Motor Learning and Physiological AdaptationEGOSNCT07278245
Effects of Active Upper-Limb Exoskeleton Training in Simulated Hyper-Gravity on Fine Motor Performance, Brain-Muscle Connectivity, Cardiovascular System and Stress Responses in Real Hyper-Gravity
A study testing Training with an exoskeleton in people with Motor Learning and Physiological Adaptation, run by Centre National d'Etudes Spatiales at 1 site in France.
Trial summary
The aim of the study presented here is to assess the effects of exoskeleton training on performance in a real hypergravity situation. In particular, it will analyze fine motor control, autonomic nervous system regulation and metabolic responses. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Motor Learning and Physiological Adaptation
- What is being tested?
- Training with an exoskeleton
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 12 participants
- Where
- 1 siteFrance
- Study dates
- 27 Oct 2025to 27 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Maximum weight of 90 kg
- Maximum sitting butt-to-shoulder distance of 70 cm
- Certified as healthy by a comprehensive clinical assessment
- Normal or corrected to normal vision
- Right-handed tested with Edinburgh-Handedness-Inventory-Test (≥6th percentile, on https://www.brainmapping.org/shared/Edinburgh.php)
- Non smokers
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- No alcohol or drug dependence, no medical treatment on a regular basis
- Affiliated to a Social Security system and, for non-French resident, holding a European Health Insurance Card (EHIC) or a Global Health Insurance Card (GHIC).
- Free of any engagement during the study
- Test subjects must be able to understand and speak English
- Who agreed to take part in the study and signed the informed consent
Who cannot join
- Left-handed tested with Edinburgh-Handedness-Inventory-Test (<6th percentile)
- Subjects with experience in experiments on a short arm human centrifuge or under real hyper-gravity
- Non-tolerance to the centrifugation
- Any history or presence of clinically relevant chronic disease
- Refusal to give permission to contact his general practitioner,
- Subject who, in the judgment of the investigator, is likely to be non-compliant during the study, or unable to cooperate because of a language problem or poor mental development,
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- Subject in the exclusion period of a clinical research,
- Subject who has received more than 6000 Euros within 12 months for being a research subject,
- Subject who cannot be contacted in case of emergency,
- Vulnerable people according to law "Code de la Santé Publique" (L1121-5 to L1121-8)
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Active Upper-Limb Exoskeleton Training in Simulated Hyper-Gravity on Fine Motor Performance, Brain-Muscle Connectivity, Cardiovascular System and Stress Responses in Real Hyper-Gravity: the EGOS Pilot Study.
The aim of the study presented here is to assess the effects of exoskeleton training on performance in a real hypergravity situation. In particular, it will analyze fine motor control, autonomic nervous system regulation and metabolic responses. To this end, the study will compare two groups during a pointing exercise in a centrifuge (hypergravity). One group will have been trained to do this exercise using an exoskeleton, while the other will have been familiarized with the task without the exoskeleton. It will assess whether the exoskeleton can be an effective and accessible training tool for astronauts.
- Being tested
- Training with an exoskeleton
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Training with an exoskeletonOther
Training to perform an aiming task under simulated hypergravity via an exoskeleton
| Study group | Role | What they receive |
|---|---|---|
| Control | No intervention | Untrained group |
| Trained | Experimental | Trained with the exoskeleton Receives: Other: Training with an exoskeleton |
What is being measured
The primary outcome is the main question the study is designed to answer.
Task performance (movement accuracy)
Task performance (movement accuracy) is defined as the difference between the position touched on the screen and the position of the displayed target.
The participants will be required to perform an aiming movement task using their right arm, directed toward a target.The participants will need to point to the center of the displayed target.
Measured: From familiarisation sessions (Day 1 to Day 4) to testing day at Day 5.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Dec 2025
- Study start27 Oct 2025
- Primary completion27 Nov 2025
- Study completion27 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Motor Learning and Physiological AdaptationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 12 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre National d'Etudes Spatiales
- Sponsor type
- Other government
- Collaborators
- MEDES Institut de Médecine et de Physiologie Spatiales, Toulouse
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07278245
- Sponsor's protocol ID
- 23-318
- Other IDs
- ID-RCB Number: 2025-A01589-40
- Acronym
- EGOS
- Status last verified
- Feb 2026
- First submitted
- 25 Nov 2025
- Last updated
- 5 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Active Upper-Limb Exoskeleton Training in Simulated Hyper-Gravity on Fine Motor Performance, Brain-Muscle Connectivity, Cardiovascular System and Stress Responses in Real Hyper-Gravity: the EGOS Pilot Study.
- ClinicalTrials.gov ID
- NCT07278245
- Acronym / sponsor ID
- EGOS / 23-318
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 12 participants (actual)
- Lead sponsor
- Centre National d'Etudes SpatialesOther government
- Collaborators
- MEDES Institut de Médecine et de Physiologie Spatiales, Toulouse
- Study start
- 27 Oct 2025 (actual)
- Primary completion
- 27 Nov 2025 (actual)
- Study completion
- 27 Jan 2026 (actual)
- First posted
- 12 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of the study presented here is to assess the effects of exoskeleton training on performance in a real hypergravity situation. In particular, it will analyze fine motor control, autonomic nervous system regulation and metabolic responses. To this end, the study will compare two groups during a pointing exercise in a centrifuge (hypergravity). One group will have been trained to do this exercise using an exoskeleton, while the other will have been familiarized with the task without the exoskeleton. It will assess whether the exoskeleton can be an effective and accessible training tool for astronauts.
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Control | No intervention | –Untrained group |
| Trained | Experimental | Other: Training with an exoskeletonTrained with the exoskeleton |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (11 listed)
- Maximum weight of 90 kg
- Maximum sitting butt-to-shoulder distance of 70 cm
- Certified as healthy by a comprehensive clinical assessment
- Normal or corrected to normal vision
- Right-handed tested with Edinburgh-Handedness-Inventory-Test (≥6th percentile, on https://www.brainmapping.org/shared/Edinburgh.php)
Key exclusion criteria (10 listed)
- Left-handed tested with Edinburgh-Handedness-Inventory-Test (<6th percentile)
- Subjects with experience in experiments on a short arm human centrifuge or under real hyper-gravity
- Non-tolerance to the centrifugation
- Any history or presence of clinically relevant chronic disease
- Refusal to give permission to contact his general practitioner,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Training with an exoskeletonTraining to perform an aiming task under simulated hypergravity via an exoskeleton | Other | Trained |
Primary outcome
Task performance (movement accuracy)
Time frame: From familiarisation sessions (Day 1 to Day 4) to testing day at Day 5.
Task performance (movement accuracy) is defined as the difference between the position touched on the screen and the position of the displayed target. The participants will be required to perform an aiming movement task using their right arm, directed toward a target.The participants will need to point to the center of the displayed target.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Feb 2026.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Training with an exoskeleton in people with Motor Learning and Physiological Adaptation, run by Centre National d'Etudes Spatiales at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 11 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Task performance (movement accuracy) (time frame: From familiarisation sessions (Day 1 to Day 4) to testing day at Day 5.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Feb 2026.