Computed TomographyNCT07275281
Incidental Findings on Coronary Computed Tomography Angiography
An observational study of Computed Tomography and Coronary Angiography, run by Jordan Collaborating Cardiology Group at 1 site in Jordan.
Trial summary
Coronary CT angiography (CCTA) is increasingly used for ischemic heart disease diagnosis. The rising number of CCTA tests has led to a significant increase in the number of finding unexpected incidental extracardiac diseases. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Computed Tomography, Coronary Angiography, Incidental Findings
- What is being tested?
- CCTA (Review of the scans)
- How many people
- 2,000 participants
- Where
- 1 siteJordan
- Study dates
- 2 Jan 2026to 28 Feb 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: 1. All adult patients who underwent CCTA for chest pain diagnosis. 2. Scans will be reviewed seeking the presence of coronary non atherosclerotic disease in the coronaries, cardiac structure and non cardiac structures.
Who may be able to join
- Adult patients ho underwent CCTA
Who cannot join
- None
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Musa Saadeh contact
Jordan1 site
Istishari Hospital
Amman, 11184
Ayman Hammoudeh, MD, FACC, 065001000, hammoudeh_ayman@yahoo.com
Wasfi Alghween, MD, 065001000
About this study
Official title: Incidental Noncardiac Findings on Coronary Computed Tomography Angiography
Coronary CT angiography (CCTA) is increasingly used for ischemic heart disease diagnosis. The rising number of CCTA tests has led to a significant increase in the number of finding unexpected incidental extracardiac diseases.
Read the detailed description
The increasing utilization of coronary computed tomography (CT) angiography (CCTA) to diagnose and triage patients with suspected or known ischemic heart disease has led to a parallel increase in the frequency of incidental findings in the coronaries (nonatherosclerotic), noncoronary cardiac structures and noncardiac structures.
Studies have reported a prevalence of incidental findings on CCTA up to 40%. Most of these findings have no clinical relevance, but some have significant clinical implications in the care and prognosis of the patients.
We sought to assess the frequency of incidental findings on CCTA scans in consecutive studies performed in the past 5 years.
- Being tested
- CCTA (Review of the scans)
- Keywords
- Coronary artery disease, computed tomography, indidental findings
- Medical subject headings
- Coronary Artery Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
CCTA (Review of the scans)Diagnostic test
Reviewing coronary scans done in the past 5 years looking for findings other than atherosclerotic coronary artery disease.
| Study group | Role | What they receive |
|---|---|---|
| Adult patients who underwent CCTA | All adults (18 years of age and older0 who underwent CCTA to evaluate the coronary arteries in the past 5 years will have their CT scans reviewed for the presence of non coronary incidental findings. Receives: Diagnostic Test: CCTA (Review of the scans) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Non atherosclerotic coronary disease
Findings other than coronary atherosclerotic disease: coronary bridge, coronary dissection, coronary embolism, and coronary fistula.
Measured: BASELINE
Non coronary cardiac findings
Findings include valve calcifications, left atrial appendage thrombus, patent foramen ovale and septal defects, pericardial effusion, LV clots, cardiac tumors.
Measured: BASELINE
Non cardiac findings
Non cardiac findings include: a. major vascular abnormalities in the aorta and the pulmonary arteries, b. pulmonary disease: masses, lymph nodes, granulomas, and pleural effusion, and c. non pulmonary findings in the diaphragm and the hepatobiliary tree.
Measured: BASELINE
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Dec 2025
- Study start2 Jan 2026 (estimated)
- Primary completion2 Jan 2027 (estimated)
- Study completion28 Feb 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Computed TomographyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Retrospective
- Enrolment
- 2,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Jordan Collaborating Cardiology Group
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07275281
- Sponsor's protocol ID
- JOINCIDENT.CCTA.NOV2025/3
- Status last verified
- Dec 2025
- First submitted
- 28 Nov 2025
- Last updated
- 30 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The excel sheet of the incidental findings in the 2000 CCTA scans in possession of the investigators will be available to any physician upon request
Study at a glance
From the registry record, last updated by the sponsor on 30 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Incidental Noncardiac Findings on Coronary Computed Tomography Angiography
- ClinicalTrials.gov ID
- NCT07275281
- Acronym / sponsor ID
- JOINCIDENT.CCTA.NOV2025/3
- Keywords
- Coronary artery disease, computed tomography, indidental findings
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 2,000 participants (estimated)
- Lead sponsor
- Jordan Collaborating Cardiology GroupUniversity, hospital or other
- Study start
- 2 Jan 2026 (estimated)
- Primary completion
- 2 Jan 2027 (estimated)
- Study completion
- 28 Feb 2027 (estimated)
- First posted
- 10 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Coronary CT angiography (CCTA) is increasingly used for ischemic heart disease diagnosis. The rising number of CCTA tests has led to a significant increase in the number of finding unexpected incidental extracardiac diseases.
Detailed description
The increasing utilization of coronary computed tomography (CT) angiography (CCTA) to diagnose and triage patients with suspected or known ischemic heart disease has led to a parallel increase in the frequency of incidental findings in the coronaries (nonatherosclerotic), noncoronary cardiac structures and noncardiac structures.
Studies have reported a prevalence of incidental findings on CCTA up to 40%. Most of these findings have no clinical relevance, but some have significant clinical implications in the care and prognosis of the patients.
We sought to assess the frequency of incidental findings on CCTA scans in consecutive studies performed in the past 5 years.
Study design
- Observational model
- Case only
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Adult patients who underwent CCTA | – | Diagnostic Test: CCTA (Review of the scans)All adults (18 years of age and older0 who underwent CCTA to evaluate the coronary arteries in the past 5 years will have their CT scans reviewed for the presence of non coronary incidental findings. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- 1. All adult patients who underwent CCTA for chest pain diagnosis. 2. Scans will be reviewed seeking the presence of coronary non atherosclerotic disease in the coronaries, cardiac structure and non cardiac structures.
Key inclusion criteria (1 listed)
- Adult patients ho underwent CCTA
Key exclusion criteria (1 listed)
- None
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| CCTA (Review of the scans)Reviewing coronary scans done in the past 5 years looking for findings other than atherosclerotic coronary artery disease. | Diagnostic test | Adult patients who underwent CCTA |
Primary outcome
Non atherosclerotic coronary disease
Time frame: BASELINE
Findings other than coronary atherosclerotic disease: coronary bridge, coronary dissection, coronary embolism, and coronary fistula.
Non coronary cardiac findings
Time frame: BASELINE
Findings include valve calcifications, left atrial appendage thrombus, patent foramen ovale and septal defects, pericardial effusion, LV clots, cardiac tumors.
Non cardiac findings
Time frame: BASELINE
Non cardiac findings include: a. major vascular abnormalities in the aorta and the pulmonary arteries, b. pulmonary disease: masses, lymph nodes, granulomas, and pleural effusion, and c. non pulmonary findings in the diaphragm and the hepatobiliary tree.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Dec 2025.
- Individual participant dataSharing planned: Yes. The excel sheet of the incidental findings in the 2000 CCTA scans in possession of the investigators will be available to any physician upon request
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Musa Saadeh contact
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Computed Tomography and Coronary Angiography, run by Jordan Collaborating Cardiology Group at 1 site in Jordan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 30 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Jordan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Wasfi Alghween, MD (+96265001000, hammoudeh_ayman@yahoo.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Non atherosclerotic coronary disease (time frame: BASELINE). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Dec 2025.