Post Exposure ProphylaxisNCT07330427
Impact of Health Education on Knowledge, Attitude and Practice of Post-exposure Prophylaxis
A study testing Health Education in people with Post Exposure Prophylaxis and Occupational Exposure HIV Infections Hepatitis B Hepatitis C Post-Exposure Prophylaxis, run by Aswan University at 1 site in Egypt.
Trial summary
The goal of this study is to learn whether a short education programme helps healthcare workers know more about post-exposure prophylaxis (PEP). PEP is medicine taken soon after contact with blood or body fluids, to lower the chance of infection. The study takes place at Aswan University Hospital in Egypt. Read more about this study
- Who is it for?
- Ages 19 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Post Exposure Prophylaxis, Occupational Exposure HIV Infections Hepatitis B Hepatitis C Post-Exposure Prophylaxis
- What is being tested?
- Health Education
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 340 participants
- Where
- 1 siteEgypt
- Study dates
- 30 Jan 2026to 30 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 19 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- HCWs at the selected departments (physicians, nurses and housekeepers).
- Age >18 years old and below 60 years old in both Genders.
- HCWs which have direct contact with blood and body fluids.
Who cannot join
- Age<18 years old and above 60 years old.
- Non-medical staff at Aswan university hospital.
- Health care workers which have no contact with blood or body fluids.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Impact of Health Education on Knowledge, Attitude and Practice of Post-exposure Prophylaxis Among Health Care Workers at Aswan University Hospital, Egypt
The goal of this study is to learn whether a short education programme helps healthcare workers know more about post-exposure prophylaxis (PEP). PEP is medicine taken soon after contact with blood or body fluids, to lower the chance of infection. The study takes place at Aswan University Hospital in Egypt.
The main questions it aims to answer are:
Read more
Do healthcare workers know more about PEP three months after the programme than before it?
Do their attitudes toward PEP change?
Do their reported actions change, such as hepatitis B vaccination, use of PEP after an exposure, and finishing the prescribed course?
Participants are doctors, nurses, and laboratory and blood bank staff who work with patients or blood samples. They will:
Fill out a questionnaire before the programme.
Attend four 2-hour teaching sessions over two weeks.
Fill out the same questionnaire about three months later.
All participants receive the programme. There is no comparison group. Researchers will compare each person's answers before and after the programme to see what changed.
Read the detailed description
Design. This is a single-group, before-and-after (quasi-experimental) study. Each participant completes a baseline questionnaire before teaching and a follow-up questionnaire about three months after their group finishes teaching. Coded identifiers link the two questionnaires. The study ran from 30 January 2026 to 30 June 2026.
Setting and participants. The study took place at Aswan University Hospital in southern Upper Egypt. Staff were selected by stratified random sampling from three groups: physicians and clinically active academic staff, nurses, and laboratory and blood bank staff. Workers had to be actively employed in one of these groups, have worked at the hospital for at least six months, and give written informed consent. Non-clinical, housekeeping and auxiliary staff were excluded. In total, 380 workers were selected, and the target was 340 with complete before-and-after data.
Intervention. The programme had four 2-hour sessions over two weeks. Topics were:
Recognising and reporting an exposure.
First aid.
Assessing the source patient and the exposure.
Access to PEP in the hospital.
Hepatitis B vaccination.
HIV PEP timing and duration.
Adherence, counselling and follow-up testing.
The programme also covered the difference between HIV prophylaxis, hepatitis B prevention and hepatitis C follow-up. Teaching used slides, short videos, case scenarios, group discussion and printed materials. Physicians were taught in English, and nurses and laboratory staff in Arabic.
Measures. A questionnaire, adapted from published PEP surveys and available in Arabic and English, was used at both time points.
Primary outcome: change in a five-item knowledge score (0-5), calculated as follow-up score minus baseline score.
Secondary outcomes: change in a seven-item attitude and belief score (0-7), and individual practice indicators. These are self-reported hepatitis B vaccination, PEP use after exposure, time to starting PEP, and completion of the prescribed course.
Analysis. Paired changes are tested with the Wilcoxon signed-rank test for scores and the exact McNemar test for yes/no responses. Confidence intervals are reported for paired differences. The sample size was calculated to estimate a proportion with 5% precision, not to detect a difference between paired groups.
