Intellectual Developmental DisorderEmoTDINCT07303270
Emotional Processes in Adults With Intellectual Developmental Disorder
A study testing ACQUISS protocol assessing emotional processing. in people with Intellectual Developmental Disorder, run by Hôpital le Vinatier at 1 site in France.
Trial summary
Emotions play a crucial part in the quality of life, interpersonal relationships and mental health in general. In adults presenting with intellectual developmental disorder (IDD), emotional abilities may be hindered, thus leading to more challenging behaviors. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Intellectual Developmental Disorder
- What is being tested?
- ACQUISS protocol assessing emotional processing.
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteFrance
- Study dates
- 19 Feb 2026to 20 Nov 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- IDD group :
- Diagnosis of IDD according to DSM-V criteria
- aged between 18 and 3 years
- French speaking
- Membership or entitlement to a social security plan
- informed consent, or that of the tutor, to take part in the study
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- presence of a caregiver to complete the questionnaires at V2.
- Control group :
- aged between 18 and 35 years
- French speaking
- Membership or entitlement to a social security plan
- Informed written consent to take part in the study.
Who cannot join
- IDD group :
- visual or auditory impairments, evaluated at V1
- non stabilized epilepsy
- undergoing treatments that can impact brain or psychological functioning
- major motor disorders
- breastfeeding or pregnant woman
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- Control group :
- neurodevelopmental or psychiatric disorder
- history of brain trauma (TBI, stroke, etc…) or non-stabilized epilepsy
- visual or auditory impairments, evaluated at V1
- non stabilized epilepsy
- undergoing treatments that can impact brain or psychological functioning
- major motor disorders
- breastfeeding or pregnant woman
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
CH Le Vinatier
Bron, 69500
Marie-Noelle Babinet, PhD, +33437915380, marie-noelle.babinet@ch-le-vinatier.fr
About this study
Official title: Assessing Emotional Processes in Adults With Intellectual Developmental Disorder Using the ACQUISS Battery
Emotions play a crucial part in the quality of life, interpersonal relationships and mental health in general. In adults presenting with intellectual developmental disorder (IDD), emotional abilities may be hindered, thus leading to more challenging behaviors. A better understanding of emotional processes of adults with IDD may help improve the efficiency of behavioral interventions and better improve their quality of life.
The primary goal of this study is to better characterize the abilities and weaknesses of adults with IDD concerning their emotional processes, in comparison to a healthy population. The secondary goals are :
- to determine if these difficulties are underlined by oculomotor and attention (auditory and visual) processes
- to determine if behavioral difficulties, as reported by the families of adults with IDD, are underlined by specific difficulties in facial emotion recognition, emotion identification in context and/or identification of vocal emotions.
Read the detailed description
The study will be carried out in 3 steps :
Step 1: All participants will undergo tests to evaluate their intellectual abilities, and auditory and visual screening tests.
Step 2 : All participants will undergo neuropsychological tests assessing attentional and oculomotor abilities (1 hour). During this time, the participant's family member will complete the questionnaires assessing behavior.
Step 3 : All participants will undergo the experimental ACQUISS protocol (task 1 : faces; task 2 : faces in context; task 3 : prosody) (1 hour).
Detailed Description:
Step 1 :
During this first step, all participants (both groups), will undergo the Raven Progressive Matrices (John and Raven 2003) to assess their intellectual abilities. They will then undergo an auditory screening test (tonality test) and a visual screening task (the Rossano-Weiss scale and the Palettes de Léa Grattins task).
Step 2 :
During this second step, all participants (both groups) will undergo :
- - the tangled lines test (Rey, 1964) : in this task, the participant must follow by gaze entangled lines to determine the beginning and end of each line.
- - the NSUCO oculomotor test (Maillet, 2015) : the orthoptist will evaluate the ability of the participant to carry out ocular saccades and movement pursuit.
- - the Auditory attention task of the NEPSY-II battery (Korkman et al., 2012)
- - 2 cancellation tests from the EVA battery (Chokron, 2010):
- the TeddyBear Cancellation test
- the single-letter cancellation test
Step 3:
During this step, all participants from both groups will undergo the ACQUISS protocol.
- Conditions
- Intellectual Developmental Disorder
- Being tested
- ACQUISS protocol assessing emotional processing.
