Chronic Heart FailureNCT07325942
Effectiveness of Low -Versus High -Volume High -Intensity Interval Training in Patients With Chronic Heart Failure
A study testing low-volume high intensity interval training, High volume high intensity interval training and Standard medical treatment in people with Chronic Heart Failure, run by Cairo University at 1 site in Egypt.
Trial summary
this study aims to investigate the effect of low vs high volume- high intensity interval training on functional capacity and quality of life in chronic heart failure patients Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Chronic Heart Failure
- What is being tested?
- low-volume high intensity interval training, High volume high intensity interval training and Standard medical treatment
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 45 participants
- Where
- 1 siteEgypt
- Study dates
- 10 Dec 2025to 6 Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Chronic stable heart failure patient with reduced ejection fraction (EF <40)
- Age Above 18 years old
- Both males and females
- The ability to provide informed consent
Who cannot join
- Based on the Scientific Statement from the American Heart Association: contraindications for exercise Testing and Training. (Fletcher et al., 2013)
- Acute myocardial infarction (MI), within 2 days
- Ongoing unstable angina
- Uncontrolled cardiac tachy or brady arrhythmia with hemodynamic compromise
- Active endocarditis
- Symptomatic severe aortic stenosis
Show all 18Show fewer
- Decompensated heart failure
- Acute pulmonary embolism, pulmonary infarction, or deep vein thrombosis
- Acute myocarditis or pericarditis
- Acute aortic dissection
- Physical disability that precludes safe and adequate testing or training
- Known obstructive left main coronary artery stenosis
- Hypertrophic obstructive cardiomyopathy with severe resting gradient
- Recent stroke or transient ischemic attack
- Mental impairment with limited ability to cooperate
- Resting hypertension with systolic or diastolic blood pressures >200/110 mmHg
- Uncorrected medical conditions, such as significant anemia, important electrolyte imbalance, and hyperthyroidism
- Acute decompensated heart failure NYHA class IV
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Cairo University
Cairo, Giza Governorate
Aya I Elshenawy, +201098811085, dr.aya_ebrahime@yahoo.com
About this study
this study aims to investigate the effect of low vs high volume- high intensity interval training on functional capacity and quality of life in chronic heart failure patients
- Conditions
- Chronic Heart Failure
- Being tested
- low-volume high intensity interval training, High volume high intensity interval training, Standard medical treatment
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
low-volume high intensity interval trainingOther
Low-volume HIIT (LV-HIIT) is a particularly time-efficient subtype of interval training, which has gained increasing attention in recent years. As per the previous definition, these brief training protocols typically involve≤10 min of intense exercise within a session lasting≤30 min including warm-up, recovery phases between intervals, and cool-down
High volume high intensity interval trainingOther
long (2-4 min) bouts of high (not maximum) intensity exercise interspersed with recovery periods which have wide varieties in the protocols according to the intensity, duration, and number of intervals performed
Standard medical treatmentDrug
standard medical treatment for chronic heart failure as per international guidlines
| Study group | Role | What they receive |
|---|---|---|
| Low volume high intensity interval training | Experimental | This group will receive the usual care (standard medical treatment) in addition to LV-HIIT on a treadmill for 8 weeks, 2 sessions per week. Receives: Other: low-volume high intensity interval training; Drug: Standard medical treatment |
| high volume high intensity interval training | Experimental | In this group, the patients will receive the usual care (standard treatment) in addition to HV-HIIT on a treadmill for 8 weeks, 2 sessions per week Receives: Other: High volume high intensity interval training; Drug: Standard medical treatment |
| control group | Other | It includes 15 patients who will receive standard medical treatment only Receives: Drug: Standard medical treatment |
What is being measured
The primary outcome is the main question the study is designed to answer.
6 minute walk test
self-paced submaximal field exercise test to assess submaximal functional capacity of the patient , the distance walked by the patient for six minutes will be measured by meters
Measured: at enrolment and at the end of treatment at 8 weeks
2D Echocardiographic parameters
Left ventricle geometry: left ventricular end-diastolic diameter (LVEDD) mm, left ventricular end-systolic diameter (LVESD) mm, left ventricular end-systolic volume (LVESV) ml. and, left ventricular end-diastolic volume (LVEDV) ml.
