Healthy Subjects/VolunteersNCT07324226
Effects of Combined Heat Application and Acupressure to the Carotid Artery Region on Cerebral Blood Flow in Healthy Adults
A study testing Combined heat and acupressure in people with Healthy Subjects/Volunteers, run by Pusan National University Yangsan Hospital at 1 site in South Korea.
Trial summary
The aim of this study is to investigate the effects of combined heat application and acupressure to the carotid artery region on cerebral blood flow in healthy adults Read more about this study
- Who is it for?
- Ages 40 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Subjects/Volunteers
- What is being tested?
- Combined heat and acupressure
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 9 participants
- Where
- 1 siteSouth Korea
- Study dates
- 1 Feb 2026to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Adults aged 40 to 65 years.
- Individuals with no history of cerebrovascular, cardiovascular, or neurological diseases.
- Individuals who have signed the informed consent form and voluntarily agreed to participate in the study
Who cannot join
- Individuals with a history of cerebrovascular, cardiovascular, or neurological diseases (e.g., stroke, angina, epilepsy).
- Individuals currently taking medications that may affect cerebral blood flow (such as antihypertensive agents or antidepressants).
- Individuals with skin diseases or lesions that make it difficult to apply heat or acupressure devices to the carotid artery region, and individuals who are pregnant or breastfeeding.
- Individuals with a history of seizures.
- Individuals who have participated in clinical studies two or more times in the same year, or who have participated in another clinical study within the past 6 months.
- Individuals who, in the judgment of the principal investigator or sub-investigator, have clinically significant findings that make them unsuitable for participation in this study.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
South Korea1 site, 1 recruiting
- Recruiting
Rehab lab, Pusan National University Yangsan Hospital
Yangsan, Gyeongsangnam-do, 50612
Jisoo Baik, Doctoral, 82+55-360-4159, zisoo@pusan.ac.kr
About this study
Official title: Effects of Combined Heat Application and Acupressure to the Carotid Artery Region on Cerebral Blood Flow in Healthy Adults: An Investigator-Initiated, Single-Group, Single-Center, Prospective Case Study
The aim of this study is to investigate the effects of combined heat application and acupressure to the carotid artery region on cerebral blood flow in healthy adults
- Conditions
- Healthy Subjects/Volunteers
- Being tested
- Combined heat and acupressure
- Keywords
- Carotid artery, Heat application, SPECT imaging, Acupressure Combined heat and acupressure, Cerebral blood flow, Single-group prospective study, Single-center study
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Combined heat and acupressureDevice
Press the start button to activate the automatic mode. When the start button is pressed, the device operates for approximately 40 minutes.
When the start button is pressed, acupressure massage is performed with a single back-and-forth cycle from acupressure bar No. 1 to No. 18.
The device then performs back-and-forth acupressure massage between acupressure bars No. 18 and No. 13 for the remaining time.
After operating for 40 minutes in automatic mode, the mattress heating unit, the acupressure bar heating unit, and the acupressure bar movement are all turned off.
- Press the shoulder button. The acupressure bar operates in the neck-to-shoulder section (acupressure bars No. 1 to 6), and both the mattress heating unit and the acupressure bar heating unit are activated.
- After operating for 20 minutes in manual mode, the mattress heating unit, the acupressure bar heating unit, and the acupressure bar movement are turned off.
| Study group | Role | What they receive |
|---|---|---|
| Combined heat and acupressure | Experimental | Combined heat and acupressure Receives: Device: Combined heat and acupressure |
What is being measured
The primary outcome is the main question the study is designed to answer.
A SPECT CT brain scan
Cerebral blood flow change rate analysis: For each participant, the percentage change in cerebral blood flow (CBF) observed on SPECT imaging compared with the baseline time point will be quantitatively analyzed at the following three time points.
Radiopharmaceutical injection reference times: 5 minutes, 10 minutes, and 20 minutes after injection.
Measured: In the post-SPECT protocol, the radiopharmaceutical will be administered at 5 minutes (n=3), 10 minutes (n=3), and 20 minutes (n=3) after the start of image acquisition.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Jan 2026
- Study start1 Feb 2026 (estimated)
- Primary completion30 Sep 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy Subjects/VolunteersStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 9 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Pusan National University Yangsan Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yong-il Shin, Pusan National University Yangsan Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07324226
- Sponsor's protocol ID
- 21-2025-010
- Status last verified
- Dec 2025
- First submitted
- 23 Dec 2025
- Last updated
- 7 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data (IPD) cannot be shared due to protection of participants' personal infand regulatory restrictions of our hospital.