- Keywords
- Intellectual Developmental Disorder, emotional processing, Cognitive assessments, Social cognition
- Medical subject headings
- Intellectual Disability
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ACQUISS protocol assessing emotional processing.Other
Task 1: 5 minute facial emotion recognition test to identify isolated facial expressions. 6 drawn faces, without gender bias, without hair, expressing the 6 universal emotions will be presented. The emotions are: happiness, sadness, anger, fear, surprise and disgust.
Task 2 : identifying a character's emotion in a social context (20 min). The subject is presented with drawn social contexts, one character is always in orange, and the face is left blank. The subject then has to choose amongst 6 emotions (happiness, sadness, anger, fear, surprise and disgust) which one would correspond the most to the emotion expressed by the character in orange.
Task 3 : recognizing vocal emotions (15 min). The subject is presented with dialogues of 3 sentences. The 3 sentences are expressed with a vocal emotion (same emotion for the 3 sentences). The contents of the sentences are neutral At the end of each dialogue, the subject has to show which emotion was expressed.
| Study group | Role | What they receive |
|---|---|---|
| IDD group | Experimental | adults with Intellectual Developmental Disorder Receives: Other: ACQUISS protocol assessing emotional processing. |
| Control group | Other | healthy adults Receives: Other: ACQUISS protocol assessing emotional processing. |
What is being measured
The primary outcome is the main question the study is designed to answer.
proportion of correct answers on the ACQUISS battery
proportion of correct answers in each of the 3 tasks
Measured: Baseline
Secondary outcomes (7)
Proportion of correct answers on the Entangled lines test
Measured: Baseline
Proportion of correct answers on the NSUCO test
Northeastern State University College of Optometry test.
Measured: Baseline
Proportion of correct answers on an auditory attentional task (NEPSY-II)
Measured: Baseline
Proportion of correct signs barred on the TeddyBear task
Measured: Baseline
Proportion of correct signs barred on the letter task
Measured: Baseline
Score on the Agressivity questionnaire
Score on the Agressivity questionnaire ("Problematic behavior in group settings"), filled in by a caregiver. Minimum score = 6; Maximum score = 30. Higher scores suggest greater agressivity.
Measured: Baseline
Score on the Aberrant Behavior Checklist
Score on the Aberrant Behavior Checklist, filled in by a caregiver. Minimum = 0; Maximum = 174. Higher scores reflect more severe levels of challenging behavior.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Dec 2025
- Study start19 Feb 2026
- Primary completionAug 2028 (estimated)
- Study completion20 Nov 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Intellectual Developmental DisorderStudies of the same condition, open and under way.
- More trials run by Hôpital le VinatierThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- IDD group compared to control group
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Hôpital le Vinatier
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07303270
- Sponsor's protocol ID
- 2025-A01946-43
- Acronym
- EmoTDI
- Status last verified
- Mar 2026
- First submitted
- 11 Dec 2025
- Last updated
- 1 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 1 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Assessing Emotional Processes in Adults With Intellectual Developmental Disorder Using the ACQUISS Battery
- ClinicalTrials.gov ID
- NCT07303270
- Acronym / sponsor ID
- EmoTDI / 2025-A01946-43
- Conditions
- Intellectual Developmental Disorder
- Keywords
- Intellectual Developmental Disorder, emotional processing, Cognitive assessments, Social cognition
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Hôpital le VinatierUniversity, hospital or other
- Study start
- 19 Feb 2026 (actual)
- Primary completion
- Aug 2028 (estimated)
- Study completion
- 20 Nov 2028 (estimated)
- First posted
- 24 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Emotions play a crucial part in the quality of life, interpersonal relationships and mental health in general. In adults presenting with intellectual developmental disorder (IDD), emotional abilities may be hindered, thus leading to more challenging behaviors. A better understanding of emotional processes of adults with IDD may help improve the efficiency of behavioral interventions and better improve their quality of life.
The primary goal of this study is to better characterize the abilities and weaknesses of adults with IDD concerning their emotional processes, in comparison to a healthy population. The secondary goals are :
- to determine if these difficulties are underlined by oculomotor and attention (auditory and visual) processes
- to determine if behavioral difficulties, as reported by the families of adults with IDD, are underlined by specific difficulties in facial emotion recognition, emotion identification in context and/or identification of vocal emotions.
