CancerCANNCT07300319
The Effects of Chiropractic on Cancer-related Fatigue
A study testing Immediate Chiropractic Care and Delayed Chiropractic Care in people with Cancer and Fatigue, run by Life University at 1 site in United States.
Trial summary
The goal of this randomized controlled study is to investigate the impact of chiropractic care on CCRF (Chronic Cancer Related Fatigue) and other health-related challenges that burden cancer survivors. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- What is being tested?
- Immediate Chiropractic Care and Delayed Chiropractic Care
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Feb 2027to 1 Feb 2028
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- 18-65 years of age.
- Self-report that they have been informed by their primary health care provider that they are cancer-free (this is sometimes referred to as 'complete remission' or 'cured').
- Minimum of 3 months since the completion of their primary curative-intent cancer therapies including surgery, chemotherapy, radiotherapy, and/or immunotherapy (long-term hormone therapy permitted)
- Scores in the moderate-to-severe range (i.e., at or above the 60th percentile) on the FACIT-Fatigue scale.
- Fatigue onset was at some point during their illness/treatment \& negatively impacts their quality of life \& daily functioning.
Who cannot join
- Chiropractic care within the past 2 weeks
- Taking short-acting benzodiazepines which include midazolam/Versed \& triazolam/Halcion.
- Taking GLP-1 medications
- Taking other types of prescription medications (including hormone therapy) and hasn't been on a stable dose for a minimum of 6 weeks with plans to change medications or doses during the study.
- Disorders that cause fainting during rapid postural changes (e.g., POTS, orthostatic hypotension).
- Not able to make a fist or grip objects with one or both hands
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- Deaf in one or both ears (hearing aids are ok)
- Heart conditions, including pacemakers, which impact heart function
- Diagnosed with rheumatoid arthritis, osteoporosis, or medically diagnosed cervical spine instability.
- Current litigation related to a physical, health-related injury.
- Pregnant
Trial locations and contacts
1 site in 1 country.
United States1 site
Center for Chiropractic Research
Marietta, Georgia, 30060
About this study
Official title: The Effects of Chiropractic Care on Adults With Chronic Cancer-related Fatigue: a Pilot Trial
The goal of this randomized controlled study is to investigate the impact of chiropractic care on CCRF (Chronic Cancer Related Fatigue) and other health-related challenges that burden cancer survivors.
Read the detailed description
To our knowledge, the impact of chiropractic care on CCRF and other health-related challenges that burden cancer survivors has yet to be investigated. Because this is a pilot trial, the primary outcomes center around feasibility and include 1) randomization, 2) compliance, 3) tolerability, 4) adherence, and 5) retention in each arm. Secondary outcomes include changes in patient-reported outcomes (PROs), electrocardiography (ECG) derived heart rate variability (HRV), impedance cardiography (ICG) derived pre-ejection period (PEP), and number of completed sit-to-stands.
- Being tested
- Immediate Chiropractic Care, Delayed Chiropractic Care
- Keywords
- Cancer, Fatigue, Chiropractic Care, Delayed Start
- Medical subject headings
- Neoplasms, Fatigue
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Immediate Chiropractic CareOther
Participants in the immediate start group will be assigned to chiropractic care for 12 weeks. Participants will have their upper cervical spine (C1/C2) assessed for the presence of vertebral subluxations per the chiropractor's normal and customary procedures and adjusted if necessary.
Delayed Chiropractic CareOther
Participants in the delayed start group will be assigned to chiropractic care for 6 weeks. Participants will have their upper cervical spine (C1/C2) assessed for the presence of vertebral subluxations per the chiropractor's normal and customary procedures and adjusted if necessary.
| Study group | Role | What they receive |
|---|---|---|
| Delayed Group | Active comparator | After the 6-week lab assessments, the participants in the delayed group will be offered 6 weeks of chiropractic care. Receives: Other: Delayed Chiropractic Care |
| Immediate Group | Experimental | After the baseline assessment, the participants in the intervention group will receive 12 weeks of chiropractic care. Receives: Other: Immediate Chiropractic Care |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of Eligible Randomized Participants
The proportion of eligible participants randomized into the study
Measured: 2 years
Number of Participants Who Adhere to Study
Proportion of enrolled participants who adhere to the pre-baseline assessment lifestyle restrictions as instructed. This assesses compliance.
Measured: 2 years
Number of Participants That Can Fulfill Study Activities
Proportion of participants that can fulfill the given baseline assessment as directed. This assesses tolerability
Measured: 2 years
Number of Participants Who Chiropractic Sessions
Proportion of randomized adults attending ≥90% of chiro sessions within 7 days of the prescribed time frame. This assesses adherence to treatment.
Measured: 2 years
Number of Enrolled Intervention Group Participants
Proportion of the immediate-start group attending the final assessment session. This assesses retention.
