Spinal Cord Injuries (SCI)NCT07293949
Ultrasonographic Evaluation of Talar Cartilage Thickness in Patients With Spinal Cord Injury
An observational study of Spinal Cord Injuries (SCI) and Osteoarthritis (OA), run by Gaziosmanpasa Research and Education Hospital at 1 site in Turkey (Türkiye).
Trial summary
Spinal cord injury patients often present with musculoskeletal comorbidities, including osteoarthritis. Early detection of cartilage damage is important for preventing osteoarthritis progression. This study aims to compare the talar cartilage thicknesses of spinal cord injury patients with healthy subjects. Read more about this study
- Who is it for?
- Ages 18 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Spinal Cord Injuries (SCI), Osteoarthritis (OA)
- How many people
- 76 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 20 Dec 2025to 1 Jun 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: Thirty-eight SCI patients who apply to Physical Medicine and Rehabilitation outpatient and inpatient clinic between November 2025-January 2026 will be included in the study. Thirty-eight age, gender, and BMI-matched healthy participants who are literate, give oral and written consent without any additional disease will be formed as the control group.
Who may be able to join
- Aged between 18 to 60 years,
- Cervical, thoracal or lumber level of spinal cord injury
- AIS (American Spinal Injury Association Impairment Scale) Level A, B, C, or D
- Assisted ambulation of any kind
- Literacy
- Giving oral and written consent to participate in the study
Who cannot join
- Patients with sacral level injury
- AIS E
- MAS 4 level of spasticity
- History of any lower extremity operation
- History of fracture
- Botulinum toxin injection in the last 6 months
- Existing diagnosis of any rheumatologic or endocrine diseases
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Gaziosmanpasa Training and Research Hospital
Istanbul
About this study
Official title: Ultrasonographic Evaluation of Talar Cartilage Thickness in Patients With Spinal Cord Injury: A Cross-Sectional Case-Control Study
Spinal cord injury patients often present with musculoskeletal comorbidities, including osteoarthritis. Early detection of cartilage damage is important for preventing osteoarthritis progression. This study aims to compare the talar cartilage thicknesses of spinal cord injury patients with healthy subjects. The secondary aim is to investigate a correlation between the talar cartilage thickness and disease-related parameters. The patient group is to be assessed for talar cartilage thickness (via ultrasound), functional status, spasticity, and ambulation levels.
- Conditions
- Spinal Cord Injuries (SCI), Osteoarthritis (OA)
- Keywords
- spinal cord injury, osteoarthritis, musculoskeletal ultrasound, talar cartilage
- Medical subject headings
- Spinal Cord Injuries, Osteoarthritis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Patient group | Spinal cord injury patients | |
| Control group | Age, sex, and BMI matched healthy controls |
What is being measured
The primary outcome is the main question the study is designed to answer.
Talar cartilage thickness
The talar cartilage of both lower extremities are to be assessed with ultrasound
Measured: Baseline
Secondary outcomes (3)
Functional Independence Measure (FIM) score
Functional Independence Measure scores will be held for the patient group in order to assess functional independence. This 18-item scale ranges between 18-126, higher scores indicating better outcomes.
Measured: Baseline
Modified Ashworth Scale (MAS)
The spasticity level of patients are to be recorded for both ankle flexor and extensors via Modified Ashworth Scale. This scale ranges from 0 to 4; 0 indicating no spasticity, and 4 indicating severe increase in muscle tone with rigid joint.
Measured: Baseline
Walking Index for Spinal Cord Injury II (WISCI II)
Ambulatory status of the patients will be recorded with this measuring scale, ranging between 0 (non ambulatory) to 20 (able to walk 10 meters with no devices/orthosis/assistance).
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Dec 2025
- Study start20 Dec 2025
- Primary completion10 Apr 2026
- Study completion1 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Spinal Cord Injuries (SCI)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 76 participants (actual)
Sponsor and investigators
- Lead sponsor
- Gaziosmanpasa Research and Education Hospital
- Sponsor type
- Other government
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07293949
- Sponsor's protocol ID
- 172
- Status last verified
- Jul 2026
- First submitted
- 22 Nov 2025
- Last updated
- 28 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The datasets of the study (patient and volunteer demographics, clinical data, and statistical data) will be shared after completion of the study with third parties upon reasonable request.
Study at a glance
From the registry record, last updated by the sponsor on 28 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Ultrasonographic Evaluation of Talar Cartilage Thickness in Patients With Spinal Cord Injury: A Cross-Sectional Case-Control Study
- ClinicalTrials.gov ID
- NCT07293949
- Acronym / sponsor ID
- 172
- Conditions
- Spinal Cord Injuries (SCI), Osteoarthritis (OA)
- Keywords
- spinal cord injury, osteoarthritis, musculoskeletal ultrasound, talar cartilage
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 76 participants (actual)
- Lead sponsor
- Gaziosmanpasa Research and Education HospitalOther government
- Study start
- 20 Dec 2025 (actual)
- Primary completion
- 10 Apr 2026 (actual)
- Study completion
- 1 Jun 2026 (actual)
- First posted
- 19 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Spinal cord injury patients often present with musculoskeletal comorbidities, including osteoarthritis. Early detection of cartilage damage is important for preventing osteoarthritis progression. This study aims to compare the talar cartilage thicknesses of spinal cord injury patients with healthy subjects. The secondary aim is to investigate a correlation between the talar cartilage thickness and disease-related parameters. The patient group is to be assessed for talar cartilage thickness (via ultrasound), functional status, spasticity, and ambulation levels.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Patient group | – | –Spinal cord injury patients |
| Control group | – | –Age, sex, and BMI matched healthy controls |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- Thirty-eight SCI patients who apply to Physical Medicine and Rehabilitation outpatient and inpatient clinic between November 2025-January 2026 will be included in the study. Thirty-eight age, gender, and BMI-matched healthy participants who are literate, give oral and written consent without any additional disease will be formed as the control group.
Key inclusion criteria (6 listed)
- Aged between 18 to 60 years,
- Cervical, thoracal or lumber level of spinal cord injury
- AIS (American Spinal Injury Association Impairment Scale) Level A, B, C, or D
- Assisted ambulation of any kind
- Literacy
Key exclusion criteria (7 listed)
- Patients with sacral level injury
- AIS E
- MAS 4 level of spasticity
- History of any lower extremity operation
- History of fracture
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Talar cartilage thickness
Time frame: Baseline
The talar cartilage of both lower extremities are to be assessed with ultrasound
3 secondary outcomes
Functional Independence Measure (FIM) score
Time frame: Baseline
Modified Ashworth Scale (MAS)
Time frame: Baseline
Walking Index for Spinal Cord Injury II (WISCI II)
Time frame: Baseline
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Jul 2026.
- Individual participant dataSharing planned: Yes. The datasets of the study (patient and volunteer demographics, clinical data, and statistical data) will be shared after completion of the study with third parties upon reasonable request.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Spinal Cord Injuries (SCI) and Osteoarthritis (OA), run by Gaziosmanpasa Research and Education Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Talar cartilage thickness (time frame: Baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Jul 2026.