Detailed description
The study will be carried out in 3 steps :
Step 1: All participants will undergo tests to evaluate their intellectual abilities, and auditory and visual screening tests.
Step 2 : All participants will undergo neuropsychological tests assessing attentional and oculomotor abilities (1 hour). During this time, the participant's family member will complete the questionnaires assessing behavior.
Step 3 : All participants will undergo the experimental ACQUISS protocol (task 1 : faces; task 2 : faces in context; task 3 : prosody) (1 hour).
Detailed Description:
Step 1 :
During this first step, all participants (both groups), will undergo the Raven Progressive Matrices (John and Raven 2003) to assess their intellectual abilities. They will then undergo an auditory screening test (tonality test) and a visual screening task (the Rossano-Weiss scale and the Palettes de Léa Grattins task).
Step 2 :
During this second step, all participants (both groups) will undergo :
- - the tangled lines test (Rey, 1964) : in this task, the participant must follow by gaze entangled lines to determine the beginning and end of each line.
- - the NSUCO oculomotor test (Maillet, 2015) : the orthoptist will evaluate the ability of the participant to carry out ocular saccades and movement pursuit.
- - the Auditory attention task of the NEPSY-II battery (Korkman et al., 2012)
- - 2 cancellation tests from the EVA battery (Chokron, 2010):
- the TeddyBear Cancellation test
- the single-letter cancellation test
Step 3:
During this step, all participants from both groups will undergo the ACQUISS protocol.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- IDD group compared to control group
| Arm | Type | Receives |
|---|---|---|
| IDD group | Experimental | Other: ACQUISS protocol assessing emotional processing.adults with Intellectual Developmental Disorder |
| Control group | Other | Other: ACQUISS protocol assessing emotional processing.healthy adults |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (12 listed)
- Diagnosis of IDD according to DSM-V criteria
- aged between 18 and 3 years
- French speaking
- Membership or entitlement to a social security plan
- informed consent, or that of the tutor, to take part in the study
Key exclusion criteria (14 listed)
- visual or auditory impairments, evaluated at V1
- non stabilized epilepsy
- undergoing treatments that can impact brain or psychological functioning
- major motor disorders
- breastfeeding or pregnant woman
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ACQUISS protocol assessing emotional processing.Task 1: 5 minute facial emotion recognition test to identify isolated facial expressions. 6 drawn faces, without gender bias, without hair, expressing the 6 universal emotions will be presented. The emotions are: happiness, sadness, anger, fear, surprise and disgust. Task 2 : identifying a character's emotion in a social context (20 min). The subject is presented with drawn social contexts, one character is always in orange, and the face is left blank. The subject then has to choose amongst 6 emotions (happiness, sadness, anger, fear, surprise and disgust) which one would correspond the most to the emotion expressed by the character in orange. Task 3 : recognizing vocal emotions (15 min). The subject is presented with dialogues of 3 sentences. The 3 sentences are expressed with a vocal emotion (same emotion for the 3 sentences). The contents of the sentences are neutral At the end of each dialogue, the subject has to show which emotion was expressed. | Other | Control group, IDD group |
Primary outcome
proportion of correct answers on the ACQUISS battery
Time frame: Baseline
proportion of correct answers in each of the 3 tasks
7 secondary outcomes
Proportion of correct answers on the Entangled lines test
Time frame: Baseline
Proportion of correct answers on the NSUCO test
Time frame: Baseline
Proportion of correct answers on an auditory attentional task (NEPSY-II)
Time frame: Baseline
Proportion of correct signs barred on the TeddyBear task
Time frame: Baseline
Proportion of correct signs barred on the letter task
Time frame: Baseline
Score on the Agressivity questionnaire
Time frame: Baseline
Score on the Aberrant Behavior Checklist
Time frame: Baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Apr 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing ACQUISS protocol assessing emotional processing. in people with Intellectual Developmental Disorder, run by Hôpital le Vinatier at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 12 inclusion and 14 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 1 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Marie-Noelle Babinet, PhD (+33437915380, marie-noelle.babinet@ch-le-vinatier.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
proportion of correct answers on the ACQUISS battery (time frame: Baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Apr 2026.