Laryngoscopic Stress ResponsePhase 4NCT07300878
Effect of Video Laryngoscopy Versus Conventional Laryngoscopy Upon Hemodynamics
A Phase 4 study testing C MAC hyperangulated video laryngoscopy and Conventional macintosh laryngoscopy in people with Laryngoscopic Stress Response and Video Laryngoscopy, run by Pakistan Institute of Medical Sciences at 1 site in Pakistan.
Trial summary
In general anestheisa airway is secured by passing a tube down the widpipe. This helps the patient to breath via ventilator during anesthesia. For placing this tube laryngoscopy is done which results in increase in blood pressure and heart rate. Read more about this study
- Who is it for?
- Ages 16 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Laryngoscopic Stress Response, Video Laryngoscopy, Conventional Laryngoscopy
- What is being tested?
- C MAC hyperangulated video laryngoscopy and Conventional macintosh laryngoscopy
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 208 participants
- Where
- 1 sitePakistan
- Study dates
- 22 Dec 2025to 15 May 2026
- Phase
- Phase 4
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 to 80 years
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- Elective surgeries under General Endotracheal Anesthesia. ASA class I and II.
Who cannot join
- Pregnancy
- Body mass index >35 kg/m2
- No teeth
- Maxillofacial trauma
- Limited Cervical spine movement
- Upper Airway Tumors
- Preoperative assessment indicating difficult airway requiring use of video laryngoscope or fiberoptic intubation.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparison Of Hemodynamic Stress Response To Laryngoscopy With Video Laryngoscopy Versus Macintosh Laryngoscopy In Patients Undergoing Elective Surgeries Under General Anesthesia
In general anestheisa airway is secured by passing a tube down the widpipe. This helps the patient to breath via ventilator during anesthesia. For placing this tube laryngoscopy is done which results in increase in blood pressure and heart rate. This study will compare the rise in blood pressure and heart rate among when using video laryngoscope with conventional laryngoscope.
Read the detailed description
In this study Patients will be randomly divided into two groups with group V patients being intubated using Videolaryngoscope while group M patients will be intubated using Macintosh laryngoscope. The amount of rise in blood pressure and heart rate as a result of laryngoscopy will be noted.
- Being tested
- C MAC hyperangulated video laryngoscopy, Conventional macintosh laryngoscopy
- Keywords
- Laryngoscopic stress response, Video laryngoscopy, Conventional laryngoscopy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
C MAC hyperangulated video laryngoscopyDevice
Patient will be intubated using hyperangulated C MAC video laryngoscope
Conventional macintosh laryngoscopyDevice
Patient in this group will be intubated using conventional macintosh laryngoscopy
| Study group | Role | What they receive |
|---|---|---|
| Video laryngoscopy | Experimental | Patient in this group will be intubated using hyperangulated C MAC video laryngoscope Receives: Device: C MAC hyperangulated video laryngoscopy |
| Conventional Laryngoscopy | Active comparator | Patient in this group will be intubated using conventional macintosh laryngoscopic blade Receives: Device: Conventional macintosh laryngoscopy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Heart Rate
Measured: Upon arrival in OR (baseline) then immediately following intubation (T1) and then at 3,5,10 minutes following intubation
Secondary outcomes (3)
Mean Blood Pressure
Measured: This will be measured upon arrival in OR (baseline) immediately following intubation(T1) and then at 3,5,10 minutes following intubation
Systolic Blood Pressure
Measured: This will be measured upon arrival in OR (baseline) immediately following intubation(T1) and then at 3,5,10 minutes following intubation
Diastolic Blood Pressure
Measured: This will be measured upon arrival in OR (baseline) immediately following intubation(T1) and then at 3,5,10 minutes following intubation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Dec 2025
- Study start22 Dec 2025
- Primary completion15 May 2026
- Study completion15 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Laryngoscopic Stress ResponseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 4
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 208 participants (actual)
Sponsor and investigators
- Lead sponsor
- Pakistan Institute of Medical Sciences
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Muhammad Haroon Anwar, Pakistan Institute of Medical Sciences
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07300878
- Sponsor's protocol ID
- F.5.2/2024(ERRC)/PIMS
- Status last verified
- May 2026
- First submitted
- 21 Dec 2025
- Last updated
- 29 May 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No: This is due to hospital and ethical committee policies
Publications
Wang L, Li H, Zhong Y, Ye S, Deng J, Pan T, Zhang Y. Comparative Analysis of Hemodynamic Responses and Oropharyngeal Complications in Tracheal Intubation: Evaluating Conventional, Video, and Rigid Video Laryngoscopes Under General Anesthesia. Med Sci Monit. 2024 Sep 5;30:e944916. doi: 10.12659/MSM.944916.
