Chronic Traumatic EncephalopathyBQ TC-footNCT07302503
Pilot Study Evaluating brainQuant's Ability to Detect Alterations in White Matter in Diffusion MRI, Indicative of Post-traumatic Lesions
An observational study of Chronic Traumatic Encephalopathy, run by University Hospital, Strasbourg, France at 1 site in France.
Trial summary
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease described in boxing, but also in contact sports such as American football. Soccer, due to repeated headers, could also be associated, albeit to a lesser degree, with the development of this type of pathology. Read more about this study
- Who is it for?
- Ages 32 to 60 years, men only
- Conditions the study is for
- Chronic Traumatic Encephalopathy
- How many people
- 80 participants
- Where
- 1 siteFrance
- Study dates
- 10 Sep 2024to Mar 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 32 to 60 years
- Men only
- Adult
Study population: Male subject aged 32 to 60 years
Who may be able to join
- Male subject
- Aged 32 to 60 years inclusive
- Professional footballer nearing the end of their career or recently retired, or subject who has never regularly participated in sports that expose them to head trauma (particularly rugby, basketball, handball, American football, hockey, combat sports, etc.)
Who cannot join
- Subject who expressed their opposition to participating in the study
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
Service d'Imagerie 2 - Réanimation - CHU de Strasbourg - France
Strasbourg, 67091
Stéphane KREMER, Stéphane KREMERMD, PhD, 33 3 88 12 78 48, stephane.kremer@chru-strasbourg.fr
Stéphane KREMER, MD, PhD
About this study
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease described in boxing, but also in contact sports such as American football.
Soccer, due to repeated headers, could also be associated, albeit to a lesser degree, with the development of this type of pathology.
Read more
Indeed, it has been shown that playing soccer can be accompanied by cognitive impairments, and neurodegenerative brain abnormalities have been described in neuropathology studies of former professional soccer players. Subradiological brain abnormalities have been found in multimodal MRI in various sports. Similarly, a decrease in cognitive performance has been described.
The discovery of this type of anomaly in a population of professional footballers nearing the end of their careers could lead to:
- The implementation of appropriate monitoring for professional footballers through early detection of lesions via MRI and cognitive disorders
- The implementation of preventative measures for professional footballers, but also for amateur footballers from a very young age.
- Conditions
- Chronic Traumatic Encephalopathy
- Keywords
- Chronic Traumatic Encephalopathy, Post-traumatic lesions, Neurodegenerative brain abnormalities, Professional soccer players
- Medical subject headings
- Chronic Traumatic Encephalopathy
What is being measured
The primary outcome is the main question the study is designed to answer.
Changes found in MRI diffusion tensor imaging of professional football players
Measured: day 1 post-consultation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Dec 2025
- Study start10 Sep 2024
- Primary completionMar 2028 (estimated)
- Study completionMar 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic Traumatic EncephalopathyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Retrospective
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Strasbourg, France
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07302503
- Sponsor's protocol ID
- 9451
- Acronym
- BQ TC-foot
- Status last verified
- Dec 2025
- First submitted
- 10 Dec 2025
- Last updated
- 24 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 24 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Pilot Study Evaluating brainQuant's Ability to Detect Alterations in White Matter in Diffusion MRI, Indicative of Post-traumatic Lesions
- ClinicalTrials.gov ID
- NCT07302503
- Acronym / sponsor ID
- BQ TC-foot / 9451
- Conditions
- Chronic Traumatic Encephalopathy
- Keywords
- Chronic Traumatic Encephalopathy, Post-traumatic lesions, Neurodegenerative brain abnormalities, Professional soccer players
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- University Hospital, Strasbourg, FranceUniversity, hospital or other
- Study start
- 10 Sep 2024 (actual)
- Primary completion
- Mar 2028 (estimated)
- Study completion
- Mar 2028 (estimated)
- First posted
- 24 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease described in boxing, but also in contact sports such as American football.
Soccer, due to repeated headers, could also be associated, albeit to a lesser degree, with the development of this type of pathology.
Indeed, it has been shown that playing soccer can be accompanied by cognitive impairments, and neurodegenerative brain abnormalities have been described in neuropathology studies of former professional soccer players. Subradiological brain abnormalities have been found in multimodal MRI in various sports. Similarly, a decrease in cognitive performance has been described.
The discovery of this type of anomaly in a population of professional footballers nearing the end of their careers could lead to:
- The implementation of appropriate monitoring for professional footballers through early detection of lesions via MRI and cognitive disorders
- The implementation of preventative measures for professional footballers, but also for amateur footballers from a very young age.
Study design
- Observational model
- Case only
- Time perspective
- Retrospective
Who may qualify
- Ages
- 32 to 60 years
- Sex
- Male only
- Age groups
- Adult
- Study population
- Male subject aged 32 to 60 years
Key inclusion criteria (3 listed)
- Male subject
- Aged 32 to 60 years inclusive
- Professional footballer nearing the end of their career or recently retired, or subject who has never regularly participated in sports that expose them to head trauma (particularly rugby, basketball, handball, American football, hockey, combat sports, etc.)
Key exclusion criteria (1 listed)
- Subject who expressed their opposition to participating in the study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Changes found in MRI diffusion tensor imaging of professional football players
Time frame: day 1 post-consultation
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Dec 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Chronic Traumatic Encephalopathy, run by University Hospital, Strasbourg, France at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 24 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Stéphane KREMER, MD, PhD (33 3 88 12 78 48, stephane.kremer@chru-strasbourg.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Changes found in MRI diffusion tensor imaging of professional football players (time frame: day 1 post-consultation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Dec 2025.