Changes from the original registration. The original record described nine knowledge questions and threshold-based classifications of knowledge, attitude and practice. The final analysis uses a five-item knowledge score, a seven-item attitude total without an overall classification, and individual practice indicators. The dates were updated to the actual start (30 January 2026) and completion (30 June 2026).
- Conditions
- Post Exposure Prophylaxis, Occupational Exposure HIV Infections Hepatitis B Hepatitis C Post-Exposure Prophylaxis
- Being tested
- Health Education
- Keywords
- post-exposure prophylaxis, healthcare workers, occupational exposure, health education, HIV, hepatitis B
- Medical subject headings
- Health Education, Hepatitis B
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Health EducationProcedure or surgery
- Assess the baseline knowledge, attitudes and practices of health care workers at Aswan university hospital towards postexposure prophylaxis against blood-borne viral infection.
- Provide an intense post exposure prophylaxis health education sessions.
- Evaluate changes in post exposure prophylaxis knowledge, attitudes and practices after the health education intervention.
| Study group | Role | What they receive |
|---|---|---|
| Health Care workers | Experimental | About 340 participants of heath care workers undergoing assessment of knowledge, attitude and practice about post-exposure prophylaxis among health care workers at Aswan university hospital, Egypt Then they will undergo lecturers about about post-exposure prophylaxis, then reassessment will be done after 3 months Receives: Procedure: Health Education |
What is being measured
The primary outcome is the main question the study is designed to answer.
Health Practice Change
Assessment of participants after taking health education lecturers about post-exposure prophylaxis regrading to knowledge, attitude and practice and this done by questionnaire as :The questionnaire consisted of three sections assessing knowledge, attitude, and practice regarding post-exposure prophylaxis (PEP).
Section B assessed knowledge using nine close-ended questions, with adequate knowledge defined as ≥75% correct answers.
Section C included seven items evaluating attitudes toward the importance and effectiveness of PEP, with scores ≥75% indicating a good attitude.
Section D assessed PEP practices through nine questions, and good practice was defined as positive responses to more than 75% of items.
Measured: 3 Months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Jan 2026
- Study start30 Jan 2026
- Primary completion30 Jun 2026
- Study completion30 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Post Exposure ProphylaxisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 340 participants (actual)
Sponsor and investigators
- Lead sponsor
- Aswan University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Fatma Ali Mahmoud Hussein, Aswan University
- Investigators
- Shaimaa Sayed Abdelrheem, M.D, Study chair, Associate Professor of Public Health and Community Medicine, Faculty of medicine, Aswan University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07330427
- Sponsor's protocol ID
- Post-exposure prophylaxis
- Status last verified
- Nov 2026
- First submitted
- 11 Dec 2025
- Last updated
- 4 Nov 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 4 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Health Education on Knowledge, Attitude and Practice of Post-exposure Prophylaxis Among Health Care Workers at Aswan University Hospital, Egypt
- ClinicalTrials.gov ID
- NCT07330427
- Acronym / sponsor ID
- Post-exposure prophylaxis
- Conditions
- Post Exposure Prophylaxis, Occupational Exposure HIV Infections Hepatitis B Hepatitis C Post-Exposure Prophylaxis
- Keywords
- post-exposure prophylaxis, healthcare workers, occupational exposure, health education, HIV, hepatitis B
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 340 participants (actual)
- Lead sponsor
- Aswan UniversityUniversity, hospital or other
- Study start
- 30 Jan 2026 (actual)
- Primary completion
- 30 Jun 2026 (actual)
- Study completion
- 30 Jun 2026 (actual)
- First posted
- 9 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this study is to learn whether a short education programme helps healthcare workers know more about post-exposure prophylaxis (PEP). PEP is medicine taken soon after contact with blood or body fluids, to lower the chance of infection. The study takes place at Aswan University Hospital in Egypt.
The main questions it aims to answer are:
Do healthcare workers know more about PEP three months after the programme than before it?
Do their attitudes toward PEP change?
Do their reported actions change, such as hepatitis B vaccination, use of PEP after an exposure, and finishing the prescribed course?
Participants are doctors, nurses, and laboratory and blood bank staff who work with patients or blood samples. They will:
Fill out a questionnaire before the programme.
Attend four 2-hour teaching sessions over two weeks.
Fill out the same questionnaire about three months later.
All participants receive the programme. There is no comparison group. Researchers will compare each person's answers before and after the programme to see what changed.
