Rebound Pain Impact After Hip Surgery With Nerve BlockNCT07295184

Effect of Rebound Pain on Postoperative Intensive Care Delirium in Patients Undergoing Hip Surgery With Peripheral Nerve Block

An observational study of Rebound Pain Impact After Hip Surgery With Nerve Block, run by Konya City Hospital at 1 site in Turkey (Türkiye).

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

Postoperative delirium is a significant and commonly encountered complication in patients undergoing hip surgery, particularly among the elderly. Postoperative delirium is associated with serious consequences, including prolonged intensive care unit stay, increased complication rates, higher mortality risk, and rising… Read more about this study

Who is it for?: Ages 18 to 80 years
Conditions the study is for: Rebound Pain Impact After Hip Surgery With Nerve Block
What is being tested?: Peripheral nerve block applied and Only multimodal analgesia applied
Type of treatment: Pill or oral medicine, Injection or infusion
How many people: 90 participants
Where: 1 siteTurkey (Türkiye)
Study dates: 12 May 2026to 29 Sep 2026
Phase: Observational

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 to 80 years
All sexes
No healthy volunteers
Adult, Older adult

Study population: We conducted a pilot study on 20 patients using the 'goodness-of-fit tests: contingency tables' test with G Power software. In our study, the incidence of rebound pain was 40%, and postoperative delirium developed in 50% of patients with rebound pain, compared to 8.3% in patients without rebound pain. Based on these data, an effect size of 0.356 was found, and an analysis was conducted using α=0.05, 90% power. The sample size was calculated as 83 patients. Considering the dropout rate, a total of 90 patients (36 patients with rebound pain and 54 patients without rebound pain) were calculated to be included in the study.

Who may be able to join

Patients aged 18-80
ASA I-III risk groups
Undergoing elective hip surgery

Who cannot join

Preoperative history of delirium, dementia, or major neurological disease
Present cognitive impairment or severe hearing or visual impairment that could affect pain assessment
Development of mechanical ventilation requirement in the intensive care unit; Need for bilateral hip surgery
Failure to provide meaningful analgesia after block application due to surgical pain outside the scope of the block
Patient's inability to complete the pain diary during postoperative follow-up;
Urgent hip surgery
Voluntary failure to give consent or request to withdraw from the study.

Trial locations and contacts

1 site in 1 country.

Turkey (Türkiye)1 site

Konya City Hospital
Konya, Konya, 42020

Other trials in Turkey (Türkiye)

About this study

Official title: Effect of Rebound Pain on Postoperative Intensive Care Delirium in Patients Undergoing Hip Surgery With Peripheral Nerve Block: A Prospective Observational Study

The incidence of Postoperative delirium after hip fracture surgery has been reported to range between 13% and 55.9%, indicating a substantial clinical burden.

Effective postoperative pain control is critical not only for maintaining quality of life but also for preserving cognitive well-being. In this context, peripheral nerve blocks are frequently used for pain management following hip surgery.

Read the detailed description

The incidence of Postoperative delirium after hip fracture surgery has been reported to range between 13% and 55.9%, indicating a substantial clinical burden.

In recent years, the Pericapsular Nerve Group block and the supra-inguinal fascia iliaca block have gained attention as regional anesthesia techniques that provide effective analgesia by targeting the nerve branches innervating the anterior capsule of the hip joint.

Conditions: Rebound Pain Impact After Hip Surgery With Nerve Block
Being tested: Peripheral nerve block applied, Only multimodal analgesia applied

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Peripheral nerve block appliedOther
Pericapsular Nerve Group block and the supra-inguinal fascia iliaca block applied
Only multimodal analgesia appliedOther
Postoperative analgesia (paracetamol 1000 mg intravenously every 8 hours and celecoxib 200 mg orally every 12 hours)

What is being measured

The primary outcome is the main question the study is designed to answer.

Incidence of delirium
The incidence of delirium will be evaluated in the first 72 hours postoperatively in the intensive care unit.
Measured: 72 hours

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

12 May 202629 Sep 2026

First posted19 Dec 2025
Study start12 May 2026
Primary completion29 Sep 2026
Study completion29 Sep 2026

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for Rebound Pain Impact After Hip Surgery With Nerve BlockStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Observational
Observational model: Case-control
Time perspective: Prospective
Enrolment: 90 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07295184
Sponsor's protocol ID: Rebound pain
Status last verified: Sep 2026
First submitted: 8 Dec 2025
Last updated: 30 Sep 2026
Results posted: No
FDA-regulated drug: No
FDA-regulated device: No