PeriodontitisNCT07287540
Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy
An observational study of Periodontitis, run by Recep Tayyip Erdogan University Training and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
This study aimed to determine the effect of anti-inflammatory nutrition on non-surgical periodontal treatment in individuals with periodontitis by evaluating gingival crevicular fluid (GCF) and serum biomarkers and clinical periodontal parameters. Read more about this study
- Who is it for?
- Ages 20 to 65 years
- Conditions the study is for
- Periodontitis
- What is being tested?
- non surgical periodontal trearment and anti-inflammatory nutrition education
- How many people
- 100 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 22 Nov 2025to 4 Jul 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 65 years
- All sexes
- Adult, Older adult
Study population: This study included individuals who applied to Recep Tayyip Erdogan University, Faculty of Dentistry, Department of Periodontology for treatment
Who may be able to join
- Being systemically healthy
- Not smoking
- Not using anti-inflammatory drugs in the last 3 months, antibiotics, or systemic corticosteroids in the last 6 months
- Not being pregnant or lactating
- Not having received periodontal treatment in the last 6 months
- Having at least 20 teeth in the mouth
- Being diagnosed with periodontitis by the investigator
- Having a dietary inflammatory index >0
Who cannot join
- Having a systemic disease
- Smoking
- Using anti-inflammatory drugs within the last 3 months, antibiotics within the last 6 months, or systemic corticosteroids
- Being pregnant or lactating
- Having received periodontal treatment within the last 6 months
- Having fewer than 20 teeth in the mouth
- No periodontitis
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Recep Tayyip Erdoğan University
Rize, 53020
Hatice Yemenoglu, +904642220000, htcymnglu@hotmail.com
About this study
Official title: Evaluation of the Effects of Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy in Individuals With Periodontitis
This study aimed to determine the effect of anti-inflammatory nutrition on non-surgical periodontal treatment in individuals with periodontitis by evaluating gingival crevicular fluid (GCF) and serum biomarkers and clinical periodontal parameters.
A total of 100 volunteers identified as having a pro-inflammatory diet (Q3 and Q4) will be included in the study. Individuals will be assigned to two groups. These groups will then be further divided into two groups based on whether or not they will receive anti-inflammatory nutrition education. Group Q3-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q3-2 (n=25) will receive only non-surgical periodontal treatment. Group Q4-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q4-2 (n=25) will receive only non-surgical periodontal treatment. After the periodontal index measurements are completed, the patients will receive non-surgical periodontal treatment. GCF and serum samples, periodontal clinical parameters and Dietary Inflammatory Index will be collected 3 times: at baseline, 1.5 and 3 months after non-surgical periodontal treatment. Levels of interleukin (IL)-1β, IL-10, tumor necrosis factor (TNF)-α, total oxidant status (TOS), total antioxidant status (TAS), and C-reactive protein (CRP) will be assessed from these samples. This will investigate the role of anti-inflammatory nutrition in reducing periodontal inflammation and increasing treatment success.
- Conditions
- Periodontitis
- Being tested
- non surgical periodontal trearment, anti-inflammatory nutrition education
- Keywords
- periodontitis, diet inflammatory index, anti-inflammatory nutrition
- Medical subject headings
- Periodontitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
non surgical periodontal trearmentOther
All participants will receive nonsurgical periodontal treatment
anti-inflammatory nutrition educationOther
Participants in Groups Q3-1 and Q4-1 will receive anti-inflammatory nutrition education
| Study group | Role | What they receive |
|---|---|---|
| Q3-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education | Not described Receives: Other: non surgical periodontal trearment; Other: anti-inflammatory nutrition education | |
| Q3-2: Only nonsurgical periodontal treatment | Not described Receives: Other: non surgical periodontal trearment | |
| Q4-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education | Not described Receives: Other: non surgical periodontal trearment; Other: anti-inflammatory nutrition education | |
| Q4-2: Only nonsurgical periodontal treatment | Not described Receives: Other: non surgical periodontal trearment |
What is being measured
The primary outcome is the main question the study is designed to answer.
periodontal pocket depth
It will be calculated by measuring the distance between the gingival margin and the pocket base. It will be measured from the six surfaces of each tooth and the average will be taken higher scores indicate worse outcome.
Measured: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
Clinical attachment loss
It will be calculated by measuring the distance between the cementoenemal border and the pocket base. It will be measured from the six surfaces of each tooth and the average will be taken higher scores indicate worse outcome.
Measured: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
Secondary outcomes (6)
interleukin (IL)-1β level
IL-1β levels will be measured with biochemical kits.
Measured: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
interleukin (IL)-10 level
IL-10 levels will be measured with biochemical kits.
Measured: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
tumor necrosis factor (TNF)-α level
TNF-α levels will be measured with biochemical kits.
Measured: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
serum total oxidant status (TOS) level
TOS levels in serum will be measured with biochemical kits.
Measured: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
serum total antioxidant status (TAS) level
TAS levels in serum will be measured with biochemical kits.
Measured: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
serum C-reactive protein (CRP) level
CRP levels in serum will be measured with biochemical kits.
