Pulmonary NodulesNCT07302217
Effect of Technology-Assisted Preoperative Home Exercise on Postoperative Handgrip Strength, Muscle Endurance, and Psychological Distress in Patients With Pulmonary Nodules Undergoing Video-Assisted Thoracoscopic Surgery
A study testing Technology-Assisted Preoperative Home-Based Exercise Program in people with Pulmonary Nodules, run by National Taiwan University Hospital at 1 site in Taiwan.
Trial summary
This study aims to evaluate the effects of a technology-assisted preoperative home-based exercise program, delivered through a LINE Official Account and LINE BOT, on postoperative hand-grip strength, muscle endurance, and psychological distress in patients undergoing thoracoscopic pulmonary nodule resection. Read more about this study
- Who is it for?
- Ages 20 years and older
- Conditions the study is for
- Pulmonary Nodules
- What is being tested?
- Technology-Assisted Preoperative Home-Based Exercise Program
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteTaiwan
- Study dates
- 17 Dec 2025to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients with pulmonary nodules who are scheduled to undergo video-assisted thoracoscopic surgery for nodule resection (including wedge resection, segmentectomy, or lobectomy).
- Aged 20 years or older and assessed by a healthcare provider as medically suitable to participate in exercise training.
- At least one week between the date of enrollment and the scheduled surgery.
- Willing to provide written informed consent and complete all study procedures, including joining the LINE Official Account, participating in the exercise training, completing questionnaires, and undergoing outcome assessments.
Who cannot join
- Metastatic tumors or contraindications to exercise participation.
- Engagement in regular aerobic or resistance exercise within the past month (defined as ≥2 sessions per week, ≥30 minutes per session).
- Inability to communicate in Mandarin or Taiwanese.
- Inability to use technology-assisted applications (e.g., LINE APP).
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Taiwan1 site
National Taiwan University Cancer Center
Taipei
Li-Ping Chen, 886-2-23220322#238070, A00727@ntucc.gov.tw
About this study
Official title: Effect of Technology-Assisted Intervention Program on Postoperative Handgrip Strength, Muscle Endurance, and Psychological Distress in Patients With Pulmonary Nodules
This study aims to evaluate the effects of a technology-assisted preoperative home-based exercise program, delivered through a LINE Official Account and LINE BOT, on postoperative hand-grip strength, muscle endurance, and psychological distress in patients undergoing thoracoscopic pulmonary nodule resection. The study adopts a single-group pretest post-test design and plans to recruit 60 eligible patients.
The intervention consists of at least one week of home exercise training before surgery, incorporating aerobic, resistance, and breathing exercises. Education, guidance, and interactive feedback are provided through the LINE platform to support adherence and exercise performance. Outcomes will be assessed at three time points: baseline (T0), immediately before surgery (T1), and two weeks after surgery (T2).
Read the detailed description
Lung cancer remains the leading cause of cancer-related mortality in Taiwan, and pulmonary nodule resection is a common surgical intervention. Patients often experience postoperative declines in physical function, including hand-grip strength, muscle endurance, and aerobic capacity, along with increased psychological distress such as anxiety and depression. Preoperative rehabilitation has been shown to improve peri-operative outcomes; however, traditional in-person programs are often limited by time constraints, travel burden, and access barriers. Technology-assisted remote health interventions have emerged as a feasible approach to enhancing patient engagement and extending preoperative support.
This study aims to evaluate the effectiveness of a technology-assisted preoperative home-based exercise program delivered through a LINE Official Account and LINE BOT platform. The program is designed to improve postoperative hand-grip strength, muscle endurance, body composition, and psychological distress among patients undergoing thoracoscopic pulmonary nodule resection. The study adopts a quasi-experimental single-group pretest-posttest design and plans to enroll approximately 60 eligible participants.
The intervention includes at least one week of home-based exercise training before surgery and consists of aerobic exercises (such as walking or marching), resistance training movements (including high-knee marching, sit-to-stand, and other functional muscle-strengthening exercises), and breathing exercises (including pursed-lip breathing and diaphragmatic breathing). Educational materials, reminders, guidance, and interactive feedback will be delivered through the LINE platform to enhance adherence, reinforce correct techniques, and support patient engagement.
Outcome assessments will be conducted at three time points: baseline (T0) during the outpatient visit when surgery is scheduled; immediately before surgery at hospital admission (T1); and two weeks after surgery (T2). Primary outcomes include hand-grip strength and muscle endurance, while secondary outcomes include body composition and psychological distress (anxiety and depression).
This study is expected to establish a feasible, sustainable, and flexible model for technology-assisted preoperative health promotion. Findings may provide evidence for integrating digital health tools into peri-operative care pathways to support enhanced recovery following thoracic surgery.
