PeriodontitisNCT07307144
Fractalkine-CX3CR1 Axis in Periodontal Therapy
A study testing Non-surgical periodontal treatment in people with Periodontitis and Gingivitis, run by Giresun University at 1 site in Turkey (Türkiye).
Trial summary
This study aimed to evaluate gingival crevicular fluid (GCF) levels of fractalkine/CX3CL1 and CX3CR1 in patients with gingivitis and periodontitis before and after non-surgical periodontal therapy. Read more about this study
- Who is it for?
- Ages 25 to 47 yearsHealthy volunteers can take part
- Conditions the study is for
- Periodontitis, Gingivitis, Inflammation Biomarkers
- What is being tested?
- Non-surgical periodontal treatment
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 90 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 May 2022to 10 Dec 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 25 to 47 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- 25-50 years of age
- having at least 20 natural teeth, excluding third molars
- having no systemic disease
- non-smokers
- criteria for healthy control group: BOP < 10% and PD ≤ 3 mm without clinical attachment loss or radiographic sign of alveolar bone destruction
- criteria for stage 3 periodontitis group: interdental CAL ≥ 5 mm at least 2 non-adjacent teeth, PD ≥ 6 mm and radiographic bone loss extending to the mid-third of the root or beyond.
Who cannot join
- having any systemic diseases,
- smoking
- current pregnancy or lactation
- a history of periodontal treatment in the past 6 months
- using antibiotic, anti-inflammatory drugs or any other drugs within the past 6 months.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Fractalkine and CX3CR1 Dynamics in Gingivitis and Periodontitis Before and After Therapy
This study aimed to evaluate gingival crevicular fluid (GCF) levels of fractalkine/CX3CL1 and CX3CR1 in patients with gingivitis and periodontitis before and after non-surgical periodontal therapy.
Read the detailed description
Thirty stage 3 periodontitis, thirty gingivitis and thirty periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; gingivitis and periodontitis patients underwent non-surgical periodontal treatment, and GCF samples were collected at baseline and at 1 and 3 months after treatment. CX3CL1 and CX3CR1 were determined by ELISA.
- Conditions
- Periodontitis, Gingivitis, Inflammation Biomarkers
- Being tested
- Non-surgical periodontal treatment
- Keywords
- periodontitis, gingivitis, gingival crevicular fluid
- Medical subject headings
- Periodontitis, Gingivitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Non-surgical periodontal treatmentOther
Scaling and root planing, oral hygiene education and motivation.
| Study group | Role | What they receive |
|---|---|---|
| stage 3 periodontitis | Active comparator | GCF samples were collected at baseline and at 1 and 3 months after treatment from periodontitis patients. Receives: Other: Non-surgical periodontal treatment |
| Gingivitis | Active comparator | GCF samples were collected at baseline and at 1 and 3 months after treatment from gingivitis patients. Receives: Other: Non-surgical periodontal treatment |
| Periodontally healthy controls | No intervention | GCF samples were collected from periodontally healthy controls at baseline for once. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Changes in the levels of biochemical parameters
The levels of Fractalkine and CX3CR1 before and after periodontal treatment in gingivitis and periodontitis patients.
Measured: Baseline and 1 and 3 months after treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Dec 2025
- Study start15 May 2022
- Primary completion15 Nov 2023
- Study completion10 Dec 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PeriodontitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 90 participants (actual)
Sponsor and investigators
- Lead sponsor
- Giresun University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Zeynep Pınar Yucel, Giresun University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07307144
- Sponsor's protocol ID
- OMU KAEK 2022/85
- Other IDs
- SAĞ-BAP-A-240222-47
- Status last verified
- Dec 2025
- First submitted
- 13 Dec 2025
- Last updated
- 29 Dec 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Fractalkine and CX3CR1 Dynamics in Gingivitis and Periodontitis Before and After Therapy
- ClinicalTrials.gov ID
- NCT07307144
- Acronym / sponsor ID
- OMU KAEK 2022/85
- Conditions
- Periodontitis, Gingivitis, Inflammation Biomarkers
- Keywords
- periodontitis, gingivitis, gingival crevicular fluid
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 90 participants (actual)
- Lead sponsor
- Giresun UniversityUniversity, hospital or other
- Study start
- 15 May 2022 (actual)
- Primary completion
- 15 Nov 2023 (actual)
- Study completion
- 10 Dec 2023 (actual)
- First posted
- 29 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aimed to evaluate gingival crevicular fluid (GCF) levels of fractalkine/CX3CL1 and CX3CR1 in patients with gingivitis and periodontitis before and after non-surgical periodontal therapy.
Detailed description
Thirty stage 3 periodontitis, thirty gingivitis and thirty periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; gingivitis and periodontitis patients underwent non-surgical periodontal treatment, and GCF samples were collected at baseline and at 1 and 3 months after treatment. CX3CL1 and CX3CR1 were determined by ELISA.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| stage 3 periodontitis | Active comparator | Other: Non-surgical periodontal treatmentGCF samples were collected at baseline and at 1 and 3 months after treatment from periodontitis patients. |
| Gingivitis | Active comparator | Other: Non-surgical periodontal treatmentGCF samples were collected at baseline and at 1 and 3 months after treatment from gingivitis patients. |
| Periodontally healthy controls | No intervention | –GCF samples were collected from periodontally healthy controls at baseline for once. |
Who may qualify
- Ages
- 25 to 47 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- 25-50 years of age
- having at least 20 natural teeth, excluding third molars
- having no systemic disease
- non-smokers
- criteria for healthy control group: BOP < 10% and PD ≤ 3 mm without clinical attachment loss or radiographic sign of alveolar bone destruction
Key exclusion criteria (5 listed)
- having any systemic diseases,
- smoking
- current pregnancy or lactation
- a history of periodontal treatment in the past 6 months
- using antibiotic, anti-inflammatory drugs or any other drugs within the past 6 months.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Non-surgical periodontal treatmentScaling and root planing, oral hygiene education and motivation. | Other | Gingivitis, stage 3 periodontitis |
Primary outcome
Changes in the levels of biochemical parameters
Time frame: Baseline and 1 and 3 months after treatment
The levels of Fractalkine and CX3CR1 before and after periodontal treatment in gingivitis and periodontitis patients.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Dec 2025.
Related trials for Periodontitis
Recruiting
Effect of Cryotherapeutic and Nanotherapeutic Sodium Hypochlorite on Post-Operative Endodontic Pain.
Symptomatic Irreversible Pulpitis, Symptomatic Apical Periodontitis
Active, not recruitingObservational study
A Retrospective Comparative Evaluation of Omega-3 and Resveratrol Supplementation in Patients With Periodontitis
Periodontitis
Recruiting
Probiotics Versus Antibiotics as an Adjuvant to Non-surgical Periodontal Treatment Among Smokers With Stage II, Grade B Periodontitis
Probiotics, Antibiotics
Recruiting
Effects of Different Activation Techniques on Antimicrobial Photodynamic Therapy in Apical Periodontitis
Apical Periodontitis, Endodontic Retreatment
Recruiting
Ozone Gel Versus Chlorohexidine Gel as an Adjunct to Non-Surgical Treatment of Stage II Periodontitis Grade B Among Smokers Patients
Ozone Gel, Chlorohexidine Gel
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Non-surgical periodontal treatment in people with Periodontitis and Gingivitis, run by Giresun University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Changes in the levels of biochemical parameters (time frame: Baseline and 1 and 3 months after treatment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Dec 2025.