Adhesive CapsulitisRCTNCT07323225
Neural Mobilization and Capsular Stretching in Adhesive Capsulitis
A study testing capsular stretching plus neural mobilization, anterior, inferior and posterior capsular stretching and traditional exercises in people with Adhesive Capsulitis, run by Prince Sattam Bin Abdulaziz University at 1 site in Saudi Arabia.
Trial summary
Restriction of glenohumeral (GH) mobility in patients with adhesive capsulitis (AC) was known owing to capsular adhesion. There is a little evidence about the involvement of neural restriction in limiting range of motion (ROM) of the GH joint in patients with AC. Read more about this study
- Who is it for?
- Ages 40 to 70 years
- Conditions the study is for
- Adhesive Capsulitis
- What is being tested?
- capsular stretching plus neural mobilization, anterior, inferior and posterior capsular stretching and traditional exercises
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteSaudi Arabia
- Study dates
- 1 Jan 2026to 10 Apr 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients from both gender (male \&female) will be included if they would have second or third stage AC with their age between forty and seventy years
- experiencing pain, capsular adhesions, and a reduction of greater than fifty percentage in passive ROM of the GH joint (external rotation, abduction, and internal rotation compared to the sound side
- lasting for a minimum of three months. Patients with positive upper limb tension test-1 will be also included in this study
Who cannot join
- they would have stroke,Parkinson's diseases that interfere with shoulder muscles activity
- diabetes
- traumatic shoulder conditions
- glenohumeral osteoarthritis confirmed by x-ray
- previous surgery, and manipulation of the affected GH joint under general anesthesia
- Patients with passive elbow extension ROM
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Saudi Arabia1 site
Prince Sattam bin Abdulaziz University
Al Kharj, 16242
Mohammed, Phd, 00966115886387 ext. 00966115886387, m.hegazy@psau.edu.sa
About this study
Official title: Effectiveness of Combined Neural Mobilization Techniques and Capsular Stretching Exercises in Patients With Adhesive Capsulitis.
Restriction of glenohumeral (GH) mobility in patients with adhesive capsulitis (AC) was known owing to capsular adhesion. There is a little evidence about the involvement of neural restriction in limiting range of motion (ROM) of the GH joint in patients with AC. Objectives: The purpose of this study is to investigate the combined effect of median nerve mobilization and capsular stretching on improving shoulder external rotation, abduction and internal rotation ROM among patients with AC. Methods Thirty patients will be randomly assigned into two equal groups : Group (A) will receive median nerve mobilization and capsular stretching while Group (B) will receive only capsular stretching (anterior, posterior and anteroinferior capsular stretching). Both groups will receive passive and self-assisted exercises. All patients in both groups will be evaluated pre and post treatment for GH external rotation, abduction and internal rotation ROM.
- Conditions
- Adhesive Capsulitis
- Being tested
- capsular stretching plus neural mobilization, anterior, inferior and posterior capsular stretching, traditional exercises
- Keywords
- Adhesive capsulitis, neural mobilization, capsular stretch
- Medical subject headings
- Bursitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
capsular stretching plus neural mobilizationOther
anterior, posterior and inferior capsular stretching and neural mobilization
anterior, inferior and posterior capsular stretchingOther
anterior, inferior and posterior glenohumeral capsular stretching
traditional exercisesOther
stretching exercises for anterior GH musculture plus auto passive exercises and pendulum exercises
| Study group | Role | What they receive |
|---|---|---|
| Neural mobilization group | Experimental | neural mobilization plus capsular stretching Receives: Other: capsular stretching plus neural mobilization |
| Capsular stretching group | Active comparator | capsular stretching Receives: Other: anterior, inferior and posterior capsular stretching |
| Control group | Active comparator | traditional execises Receives: Other: traditional exercises |
What is being measured
The primary outcome is the main question the study is designed to answer.
pain intensity
pain was assessed by VAS which has two ends. the left end indicates no pain where the right end indicates maximal pain
Measured: 4 Weeks
central sensitization
central sensitization will be assessed by the the arabic version of central sensitizatuion questionnaire. To understand CSI scores, the following severity categories have been established: subclinical = 0 to 29; mild = 30 to 39; moderate = 40 to 49; severe = 50 to 59; and extreme = 60 to 100
Measured: 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Jan 2026
- Study start1 Jan 2026 (estimated)
- Primary completion1 Apr 2026 (estimated)
- Study completion10 Apr 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Adhesive CapsulitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- three groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Prince Sattam Bin Abdulaziz University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mohammad Moustafa Aldosoukki Hegazy, Prince Sattam Bin Abdulaziz University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07323225
- Sponsor's protocol ID
- RHPT/024/009
- Acronym
- RCT
- Status last verified
- Dec 2025
- First submitted
- 15 Dec 2025
- Last updated
- 7 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Coppieters MW, Butler DS. Do 'sliders' slide and 'tensioners' tension? An analysis of neurodynamic techniques and considerations regarding their application. Man Ther. 2008 Jun;13(3):213-21. doi: 10.1016/j.math.2006.12.008. Epub 2007 Mar 30.