- Conditions
- Pulmonary Nodules
- Being tested
- Technology-Assisted Preoperative Home-Based Exercise Program
- Keywords
- exercise, APP LINE, Lung nodule
- Medical subject headings
- Multiple Pulmonary Nodules, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Technology-Assisted Preoperative Home-Based Exercise ProgramBehavioural
This behavioral intervention uses a technology-assisted approach to deliver preoperative home-based exercise training for patients scheduled to undergo video-assisted lung nodule resection. The intervention integrates a LINE Official Account with an automated LINE Bot that provides exercise instructions, educational materials, reminders, and self-report mechanisms.
The exercise program is based on published preoperative home-exercise protocols for lung cancer surgery patients. It includes:
- Aerobic exercise - walking or marching in place for 30 minutes, three times per week;
- Resistance training - six exercises (high-knee marching, bridging, sit-to-stand, shoulder press, biceps curl, heel raise), performed twice weekly (non-consecutive), 30 repetitions each;
- Breathing exercises - pursed-lip and diaphragmatic breathing, 10 repetitions each, three times per week;
- Warm-up and cool-down for 5 minutes before and after exercise. The LINE Bot system provides video demonstration
| Study group | Role | What they receive |
|---|---|---|
| Technology-Assisted Preoperative Home-Based Exercise Program | Experimental | Participants in this arm will receive a technology-assisted preoperative home-based exercise program delivered through a LINE APP. The program includes aerobic, resistance, and breathing exercises performed for at least one week before surgery. Educational messages, reminders, and interactive feedback are provided through the LINE platform to support exercise adherence. Receives: Behavioral: Technology-Assisted Preoperative Home-Based Exercise Program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Hand-grip Strength
Hand-grip strength will be measured using a calibrated handheld dynamometer. Measurements will be collected at three time points:
Baseline at outpatient visit when surgery is scheduled (T0), Preoperative assessment on the day of admission (T1), Two weeks after surgery (T2). The primary outcome is the change in dominant-hand grip strength from T0 to T2. Higher values indicate greater muscle strength. The measure reflects postoperative functional recovery and the effectiveness of the technology-assisted preoperative exercise program.
Measured: Before surgery (T0) to 2 weeks post-surgery (T2)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Dec 2025
- Study start17 Dec 2025 (estimated)
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pulmonary NodulesStudies of the same condition, open and under way.
- More trials run by National Taiwan University HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- This study uses a single-group assignment model without a control group. All participants receive the LINE-based preoperative exercise intervention, and outcomes are compared across baseline, pre-surgery, and two-week postoperative assessments.
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Taiwan University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07302217
- Sponsor's protocol ID
- 202509080RINB
- Status last verified
- Dec 2025
- First submitted
- 11 Dec 2025
- Last updated
- 24 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: The plan for sharing individual participant data (IPD) has not yet been determined. Decisions regarding data sharing will depend on institutional policies, ethical considerations, and data privacy regulations. IPD will only be shared if appropriate safeguards and approvals are in place.
Study at a glance
From the registry record, last updated by the sponsor on 24 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Technology-Assisted Intervention Program on Postoperative Handgrip Strength, Muscle Endurance, and Psychological Distress in Patients With Pulmonary Nodules
- ClinicalTrials.gov ID
- NCT07302217
- Acronym / sponsor ID
- 202509080RINB
- Conditions
- Pulmonary Nodules
- Keywords
- exercise, APP LINE, Lung nodule
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- National Taiwan University HospitalUniversity, hospital or other
- Study start
- 17 Dec 2025 (estimated)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 24 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to evaluate the effects of a technology-assisted preoperative home-based exercise program, delivered through a LINE Official Account and LINE BOT, on postoperative hand-grip strength, muscle endurance, and psychological distress in patients undergoing thoracoscopic pulmonary nodule resection. The study adopts a single-group pretest post-test design and plans to recruit 60 eligible patients.
The intervention consists of at least one week of home exercise training before surgery, incorporating aerobic, resistance, and breathing exercises. Education, guidance, and interactive feedback are provided through the LINE platform to support adherence and exercise performance. Outcomes will be assessed at three time points: baseline (T0), immediately before surgery (T1), and two weeks after surgery (T2).
Detailed description
Lung cancer remains the leading cause of cancer-related mortality in Taiwan, and pulmonary nodule resection is a common surgical intervention. Patients often experience postoperative declines in physical function, including hand-grip strength, muscle endurance, and aerobic capacity, along with increased psychological distress such as anxiety and depression. Preoperative rehabilitation has been shown to improve peri-operative outcomes; however, traditional in-person programs are often limited by time constraints, travel burden, and access barriers. Technology-assisted remote health interventions have emerged as a feasible approach to enhancing patient engagement and extending preoperative support.
This study aims to evaluate the effectiveness of a technology-assisted preoperative home-based exercise program delivered through a LINE Official Account and LINE BOT platform. The program is designed to improve postoperative hand-grip strength, muscle endurance, body composition, and psychological distress among patients undergoing thoracoscopic pulmonary nodule resection. The study adopts a quasi-experimental single-group pretest-posttest design and plans to enroll approximately 60 eligible participants.
