Alveolar Bone ResorptionNCT07272694
Split Crest Procedure: Is It Necessary to Fill the Gap?
A study testing Split Crest Technique in people with Alveolar Bone Resorption and Alveolar Bone Grafting, run by Vladimir Biocanin at 1 site in Serbia.
Trial summary
This prospective controlled clinical study evaluates the effectiveness of adding bone graft or dentin graft material during the split crest (alveolar ridge splitting) procedure for horizontal ridge augmentation with simultaneous implant placement. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Alveolar Bone Resorption, Alveolar Bone Grafting, Bone Expansion
- What is being tested?
- Split Crest Technique
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 1 siteSerbia
- Study dates
- 13 Mar 2024to 14 Mar 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Adult patients aged 18-65 years
- Indication for tooth extraction in posterior mandibular region with planned implant placement
- Presence of post-extraction alveolar bone defect requiring ridge preservation procedure
- Good general health (ASA I or ASA II)
- Ability to understand the study procedures and provide written informed consent
- Willingness to comply with scheduled follow-up visits and study protocol
Who cannot join
- Systemic diseases affecting bone healing (e.g. uncontrolled diabetes, osteoporosis, metabolic bone disorders)
- History of radiotherapy in the head and neck region
- Use of bisphosphonates or other antiresorptive medications
- Active periodontal or periapical infection at the surgical site
- Heavy smokers (>10 cigarettes per day)
- Pregnancy or breastfeeding
- Known allergies to materials used in the study
- Poor oral hygiene or lack of complianc
Trial locations and contacts
1 site in 1 country.
Serbia1 site
Faculty of Stomatology, Department of Oral Surgery, University Business Academy in Novi Sad,
Pančevo, 26000
About this study
Official title: A Prospective Controlled Clinical Study Evaluating the Effect of Bone and Autologous Dentin Grafting in the Osteotomy Gap During the Split Crest Procedure With Simultaneous Implant Placement
This prospective controlled clinical study evaluates the effectiveness of adding bone graft or dentin graft material during the split crest (alveolar ridge splitting) procedure for horizontal ridge augmentation with simultaneous implant placement.
The study includes patients with narrow alveolar ridges requiring implant-supported rehabilitation. Participants are divided into three groups: split crest without grafting, split crest with bone graft, and split crest with dentin graft. The aim is to determine whether the addition of graft material to the osteotomy gap improves bone width, bone density, and primary implant stability compared to the split crest technique alone.
Read more
Clinical and radiographic assessments are performed using cone-beam computed tomography (CBCT) and implant stability measurements (ISQ values) before surgery, immediately after implant placement, and three months postoperatively. All patients are monitored over a one-year follow-up period to evaluate healing progression and treatment outcomes.
This study seeks to identify the most effective approach for horizontal ridge augmentation and to improve clinical decision-making in implant dentistry. The findings aim to contribute to optimizing surgical protocols, enhancing implant stability, and improving long-term functional outcomes for patients.
Participation is voluntary, and all procedures are conducted in accordance with approved ethical standards and clinical guidelines.
- Being tested
- Split Crest Technique
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Split Crest TechniqueProcedure or surgery
A surgical split crest (alveolar ridge splitting) procedure performed to increase horizontal alveolar bone width and enable simultaneous dental implant placement. A controlled osteotomy is created along the crest of the ridge, followed by gradual expansion of the buccal cortical plate to form an osteotomy gap for implant insertion.
| Study group | Role | What they receive |
|---|---|---|
| Split Crest Only | Active comparator | Not described Receives: Procedure: Split Crest Technique |
| Split Crest + Bone Graft | Experimental | Not described Receives: Procedure: Split Crest Technique |
| Split Crest + Dentin Graft | Experimental | Not described Receives: Procedure: Split Crest Technique |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in alveolar ridge width following split crest proceduree with or without bone or dentin grafting
Measured: Preoparative, Immediately postoperative, and 3 months after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Dec 2025
- Study start13 Mar 2024
- Primary completion18 Jun 2024
- Study completion14 Mar 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alveolar Bone ResorptionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 24 participants (actual)
Sponsor and investigators
- Lead sponsor
- Vladimir Biocanin
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Vladimir Biocanin, Faculty of Stomatology in Pancevo
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07272694
- Sponsor's protocol ID
- SC-DENTIN-2024-01
- Status last verified
- Nov 2025
- First submitted
- 26 Nov 2025
- Last updated
- 9 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 9 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Prospective Controlled Clinical Study Evaluating the Effect of Bone and Autologous Dentin Grafting in the Osteotomy Gap During the Split Crest Procedure With Simultaneous Implant Placement
- ClinicalTrials.gov ID
- NCT07272694
- Acronym / sponsor ID
- SC-DENTIN-2024-01
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 24 participants (actual)
- Lead sponsor
- Vladimir BiocaninUniversity, hospital or other
- Study start
- 13 Mar 2024 (actual)
- Primary completion
- 18 Jun 2024 (actual)
- Study completion
- 14 Mar 2025 (actual)
- First posted
- 9 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective controlled clinical study evaluates the effectiveness of adding bone graft or dentin graft material during the split crest (alveolar ridge splitting) procedure for horizontal ridge augmentation with simultaneous implant placement.