Measured: 2 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Dec 2025
- Study start1 Feb 2027 (estimated)
- Primary completion1 Feb 2028 (estimated)
- Study completion1 Feb 2028 (estimated)
Why it stopped: Lack of funding
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for CancerStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Life University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Tyson Perez, DC, PhD, Life University
- Investigators
- Tyson Perez, DC, PhD, Principal investigator, Life University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07300319
- Sponsor's protocol ID
- I-0037
- Acronym
- CAN
- Status last verified
- Mar 2026
- First submitted
- 10 Dec 2025
- Last updated
- 30 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effects of Chiropractic Care on Adults With Chronic Cancer-related Fatigue: a Pilot Trial
- ClinicalTrials.gov ID
- NCT07300319
- Acronym / sponsor ID
- CAN / I-0037
- Keywords
- Cancer, Fatigue, Chiropractic Care, Delayed Start
- Study type
- Interventional
- Recruitment status
- SuspendedReason stopped: Lack of funding
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Life UniversityUniversity, hospital or other
- Study start
- 1 Feb 2027 (estimated)
- Primary completion
- 1 Feb 2028 (estimated)
- Study completion
- 1 Feb 2028 (estimated)
- First posted
- 23 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this randomized controlled study is to investigate the impact of chiropractic care on CCRF (Chronic Cancer Related Fatigue) and other health-related challenges that burden cancer survivors.
Detailed description
To our knowledge, the impact of chiropractic care on CCRF and other health-related challenges that burden cancer survivors has yet to be investigated. Because this is a pilot trial, the primary outcomes center around feasibility and include 1) randomization, 2) compliance, 3) tolerability, 4) adherence, and 5) retention in each arm. Secondary outcomes include changes in patient-reported outcomes (PROs), electrocardiography (ECG) derived heart rate variability (HRV), impedance cardiography (ICG) derived pre-ejection period (PEP), and number of completed sit-to-stands.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Delayed Group | Active comparator | Other: Delayed Chiropractic CareAfter the 6-week lab assessments, the participants in the delayed group will be offered 6 weeks of chiropractic care. |
| Immediate Group | Experimental | Other: Immediate Chiropractic CareAfter the baseline assessment, the participants in the intervention group will receive 12 weeks of chiropractic care. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- 18-65 years of age.
- Self-report that they have been informed by their primary health care provider that they are cancer-free (this is sometimes referred to as 'complete remission' or 'cured').
- Minimum of 3 months since the completion of their primary curative-intent cancer therapies including surgery, chemotherapy, radiotherapy, and/or immunotherapy (long-term hormone therapy permitted)
- Scores in the moderate-to-severe range (i.e., at or above the 60th percentile) on the FACIT-Fatigue scale.
- Fatigue onset was at some point during their illness/treatment \& negatively impacts their quality of life \& daily functioning.
Key exclusion criteria (11 listed)
- Chiropractic care within the past 2 weeks
- Taking short-acting benzodiazepines which include midazolam/Versed \& triazolam/Halcion.
- Taking GLP-1 medications
- Taking other types of prescription medications (including hormone therapy) and hasn't been on a stable dose for a minimum of 6 weeks with plans to change medications or doses during the study.
- Disorders that cause fainting during rapid postural changes (e.g., POTS, orthostatic hypotension).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Immediate Chiropractic CareParticipants in the immediate start group will be assigned to chiropractic care for 12 weeks. Participants will have their upper cervical spine (C1/C2) assessed for the presence of vertebral subluxations per the chiropractor's normal and customary procedures and adjusted if necessary. | Other | Immediate Group |
| Delayed Chiropractic CareParticipants in the delayed start group will be assigned to chiropractic care for 6 weeks. Participants will have their upper cervical spine (C1/C2) assessed for the presence of vertebral subluxations per the chiropractor's normal and customary procedures and adjusted if necessary. | Other | Delayed Group |
Primary outcome
Number of Eligible Randomized Participants
Time frame: 2 years
The proportion of eligible participants randomized into the study
Number of Participants Who Adhere to Study
Time frame: 2 years
Proportion of enrolled participants who adhere to the pre-baseline assessment lifestyle restrictions as instructed. This assesses compliance.
Number of Participants That Can Fulfill Study Activities
Time frame: 2 years
Proportion of participants that can fulfill the given baseline assessment as directed. This assesses tolerability
Number of Participants Who Chiropractic Sessions
Time frame: 2 years
Proportion of randomized adults attending ≥90% of chiro sessions within 7 days of the prescribed time frame. This assesses adherence to treatment.
Number of Enrolled Intervention Group Participants
Time frame: 2 years
Proportion of the immediate-start group attending the final assessment session. This assesses retention.
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Mar 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Tyson Perez, DC, PhD principal investigator
Life University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Immediate Chiropractic Care and Delayed Chiropractic Care in people with Cancer and Fatigue, run by Life University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: paused, as of the sponsor's last update on 30 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of Eligible Randomized Participants (time frame: 2 years). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Mar 2026.