Severe Hypertriglyceridemia With a High Risk of Acute PancreatitisPhase 2NCT07308392
Phase II Clinical Trial Evaluating the Efficacy and Safety of HRS-7249 and SHR-1918 in Patients With Severe Hypertriglyceridemia at High Risk of Acute Pancreatitis
A Phase 2 study testing HRS-7249 injection set and SHR-1918 injection set in people with Severe Hypertriglyceridemia With a High Risk of Acute Pancreatitis, run by Fujian Shengdi Pharmaceutical Co., Ltd. at 1 site in China.
Trial summary
Phase II clinical trial evaluating the efficacy and safety of HRS-7249 and SHR-1918 in patients with severe hypertriglyceridemia at high risk of acute pancreatitis Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Severe Hypertriglyceridemia With a High Risk of Acute Pancreatitis
- What is being tested?
- HRS-7249 injection set and SHR-1918 injection set
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 119 participants
- Where
- 1 siteChina
- Study dates
- 25 Feb 2026to Jun 2027
- Phase
- Phase 2
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Understand the research procedures and methods, voluntarily participate in this trial, and sign the informed consent form in writing;
- Male or female aged ≥18 years and <80 years on the day of signing the informed consent form.
Who cannot join
- History of gallstones at the time of screening or previously (except for patients who had their gallbladder removed more than 3 months ago);
- Acute pancreatitis that has clinically recovered ≤4 weeks before screening or randomization;
- Malignant tumor within 5 years before screening or randomization (except for non-melanoma skin cancer or cervical carcinoma in situ that has been radically treated);
- Grade 3/4 heart failure at the time of screening or before randomization;
- Acute coronary syndrome (such as myocardial infarction, unstable angina), history of coronary artery bypass grafting, percutaneous coronary intervention, peripheral artery revascularization, cerebrovascular diseases (such as stroke, transient ischemic attack), heart failure hospitalization, etc., within 3 months before screening or randomization;
- Severe arrhythmias within 3 months before screening or randomization, such as recurrent symptomatic frequent ventricular premature beats, ventricular tachycardia, atrial fibrillation with rapid ventricular rate;
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- Severe infection within 3 months before screening;
- History or presence of nephrotic syndrome, severe liver disease, Cushing's syndrome, or other diseases significantly affecting lipid levels at screening;
- History or presence of hyperthyroidism or hypothyroidism at screening;
- Poorly controlled hypertension at screening or before randomization (systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥110 mmHg);
- Diabetes with any of the following: a. Newly diagnosed within 12 weeks before screening or randomization; b. HbA1c ≥8.0% at screening; c. Type 1 diabetes;
- Unstable or severe liver, kidney, cardiovascular, psychiatric, neurological, endocrine, hematologic, or other diseases at screening or before randomization, where the investigator determines participation poses an unacceptable risk to the subject;
- Serious trauma or major surgery within 6 months before screening, or planning major surgery during the trial;
- Plasma exchange therapy within 4 weeks before screening or randomization, or planned during the trial;
- Use of other drugs significantly affecting lipid levels within 4 weeks before screening or randomization, or planned during the trial, such as traditional Chinese medicine containing statins (e.g., Zhibituo, Zhibitai), other lipid-lowering drugs and supplements (e.g., probucol, bile acid sequestrants, niacin, over-the-counter drugs, red yeast rice), GLP-1 agonists, other incretin analogues;
- Use of weight-loss drugs or undergoing weight-altering surgery within 2 months before screening or randomization, or planned during the study;
- History of drug abuse or alcohol abuse (including heavy drinking [average ethanol intake >80 g/day], previously diagnosed alcohol harmful use, alcohol dependence, alcohol poisoning, alcohol withdrawal, alcohol-related disorder, or alcohol-induced psychiatric or behavioral disorder);
- Significant lifestyle changes within 4 weeks before screening or randomization, or refusal to follow lifestyle guidance or limit alcohol intake to <30 g/day during the study;
- eGFR calculated by the Modification of Diet in Renal Disease (MDRD) formula <60 mL/min/1.73 m²;
- Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥3 times the upper limit of normal (ULN);
- Total bilirubin or direct bilirubin ≥2 times ULN;
- Creatine kinase (CK) >1.5 times ULN;
- Platelet count <100 x 10⁹/L (or history of thrombocytopenia);
- Hemoglobin <60 g/L;
- Confirmed active syphilis, positive test result for human immunodeficiency virus antibody (HIV-Ab) or hepatitis C virus antibody (HCV-Ab), positive hepatitis B surface antigen (HBsAg) with HBV-DNA ≥1000 copies/ml (or ≥200 IU/ml, or if the detection lower limit is higher than 1000 copies/ml or 200 IU/ml, HBV-DNA ≥ detection lower limit);
- Thyroid-stimulating hormone (TSH) below the lower limit of normal (LLN) or above 1.5 times ULN;
- Participation in any interventional drug clinical trial within 3 months prior to screening (participation is defined as administration of the investigational product to the subject), or still within 5 half-lives of the investigational product before screening, whichever is longer; previous participation in non-interventional clinical trials or device-related clinical trials may be judged by the investigator for inclusion;
- Pregnant or breastfeeding women;
- Women of childbearing potential who have not used contraception within 30 days prior to screening; women of childbearing potential and male subjects with partners of childbearing age who refuse to avoid donating sperm/eggs from the time of signing the informed consent until the end of the follow-up period, or refuse to comply with relevant contraceptive requirements;
- Other conditions deemed by the investigator to make the subject unsuitable for participation in the trial.
Trial locations and contacts
1 site in 1 country.
China1 site
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial People's Hospital)
Nanjing, Jiangsu, 210029
About this study
Official title: A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Clinical Trial Evaluating the Efficacy and Safety of HRS-7249 and SHR-1918 in Patients With Severe Hypertriglyceridemia at High Risk of Acute Pancreatitis.
Phase II clinical trial evaluating the efficacy and safety of HRS-7249 and SHR-1918 in patients with severe hypertriglyceridemia at high risk of acute pancreatitis
- Being tested
- HRS-7249 injection set, SHR-1918 injection set, HRS-7249 injection placebo set, SHR-1918 injection placebo set
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
HRS-7249 injection setDrug
HRS-7249 injection set
SHR-1918 injection setDrug
SHR-1918 injection set
HRS-7249 injection placebo setDrug
HRS-7249 injection placebo set
SHR-1918 injection placebo setDrug
SHR-1918 injection placebo set
| Study group | Role | What they receive |
|---|---|---|
| HRS-7249 injection | Experimental | Not described Receives: Drug: HRS-7249 injection set |
| HRS-7249 injection placebo | Placebo comparator | Not described Receives: Drug: HRS-7249 injection placebo set |
| SHR-1918 injection | Experimental | Not described Receives: Drug: SHR-1918 injection set |
| SHR-1918 injection placebo | Placebo comparator | Not described Receives: Drug: SHR-1918 injection placebo set |
What is being measured
The primary outcome is the main question the study is designed to answer.
Percentage change in mean TG from baseline at weeks 44 and 48 of treatment
Measured: at 44＆48 weeks after the start of administration
Proportion of subjects experiencing AP during the double-blind treatment period
Measured: within 48 weeks after the start of administration
Secondary outcomes (2)
During the double-blind treatment period, the time and severity of the first occurrence of AP
Measured: within 48 weeks after the start of administration
During the double-blind treatment period, the proportion of subjects who developed HTG-AP, the time to first occurrence of HTG-AP, and its severity
Measured: within 48 weeks after the start of administration
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Dec 2025
- Study start25 Feb 2026
- Primary completionJun 2027 (estimated)
- Study completionJun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Severe Hypertriglyceridemia With a High Risk of Acute PancreatitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 2
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 119 participants (actual)
Sponsor and investigators
- Lead sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07308392
- Sponsor's protocol ID
- HRS-7249-202
- Status last verified
- Nov 2025
- First submitted
- 15 Dec 2025
- Last updated
- 8 Sep 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided