Comparison of Advanced Platelet-Rich Fibrin Versus Platelet-Rich Fibrin as a Gap-filling MaterialA-PRF vs PRFNCT07319494
Advanced PRF vs PRF for Gap Filling in Immediate Implants
A study testing Immediate Dental Implant and A-PRF and Immediate dental implant and PRF in people with Comparison of Advanced Platelet-Rich Fibrin Versus Platelet-Rich Fibrin as a Gap-filling Material, run by Beni-Suef University at 1 site in Egypt.
Trial summary
Study type: Clinical Trial Goal: The goal of this clinical trial is to learn if Advanced Platelet-Rich Fibrin (A-PRF) versus traditional Platelet-Rich Fibrin (PRF) can improve bone healing and soft tissue outcomes in patients undergoing immediate dental implant placement. Read more about this study
- Who is it for?
- Ages 20 years and older
- Conditions the study is for
- Comparison of Advanced Platelet-Rich Fibrin Versus Platelet-Rich Fibrin as a Gap-filling Material
- What is being tested?
- Immediate Dental Implant and A-PRF and Immediate dental implant and PRF
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 16 participants
- Where
- 1 siteEgypt
- Study dates
- 25 Jun 2025to 15 Feb 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- The selected patients has a badly decayed mandibular posterior teeth which are indicated for extraction due to dental causes (periapical abscess, trauma or caries) not periodontal as diagnosed by periapical x-ray.
- Healthy patients who are classified according to the American Society of Anesthesiologists (ASA)(2022) physical status classification as class I.
- Patient age ≥ 20 years old.
- Surgical site with sufficient for implant placement.
- Sufficient interocclusal space for prosthesis.
- Good oral hygiene.
- Patients have thick biotype.
- Patients have socket class I.
Who cannot join
- Active periodontal diseases and periapical lesions not chronic infections.
- Patients have parafunctional
- History of alcohol or drug dependency, psychological factor that might affect the surgical or prosthodontic treatment.
- Smoking.
- Pregnant patients.
- Patients who are not willing to complete the study.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparison of Advanced Platelet Rich Fibrin Versus Platelet Rich Fibrin as a Gap Filling Material in Immediate Implant Placement
Study type: Clinical Trial
Goal:
Read more
The goal of this clinical trial is to learn if Advanced Platelet-Rich Fibrin (A-PRF) versus traditional Platelet-Rich Fibrin (PRF) can improve bone healing and soft tissue outcomes in patients undergoing immediate dental implant placement.
Main questions it aims to answer:
Does A-PRF provide greater buccal bone preservation compared to PRF after immediate implant placement?
Does A-PRF improve soft tissue healing and reduce postoperative complications compared to PRF?
Comparison group:
Researchers will compare A-PRF to PRF as a gap-filling material in immediate implants to see if A-PRF results in better bone and soft tissue outcomes.
Participants will:
Undergo tooth extraction followed by immediate implant placement
Receive either A-PRF or PRF as the gap-filling material in the implant site
Have CBCT scans at baseline and 6 months to measure bone thickness
Have clinical assessments of soft tissue healing and implant stability
Attend follow-up visits at 1 week, 1 month, 3 months, and 6 months post-surgery
- Conditions
- Comparison of Advanced Platelet-Rich Fibrin Versus Platelet-Rich Fibrin as a Gap-filling Material
- Being tested
- Immediate Dental Implant and A-PRF, Immediate dental implant and PRF
- Keywords
- Immediate dental implant placement and socket healing
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Immediate Dental Implant and A-PRFProcedure or surgery
Arm 1: Advanced Platelet-Rich Fibrin (A-PRF) Participants will have a tooth extracted, the socket cleaned, and A-PRF prepared from their blood placed in the socket as a gap-filling material before immediate implant placement. Follow-up visits will assess bone and soft tissue healing and implant stability.
Immediate dental implant and PRFProcedure or surgery
Arm 2: Platelet-Rich Fibrin (PRF) Participants will have a tooth extracted, the socket cleaned, and traditional PRF prepared from their blood placed in the socket as a gap-filling material before immediate implant placement. Follow-up visits will assess bone and soft tissue healing and implant stability.
| Study group | Role | What they receive |
|---|---|---|
| PRF Group | Experimental | Participants in this arm will undergo tooth extraction followed by immediate implant placement. The extraction socket will be filled with traditional Platelet-Rich Fibrin (PRF) as the gap-filling material. Receives: Procedure: Immediate dental implant and PRF |
| A-PRF Group | Experimental | Participants in this arm will undergo tooth extraction followed by immediate implant placement. The extraction socket will be filled with Advanced Platelet-Rich Fibrin (A-PRF) as the gap-filling material. Receives: Procedure: Immediate Dental Implant and A-PRF |
What is being measured
The primary outcome is the main question the study is designed to answer.