The study includes patients with narrow alveolar ridges requiring implant-supported rehabilitation. Participants are divided into three groups: split crest without grafting, split crest with bone graft, and split crest with dentin graft. The aim is to determine whether the addition of graft material to the osteotomy gap improves bone width, bone density, and primary implant stability compared to the split crest technique alone.
Clinical and radiographic assessments are performed using cone-beam computed tomography (CBCT) and implant stability measurements (ISQ values) before surgery, immediately after implant placement, and three months postoperatively. All patients are monitored over a one-year follow-up period to evaluate healing progression and treatment outcomes.
This study seeks to identify the most effective approach for horizontal ridge augmentation and to improve clinical decision-making in implant dentistry. The findings aim to contribute to optimizing surgical protocols, enhancing implant stability, and improving long-term functional outcomes for patients.
Participation is voluntary, and all procedures are conducted in accordance with approved ethical standards and clinical guidelines.
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Split Crest Only | Active comparator | Procedure: Split Crest Technique |
| Split Crest + Bone Graft | Experimental | Procedure: Split Crest Technique |
| Split Crest + Dentin Graft | Experimental | Procedure: Split Crest Technique |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (6 listed)
- Adult patients aged 18-65 years
- Indication for tooth extraction in posterior mandibular region with planned implant placement
- Presence of post-extraction alveolar bone defect requiring ridge preservation procedure
- Good general health (ASA I or ASA II)
- Ability to understand the study procedures and provide written informed consent
Key exclusion criteria (8 listed)
- Systemic diseases affecting bone healing (e.g. uncontrolled diabetes, osteoporosis, metabolic bone disorders)
- History of radiotherapy in the head and neck region
- Use of bisphosphonates or other antiresorptive medications
- Active periodontal or periapical infection at the surgical site
- Heavy smokers (>10 cigarettes per day)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Split Crest TechniqueA surgical split crest (alveolar ridge splitting) procedure performed to increase horizontal alveolar bone width and enable simultaneous dental implant placement. A controlled osteotomy is created along the crest of the ridge, followed by gradual expansion of the buccal cortical plate to form an osteotomy gap for implant insertion. | Procedure or surgery | Split Crest + Bone Graft, Split Crest + Dentin Graft, Split Crest Only |
Primary outcome
Change in alveolar ridge width following split crest proceduree with or without bone or dentin grafting
Time frame: Preoparative, Immediately postoperative, and 3 months after surgery
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Dec 2025.
- Individual participant dataSharing planned: No
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Investigation of the Effect of Horizontal Platelet Rich Fibrin Placed in Tooth Extraction Sockets on Bone Formation
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Effect of Collagen Membrane on Ridge Preservation
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Not yet recruitingPhase 1/2
Alveolar Ridge Preservation (ARP) Study Using Alloplastic Biomaterial and a Resorbable Synthetic Membrane. A Digital Workflow (CBCT/Scanner) Evaluates Hard and Soft Tissue Volumetric Changes at 4 Months, Validating Support for the Gingival Phenotype and Buccal Bone Plate.
Alveolar Ridge Augmentation, Bone Substitutes
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Split Crest Technique in people with Alveolar Bone Resorption and Alveolar Bone Grafting, run by Vladimir Biocanin at 1 site in Serbia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Serbia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in alveolar ridge width following split crest proceduree with or without bone or dentin grafting (time frame: Preoparative, Immediately postoperative, and 3 months after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Dec 2025.