Frailty in Older AdultsNCT07322809
Postoperative Frailty Trajectories and One-Year Mortality in Older Surgical Patients
An observational study of Frailty in Older Adults and All Cause Mortality, run by Chinese PLA General Hospital at 1 site in China.
Trial summary
Frailty is a key predictor of adverse outcomes in older surgical patients, yet its longitudinal evolution and potentially reversible nature remain underexplored in perioperative settings. Read more about this study
- Who is it for?
- Ages 65 years and older
- Conditions the study is for
- Frailty in Older Adults, All Cause Mortality, Trajectory
- How many people
- 4,417 participants
- Where
- 1 siteChina
- Study dates
- 1 Apr 2020to 30 Apr 2023
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- No healthy volunteers
- Older adult
Study population: Patients' frailty was assessed using the FRAIL scale at four time points: preoperatively and at 1, 3, and 6 months postoperatively. Patients were classified into distinct frailty trajectory groups using latent class trajectory modeling. One-year all-cause mortality was ascertained through structured telephone follow-up.
Who may be able to join
- Aged ≥65 years;
- Underwent elective non-cardiac, non-neurosurgical procedures;
- Completed standardized frailty assessments both preoperatively and postoperatively.
Who cannot join
- Severe dementia, language disorders, significant hearing or visual impairments, or coma;
- Cognitive function below the Mini-Mental State Examination (MMSE) thresholds (<18 for illiterate individuals, <21 for individuals with primary education, and <25 for individuals with secondary education or higher);
- Surgery performed under local anesthesia or monitored anesthesia care;
- Surgical duration ≤30 minutes;
- Missing data on postoperative complications or one-year mortality required for this study;
- Incomplete frailty assessments at 1, 3, and 6 months after surgery.
Trial locations and contacts
1 site in 1 country.
China1 site
28 Fuxing Road, Haidian District
Beijin, Beijing Municipality, 100853
About this study
Official title: Association Between Postoperative Frailty Trajectories and One-Year Mortality in Older Surgical Patients: A Prospective Longitudinal Data Study
Frailty is a key predictor of adverse outcomes in older surgical patients, yet its longitudinal evolution and potentially reversible nature remain underexplored in perioperative settings. This study aimed to characterize postoperative frailty trajectories in older patients and to examine their association with one-year mortality, as well as factors influencing trajectory group.
- Conditions
- Frailty in Older Adults, All Cause Mortality, Trajectory
- Keywords
- Frailty trajectory, older surgical patients, one-year mortality, latent class trajectory modeling
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| A retrospective cohort study based on prospectively collected data. | Patients' frailty was assessed using the FRAIL scale at four time points: preoperatively and at 1, 3, and 6 months postoperatively. Patients were classified into distinct frailty trajectory groups using latent class trajectory modeling. The study examined the associations between frailty trajectories and one-year mortality and further identified independent factors associated with frailty trajectory membership. |
What is being measured
The primary outcome is the main question the study is designed to answer.
The primary outcome was one-year all-cause mortality.
The primary outcome was one-year all-cause mortality, determined through structured telephone follow-up.
Measured: At the one-year postoperative follow-up.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Jan 2026
- Study start1 Apr 2020
- Primary completion30 Apr 2022
- Study completion30 Apr 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Frailty in Older AdultsStudies of the same condition, open and under way.
- More trials run by Chinese PLA General HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 4,417 participants (actual)
Sponsor and investigators
- Lead sponsor
- Chinese PLA General Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yanhong Liu, Chinese PLA General Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07322809
- Sponsor's protocol ID
- PLAGH - FRAIL Trajectory
- Status last verified
- Dec 2025
- First submitted
- 23 Dec 2025
- Last updated
- 9 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 9 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Association Between Postoperative Frailty Trajectories and One-Year Mortality in Older Surgical Patients: A Prospective Longitudinal Data Study
- ClinicalTrials.gov ID
- NCT07322809
- Acronym / sponsor ID
- PLAGH - FRAIL Trajectory
- Conditions
- Frailty in Older Adults, All Cause Mortality, Trajectory
- Keywords
- Frailty trajectory, older surgical patients, one-year mortality, latent class trajectory modeling
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 4,417 participants (actual)
- Lead sponsor
- Chinese PLA General HospitalUniversity, hospital or other
- Study start
- 1 Apr 2020 (actual)
- Primary completion
- 30 Apr 2022 (actual)
- Study completion
- 30 Apr 2023 (actual)
- First posted
- 7 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Frailty is a key predictor of adverse outcomes in older surgical patients, yet its longitudinal evolution and potentially reversible nature remain underexplored in perioperative settings. This study aimed to characterize postoperative frailty trajectories in older patients and to examine their association with one-year mortality, as well as factors influencing trajectory group.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| A retrospective cohort study based on prospectively collected data. | – | –Patients' frailty was assessed using the FRAIL scale at four time points: preoperatively and at 1, 3, and 6 months postoperatively. Patients were classified into distinct frailty trajectory groups using latent class trajectory modeling. The study examined the associations between frailty trajectories and one-year mortality and further identified independent factors associated with frailty trajectory membership. |
Who may qualify
- Ages
- 65 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Older adult
- Study population
- Patients' frailty was assessed using the FRAIL scale at four time points: preoperatively and at 1, 3, and 6 months postoperatively. Patients were classified into distinct frailty trajectory groups using latent class trajectory modeling. One-year all-cause mortality was ascertained through structured telephone follow-up.
Key inclusion criteria (3 listed)
- Aged ≥65 years;
- Underwent elective non-cardiac, non-neurosurgical procedures;
- Completed standardized frailty assessments both preoperatively and postoperatively.
Key exclusion criteria (6 listed)
- Severe dementia, language disorders, significant hearing or visual impairments, or coma;
- Cognitive function below the Mini-Mental State Examination (MMSE) thresholds (<18 for illiterate individuals, <21 for individuals with primary education, and <25 for individuals with secondary education or higher);
- Surgery performed under local anesthesia or monitored anesthesia care;
- Surgical duration ≤30 minutes;
- Missing data on postoperative complications or one-year mortality required for this study;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
The primary outcome was one-year all-cause mortality.
Time frame: At the one-year postoperative follow-up.
The primary outcome was one-year all-cause mortality, determined through structured telephone follow-up.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Jan 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Frailty in Older Adults and All Cause Mortality, run by Chinese PLA General Hospital at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The primary outcome was one-year all-cause mortality. (time frame: At the one-year postoperative follow-up.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jan 2026.