Study at a glance
From the registry record, last updated by the sponsor on 7 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Combined Heat Application and Acupressure to the Carotid Artery Region on Cerebral Blood Flow in Healthy Adults: An Investigator-Initiated, Single-Group, Single-Center, Prospective Case Study
- ClinicalTrials.gov ID
- NCT07324226
- Acronym / sponsor ID
- 21-2025-010
- Conditions
- Healthy Subjects/Volunteers
- Keywords
- Carotid artery, Heat application, SPECT imaging, Acupressure Combined heat and acupressure, Cerebral blood flow, Single-group prospective study, Single-center study
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 9 participants (estimated)
- Lead sponsor
- Pusan National University Yangsan HospitalUniversity, hospital or other
- Study start
- 1 Feb 2026 (estimated)
- Primary completion
- 30 Sep 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 7 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to investigate the effects of combined heat application and acupressure to the carotid artery region on cerebral blood flow in healthy adults
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Combined heat and acupressure | Experimental | Device: Combined heat and acupressureCombined heat and acupressure |
Who may qualify
- Ages
- 40 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Adults aged 40 to 65 years.
- Individuals with no history of cerebrovascular, cardiovascular, or neurological diseases.
- Individuals who have signed the informed consent form and voluntarily agreed to participate in the study
Key exclusion criteria (6 listed)
- Individuals with a history of cerebrovascular, cardiovascular, or neurological diseases (e.g., stroke, angina, epilepsy).
- Individuals currently taking medications that may affect cerebral blood flow (such as antihypertensive agents or antidepressants).
- Individuals with skin diseases or lesions that make it difficult to apply heat or acupressure devices to the carotid artery region, and individuals who are pregnant or breastfeeding.
- Individuals with a history of seizures.
- Individuals who have participated in clinical studies two or more times in the same year, or who have participated in another clinical study within the past 6 months.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Combined heat and acupressurePress the start button to activate the automatic mode. When the start button is pressed, the device operates for approximately 40 minutes. When the start button is pressed, acupressure massage is performed with a single back-and-forth cycle from acupressure bar No. 1 to No. 18. The device then performs back-and-forth acupressure massage between acupressure bars No. 18 and No. 13 for the remaining time. After operating for 40 minutes in automatic mode, the mattress heating unit, the acupressure bar heating unit, and the acupressure bar movement are all turned off. 1. Press the shoulder button. The acupressure bar operates in the neck-to-shoulder section (acupressure bars No. 1 to 6), and both the mattress heating unit and the acupressure bar heating unit are activated. 2. After operating for 20 minutes in manual mode, the mattress heating unit, the acupressure bar heating unit, and the acupressure bar movement are turned off. | Device | Combined heat and acupressure |
Primary outcome
A SPECT CT brain scan
Time frame: In the post-SPECT protocol, the radiopharmaceutical will be administered at 5 minutes (n=3), 10 minutes (n=3), and 20 minutes (n=3) after the start of image acquisition.
Cerebral blood flow change rate analysis: For each participant, the percentage change in cerebral blood flow (CBF) observed on SPECT imaging compared with the baseline time point will be quantitatively analyzed at the following three time points. Radiopharmaceutical injection reference times: 5 minutes, 10 minutes, and 20 minutes after injection.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jan 2026.
- Individual participant dataSharing planned: No. Individual participant data (IPD) cannot be shared due to protection of participants' personal infand regulatory restrictions of our hospital.
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Screening Protocol
Pain
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Combined heat and acupressure in people with Healthy Subjects/Volunteers, run by Pusan National University Yangsan Hospital at 1 site in South Korea.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 7 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in South Korea. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jisoo Baik, Doctoral (82+055-360-4159, zisoo@pusan.ac.kr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
A SPECT CT brain scan (time frame: In the post-SPECT protocol, the radiopharmaceutical will be administered at 5 minutes (n=3), 10 minutes (n=3), and 20 minutes (n=3) after the start of image acquisition.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jan 2026.