Detailed description
Design. This is a single-group, before-and-after (quasi-experimental) study. Each participant completes a baseline questionnaire before teaching and a follow-up questionnaire about three months after their group finishes teaching. Coded identifiers link the two questionnaires. The study ran from 30 January 2026 to 30 June 2026.
Setting and participants. The study took place at Aswan University Hospital in southern Upper Egypt. Staff were selected by stratified random sampling from three groups: physicians and clinically active academic staff, nurses, and laboratory and blood bank staff. Workers had to be actively employed in one of these groups, have worked at the hospital for at least six months, and give written informed consent. Non-clinical, housekeeping and auxiliary staff were excluded. In total, 380 workers were selected, and the target was 340 with complete before-and-after data.
Intervention. The programme had four 2-hour sessions over two weeks. Topics were:
Recognising and reporting an exposure.
First aid.
Assessing the source patient and the exposure.
Access to PEP in the hospital.
Hepatitis B vaccination.
HIV PEP timing and duration.
Adherence, counselling and follow-up testing.
The programme also covered the difference between HIV prophylaxis, hepatitis B prevention and hepatitis C follow-up. Teaching used slides, short videos, case scenarios, group discussion and printed materials. Physicians were taught in English, and nurses and laboratory staff in Arabic.
Measures. A questionnaire, adapted from published PEP surveys and available in Arabic and English, was used at both time points.
Primary outcome: change in a five-item knowledge score (0-5), calculated as follow-up score minus baseline score.
Secondary outcomes: change in a seven-item attitude and belief score (0-7), and individual practice indicators. These are self-reported hepatitis B vaccination, PEP use after exposure, time to starting PEP, and completion of the prescribed course.
Analysis. Paired changes are tested with the Wilcoxon signed-rank test for scores and the exact McNemar test for yes/no responses. Confidence intervals are reported for paired differences. The sample size was calculated to estimate a proportion with 5% precision, not to detect a difference between paired groups.
Changes from the original registration. The original record described nine knowledge questions and threshold-based classifications of knowledge, attitude and practice. The final analysis uses a five-item knowledge score, a seven-item attitude total without an overall classification, and individual practice indicators. The dates were updated to the actual start (30 January 2026) and completion (30 June 2026).
Study design
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Health Care workers | Experimental | Procedure: Health EducationAbout 340 participants of heath care workers undergoing assessment of knowledge, attitude and practice about post-exposure prophylaxis among health care workers at Aswan university hospital, Egypt Then they will undergo lecturers about about post-exposure prophylaxis, then reassessment will be done after 3 months |
Who may qualify
- Ages
- 19 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- HCWs at the selected departments (physicians, nurses and housekeepers).
- Age >18 years old and below 60 years old in both Genders.
- HCWs which have direct contact with blood and body fluids.
Key exclusion criteria (3 listed)
- Age<18 years old and above 60 years old.
- Non-medical staff at Aswan university hospital.
- Health care workers which have no contact with blood or body fluids.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Health Education1. Assess the baseline knowledge, attitudes and practices of health care workers at Aswan university hospital towards postexposure prophylaxis against blood-borne viral infection. 2. Provide an intense post exposure prophylaxis health education sessions. 3. Evaluate changes in post exposure prophylaxis knowledge, attitudes and practices after the health education intervention. | Procedure or surgery | Health Care workers |
Primary outcome
Health Practice Change
Time frame: 3 Months
Assessment of participants after taking health education lecturers about post-exposure prophylaxis regrading to knowledge, attitude and practice and this done by questionnaire as :The questionnaire consisted of three sections assessing knowledge, attitude, and practice regarding post-exposure prophylaxis (PEP). Section B assessed knowledge using nine close-ended questions, with adequate knowledge defined as ≥75% correct answers. Section C included seven items evaluating attitudes toward the importance and effectiveness of PEP, with scores ≥75% indicating a good attitude. Section D assessed PEP practices through nine questions, and good practice was defined as positive responses to more than 75% of items.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Nov 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Shaimaa Sayed Abdelrheem, M.D study chair
Associate Professor of Public Health and Community Medicine, Faculty of medicine, Aswan University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Health Education in people with Post Exposure Prophylaxis and Occupational Exposure HIV Infections Hepatitis B Hepatitis C Post-Exposure Prophylaxis, run by Aswan University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Health Practice Change (time frame: 3 Months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Nov 2026.