: Based on Day 30 measurements
Safety Outcomes (Adverse Event Monitoring)
Time frame: Continuous monitoring throughout 30 days
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Dec 2025.
- This study investigates the effects of jackfruit consumption on adipokine levels (irisin, omentin-1), brain-derived neurotrophic factor (BDNF), cognitive performance, and anthropometric parameters in young boxers aged 18-25.Link provided by the sponsor.
- Individual participant dataSharing planned: Yes. De-identified participant-level data including salivary irisin, omentin-1, BDNF levels, anthropometric measurements, and cognitive test results will be shared with other researchers upon reasonable request after publication of the main study results. Access will require approval from the institutional ethics committee and signing a data use agreement.
Related trials for Exercise Physiology
Enrolling by invitation
Online Exercise Program for Transplant Patients: A Pilot Study
Kidney Transplantation, Physical Function
Not yet recruiting
Effect of Box Breathing Exercise on Anxiety, Pain, and Pulmonary Function Tests in Patients Undergoing Colonoscopy
Colonoscopy
Active, not recruiting
Diaphragm Mobilization in Adolescent Idiopathic Scoliosis
Adolescent Idiopathic Scoliosis
Not yet recruitingObservational study
Validation of Uzbek SARC-F and IPAQ-SF Questionnaires in Adults With and Without Hypothyroidism
Hypothyroidism, Psychometrics
Active, not recruiting
All-extremity Exercise During Breast Cancer Chemotherapy
Breast Cancer
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
BÜLENT BAYRAKTAR principal investigator
BAYBURT ÜNİVERSİTESİ
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Jackfruit Supplement in people with Exercise Physiology and Cognitive Function, run by Bayburt University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Salivary Irisin Level (time frame: Day 0 and Day 30). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Dec 2025.