Left ventricle Systolic function: left ventricular ejection fraction (LVEF) % Left ventricle Diastolic function :E wave cm/s: early diastolic mitral inflow velocity, A wave cm/s: diastolic mitral inflow velocity during late atrial contraction , E/A ratio
Measured: at enrollment and at the end of treatment at 8 weeks
Secondary outcomes (1)
Minnesota living with heart failure questionnaire (MLHFQ)
The Minnesota Living with Heart Failure Questionnaire (MLHFQ) is the tool most widely used and recognized to assess HRQOL in adults with Hf, was developed in 1987 by Thomas Rector, focusing on the underlying relationship between pathophysiology, symptoms, functional limitations, and psychological distress, it measures the impacts of symptoms and treatment on different dimensions of HRQOL in HF patients.
Measured: at enrollment and at the end of treatment at 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Jan 2026
- Study start10 Dec 2025 (estimated)
- Primary completion6 Jun 2026 (estimated)
- Study completion6 Jun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic Heart FailureStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 45 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Aya Ibrahim Elshenawy Elshenawy, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07325942
- Sponsor's protocol ID
- P.T.REC/012/005825
- Status last verified
- Jan 2026
- First submitted
- 9 Dec 2025
- Last updated
- 8 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effectiveness of Low -Versus High -Volume High -Intensity Interval Training in Patients With Chronic Heart Failure
- ClinicalTrials.gov ID
- NCT07325942
- Acronym / sponsor ID
- P.T.REC/012/005825
- Conditions
- Chronic Heart Failure
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 45 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 10 Dec 2025 (estimated)
- Primary completion
- 6 Jun 2026 (estimated)
- Study completion
- 6 Jun 2026 (estimated)
- First posted
- 8 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
this study aims to investigate the effect of low vs high volume- high intensity interval training on functional capacity and quality of life in chronic heart failure patients
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Low volume high intensity interval training | Experimental | Other: low-volume high intensity interval training, Drug: Standard medical treatmentThis group will receive the usual care (standard medical treatment) in addition to LV-HIIT on a treadmill for 8 weeks, 2 sessions per week. |
| high volume high intensity interval training | Experimental | Other: High volume high intensity interval training, Drug: Standard medical treatmentIn this group, the patients will receive the usual care (standard treatment) in addition to HV-HIIT on a treadmill for 8 weeks, 2 sessions per week |
| control group | Other | Drug: Standard medical treatmentIt includes 15 patients who will receive standard medical treatment only |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Chronic stable heart failure patient with reduced ejection fraction (EF <40)
- Age Above 18 years old
- Both males and females
- The ability to provide informed consent
Key exclusion criteria (18 listed)
- Based on the Scientific Statement from the American Heart Association: contraindications for exercise Testing and Training. (Fletcher et al., 2013)
- Acute decompensated heart failure NYHA class IV
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| low-volume high intensity interval trainingLow-volume HIIT (LV-HIIT) is a particularly time-efficient subtype of interval training, which has gained increasing attention in recent years. As per the previous definition, these brief training protocols typically involve≤10 min of intense exercise within a session lasting≤30 min including warm-up, recovery phases between intervals, and cool-down | Other | Low volume high intensity interval training |
| High volume high intensity interval traininglong (2-4 min) bouts of high (not maximum) intensity exercise interspersed with recovery periods which have wide varieties in the protocols according to the intensity, duration, and number of intervals performed | Other | high volume high intensity interval training |
| Standard medical treatmentstandard medical treatment for chronic heart failure as per international guidlines | Drug | Low volume high intensity interval training, control group, high volume high intensity interval training |
Primary outcome
6 minute walk test
Time frame: at enrolment and at the end of treatment at 8 weeks
self-paced submaximal field exercise test to assess submaximal functional capacity of the patient , the distance walked by the patient for six minutes will be measured by meters
2D Echocardiographic parameters
Time frame: at enrollment and at the end of treatment at 8 weeks
Left ventricle geometry: left ventricular end-diastolic diameter (LVEDD) mm, left ventricular end-systolic diameter (LVESD) mm, left ventricular end-systolic volume (LVESV) ml. and, left ventricular end-diastolic volume (LVEDV) ml. Left ventricle Systolic function: left ventricular ejection fraction (LVEF) % Left ventricle Diastolic function :E wave cm/s: early diastolic mitral inflow velocity, A wave cm/s: diastolic mitral inflow velocity during late atrial contraction , E/A ratio
1 secondary outcome
Minnesota living with heart failure questionnaire (MLHFQ)
Time frame: at enrollment and at the end of treatment at 8 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Jan 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing low-volume high intensity interval training, High volume high intensity interval training and Standard medical treatment in people with Chronic Heart Failure, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 18 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 8 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Aya I Elshenawy (+01098811085, dr.aya_ebrahime@yahoo.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
6 minute walk test (time frame: at enrolment and at the end of treatment at 8 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jan 2026.