Gingival RecessionNCT07291583
Hyaluronic Acid With Connective Tissue Grafting for Gingival Recession
A study testing Hyaluronic Acid (0.8%) - Applied over CTG before flap closure (Test group only). and Connective Tissue Graft + Coronally Advanced Flap (CTG + CAF) in people with Gingival Recession, run by Saglik Bilimleri Universitesi at 1 site in Turkey (Türkiye).
Trial summary
This study evaluates whether adding 0.8% hyaluronic acid (HA) to connective tissue grafting and coronally advanced flap surgery improves clinical and esthetic outcomes in the treatment of gingival recession. Read more about this study
- Who is it for?
- Ages 18 months and older
- Conditions the study is for
- Gingival Recession
- What is being tested?
- Hyaluronic Acid (0.8%) - Applied over CTG before flap closure (Test group only). and Connective Tissue Graft + Coronally Advanced Flap (CTG + CAF)
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jul 2025to 1 Jul 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 months and older
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Presence of at least one gingival recession defect classified as Cairo RT1 or Miller Class I-II with a minimum depth of 1 mm.
- Full-mouth plaque score (FMPS) and full-mouth bleeding on probing (FMBOP) < 15%.
- Detectable cemento-enamel junction (CEJ).
- Age ≥ 18 years.
- No history of prior periodontal surgical treatment.
- Sufficient mental capacity to understand the study aims and procedures explained verbally and in writing.
- Determined to be cooperative and compliant with the clinician before, during, and after the surgical procedure.
Who cannot join
- Patients younger than 18 years.
- Periodontally healthy individuals.
- Current smokers.
- History of periodontal treatment within the past 1 year.
- Use of antibiotics within the past 3 months.
- Pregnancy or breastfeeding.
- Presence of systemic diseases such as diabetes, chronic kidney failure, cancer, bleeding disorders, connective tissue diseases, or other chronic conditions; and gingival recessions classified as Cairo RT3.
- Presence of cervical caries or restorations at the defect site.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
University of Health Sciences, Gülhane Faculty of Dentistry
Ankara, None Selected, 6220
About this study
Official title: Clinical and Aesthetic Evaluation of Hyaluronic Acid in Addition to Connective Tissue Grafts in the Treatment of Gingival Recession Defects
This study evaluates whether adding 0.8% hyaluronic acid (HA) to connective tissue grafting and coronally advanced flap surgery improves clinical and esthetic outcomes in the treatment of gingival recession. Adult patients with Miller I-II or Cairo RT1 recession defects will be randomly assigned to receive CTG alone or CTG with adjunctive HA. Mean root coverage at 6 months is the primary outcome, while secondary measures include gingival thickness, clinical attachment level, esthetic scores, postoperative morbidity, and quality of life. The study aims to determine whether HA enhances soft tissue healing and root coverage predictability compared with conventional CTG.
- Conditions
- Gingival Recession
- Being tested
- Hyaluronic Acid (0.8%) - Applied over CTG before flap closure (Test group only)., Connective Tissue Graft + Coronally Advanced Flap (CTG + CAF)
- Medical subject headings
- Gingival Recession
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Hyaluronic Acid (0.8%) - Applied over CTG before flap closure (Test group only).Biological
A 0.8% hyaluronic acid (HA) gel is applied to the connective tissue graft (CTG) before flap closure during the coronally advanced flap (CAF) procedure. The HA gel is used as an adjunctive biologic material to potentially enhance wound healing, soft tissue thickness, esthetic outcomes, and overall root coverage performance
Connective Tissue Graft + Coronally Advanced Flap (CTG + CAF)Procedure or surgery
A standardized coronally advanced flap (CAF) procedure combined with a subepithelial connective tissue graft (CTG) is performed to treat gingival recession defects. The surgical protocol includes flap elevation, graft harvesting and placement, and flap advancement and suturing.
| Study group | Role | What they receive |
|---|---|---|
| Experimental - CTG + Hyaluronic Acid | Experimental | A 0.8% hyaluronic acid (HA) gel is applied to the connective tissue graft (CTG) before flap closure during the coronally advanced flap (CAF) procedure. The HA gel is used as an adjunctive biologic material to potentially enhance wound healing, soft tissue thickness, esthetic outcomes, and overall root coverage performance. Receives: Biological: Hyaluronic Acid (0.8%) - Applied over CTG before flap closure (Test group only).; Procedure: Connective Tissue Graft + Coronally Advanced Flap (CTG + CAF) |
| CTG only | Active comparator | A standardized coronally advanced flap (CAF) procedure combined with a subepithelial connective tissue graft (CTG) is performed to treat gingival recession defects. The surgical protocol includes flap elevation, graft harvesting and placement, and flap advancement and suturing. Receives: Procedure: Connective Tissue Graft + Coronally Advanced Flap (CTG + CAF) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Impact of Adjunctive Hyaluronic Acid on Mean Root Coverage After Recession Treatment
The primary objective of this study is to evaluate the effect of adjunctive hyaluronic acid (HA) on the mean root coverage (MRC) achieved after the treatment of gingival recession defects.
