Empathy Training of Undergraduate Nursing StudentsNCT07320365
Empathy Training for Undergraduate Nursing Students
A study testing Empathy training in people with Empathy Training of Undergraduate Nursing Students, run by Hong Kong Metropolitan University at 1 site in Hong Kong.
Trial summary
This study aims to examine the effects of a newly developed training program on the empathy of undergraduate nursing students. The objectives are: (i) designing and implementing an User Interface (UI) using Unity featuring 3D virtual clients representing individuals with physical disabilities, bodily discomforts, and… Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Empathy Training of Undergraduate Nursing Students
- What is being tested?
- Empathy training
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 108 participants
- Where
- 1 siteHong Kong
- Study dates
- 1 Feb 2026to Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- undergraduate students enrolled in a nursing program
- no previous experience with empathy-related training
- no previous experience working in healthcare settings
- age 18 years or above
- native Chinese speakers.
Who cannot join
- are or were the main carers of people who are disabled or chronically ill because empathy may be promoted through experience.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Hong Kong1 site, 1 recruiting
- Recruiting
Hong Kong Metropolitan University
Ho Man Tin, Kowloon
Tai Wa Liu, PhD, 852 - 39708714, twliu@hkmu.edu.hk
Chun Yan Ho, Bachelor, 852 - 39702921, chyanho@hkmu.edu.hk
About this study
Official title: Empathy Training for Undergraduate Nursing Students Through Combined Didactic, Practical and AI-based Methods
This study aims to examine the effects of a newly developed training program on the empathy of undergraduate nursing students. The objectives are: (i) designing and implementing an User Interface (UI) using Unity featuring 3D virtual clients representing individuals with physical disabilities, bodily discomforts, and psychosocial disturbances, paired with a chatbot interface for interactive questions-and-answers; (ii) developing a brief empathy training program incorporating AI-generated virtual clients into traditional teaching methods, including didactic lectures, skills rehearsal, mindfulness-based training, and practice with AI-generated virtual clients; and (iii) assessing the impact of this training program on the empathetic attitude, empathetic communication skills, and cognitive flexibility of undergraduate nursing students.
Read the detailed description
Various traditional pedagogies have been used in empathy training for nursing students. For instance, didactic lectures often aim at introducing the scientific information of empathy, while experiential learning, such as role-playing and standardized patient interactions, are used to facilitate learning through reflection on doing and minimizing stereotypes. Additionally, mindfulness-based training is employed to promote self-awareness and cultivate essential traits in healthcare students and clinicians, such as being nonjudgmental, kind, compassionate, and altruistic. However, a previous systematic review revealed inconsistent findings about the effects of traditional pedagogies and highlighted the need for innovative teaching approaches from healthcare educators.
Perspective-taking is a crucial empathy-related phenomenon that refers to the capability of comprehending the intentions of others. Despite the use of experiential learning strategies in previous empathy training, previous studies are not without limitations. For instance, role-play and standardized patients in developing clinical empathy have been criticized for limited authenticity, variations in skills and consistency of participants, inadequate quality feedback, and resource intensity. Recent studies have also explored the use of virtual reality as an experiential learning component to render experiences of immersion, presence, and embodiment. However, these strategies cannot cover a wide range of clinical situations or provide timely feedback.
In recent years, technological advancements have provided new opportunities for innovative educational strategies. One such promising approach is the use of artificial intelligence (AI)-generated virtual clients in empathy training. AI-generated virtual clients can simulate a wide range of client interactions, offering a repeatable environment to practice and cultivate empathy. The integration of virtual clients into empathy training programs has the potential to revolutionize healthcare education. Thus, this research proposal aims to examine the effects of a brief empathy training program utilizing AI-generated virtual clients and traditional pedagogies on the empathy levels of undergraduate nursing students. By incorporating AI-generated virtual clients into newly developed empathy training protocol, along with elements of didactic lectures and mindfulness-based training, the investigators hypothesize that students will experience a significant improvement in empathetic attitude, and then leading to better empathetic communication skills and cognitive flexibility.
