Pulmonary EmbolismEPNCT07313501
Evaluation of the PERC Score and the YEARS Algorithm in the Diagnosis of Pulmonary Embolism in the Emergency Department
An observational study of Pulmonary Embolism, run by University Hospital, Strasbourg, France at 1 site in France.
Trial summary
The current diagnostic strategy for pulmonary embolism relies on clinical evaluation, followed by D-dimer testing and chest CT angiography. However, this approach leads to overuse of CT angiography. Diagnosis remains complex, with nonspecific clinical signs. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Pulmonary Embolism
- How many people
- 500 participants
- Where
- 1 siteFrance
- Study dates
- 26 Feb 2025to Feb 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: - Adult patient (≥18 years) admitted to the adult emergency department of the Strasbourg University Hospital over a 6-month period (January to June 2024), for whom a D-dimer test and chest imaging (thoracic CT angiography or ventilation/perfusion scintigraphy) were performed
Who may be able to join
- Adult patient (≥18 years)
- Patient admitted to the adult emergency department of the Strasbourg University Hospital over a 6-month period (January to June 2024), for whom a D-dimer test and chest imaging (thoracic CT angiography or ventilation/perfusion scintigraphy) were performed
Who cannot join
- No D-dimer test or test performed for another indication, no chest imaging (CT angiography or scintigraphy), long-term anticoagulant treatment.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
Service d'Urgences Médico-Chirurgicales Adules - CHU de Strasbourg - France
Strasbourg, 67091
François WEILL, MD, 33 3.88.11.54.67, francois.weill@chru-strasbourg.fr
François WEILL, MD
About this study
Official title: Evaluation of the PERC Score and the YEARS Algorithm in the Diagnosis of Pulmonary Embolism in the Emergency Department: a Retrospective Observational Study in the Emergency Department of the Strasbourg University Hospital
The current diagnostic strategy for pulmonary embolism relies on clinical evaluation, followed by D-dimer testing and chest CT angiography. However, this approach leads to overuse of CT angiography. Diagnosis remains complex, with nonspecific clinical signs. Recent studies have explored new algorithms, such as the YEARS algorithm and the PERC score, which aim to support the diagnosis and reduce the need for imaging examinations. Their use could decrease waiting times in the emergency department and limit the need for additional investigations.
- Conditions
- Pulmonary Embolism
- Keywords
- Pulmonary Embolism, PERC score, D-dimer testing, Chest CT angiography
- Medical subject headings
- Pulmonary Embolism
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of patients who would not have required imaging if the PERC score and YEARS algorithm criteria had been applied
Measured: Up to 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Jan 2026
- Study start26 Feb 2025
- Primary completionFeb 2026 (estimated)
- Study completionFeb 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pulmonary EmbolismStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Retrospective
- Enrolment
- 500 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Strasbourg, France
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07313501
- Sponsor's protocol ID
- 9611
- Acronym
- EP
- Status last verified
- Dec 2025
- First submitted
- 17 Dec 2025
- Last updated
- 2 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 2 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the PERC Score and the YEARS Algorithm in the Diagnosis of Pulmonary Embolism in the Emergency Department: a Retrospective Observational Study in the Emergency Department of the Strasbourg University Hospital
- ClinicalTrials.gov ID
- NCT07313501
- Acronym / sponsor ID
- EP / 9611
- Conditions
- Pulmonary Embolism
- Keywords
- Pulmonary Embolism, PERC score, D-dimer testing, Chest CT angiography
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 500 participants (estimated)
- Lead sponsor
- University Hospital, Strasbourg, FranceUniversity, hospital or other
- Study start
- 26 Feb 2025 (actual)
- Primary completion
- Feb 2026 (estimated)
- Study completion
- Feb 2026 (estimated)
- First posted
- 2 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The current diagnostic strategy for pulmonary embolism relies on clinical evaluation, followed by D-dimer testing and chest CT angiography. However, this approach leads to overuse of CT angiography. Diagnosis remains complex, with nonspecific clinical signs. Recent studies have explored new algorithms, such as the YEARS algorithm and the PERC score, which aim to support the diagnosis and reduce the need for imaging examinations. Their use could decrease waiting times in the emergency department and limit the need for additional investigations.
Study design
- Observational model
- Case only
- Time perspective
- Retrospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- - Adult patient (≥18 years) admitted to the adult emergency department of the Strasbourg University Hospital over a 6-month period (January to June 2024), for whom a D-dimer test and chest imaging (thoracic CT angiography or ventilation/perfusion scintigraphy) were performed
Key inclusion criteria (2 listed)
- Adult patient (≥18 years)
- Patient admitted to the adult emergency department of the Strasbourg University Hospital over a 6-month period (January to June 2024), for whom a D-dimer test and chest imaging (thoracic CT angiography or ventilation/perfusion scintigraphy) were performed
Key exclusion criteria (1 listed)
- No D-dimer test or test performed for another indication, no chest imaging (CT angiography or scintigraphy), long-term anticoagulant treatment.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Number of patients who would not have required imaging if the PERC score and YEARS algorithm criteria had been applied
Time frame: Up to 12 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Jan 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Pulmonary Embolism, run by University Hospital, Strasbourg, France at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 2 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact François WEILL, MD (33 3.88.11.54.67, francois.weill@chru-strasbourg.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of patients who would not have required imaging if the PERC score and YEARS algorithm criteria had been applied (time frame: Up to 12 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Jan 2026.