Respiratory MechanicsNCT07304479
Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery
A study testing Sevoflurane (Volatile Anesthetic) and Desflurane (volatile anesthetic) in people with Respiratory Mechanics and Intraoperative, run by National and Kapodistrian University of Athens at 1 site in Greece.
Trial summary
Inhalational anesthetics, when used in abdominal surgery, offer advantages of lung protection and reduced alveolar inflammation. There is little literature, however, in the comparative use of sevoflurane versus desflurane anesthesia in patients undergoing abdominal robotic-assisted surgery and their effects on lung… Read more about this study
- Who is it for?
- Ages 18 to 87 years
- Conditions the study is for
- Respiratory Mechanics, Intraoperative
- What is being tested?
- Sevoflurane (Volatile Anesthetic) and Desflurane (volatile anesthetic)
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteGreece
- Study dates
- 1 May 2025to 28 Feb 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 87 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age 18 to 87 years
- Undergoing elective robotic-assisted abdominal surgery
- ASA physical status I-III
Who cannot join
- ASA IV or V
- Emergency surgery
- Renal insufficiency
- Clinically significant respiratory disease
- Cardiomyopathy
- Uncontrolled hypertension
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Greece1 site, 1 recruiting
- Recruiting
Aretaieion University Hospital
Athens, 11528
Aliki Tympa, MD,PhD, 00302107286195, tympaaliki@yahoo.gr
Aikaterini Melemeni, Professor, amelemeni@med.uoa.gr
About this study
Official title: Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery on Airway Plateau Pressure: a Randomized, Prospective, Blinded Pilot Study
Inhalational anesthetics, when used in abdominal surgery, offer advantages of lung protection and reduced alveolar inflammation. There is little literature, however, in the comparative use of sevoflurane versus desflurane anesthesia in patients undergoing abdominal robotic-assisted surgery and their effects on lung mechanics.
- Conditions
- Respiratory Mechanics, Intraoperative
- Being tested
- Sevoflurane (Volatile Anesthetic), Desflurane (volatile anesthetic)
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Sevoflurane (Volatile Anesthetic)Drug
Sevoflurane for robotic assisted laparoscopic surgery
Desflurane (volatile anesthetic)Drug
Desflurane for robotic assisted laparoscopic surgery
| Study group | Role | What they receive |
|---|---|---|
| Sevoflurane (Volatile Anesthetic) | Active comparator | Not described Receives: Drug: Sevoflurane (Volatile Anesthetic) |
| Deslfurane (Volatile Anesthetic) | Active comparator | Not described Receives: Drug: Desflurane (volatile anesthetic) |
What is being measured
The primary outcome is the main question the study is designed to answer.
airway plateau pressure
Airway plateau pressure (cmH2O) as displayed on the anesthesia ventilator at the specified time points will be recorded for each participant.
Measured: Perioperatively
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Dec 2025
- Study start1 May 2025
- Primary completion30 Jan 2026 (estimated)
- Study completion28 Feb 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Respiratory MechanicsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Care provider, Investigator
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National and Kapodistrian University of Athens
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Aliki Tympa, National and Kapodistrian University of Athens
- Investigators
- Aikaterini Melemeni, Professor, Study director, Aretaieion University Hospital, National And Kapodistrian University Of Athens
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07304479
- Sponsor's protocol ID
- 705/25-07-2025
- Status last verified
- Oct 2025
- First submitted
- 29 Sep 2025
- Last updated
- 26 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Herling SF, Dreijer B, Wrist Lam G, Thomsen T, Moller AM. Total intravenous anaesthesia versus inhalational anaesthesia for adults undergoing transabdominal robotic assisted laparoscopic surgery. Cochrane Database Syst Rev. 2017 Apr 4;4(4):CD011387. doi: 10.1002/14651858.CD011387.pub2.
PubMed 28374886
Study at a glance
From the registry record, last updated by the sponsor on 26 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery on Airway Plateau Pressure: a Randomized, Prospective, Blinded Pilot Study
- ClinicalTrials.gov ID
- NCT07304479
- Acronym / sponsor ID
- 705/25-07-2025
- Conditions
- Respiratory Mechanics, Intraoperative
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- National and Kapodistrian University of AthensUniversity, hospital or other
- Study start
- 1 May 2025 (actual)
- Primary completion
- 30 Jan 2026 (estimated)
- Study completion
- 28 Feb 2026 (estimated)
- First posted
- 26 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Inhalational anesthetics, when used in abdominal surgery, offer advantages of lung protection and reduced alveolar inflammation. There is little literature, however, in the comparative use of sevoflurane versus desflurane anesthesia in patients undergoing abdominal robotic-assisted surgery and their effects on lung mechanics.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, care provider, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Sevoflurane (Volatile Anesthetic) | Active comparator | Drug: Sevoflurane (Volatile Anesthetic) |
| Deslfurane (Volatile Anesthetic) | Active comparator | Drug: Desflurane (volatile anesthetic) |
Who may qualify
- Ages
- 18 to 87 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Age 18 to 87 years
- Undergoing elective robotic-assisted abdominal surgery
- ASA physical status I-III
Key exclusion criteria (6 listed)
- ASA IV or V
- Emergency surgery
- Renal insufficiency
- Clinically significant respiratory disease
- Cardiomyopathy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Sevoflurane (Volatile Anesthetic)Sevoflurane for robotic assisted laparoscopic surgery | Drug | Sevoflurane (Volatile Anesthetic) |
| Desflurane (volatile anesthetic)Desflurane for robotic assisted laparoscopic surgery | Drug | Deslfurane (Volatile Anesthetic) |
Primary outcome
airway plateau pressure
Time frame: Perioperatively
Airway plateau pressure (cmH2O) as displayed on the anesthesia ventilator at the specified time points will be recorded for each participant.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Dec 2025.
- Results publication: PubMed 28374886Herling SF, Dreijer B, Wrist Lam G, Thomsen T, Moller AM. Total intravenous anaesthesia versus inhalational anaesthesia for adults undergoing transabdominal robotic assisted laparoscopic surgery. Cochrane Database Syst Rev. 2017 Apr 4;4(4):CD011387. doi: 10.1002/14651858.CD011387.pub2.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Aikaterini Melemeni, Professor study director
Aretaieion University Hospital, National And Kapodistrian University Of Athens
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Sevoflurane (Volatile Anesthetic) and Desflurane (volatile anesthetic) in people with Respiratory Mechanics and Intraoperative, run by National and Kapodistrian University of Athens at 1 site in Greece.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 26 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Greece. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Aliki Tympa, MD,PhD (00306955487575, alikitympa@med.uoa.gr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
airway plateau pressure (time frame: Perioperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07304479, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Dec 2025; AzTrials last refreshed its copy on 26 Oct 2026.