Measured: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Dec 2025
- Study start22 Nov 2025
- Primary completion3 Jul 2026 (estimated)
- Study completion4 Jul 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PeriodontitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
- Sponsor type
- University, hospital or other
- Collaborators
- Recep Tayyip Erdogan University
- Responsible party
- Principal investigator, Hatice Yemenoğlu, Recep Tayyip Erdogan University Training and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07287540
- Sponsor's protocol ID
- Recep TayyipErdoğan University
- Status last verified
- Nov 2025
- First submitted
- 17 Nov 2025
- Last updated
- 23 Jun 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 23 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Effects of Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy in Individuals With Periodontitis
- ClinicalTrials.gov ID
- NCT07287540
- Acronym / sponsor ID
- Recep TayyipErdoğan University
- Conditions
- Periodontitis
- Keywords
- periodontitis, diet inflammatory index, anti-inflammatory nutrition
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Recep Tayyip Erdogan University Training and Research HospitalUniversity, hospital or other
- Collaborators
- Recep Tayyip Erdogan University
- Study start
- 22 Nov 2025 (actual)
- Primary completion
- 3 Jul 2026 (estimated)
- Study completion
- 4 Jul 2026 (estimated)
- First posted
- 17 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aimed to determine the effect of anti-inflammatory nutrition on non-surgical periodontal treatment in individuals with periodontitis by evaluating gingival crevicular fluid (GCF) and serum biomarkers and clinical periodontal parameters.
A total of 100 volunteers identified as having a pro-inflammatory diet (Q3 and Q4) will be included in the study. Individuals will be assigned to two groups. These groups will then be further divided into two groups based on whether or not they will receive anti-inflammatory nutrition education. Group Q3-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q3-2 (n=25) will receive only non-surgical periodontal treatment. Group Q4-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q4-2 (n=25) will receive only non-surgical periodontal treatment. After the periodontal index measurements are completed, the patients will receive non-surgical periodontal treatment. GCF and serum samples, periodontal clinical parameters and Dietary Inflammatory Index will be collected 3 times: at baseline, 1.5 and 3 months after non-surgical periodontal treatment. Levels of interleukin (IL)-1β, IL-10, tumor necrosis factor (TNF)-α, total oxidant status (TOS), total antioxidant status (TAS), and C-reactive protein (CRP) will be assessed from these samples. This will investigate the role of anti-inflammatory nutrition in reducing periodontal inflammation and increasing treatment success.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Q3-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education | – | Other: non surgical periodontal trearment, Other: anti-inflammatory nutrition education |
| Q3-2: Only nonsurgical periodontal treatment | – | Other: non surgical periodontal trearment |
| Q4-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education | – | Other: non surgical periodontal trearment, Other: anti-inflammatory nutrition education |
| Q4-2: Only nonsurgical periodontal treatment | – | Other: non surgical periodontal trearment |
Who may qualify
- Ages
- 20 to 65 years
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- This study included individuals who applied to Recep Tayyip Erdogan University, Faculty of Dentistry, Department of Periodontology for treatment
Key inclusion criteria (8 listed)
- Being systemically healthy
- Not smoking
- Not using anti-inflammatory drugs in the last 3 months, antibiotics, or systemic corticosteroids in the last 6 months
- Not being pregnant or lactating
- Not having received periodontal treatment in the last 6 months
Key exclusion criteria (7 listed)
- Having a systemic disease
- Smoking
- Using anti-inflammatory drugs within the last 3 months, antibiotics within the last 6 months, or systemic corticosteroids
- Being pregnant or lactating
- Having received periodontal treatment within the last 6 months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| non surgical periodontal trearmentAll participants will receive nonsurgical periodontal treatment | Other | Q3-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education, Q3-2: Only nonsurgical periodontal treatment, Q4-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education, Q4-2: Only nonsurgical periodontal treatment |
| anti-inflammatory nutrition educationParticipants in Groups Q3-1 and Q4-1 will receive anti-inflammatory nutrition education | Other | Q3-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education, Q4-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education |
Primary outcome
periodontal pocket depth
Time frame: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
It will be calculated by measuring the distance between the gingival margin and the pocket base. It will be measured from the six surfaces of each tooth and the average will be taken higher scores indicate worse outcome.
Clinical attachment loss
Time frame: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
It will be calculated by measuring the distance between the cementoenemal border and the pocket base. It will be measured from the six surfaces of each tooth and the average will be taken higher scores indicate worse outcome.
6 secondary outcomes
interleukin (IL)-1β level
Time frame: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
interleukin (IL)-10 level
Time frame: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
tumor necrosis factor (TNF)-α level
Time frame: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
serum total oxidant status (TOS) level
Time frame: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
serum total antioxidant status (TAS) level
Time frame: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
serum C-reactive protein (CRP) level
Time frame: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jun 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Periodontitis, run by Recep Tayyip Erdogan University Training and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 23 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Hatice Yemenoglu (+905052977517, htcymnglu@hotmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
periodontal pocket depth (time frame: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jun 2026.