Suture TechniquesNCT07274943
End-to-Side Interrupted Versus Continuous Arterial Suturing in Living Donor Kidney Transplantation
An observational study of Suture Techniques and Suture, Interrupted, run by Assiut University.
Trial summary
This study will compare two standard ways of stitching the kidney artery to the iliac artery in adults receiving a living donor kidney transplant. The two techniques are interrupted suturing and continuous suturing. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Suture Techniques, Suture, Interrupted, Continuous Suture
- How many people
- 70 participants
- Where
- No sites listed yet
- Study dates
- Jan 2026to Feb 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Adult, Older adult
Study population: The study includes adult recipients of living donor kidney transplants performed at Assiut University Urology Hospital. Patients are selected based on having undergone or scheduled for living donor kidney transplantation, excluding those with end-to-end arterial suturing with the internal iliac artery, early acute rejection, or inadequate follow-up or data. Both retrospective cases and prospectively recruited patients with complete clinical, radiological, and laboratory data are included. The sample size is 70 patients divided equally between two arterial suturing technique groups.
Who may be able to join
- Adult patients undergoing living donor kidney transplantation at Assiut Kidney Transplantation Unit since November 2015
Who cannot join
- Patients undergoing end-to-end arterial suturing with internal iliac artery
- Patients with acute allograft rejection within the first post-transplant week
- Patients with follow-up shorter than 3 months after transplantation
- Patients with missing relevant preoperative or postoperative data
- Patients refusing participation
About this study
Official title: Patterns Of End-To-Side Arterial Suturing To The Iliac Arteries In Living Donor Kidney Transplantation
This study will compare two standard ways of stitching the kidney artery to the iliac artery in adults receiving a living donor kidney transplant. The two techniques are interrupted suturing and continuous suturing. The study will review past transplant cases and follow new patients at Assiut University Urology Hospital. For each patient, the team will record details of the operation, blood flow in the kidney artery, kidney function, and any surgical or vascular complications during the first three months after surgery. The main goals are to see whether one suturing pattern shortens cold ischemia time and improves early blood flow measurements, and to explore how these techniques affect early graft function, complication rates, and short-term graft and patient survival.
Read the detailed description
This observational study evaluates whether different patterns of arterial suturing during kidney transplantation influence short-term graft function and vascular outcomes in adult living donor kidney recipients. The study compares interrupted versus continuous end-to-side arterial anastomosis to the iliac arteries using standardized surgical and postoperative care pathways.
The research is designed as a combined retrospective and prospective non-randomized comparative cohort study conducted at the Assiut Kidney Transplantation Unit, Assiut University Urology Hospital. Adult patients who underwent or will undergo living donor kidney transplantation from November 2015 onward are assigned to one of two exposure groups based on the arterial suturing pattern chosen by the operating surgeon, without protocol-driven randomization. Preoperative assessment follows national kidney transplantation guidelines and includes detailed history, physical examination, laboratory investigations, and multimodal imaging of donors and recipients. Intraoperative management is standardized regarding donor nephrectomy technique, transplant approach, vascular anastomosis sites, ureteroneocystostomy, ischemia time recording, and immunosuppressive regimen. Postoperative follow-up extends for at least three months, with serial clinical evaluations, renal function tests, Doppler ultrasound, and radiologic imaging when indicated to detect vascular complications and characterize graft function trajectories over time. The primary goal is to determine whether one suturing pattern is associated with more favorable ischemia metrics and hemodynamic parameters, thereby informing best practice for vascular anastomosis in living donor kidney transplantation.
- Keywords
- donor kidney transplantation, end-to-side arterial suturing, iliac arteries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Interrupted Arterial Suturing | Adult living donor kidney transplant recipients whose renal artery is anastomosed end-to-side to the external or common iliac artery using interrupted 6/0 Prolene sutures as part of standard surgical practice. | |
| Continuous Arterial Suturing | Adult living donor kidney transplant recipients whose renal artery is anastomosed end-to-side to the external or common iliac artery using continuous 6/0 Prolene sutures as part of standard surgical practice. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cold Ischemia Time
Duration in minutes from the start of graft perfusion with cold preservation solution in the donor to arterial de-clamping in the recipient, compared between interrupted and continuous arterial suturing groups.
Measured: From donor graft perfusion to arterial de-clamping during the transplant operation (single intraoperative measurement).
Early Graft Arterial Blood Flow (Resistive Index and Systolic Velocity)
Mean systolic blood flow velocity and resistive index of the transplanted kidney artery measured by Doppler ultrasound and compared between interrupted and continuous arterial suturing groups.
