Hematopoietic and Lymphatic System NeoplasmNCT07325006
Impact of Physician Behavior on Cancer Distress
An observational study of Hematopoietic and Lymphatic System Neoplasm and Malignant Solid Neoplasm, run by Mayo Clinic at 1 site in United States.
Trial summary
This evaluates the impact of physician behaviors and other factors experienced during radiation treatment influence distress levels in cancer patients. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
- What is being tested?
- Non-Interventional Study
- How many people
- 5,000 participants
- Where
- 1 siteUnited States
- Study dates
- 24 Nov 2025to 30 Nov 2030
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Cancer patients who are undergoing or have completed radiation therapy within the last 30 days at Mayo Clinic in Rochester
Who may be able to join
- Adult (age 18+ years old)
- Must have a diagnosis of neoplasm
- Must be actively undergoing radiation therapy (RT) or have completed RT within the last month at Mayo Clinic in Rochester
- Able to read and write in English
- Must have email and Mayo Clinic patient portal access
Who cannot join
- Patients who have not yet started RT
- Patients who have been seen in consultation but not recommended for radiation
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
Clinical Trials Referral Office, 855-776-0015, mayocliniccancerstudies@mayo.edu
May Elbanna, MB, BCh, PhD
About this study
This evaluates the impact of physician behaviors and other factors experienced during radiation treatment influence distress levels in cancer patients.
- Being tested
- Non-Interventional Study
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Non-Interventional StudyOther
Also called Non-Interventional Observational Study, Noninterventional (Observational) Study
Non-interventional study
| Study group | Role | What they receive |
|---|---|---|
| Observational | Patients complete a survey and have their medical records reviewed on study. Patients who score a 7 or higher on the NCCN distress thermometer receive distress management patient education materials and recommendation to follow up with their care team. Receives: Other: Non-Interventional Study |
What is being measured
The primary outcome is the main question the study is designed to answer.
Explore what physician behaviors contribute to patients' cancer distress
Participants will indicate levels of distress on an 11-point Likert scale (10=extreme distress; 0=no distress). Physician behaviors that contribute to patients' cancer distress (as reported by patients) will be assessed using a free-text question. Topics and contextual factors will be identified by searching for themes with a thematic analysis. Descriptive statistics will be utilized to broadly analyze results. Data will initially be analyzed in its entirety. Subgroup analyses will then be done for patients who have vs have not experienced clinically significant distress (past or current score of 4+ on the distress thermometer). Additional subgroup analyses may be conducted depending on response.
Measured: Baseline (at enrollment)
Explore what physician behaviors lessen patients' cancer distress
Participants will indicate levels of distress on an 11-point Likert scale (10=extreme distress; 0=no distress). Physician behaviors that lessen patients' cancer distress (as reported by patients) will be assessed using a free-text question. Topics and contextual factors will be identified by searching for themes with a thematic analysis. Descriptive statistics will be utilized to broadly analyze results. Data will initially be analyzed in its entirety. Subgroup analyses will then be done for patients who have vs have not experienced clinically significant distress (past or current score of 4+ on the distress thermometer). Additional subgroup analyses may be conducted depending on response.
Measured: Baseline (at enrollment)
Explore how non-physician factors in the patient care experience contribute to patients' cancer distress
Participants will indicate levels of distress on an 11-point Likert scale (10=extreme distress; 0=no distress). Other factors that contribute to patients' cancer distress (as reported by patients) will be assessed using a free-text question. Topics and contextual factors will be identified by searching for themes with a thematic analysis. Descriptive statistics will be utilized to broadly analyze results. Data will initially be analyzed in its entirety. Subgroup analyses will then be done for patients who have vs have not experienced clinically significant distress (past or current score of 4+ on the distress thermometer). Additional subgroup analyses may be conducted depending on response.
Measured: Baseline (at enrollment)
Explore how non-physician factors in the patient care experience lessen patients' cancer distress
Participants will indicate levels of distress on an 11-point Likert scale (10=extreme distress; 0=no distress). Other factors that lessen patients' cancer distress (as reported by patients) will be assessed using a free-text question. Topics and contextual factors will be identified by searching for themes with a thematic analysis. Descriptive statistics will be utilized to broadly analyze results. Data will initially be analyzed in its entirety. Subgroup analyses will then be done for patients who have vs have not experienced clinically significant distress (past or current score of 4+ on the distress thermometer). Additional subgroup analyses may be conducted depending on response.
Measured: Baseline (at enrollment)
Patient ratings of preference for physician-initiated conversations
Patient ratings of preference for physician-initiated conversations on five sensitive topics: mental health, sexual health, financial health, cancer survival and mortality/prognosis, and personal relationship dynamics will be assessed using a study-specific survey. Responses are recorded on a Likert scale of 0-10 where 0=not at all and 10=very much so. Descriptive statistics will be utilized to analyze results.
Measured: Baseline (at enrollment)
Patient ratings of contributors to distress
Patient ratings of how much sexual health, finances, cancer survival and prognosis, and changes in personal relationship dynamics contribute to their distress will be assessed using a study-specific survey. Each item will be rated on a Likert scale of 0-10 where 0=not at all and 10=very much so. Descriptive statistics will be utilized to analyze results.
Measured: Baseline (at enrollment)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Jan 2026
- Study start24 Nov 2025
- Primary completion30 Nov 2030 (estimated)
- Study completion30 Nov 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hematopoietic and Lymphatic System NeoplasmStudies of the same condition, open and under way.
