MortalityMUSIC 2NCT07280039
Mortality and Muscle Mass Loss in Critically Ill Patients.
An observational study of Mortality and Muscle Loss, run by Brno University Hospital at 1 site in Czechia.
Trial summary
The aim of the study is to monitor changes in muscle mass in critically ill patients and to verify whether a decrease in muscle mass of ≥10% during the first 7 days of hospitalization is associated with increased 28-day mortality. We will be used ultrasound for measurement the rectus femoris cross sectional area. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Mortality, Muscle Loss
- How many people
- 386 participants
- Where
- 1 siteCzechia
- Study dates
- 27 Mar 2026to 15 Jan 2028
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Critically ill adult patients will be admitted to intensive care unit with suspect length of artificial ventilation more than 48 hours.
Who may be able to join
- age ≥18 years
- mechanical ventilation expected for at least 48 hours
Who cannot join
- Clinical Frailty Score above 7 prior admission
- Neuromuscular disease in previous medical history
- Amputated lower extremities
- Trauma of lower extremities involving tights
- Conditions affecting the nervous system with involvement of the thigh muscle
- Inability to cooperate during ultrasound examination
- Inability to perform ultrasound examination on day 7
- 9. Inability to perform ultrasound examination on day 7
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Czechia1 site, 1 recruiting
- Recruiting
The University Hospital Brno
Brno, Bohunice, 62500
Jana Fialová, M.D., +42053322305, 1149@fnbrno.cz
About this study
Official title: Mortality and Muscle Mass Loss in Critically Ill Patients: A Prospective, Observational, Multicenter Study.
The aim of the study is to monitor changes in muscle mass in critically ill patients and to verify whether a decrease in muscle mass of ≥10% during the first 7 days of hospitalization is associated with increased 28-day mortality. We will be used ultrasound for measurement the rectus femoris cross sectional area.
Read the detailed description
All patients will be admitted to participating ICU centers from December 2025 to December 2026 will be screened and enrolled based on the inclusion and exclusion criteria. Informed consent will be requested. Ultrasound measurements will be performed by the same investigator within the first 24h after ICU admission and again on day 7 of the patient´s ICU stay. All patient data will be entered into case report form by a study physician. In the follow-up will be determined 28 mortality.
- Conditions
- Mortality, Muscle Loss
- Keywords
- Mortality, Muscle loss, Muscle ultrasound, Critically ill, Rectus femoris cross area
- Medical subject headings
- Muscular Atrophy, Critical Illness
What is being measured
The primary outcome is the main question the study is designed to answer.
Relationship between muscle loss and 28 day mortality
Critically ill patients with a ≥10% decrease in rectus femoris cross-sectional area have increased 28 day mortality.
Measured: 28 days after enrollment
Secondary outcomes (2)
Incidence of a significant decrease in rectus femoris cross-sectional area
A decrease in rectus femoris cross-sectional area of 10% or more measured by ultrasound.
Measured: first 7 days of ICU stay
Incidence of an insignificant decrease in rectus femoris cross-sectional area
A decrease in rectus femoris cross-sectional area of less than 10% measured by ultrasound.
Measured: first 7 days ICU stay
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Dec 2025
- Study start27 Mar 2026
- Primary completion15 Dec 2027 (estimated)
- Study completion15 Jan 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MortalityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 386 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Brno University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Roman Gal, Brno University Hospital
- Investigators
- Roman Gal, M.D., PhD, Study chair, Brno University Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07280039
- Sponsor's protocol ID
- CT0022025
- Acronym
- MUSIC 2
- Status last verified
- Oct 2026
- First submitted
- 1 Dec 2025
- Last updated
- 19 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No