PubMed 17398140Martinez-Merinero P, Lluch E, Gallezo-Izquierdo T, Pecos-Martin D, Plaza-Manzano G, Nunez-Nagy S, Falla D. The influence of a depressed scapular alignment on upper limb neural tissue mechanosensitivity and local pressure pain sensitivity. Musculoskelet Sci Pract. 2017 Jun;29:60-65. doi: 10.1016/j.msksp.2017.03.001. Epub 2017 Mar 10.
PubMed 28319883
Study at a glance
From the registry record, last updated by the sponsor on 7 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effectiveness of Combined Neural Mobilization Techniques and Capsular Stretching Exercises in Patients With Adhesive Capsulitis.
- ClinicalTrials.gov ID
- NCT07323225
- Acronym / sponsor ID
- RCT / RHPT/024/009
- Conditions
- Adhesive Capsulitis
- Keywords
- Adhesive capsulitis, neural mobilization, capsular stretch
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Prince Sattam Bin Abdulaziz UniversityUniversity, hospital or other
- Study start
- 1 Jan 2026 (estimated)
- Primary completion
- 1 Apr 2026 (estimated)
- Study completion
- 10 Apr 2026 (estimated)
- First posted
- 7 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Restriction of glenohumeral (GH) mobility in patients with adhesive capsulitis (AC) was known owing to capsular adhesion. There is a little evidence about the involvement of neural restriction in limiting range of motion (ROM) of the GH joint in patients with AC. Objectives: The purpose of this study is to investigate the combined effect of median nerve mobilization and capsular stretching on improving shoulder external rotation, abduction and internal rotation ROM among patients with AC. Methods Thirty patients will be randomly assigned into two equal groups : Group (A) will receive median nerve mobilization and capsular stretching while Group (B) will receive only capsular stretching (anterior, posterior and anteroinferior capsular stretching). Both groups will receive passive and self-assisted exercises. All patients in both groups will be evaluated pre and post treatment for GH external rotation, abduction and internal rotation ROM.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
- Model description
- three groups
| Arm | Type | Receives |
|---|---|---|
| Neural mobilization group | Experimental | Other: capsular stretching plus neural mobilizationneural mobilization plus capsular stretching |
| Capsular stretching group | Active comparator | Other: anterior, inferior and posterior capsular stretchingcapsular stretching |
| Control group | Active comparator | Other: traditional exercisestraditional execises |
Who may qualify
- Ages
- 40 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Patients from both gender (male \&female) will be included if they would have second or third stage AC with their age between forty and seventy years
- experiencing pain, capsular adhesions, and a reduction of greater than fifty percentage in passive ROM of the GH joint (external rotation, abduction, and internal rotation compared to the sound side
- lasting for a minimum of three months. Patients with positive upper limb tension test-1 will be also included in this study
Key exclusion criteria (6 listed)
- they would have stroke,Parkinson's diseases that interfere with shoulder muscles activity
- diabetes
- traumatic shoulder conditions
- glenohumeral osteoarthritis confirmed by x-ray
- previous surgery, and manipulation of the affected GH joint under general anesthesia
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| capsular stretching plus neural mobilizationanterior, posterior and inferior capsular stretching and neural mobilization | Other | Neural mobilization group |
| anterior, inferior and posterior capsular stretchinganterior, inferior and posterior glenohumeral capsular stretching | Other | Capsular stretching group |
| traditional exercisesstretching exercises for anterior GH musculture plus auto passive exercises and pendulum exercises | Other | Control group |
Primary outcome
pain intensity
Time frame: 4 Weeks
pain was assessed by VAS which has two ends. the left end indicates no pain where the right end indicates maximal pain
central sensitization
Time frame: 4 weeks
central sensitization will be assessed by the the arabic version of central sensitizatuion questionnaire. To understand CSI scores, the following severity categories have been established: subclinical = 0 to 29; mild = 30 to 39; moderate = 40 to 49; severe = 50 to 59; and extreme = 60 to 100
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jan 2026.
- Results publication: PubMed 17398140Coppieters MW, Butler DS. Do 'sliders' slide and 'tensioners' tension? An analysis of neurodynamic techniques and considerations regarding their application. Man Ther. 2008 Jun;13(3):213-21. doi: 10.1016/j.math.2006.12.008. Epub 2007 Mar 30.
- Results publication: PubMed 28319883Martinez-Merinero P, Lluch E, Gallezo-Izquierdo T, Pecos-Martin D, Plaza-Manzano G, Nunez-Nagy S, Falla D. The influence of a depressed scapular alignment on upper limb neural tissue mechanosensitivity and local pressure pain sensitivity. Musculoskelet Sci Pract. 2017 Jun;29:60-65. doi: 10.1016/j.msksp.2017.03.001. Epub 2017 Mar 10.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing capsular stretching plus neural mobilization, anterior, inferior and posterior capsular stretching and traditional exercises in people with Adhesive Capsulitis, run by Prince Sattam Bin Abdulaziz University at 1 site in Saudi Arabia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 7 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Saudi Arabia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Mohammed Hegazy (00966566169893 ext. 00966115886387, mohamed.mostafa@pt.cu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
pain intensity (time frame: 4 Weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07323225, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jan 2026.