- More trials run by Mayo ClinicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Enrolment
- 5,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mayo Clinic
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- May Elbanna, MB, BCh, PhD, Principal investigator, Mayo Clinic
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07325006
- Sponsor's protocol ID
- ROR2503
- Other IDs
- NCI-2025-09164, 24-011548
- Status last verified
- Jul 2026
- First submitted
- 22 Dec 2025
- Last updated
- 7 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 7 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Physician Behavior on Cancer Distress
- ClinicalTrials.gov ID
- NCT07325006
- Acronym / sponsor ID
- ROR2503
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 5,000 participants (estimated)
- Lead sponsor
- Mayo ClinicUniversity, hospital or other
- Study start
- 24 Nov 2025 (actual)
- Primary completion
- 30 Nov 2030 (estimated)
- Study completion
- 30 Nov 2030 (estimated)
- First posted
- 8 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This evaluates the impact of physician behaviors and other factors experienced during radiation treatment influence distress levels in cancer patients.
Study design
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Observational | – | Other: Non-Interventional StudyPatients complete a survey and have their medical records reviewed on study. Patients who score a 7 or higher on the NCCN distress thermometer receive distress management patient education materials and recommendation to follow up with their care team. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Cancer patients who are undergoing or have completed radiation therapy within the last 30 days at Mayo Clinic in Rochester
Key inclusion criteria (5 listed)
- Adult (age 18+ years old)
- Must have a diagnosis of neoplasm
- Must be actively undergoing radiation therapy (RT) or have completed RT within the last month at Mayo Clinic in Rochester
- Able to read and write in English
- Must have email and Mayo Clinic patient portal access
Key exclusion criteria (2 listed)
- Patients who have not yet started RT
- Patients who have been seen in consultation but not recommended for radiation
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Non-Interventional StudyAlso: Non-Interventional Observational Study, Noninterventional (Observational) StudyNon-interventional study | Other | Observational |
Primary outcome
Explore what physician behaviors contribute to patients' cancer distress
Time frame: Baseline (at enrollment)
Participants will indicate levels of distress on an 11-point Likert scale (10=extreme distress; 0=no distress). Physician behaviors that contribute to patients' cancer distress (as reported by patients) will be assessed using a free-text question. Topics and contextual factors will be identified by searching for themes with a thematic analysis. Descriptive statistics will be utilized to broadly analyze results. Data will initially be analyzed in its entirety. Subgroup analyses will then be done for patients who have vs have not experienced clinically significant distress (past or current score of 4+ on the distress thermometer). Additional subgroup analyses may be conducted depending on response.
Explore what physician behaviors lessen patients' cancer distress
Time frame: Baseline (at enrollment)
Participants will indicate levels of distress on an 11-point Likert scale (10=extreme distress; 0=no distress). Physician behaviors that lessen patients' cancer distress (as reported by patients) will be assessed using a free-text question. Topics and contextual factors will be identified by searching for themes with a thematic analysis. Descriptive statistics will be utilized to broadly analyze results. Data will initially be analyzed in its entirety. Subgroup analyses will then be done for patients who have vs have not experienced clinically significant distress (past or current score of 4+ on the distress thermometer). Additional subgroup analyses may be conducted depending on response.
Explore how non-physician factors in the patient care experience contribute to patients' cancer distress
Time frame: Baseline (at enrollment)
Participants will indicate levels of distress on an 11-point Likert scale (10=extreme distress; 0=no distress). Other factors that contribute to patients' cancer distress (as reported by patients) will be assessed using a free-text question. Topics and contextual factors will be identified by searching for themes with a thematic analysis. Descriptive statistics will be utilized to broadly analyze results. Data will initially be analyzed in its entirety. Subgroup analyses will then be done for patients who have vs have not experienced clinically significant distress (past or current score of 4+ on the distress thermometer). Additional subgroup analyses may be conducted depending on response.
Explore how non-physician factors in the patient care experience lessen patients' cancer distress
Time frame: Baseline (at enrollment)
Participants will indicate levels of distress on an 11-point Likert scale (10=extreme distress; 0=no distress). Other factors that lessen patients' cancer distress (as reported by patients) will be assessed using a free-text question. Topics and contextual factors will be identified by searching for themes with a thematic analysis. Descriptive statistics will be utilized to broadly analyze results. Data will initially be analyzed in its entirety. Subgroup analyses will then be done for patients who have vs have not experienced clinically significant distress (past or current score of 4+ on the distress thermometer). Additional subgroup analyses may be conducted depending on response.
Patient ratings of preference for physician-initiated conversations
Time frame: Baseline (at enrollment)
Patient ratings of preference for physician-initiated conversations on five sensitive topics: mental health, sexual health, financial health, cancer survival and mortality/prognosis, and personal relationship dynamics will be assessed using a study-specific survey. Responses are recorded on a Likert scale of 0-10 where 0=not at all and 10=very much so. Descriptive statistics will be utilized to analyze results.
Patient ratings of contributors to distress
Time frame: Baseline (at enrollment)
Patient ratings of how much sexual health, finances, cancer survival and prognosis, and changes in personal relationship dynamics contribute to their distress will be assessed using a study-specific survey. Each item will be rated on a Likert scale of 0-10 where 0=not at all and 10=very much so. Descriptive statistics will be utilized to analyze results.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jul 2026.
- Mayo Clinic Clinical TrialsLink provided by the sponsor.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
May Elbanna, MB, BCh, PhD principal investigator
Mayo Clinic
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Hematopoietic and Lymphatic System Neoplasm and Malignant Solid Neoplasm, run by Mayo Clinic at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 7 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Clinical Trials Referral Office (855-776-0015, mayocliniccancerstudies@mayo.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Explore what physician behaviors contribute to patients' cancer distress (time frame: Baseline (at enrollment)). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jul 2026.