- Being tested
- Empathy training
- Keywords
- Empathy, AI-generated virtual clients
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Empathy trainingOther
Participants in the intervention group will undertake two sessions, each lasting four hours, of empathy training over a one-week period with group size of 6 to 8 participants. The empathy training will base on our newly developed protocol, including: (i) didactic lectures; (ii) practical skills demonstration and role-play, (iii) a mindfulness-based training; and (iv) practice of empathic skills in two different randomly selected scenarios with feedback from the AI system. Each participants will encounter different scenarios that simulate diverse clinical challenges.
| Study group | Role | What they receive |
|---|---|---|
| Control | No intervention | Not described |
| Intervention | Experimental | Participants in the intervention group will undertake two sessions, each lasting four hours, of empathy training over a one-week period with group size of 6 to 8 participants. The first training session consists of a 4-hour didactic component focused on empathy frameworks and communication strategies. The second training session includes a 2-hour mindfulness training component followed by a 2-hour AI demonstration and practice component where participants engage with virtual client scenarios. Receives: Other: Empathy training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Interpersonal Reactivity Index
The Interpersonal Reactivity Index (IRI) will be used to assess self-reported empathetic attitude. IRI consists of 4 subscale with 28 items rating on a 5 - point Likert scale (0 - 4). Score ranges from 0 - 112, higher score means better empathy.
Measured: Baseline assessment (prior to any training), (ii) immediate post-training assessment (immediately after the final training session, end of week 1), and (iii) 1-month follow-up assessment (approximately 4 weeks after the final training session).
Secondary outcomes (2)
Consultation and Relational Empathy
The Consultation and Relational Empathy (CARE) measure will be used to assess participants' empathic communication skills, focusing on patient-perceived empathy during clinical interactions. CARE consists of 10 items rating on a 5 point Likert scale. Score ranges from 10 - 50, higher score means better perceived relational empathy.
Measured: Baseline assessment (prior to any training), (ii) immediate post-training assessment (immediately after the final training session, end of week 1), and (iii) 1-month follow-up assessment (approximately 4 weeks after the final training session).
Cognitive Flexibility Inventory
Cognitive Flexibility Inventory (CFI) will be used to assess self-reported cognitive flexibility. CFI consists of 20 items rating on 1-7 Likert scale (score range 20 - 140), higher score means greater flexibiity and lower score means more cognitive rigidity.
Measured: Baseline assessment (prior to any training), (ii) immediate post-training assessment (immediately after the final training session, end of week 1), and (iii) 1-month follow-up assessment (approximately 4 weeks after the final training session).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Jan 2026
- Study start1 Feb 2026
- Primary completionDec 2026 (estimated)
- Study completionDec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Empathy Training of Undergraduate Nursing StudentsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 108 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Hong Kong Metropolitan University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Dr Liu Tai Wa, Hong Kong Metropolitan University
- Investigators
- Tai Wa Liu, PhD, Principal investigator, Hong Kong Metropolitan University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07320365
- Sponsor's protocol ID
- REC Reference No:HE-T&L2025/02
- Status last verified
- Jun 2026
- First submitted
- 12 Dec 2025
- Last updated
- 23 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Non-identifiable individual participant data is available upon reasonable request to the corresponding author after the report published.
Study at a glance
From the registry record, last updated by the sponsor on 23 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Empathy Training for Undergraduate Nursing Students Through Combined Didactic, Practical and AI-based Methods
- ClinicalTrials.gov ID
- NCT07320365
- Acronym / sponsor ID
- REC Reference No:HE-T&L2025/02
- Keywords
- Empathy, AI-generated virtual clients
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 108 participants (estimated)
- Lead sponsor
- Hong Kong Metropolitan UniversityUniversity, hospital or other
- Study start
- 1 Feb 2026 (actual)
- Primary completion
- Dec 2026 (estimated)
- Study completion
- Dec 2026 (estimated)
- First posted
- 6 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to examine the effects of a newly developed training program on the empathy of undergraduate nursing students. The objectives are: (i) designing and implementing an User Interface (UI) using Unity featuring 3D virtual clients representing individuals with physical disabilities, bodily discomforts, and psychosocial disturbances, paired with a chatbot interface for interactive questions-and-answers; (ii) developing a brief empathy training program incorporating AI-generated virtual clients into traditional teaching methods, including didactic lectures, skills rehearsal, mindfulness-based training, and practice with AI-generated virtual clients; and (iii) assessing the impact of this training program on the empathetic attitude, empathetic communication skills, and cognitive flexibility of undergraduate nursing students.
Detailed description
Various traditional pedagogies have been used in empathy training for nursing students. For instance, didactic lectures often aim at introducing the scientific information of empathy, while experiential learning, such as role-playing and standardized patient interactions, are used to facilitate learning through reflection on doing and minimizing stereotypes. Additionally, mindfulness-based training is employed to promote self-awareness and cultivate essential traits in healthcare students and clinicians, such as being nonjudgmental, kind, compassionate, and altruistic. However, a previous systematic review revealed inconsistent findings about the effects of traditional pedagogies and highlighted the need for innovative teaching approaches from healthcare educators.