PubMed 39233395
Study at a glance
From the registry record, last updated by the sponsor on 29 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison Of Hemodynamic Stress Response To Laryngoscopy With Video Laryngoscopy Versus Macintosh Laryngoscopy In Patients Undergoing Elective Surgeries Under General Anesthesia
- ClinicalTrials.gov ID
- NCT07300878
- Acronym / sponsor ID
- F.5.2/2024(ERRC)/PIMS
- Keywords
- Laryngoscopic stress response, Video laryngoscopy, Conventional laryngoscopy
- Phase
- Phase 4
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 208 participants (actual)
- Lead sponsor
- Pakistan Institute of Medical SciencesOther government
- Study start
- 22 Dec 2025 (actual)
- Primary completion
- 15 May 2026 (actual)
- Study completion
- 15 May 2026 (actual)
- First posted
- 24 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In general anestheisa airway is secured by passing a tube down the widpipe. This helps the patient to breath via ventilator during anesthesia. For placing this tube laryngoscopy is done which results in increase in blood pressure and heart rate. This study will compare the rise in blood pressure and heart rate among when using video laryngoscope with conventional laryngoscope.
Detailed description
In this study Patients will be randomly divided into two groups with group V patients being intubated using Videolaryngoscope while group M patients will be intubated using Macintosh laryngoscope. The amount of rise in blood pressure and heart rate as a result of laryngoscopy will be noted.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Video laryngoscopy | Experimental | Device: C MAC hyperangulated video laryngoscopyPatient in this group will be intubated using hyperangulated C MAC video laryngoscope |
| Conventional Laryngoscopy | Active comparator | Device: Conventional macintosh laryngoscopyPatient in this group will be intubated using conventional macintosh laryngoscopic blade |
Who may qualify
- Ages
- 16 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (1 listed)
- Elective surgeries under General Endotracheal Anesthesia. ASA class I and II.
Key exclusion criteria (7 listed)
- Pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| C MAC hyperangulated video laryngoscopyPatient will be intubated using hyperangulated C MAC video laryngoscope | Device | Video laryngoscopy |
| Conventional macintosh laryngoscopyPatient in this group will be intubated using conventional macintosh laryngoscopy | Device | Conventional Laryngoscopy |
Primary outcome
Heart Rate
Time frame: Upon arrival in OR (baseline) then immediately following intubation (T1) and then at 3,5,10 minutes following intubation
3 secondary outcomes
Mean Blood Pressure
Time frame: This will be measured upon arrival in OR (baseline) immediately following intubation(T1) and then at 3,5,10 minutes following intubation
Systolic Blood Pressure
Time frame: This will be measured upon arrival in OR (baseline) immediately following intubation(T1) and then at 3,5,10 minutes following intubation
Diastolic Blood Pressure
Time frame: This will be measured upon arrival in OR (baseline) immediately following intubation(T1) and then at 3,5,10 minutes following intubation
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 May 2026.
- Background: PubMed 39233395Wang L, Li H, Zhong Y, Ye S, Deng J, Pan T, Zhang Y. Comparative Analysis of Hemodynamic Responses and Oropharyngeal Complications in Tracheal Intubation: Evaluating Conventional, Video, and Rigid Video Laryngoscopes Under General Anesthesia. Med Sci Monit. 2024 Sep 5;30:e944916. doi: 10.12659/MSM.944916.
- Individual participant dataSharing planned: No. This is due to hospital and ethical committee policies
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Laryngoscopic Stress Response, Dexmedetomidine
RecruitingPhase 4
Effect of Nalbuphine Versus Fentanyl on Hemdoynamic Effects of Laryngoscopy
Laryngoscopy, Hemodynamic Changes
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 4 study testing C MAC hyperangulated video laryngoscopy and Conventional macintosh laryngoscopy in people with Laryngoscopic Stress Response and Video Laryngoscopy, run by Pakistan Institute of Medical Sciences at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 4 studies take place after a treatment is approved, to learn more about its long-term benefits and risks in everyday use.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Heart Rate (time frame: Upon arrival in OR (baseline) then immediately following intubation (T1) and then at 3,5,10 minutes following intubation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07300878, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 May 2026.