Cervical DiseaseNCT07324811
Effectiveness of a Home-based Cervical Motor Control Exercise Programme Versus Conventional Manual Therapy in Patients With Post-whiplash Neck Pain.
A study testing conventional physiotherapy treatment in people with Cervical Disease, run by Universidad Pontificia de Salamanca at 1 site in Spain.
Trial summary
Whiplash-associated disorders are a common cause of persistent neck pain following traffic accidents and are frequently associated with impairments in cervical motor control, pain, and functional disability. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Cervical Disease
- What is being tested?
- conventional physiotherapy treatment
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 siteSpain
- Study dates
- 10 Jan 2025to 10 Sep 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients who met the following criteria were included:
- Age between 18 and 65 years.
- Clinical diagnosis of post-whiplash neck pain resulting from a traffic accident.
- Symptoms lasting longer than four weeks.
- Presence of neck pain with a minimum intensity of 3 points on the Visual Analogue Scale.
- Ability to understand and follow the instructions of the home exercise programme.
- Signed informed consent.
Who cannot join
- Patients with the following conditions were excluded:
- Signs of severe neurological compromise or significant structural cervical pathology (fractures, cervical instability, myelopathy).
- History of cervical surgery.
- Rheumatic, neurological, or systemic diseases that could influence the results.
- Previous physiotherapy treatment for the same episode in the three months prior to the study.
- Pregnancy or any medical contraindication for therapeutic exercise.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effectiveness of a Home-based Cervical Motor Control Exercise Programme Versus Conventional Manual Therapy in Patients With Post-whiplash Neck Pain: a Randomised Clinical Trial.
Whiplash-associated disorders are a common cause of persistent neck pain following traffic accidents and are frequently associated with impairments in cervical motor control, pain, and functional disability. Therapeutic exercise aimed at restoring cervical motor control has shown promising results; however, evidence regarding the effectiveness of structured home-based exercise programs compared with conventional physiotherapy remains limited. The aim of this study was to compare the effectiveness of a home-based cervical motor control exercise program versus conventional physiotherapy in patients with whiplash-associated neck pain.
A randomized controlled trial with two parallel groups was conducted. Patients diagnosed with whiplash-associated neck pain were randomly assigned to either an experimental group performing a structured home-based cervical motor control exercise program or a control group receiving conventional physiotherapy based on manual therapy and cervical mobilization techniques. Outcome measures included pain intensity assessed using the Visual Analogue Scale, functional disability measured with the Neck Disability Index, and active cervical range of motion. Assessments were performed at baseline and after an eight-week intervention period.
- Conditions
- Cervical Disease
- Being tested
- home-based cervical motor control exercise programme, conventional physiotherapy treatment
- Keywords
- Whiplash, pain, exercise
- Medical subject headings
- Uterine Cervical Diseases, Whiplash Injuries, Pain, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
home-based cervical motor control exercise programmeProcedure or surgery
home-based programme of active cervical motor control exercises supervised by physiotherapists
conventional physiotherapy treatmentProcedure or surgery
Conventional physiotherapy treatment with passive therapy (manual therapy) carried out in a physiotherapy clinic.
| Study group | Role | What they receive |
|---|---|---|
| home-based cervical motor control exercise programme | Experimental | home-based cervical motor control exercise programme monitored by physiotherapists Receives: Procedure: home-based cervical motor control exercise programme |
| conventional physiotherapy treatment | Active comparator | Conventional physiotherapy treatment including passive therapies (manual therapy) in the physiotherapy clinic. Receives: Procedure: conventional physiotherapy treatment |
What is being measured
The primary outcome is the main question the study is designed to answer.
pain
measured using the visual analogue pain scale (VAS) (where 0 is the least possible pain and 10 is the maximum possible pain)
Measured: 2 months
Secondary outcomes (1)
range of motion
The range of active cervical movement was assessed using goniometry, recording the movements of flexion, extension, rotation, and lateralisation of the cervical spine.
Measured: 2 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Jan 2026
- Study start10 Jan 2025
- Primary completion10 Apr 2025
- Study completion10 Sep 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Cervical DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 80 participants (actual)
Sponsor and investigators
- Lead sponsor
- Universidad Pontificia de Salamanca
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jorge Velazquez, Universidad Pontificia de Salamanca
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07324811
- Sponsor's protocol ID
- 00043
- Status last verified
- Dec 2025
- First submitted
- 23 Dec 2025
- Last updated
- 8 Jan 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Randlov A, Ostergaard M, Manniche C, Kryger P, Jordan A, Heegaard S, Holm B. Intensive dynamic training for females with chronic neck/shoulder pain. A randomized controlled trial. Clin Rehabil. 1998 Jun;12(3):200-10. doi: 10.1191/026921598666881319.
PubMed 9688035Jordan A, Bendix T, Nielsen H, Hansen FR, Host D, Winkel A. Intensive training, physiotherapy, or manipulation for patients with chronic neck pain. A prospective, single-blinded, randomized clinical trial. Spine (Phila Pa 1976). 1998 Feb 1;23(3):311-8; discussion 319. doi: 10.1097/00007632-199802010-00005.
PubMed 9507618Bronfort G, Evans R, Nelson B, Aker PD, Goldsmith CH, Vernon H. A randomized clinical trial of exercise and spinal manipulation for patients with chronic neck pain. Spine (Phila Pa 1976). 2001 Apr 1;26(7):788-97; discussion 798-9. doi: 10.1097/00007632-200104010-00020.