Perspective-taking is a crucial empathy-related phenomenon that refers to the capability of comprehending the intentions of others. Despite the use of experiential learning strategies in previous empathy training, previous studies are not without limitations. For instance, role-play and standardized patients in developing clinical empathy have been criticized for limited authenticity, variations in skills and consistency of participants, inadequate quality feedback, and resource intensity. Recent studies have also explored the use of virtual reality as an experiential learning component to render experiences of immersion, presence, and embodiment. However, these strategies cannot cover a wide range of clinical situations or provide timely feedback.
In recent years, technological advancements have provided new opportunities for innovative educational strategies. One such promising approach is the use of artificial intelligence (AI)-generated virtual clients in empathy training. AI-generated virtual clients can simulate a wide range of client interactions, offering a repeatable environment to practice and cultivate empathy. The integration of virtual clients into empathy training programs has the potential to revolutionize healthcare education. Thus, this research proposal aims to examine the effects of a brief empathy training program utilizing AI-generated virtual clients and traditional pedagogies on the empathy levels of undergraduate nursing students. By incorporating AI-generated virtual clients into newly developed empathy training protocol, along with elements of didactic lectures and mindfulness-based training, the investigators hypothesize that students will experience a significant improvement in empathetic attitude, and then leading to better empathetic communication skills and cognitive flexibility.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Control | No intervention | – |
| Intervention | Experimental | Other: Empathy trainingParticipants in the intervention group will undertake two sessions, each lasting four hours, of empathy training over a one-week period with group size of 6 to 8 participants. The first training session consists of a 4-hour didactic component focused on empathy frameworks and communication strategies. The second training session includes a 2-hour mindfulness training component followed by a 2-hour AI demonstration and practice component where participants engage with virtual client scenarios. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- undergraduate students enrolled in a nursing program
- no previous experience with empathy-related training
- no previous experience working in healthcare settings
- age 18 years or above
- native Chinese speakers.
Key exclusion criteria (1 listed)
- are or were the main carers of people who are disabled or chronically ill because empathy may be promoted through experience.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Empathy trainingParticipants in the intervention group will undertake two sessions, each lasting four hours, of empathy training over a one-week period with group size of 6 to 8 participants. The empathy training will base on our newly developed protocol, including: (i) didactic lectures; (ii) practical skills demonstration and role-play, (iii) a mindfulness-based training; and (iv) practice of empathic skills in two different randomly selected scenarios with feedback from the AI system. Each participants will encounter different scenarios that simulate diverse clinical challenges. | Other | Intervention |
Primary outcome
Interpersonal Reactivity Index
Time frame: Baseline assessment (prior to any training), (ii) immediate post-training assessment (immediately after the final training session, end of week 1), and (iii) 1-month follow-up assessment (approximately 4 weeks after the final training session).
The Interpersonal Reactivity Index (IRI) will be used to assess self-reported empathetic attitude. IRI consists of 4 subscale with 28 items rating on a 5 - point Likert scale (0 - 4). Score ranges from 0 - 112, higher score means better empathy.
2 secondary outcomes
Consultation and Relational Empathy
Time frame: Baseline assessment (prior to any training), (ii) immediate post-training assessment (immediately after the final training session, end of week 1), and (iii) 1-month follow-up assessment (approximately 4 weeks after the final training session).
Cognitive Flexibility Inventory
Time frame: Baseline assessment (prior to any training), (ii) immediate post-training assessment (immediately after the final training session, end of week 1), and (iii) 1-month follow-up assessment (approximately 4 weeks after the final training session).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jun 2026.
- Individual participant dataSharing planned: Yes. Non-identifiable individual participant data is available upon reasonable request to the corresponding author after the report published.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Tai Wa Liu, PhD principal investigator
Hong Kong Metropolitan University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Empathy training in people with Empathy Training of Undergraduate Nursing Students, run by Hong Kong Metropolitan University at 1 site in Hong Kong.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 23 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Hong Kong. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Interpersonal Reactivity Index (time frame: Baseline assessment (prior to any training), (ii) immediate post-training assessment (immediately after the final training session, end of week 1), and (iii) 1-month follow-up assessment (approximately 4 weeks after the final training session).). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jun 2026.