Clinical evaluation
Implant stability will be measured by resonance frequency analysis (RFA) values expressed as implant stability quotient (ISQ) unit at 6 months post-operative
Measured: 6 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Jan 2026
- Study start25 Jun 2025
- Primary completion26 Nov 2025
- Study completion15 Feb 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Comparison of Advanced Platelet-Rich Fibrin Versus Platelet-Rich Fibrin as a Gap-filling MaterialStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 16 participants (actual)
Sponsor and investigators
- Lead sponsor
- Beni-Suef University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Eman Magdy Ahmed, Beni-Suef University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07319494
- Sponsor's protocol ID
- DU:024111959
- Acronym
- A-PRF vs PRF
- Status last verified
- Dec 2025
- First submitted
- 30 Nov 2025
- Last updated
- 6 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Advanced Platelet Rich Fibrin Versus Platelet Rich Fibrin as a Gap Filling Material in Immediate Implant Placement
- ClinicalTrials.gov ID
- NCT07319494
- Acronym / sponsor ID
- A-PRF vs PRF / DU:024111959
- Conditions
- Comparison of Advanced Platelet-Rich Fibrin Versus Platelet-Rich Fibrin as a Gap-filling Material
- Keywords
- Immediate dental implant placement and socket healing
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 16 participants (actual)
- Lead sponsor
- Beni-Suef UniversityUniversity, hospital or other
- Study start
- 25 Jun 2025 (actual)
- Primary completion
- 26 Nov 2025 (actual)
- Study completion
- 15 Feb 2026 (estimated)
- First posted
- 6 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Study type: Clinical Trial
Goal:
The goal of this clinical trial is to learn if Advanced Platelet-Rich Fibrin (A-PRF) versus traditional Platelet-Rich Fibrin (PRF) can improve bone healing and soft tissue outcomes in patients undergoing immediate dental implant placement.
Main questions it aims to answer:
Does A-PRF provide greater buccal bone preservation compared to PRF after immediate implant placement?
Does A-PRF improve soft tissue healing and reduce postoperative complications compared to PRF?
Comparison group:
Researchers will compare A-PRF to PRF as a gap-filling material in immediate implants to see if A-PRF results in better bone and soft tissue outcomes.
Participants will:
Undergo tooth extraction followed by immediate implant placement
Receive either A-PRF or PRF as the gap-filling material in the implant site
Have CBCT scans at baseline and 6 months to measure bone thickness
Have clinical assessments of soft tissue healing and implant stability
Attend follow-up visits at 1 week, 1 month, 3 months, and 6 months post-surgery
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| PRF Group | Experimental | Procedure: Immediate dental implant and PRFParticipants in this arm will undergo tooth extraction followed by immediate implant placement. The extraction socket will be filled with traditional Platelet-Rich Fibrin (PRF) as the gap-filling material. |
| A-PRF Group | Experimental | Procedure: Immediate Dental Implant and A-PRFParticipants in this arm will undergo tooth extraction followed by immediate implant placement. The extraction socket will be filled with Advanced Platelet-Rich Fibrin (A-PRF) as the gap-filling material. |
Who may qualify
- Ages
- 20 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- The selected patients has a badly decayed mandibular posterior teeth which are indicated for extraction due to dental causes (periapical abscess, trauma or caries) not periodontal as diagnosed by periapical x-ray.
- Healthy patients who are classified according to the American Society of Anesthesiologists (ASA)(2022) physical status classification as class I.
- Patient age ≥ 20 years old.
- Surgical site with sufficient for implant placement.
- Sufficient interocclusal space for prosthesis.
Key exclusion criteria (6 listed)
- Active periodontal diseases and periapical lesions not chronic infections.
- Patients have parafunctional
- History of alcohol or drug dependency, psychological factor that might affect the surgical or prosthodontic treatment.
- Smoking.
- Pregnant patients.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Immediate Dental Implant and A-PRFArm 1: Advanced Platelet-Rich Fibrin (A-PRF) Participants will have a tooth extracted, the socket cleaned, and A-PRF prepared from their blood placed in the socket as a gap-filling material before immediate implant placement. Follow-up visits will assess bone and soft tissue healing and implant stability. | Procedure or surgery | A-PRF Group |
| Immediate dental implant and PRFArm 2: Platelet-Rich Fibrin (PRF) Participants will have a tooth extracted, the socket cleaned, and traditional PRF prepared from their blood placed in the socket as a gap-filling material before immediate implant placement. Follow-up visits will assess bone and soft tissue healing and implant stability. | Procedure or surgery | PRF Group |
Primary outcome
Clinical evaluation
Time frame: 6 month
Implant stability will be measured by resonance frequency analysis (RFA) values expressed as implant stability quotient (ISQ) unit at 6 months post-operative
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Jan 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Immediate Dental Implant and A-PRF and Immediate dental implant and PRF in people with Comparison of Advanced Platelet-Rich Fibrin Versus Platelet-Rich Fibrin as a Gap-filling Material, run by Beni-Suef University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 6 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Clinical evaluation (time frame: 6 month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jan 2026.