PubMed 11295901Kjellman GV, Skargren EI, Oberg BE. A critical analysis of randomised clinical trials on neck pain and treatment efficacy. A review of the literature. Scand J Rehabil Med. 1999 Sep;31(3):139-52. doi: 10.1080/003655099444489.
PubMed 10458312
Study at a glance
From the registry record, last updated by the sponsor on 8 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effectiveness of a Home-based Cervical Motor Control Exercise Programme Versus Conventional Manual Therapy in Patients With Post-whiplash Neck Pain: a Randomised Clinical Trial.
- ClinicalTrials.gov ID
- NCT07324811
- Acronym / sponsor ID
- 00043
- Conditions
- Cervical Disease
- Keywords
- Whiplash, pain, exercise
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 80 participants (actual)
- Lead sponsor
- Universidad Pontificia de SalamancaUniversity, hospital or other
- Study start
- 10 Jan 2025 (actual)
- Primary completion
- 10 Apr 2025 (actual)
- Study completion
- 10 Sep 2025 (actual)
- First posted
- 8 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Whiplash-associated disorders are a common cause of persistent neck pain following traffic accidents and are frequently associated with impairments in cervical motor control, pain, and functional disability. Therapeutic exercise aimed at restoring cervical motor control has shown promising results; however, evidence regarding the effectiveness of structured home-based exercise programs compared with conventional physiotherapy remains limited. The aim of this study was to compare the effectiveness of a home-based cervical motor control exercise program versus conventional physiotherapy in patients with whiplash-associated neck pain.
A randomized controlled trial with two parallel groups was conducted. Patients diagnosed with whiplash-associated neck pain were randomly assigned to either an experimental group performing a structured home-based cervical motor control exercise program or a control group receiving conventional physiotherapy based on manual therapy and cervical mobilization techniques. Outcome measures included pain intensity assessed using the Visual Analogue Scale, functional disability measured with the Neck Disability Index, and active cervical range of motion. Assessments were performed at baseline and after an eight-week intervention period.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| home-based cervical motor control exercise programme | Experimental | Procedure: home-based cervical motor control exercise programmehome-based cervical motor control exercise programme monitored by physiotherapists |
| conventional physiotherapy treatment | Active comparator | Procedure: conventional physiotherapy treatmentConventional physiotherapy treatment including passive therapies (manual therapy) in the physiotherapy clinic. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Patients who met the following criteria were included:
- Age between 18 and 65 years.
- Clinical diagnosis of post-whiplash neck pain resulting from a traffic accident.
- Symptoms lasting longer than four weeks.
- Presence of neck pain with a minimum intensity of 3 points on the Visual Analogue Scale.
Key exclusion criteria (6 listed)
- Patients with the following conditions were excluded:
- Signs of severe neurological compromise or significant structural cervical pathology (fractures, cervical instability, myelopathy).
- History of cervical surgery.
- Rheumatic, neurological, or systemic diseases that could influence the results.
- Previous physiotherapy treatment for the same episode in the three months prior to the study.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| home-based cervical motor control exercise programmehome-based programme of active cervical motor control exercises supervised by physiotherapists | Procedure or surgery | home-based cervical motor control exercise programme |
| conventional physiotherapy treatmentConventional physiotherapy treatment with passive therapy (manual therapy) carried out in a physiotherapy clinic. | Procedure or surgery | conventional physiotherapy treatment |
Primary outcome
pain
Time frame: 2 months
measured using the visual analogue pain scale (VAS) (where 0 is the least possible pain and 10 is the maximum possible pain)
1 secondary outcome
range of motion
Time frame: 2 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Jan 2026.
- Results publication: PubMed 9688035Randlov A, Ostergaard M, Manniche C, Kryger P, Jordan A, Heegaard S, Holm B. Intensive dynamic training for females with chronic neck/shoulder pain. A randomized controlled trial. Clin Rehabil. 1998 Jun;12(3):200-10. doi: 10.1191/026921598666881319.
- Results publication: PubMed 9507618Jordan A, Bendix T, Nielsen H, Hansen FR, Host D, Winkel A. Intensive training, physiotherapy, or manipulation for patients with chronic neck pain. A prospective, single-blinded, randomized clinical trial. Spine (Phila Pa 1976). 1998 Feb 1;23(3):311-8; discussion 319. doi: 10.1097/00007632-199802010-00005.
- Results publication: PubMed 11295901Bronfort G, Evans R, Nelson B, Aker PD, Goldsmith CH, Vernon H. A randomized clinical trial of exercise and spinal manipulation for patients with chronic neck pain. Spine (Phila Pa 1976). 2001 Apr 1;26(7):788-97; discussion 798-9. doi: 10.1097/00007632-200104010-00020.
- Results publication: PubMed 10458312Kjellman GV, Skargren EI, Oberg BE. A critical analysis of randomised clinical trials on neck pain and treatment efficacy. A review of the literature. Scand J Rehabil Med. 1999 Sep;31(3):139-52. doi: 10.1080/003655099444489.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing conventional physiotherapy treatment in people with Cervical Disease, run by Universidad Pontificia de Salamanca at 1 site in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
pain (time frame: 2 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07324811, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jan 2026.