The intervention includes at least one week of home-based exercise training before surgery and consists of aerobic exercises (such as walking or marching), resistance training movements (including high-knee marching, sit-to-stand, and other functional muscle-strengthening exercises), and breathing exercises (including pursed-lip breathing and diaphragmatic breathing). Educational materials, reminders, guidance, and interactive feedback will be delivered through the LINE platform to enhance adherence, reinforce correct techniques, and support patient engagement.
Outcome assessments will be conducted at three time points: baseline (T0) during the outpatient visit when surgery is scheduled; immediately before surgery at hospital admission (T1); and two weeks after surgery (T2). Primary outcomes include hand-grip strength and muscle endurance, while secondary outcomes include body composition and psychological distress (anxiety and depression).
This study is expected to establish a feasible, sustainable, and flexible model for technology-assisted preoperative health promotion. Findings may provide evidence for integrating digital health tools into peri-operative care pathways to support enhanced recovery following thoracic surgery.
Study design
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- This study uses a single-group assignment model without a control group. All participants receive the LINE-based preoperative exercise intervention, and outcomes are compared across baseline, pre-surgery, and two-week postoperative assessments.
| Arm | Type | Receives |
|---|---|---|
| Technology-Assisted Preoperative Home-Based Exercise Program | Experimental | Behavioral: Technology-Assisted Preoperative Home-Based Exercise ProgramParticipants in this arm will receive a technology-assisted preoperative home-based exercise program delivered through a LINE APP. The program includes aerobic, resistance, and breathing exercises performed for at least one week before surgery. Educational messages, reminders, and interactive feedback are provided through the LINE platform to support exercise adherence. |
Who may qualify
- Ages
- 20 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Patients with pulmonary nodules who are scheduled to undergo video-assisted thoracoscopic surgery for nodule resection (including wedge resection, segmentectomy, or lobectomy).
- Aged 20 years or older and assessed by a healthcare provider as medically suitable to participate in exercise training.
- At least one week between the date of enrollment and the scheduled surgery.
- Willing to provide written informed consent and complete all study procedures, including joining the LINE Official Account, participating in the exercise training, completing questionnaires, and undergoing outcome assessments.
Key exclusion criteria (4 listed)
- Metastatic tumors or contraindications to exercise participation.
- Engagement in regular aerobic or resistance exercise within the past month (defined as ≥2 sessions per week, ≥30 minutes per session).
- Inability to communicate in Mandarin or Taiwanese.
- Inability to use technology-assisted applications (e.g., LINE APP).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Technology-Assisted Preoperative Home-Based Exercise ProgramThis behavioral intervention uses a technology-assisted approach to deliver preoperative home-based exercise training for patients scheduled to undergo video-assisted lung nodule resection. The intervention integrates a LINE Official Account with an automated LINE Bot that provides exercise instructions, educational materials, reminders, and self-report mechanisms. The exercise program is based on published preoperative home-exercise protocols for lung cancer surgery patients. It includes: 1. Aerobic exercise - walking or marching in place for 30 minutes, three times per week; 2. Resistance training - six exercises (high-knee marching, bridging, sit-to-stand, shoulder press, biceps curl, heel raise), performed twice weekly (non-consecutive), 30 repetitions each; 3. Breathing exercises - pursed-lip and diaphragmatic breathing, 10 repetitions each, three times per week; 4. Warm-up and cool-down for 5 minutes before and after exercise. The LINE Bot system provides video demonstration | Behavioural | Technology-Assisted Preoperative Home-Based Exercise Program |
Primary outcome
Hand-grip Strength
Time frame: Before surgery (T0) to 2 weeks post-surgery (T2)
Hand-grip strength will be measured using a calibrated handheld dynamometer. Measurements will be collected at three time points: Baseline at outpatient visit when surgery is scheduled (T0), Preoperative assessment on the day of admission (T1), Two weeks after surgery (T2). The primary outcome is the change in dominant-hand grip strength from T0 to T2. Higher values indicate greater muscle strength. The measure reflects postoperative functional recovery and the effectiveness of the technology-assisted preoperative exercise program.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Dec 2025.
- Individual participant dataSharing planned: Undecided. The plan for sharing individual participant data (IPD) has not yet been determined. Decisions regarding data sharing will depend on institutional policies, ethical considerations, and data privacy regulations. IPD will only be shared if appropriate safeguards and approvals are in place.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Technology-Assisted Preoperative Home-Based Exercise Program in people with Pulmonary Nodules, run by National Taiwan University Hospital at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 24 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Li-Ping Chen, RN, NP (886-2--23123456#238070, A00727@ntucc.gov.tw), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Hand-grip Strength (time frame: Before surgery (T0) to 2 weeks post-surgery (T2)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Dec 2025.