Measured: Within the first 3 months after transplantation (assessments at approximately 1 week, 1 month, and 3 months post-transplant).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Dec 2025
- Study startJan 2026 (estimated)
- Primary completionJan 2027 (estimated)
- Study completionFeb 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Suture TechniquesStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 70 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Aly Adel Abdelhamid Ahmed Elyounsy, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07274943
- Sponsor's protocol ID
- Arterial suturing in kidney
- Status last verified
- Nov 2025
- First submitted
- 28 Nov 2025
- Last updated
- 10 Dec 2025
- Results posted
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Patterns Of End-To-Side Arterial Suturing To The Iliac Arteries In Living Donor Kidney Transplantation
- ClinicalTrials.gov ID
- NCT07274943
- Acronym / sponsor ID
- Arterial suturing in kidney
- Keywords
- donor kidney transplantation, end-to-side arterial suturing, iliac arteries
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 70 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- Jan 2026 (estimated)
- Primary completion
- Jan 2027 (estimated)
- Study completion
- Feb 2027 (estimated)
- First posted
- 10 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will compare two standard ways of stitching the kidney artery to the iliac artery in adults receiving a living donor kidney transplant. The two techniques are interrupted suturing and continuous suturing. The study will review past transplant cases and follow new patients at Assiut University Urology Hospital. For each patient, the team will record details of the operation, blood flow in the kidney artery, kidney function, and any surgical or vascular complications during the first three months after surgery. The main goals are to see whether one suturing pattern shortens cold ischemia time and improves early blood flow measurements, and to explore how these techniques affect early graft function, complication rates, and short-term graft and patient survival.
Detailed description
This observational study evaluates whether different patterns of arterial suturing during kidney transplantation influence short-term graft function and vascular outcomes in adult living donor kidney recipients. The study compares interrupted versus continuous end-to-side arterial anastomosis to the iliac arteries using standardized surgical and postoperative care pathways.
The research is designed as a combined retrospective and prospective non-randomized comparative cohort study conducted at the Assiut Kidney Transplantation Unit, Assiut University Urology Hospital. Adult patients who underwent or will undergo living donor kidney transplantation from November 2015 onward are assigned to one of two exposure groups based on the arterial suturing pattern chosen by the operating surgeon, without protocol-driven randomization. Preoperative assessment follows national kidney transplantation guidelines and includes detailed history, physical examination, laboratory investigations, and multimodal imaging of donors and recipients. Intraoperative management is standardized regarding donor nephrectomy technique, transplant approach, vascular anastomosis sites, ureteroneocystostomy, ischemia time recording, and immunosuppressive regimen. Postoperative follow-up extends for at least three months, with serial clinical evaluations, renal function tests, Doppler ultrasound, and radiologic imaging when indicated to detect vascular complications and characterize graft function trajectories over time. The primary goal is to determine whether one suturing pattern is associated with more favorable ischemia metrics and hemodynamic parameters, thereby informing best practice for vascular anastomosis in living donor kidney transplantation.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Interrupted Arterial Suturing | – | –Adult living donor kidney transplant recipients whose renal artery is anastomosed end-to-side to the external or common iliac artery using interrupted 6/0 Prolene sutures as part of standard surgical practice. |
| Continuous Arterial Suturing | – | –Adult living donor kidney transplant recipients whose renal artery is anastomosed end-to-side to the external or common iliac artery using continuous 6/0 Prolene sutures as part of standard surgical practice. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- The study includes adult recipients of living donor kidney transplants performed at Assiut University Urology Hospital. Patients are selected based on having undergone or scheduled for living donor kidney transplantation, excluding those with end-to-end arterial suturing with the internal iliac artery, early acute rejection, or inadequate follow-up or data. Both retrospective cases and prospectively recruited patients with complete clinical, radiological, and laboratory data are included. The sample size is 70 patients divided equally between two arterial suturing technique groups.
Key inclusion criteria (1 listed)
- Adult patients undergoing living donor kidney transplantation at Assiut Kidney Transplantation Unit since November 2015
Key exclusion criteria (5 listed)
- Patients undergoing end-to-end arterial suturing with internal iliac artery
- Patients with acute allograft rejection within the first post-transplant week
- Patients with follow-up shorter than 3 months after transplantation
- Patients with missing relevant preoperative or postoperative data
- Patients refusing participation
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Cold Ischemia Time
Time frame: From donor graft perfusion to arterial de-clamping during the transplant operation (single intraoperative measurement).
Duration in minutes from the start of graft perfusion with cold preservation solution in the donor to arterial de-clamping in the recipient, compared between interrupted and continuous arterial suturing groups.
Early Graft Arterial Blood Flow (Resistive Index and Systolic Velocity)
Time frame: Within the first 3 months after transplantation (assessments at approximately 1 week, 1 month, and 3 months post-transplant).
Mean systolic blood flow velocity and resistive index of the transplanted kidney artery measured by Doppler ultrasound and compared between interrupted and continuous arterial suturing groups.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Dec 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Suture Techniques and Suture, Interrupted, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 10 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cold Ischemia Time (time frame: From donor graft perfusion to arterial de-clamping during the transplant operation (single intraoperative measurement).). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Dec 2025.