Measured: From enrollment to the end of treatment at 6 months"
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Dec 2025
- Study start1 Jul 2025
- Primary completion1 Feb 2026
- Study completion1 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Gingival RecessionStudies of the same condition, open and under way.
- More trials run by Saglik Bilimleri UniversitesiThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- Saglik Bilimleri Universitesi
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Şeyma Çardakçı, Saglik Bilimleri Universitesi
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07291583
- Sponsor's protocol ID
- Seyma9319
- Status last verified
- Jul 2026
- First submitted
- 5 Dec 2025
- Last updated
- 21 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 21 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical and Aesthetic Evaluation of Hyaluronic Acid in Addition to Connective Tissue Grafts in the Treatment of Gingival Recession Defects
- ClinicalTrials.gov ID
- NCT07291583
- Acronym / sponsor ID
- Seyma9319
- Conditions
- Gingival Recession
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- Saglik Bilimleri UniversitesiUniversity, hospital or other
- Study start
- 1 Jul 2025 (actual)
- Primary completion
- 1 Feb 2026 (actual)
- Study completion
- 1 Jul 2026 (actual)
- First posted
- 18 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study evaluates whether adding 0.8% hyaluronic acid (HA) to connective tissue grafting and coronally advanced flap surgery improves clinical and esthetic outcomes in the treatment of gingival recession. Adult patients with Miller I-II or Cairo RT1 recession defects will be randomly assigned to receive CTG alone or CTG with adjunctive HA. Mean root coverage at 6 months is the primary outcome, while secondary measures include gingival thickness, clinical attachment level, esthetic scores, postoperative morbidity, and quality of life. The study aims to determine whether HA enhances soft tissue healing and root coverage predictability compared with conventional CTG.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Experimental - CTG + Hyaluronic Acid | Experimental | Biological: Hyaluronic Acid (0.8%) - Applied over CTG before flap closure (Test group only)., Procedure: Connective Tissue Graft + Coronally Advanced Flap (CTG + CAF)A 0.8% hyaluronic acid (HA) gel is applied to the connective tissue graft (CTG) before flap closure during the coronally advanced flap (CAF) procedure. The HA gel is used as an adjunctive biologic material to potentially enhance wound healing, soft tissue thickness, esthetic outcomes, and overall root coverage performance. |
| CTG only | Active comparator | Procedure: Connective Tissue Graft + Coronally Advanced Flap (CTG + CAF)A standardized coronally advanced flap (CAF) procedure combined with a subepithelial connective tissue graft (CTG) is performed to treat gingival recession defects. The surgical protocol includes flap elevation, graft harvesting and placement, and flap advancement and suturing. |
Who may qualify
- Ages
- 18 months and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (7 listed)
- Presence of at least one gingival recession defect classified as Cairo RT1 or Miller Class I-II with a minimum depth of 1 mm.
- Full-mouth plaque score (FMPS) and full-mouth bleeding on probing (FMBOP) < 15%.
- Detectable cemento-enamel junction (CEJ).
- Age ≥ 18 years.
- No history of prior periodontal surgical treatment.
Key exclusion criteria (8 listed)
- Patients younger than 18 years.
- Periodontally healthy individuals.
- Current smokers.
- History of periodontal treatment within the past 1 year.
- Use of antibiotics within the past 3 months.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Hyaluronic Acid (0.8%) - Applied over CTG before flap closure (Test group only).A 0.8% hyaluronic acid (HA) gel is applied to the connective tissue graft (CTG) before flap closure during the coronally advanced flap (CAF) procedure. The HA gel is used as an adjunctive biologic material to potentially enhance wound healing, soft tissue thickness, esthetic outcomes, and overall root coverage performance | Biological | Experimental - CTG + Hyaluronic Acid |
| Connective Tissue Graft + Coronally Advanced Flap (CTG + CAF)A standardized coronally advanced flap (CAF) procedure combined with a subepithelial connective tissue graft (CTG) is performed to treat gingival recession defects. The surgical protocol includes flap elevation, graft harvesting and placement, and flap advancement and suturing. | Procedure or surgery | CTG only, Experimental - CTG + Hyaluronic Acid |
Primary outcome
Impact of Adjunctive Hyaluronic Acid on Mean Root Coverage After Recession Treatment
Time frame: From enrollment to the end of treatment at 6 months"
The primary objective of this study is to evaluate the effect of adjunctive hyaluronic acid (HA) on the mean root coverage (MRC) achieved after the treatment of gingival recession defects.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Jul 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Hyaluronic Acid (0.8%) - Applied over CTG before flap closure (Test group only). and Connective Tissue Graft + Coronally Advanced Flap (CTG + CAF) in people with Gingival Recession, run by Saglik Bilimleri Universitesi at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 21 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Impact of Adjunctive Hyaluronic Acid on Mean Root Coverage After Recession Treatment (time frame: From enrollment to the end of treatment at 6 months"). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Jul 2026.