Non Specific Low Back PainNCT07337213
Effect of Knee Extensor Training on the Lumbar Spine
A study testing back strengthening exercise, OKC Exercise and CKC Exercise in people with Non Specific Low Back Pain, run by Lincoln University College.
Trial summary
The goal of this clinical trial is to learn if knee extensor training with different protocols works to treat LBP in adults.. The main questions it aims to answer are: What are the comparative effects of open and closed kinetic chain knee extensor strengthening exercises versus lumbar stabilization exercises on lumbar… Read more about this study
- Who is it for?
- Ages 40 to 60 years, men only
- Conditions the study is for
- Non Specific Low Back Pain
- What is being tested?
- back strengthening exercise, OKC Exercise and CKC Exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 128 participants
- Where
- No sites listed yet
- Study dates
- 1 Feb 2026to 1 Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 60 years
- Men only
- No healthy volunteers
- Adult
Who may be able to join
- Males aged 40 to 60 years, II. nonsmokers, III. with normal body mass index IV. of Saudi nationality, V. office workers, VI. suffering from chronic NLBP for 12 weeks or more with a moderate disability according to the Oswestry Disability Index (score of 21 - 40%) moderate activity level according to the Arabic version of the International Physical Activity Questionnaire short form .
Who cannot join
- Previous spinal surgery, fracture, deformity, or disease. II. Neurological deficit and Lower limb deformity or fracture, or disease. III. Mental or psychological illness. The Arabic version of the Self-Reporting Questionnaire (SRQ-20) developed by the World Health Organization (WHO) to screen for common mental disorders such as depression and anxiety, uses a cut-off score to distinguish between individuals with and without significant psychological distress. A score of 7 or below is generally considered "normal", indicating no significant psychological distress (Al-Subaie et al., 1998).
- Systematic chronic illnesses such as hypertension, cardiac and respiratory disorders, and diabetes mellitus.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Knee Extensor-Focused Biomechanical Intervention for Pain, Posture, and Disability in Non-Specific Low Back Pain: A Randomized Controlled Trial
The goal of this clinical trial is to learn if knee extensor training with different protocols works to treat LBP in adults.. The main questions it aims to answer are:
What are the comparative effects of open and closed kinetic chain knee extensor strengthening exercises versus lumbar stabilization exercises on lumbar curvature, postural control, and disability in individuals with non-specific low back pain? 1.4.2. How does open kinetic chain knee extensor strengthening affect pain, functional capacity, and lumbar spine stability compared to closed kinetic chain exercises in individuals with non-specific low back pain? 1.4.3 What is the effect of open kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability compared to conventional lumbar muscle exercises in individuals with non-specific low back pain? 1.4.4 What is the effect of closed kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability compared to conventional lumbar muscle exercises in individuals with non-specific low back pain? 1.4.5 What is the effect of open kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain? 1.4.6 What is the effect of close kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain? 1.4.7 What is the effect of conventional lumbar extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain Researchers will compare three different exercise protocols to a control group (will not receive exercise) to see if knee extensor training has an effect on problems associated with LBP.
Read more
Participants will:
- Exercise three times per week for 8 weeks
- Be assessed before, 4 weeks after, and 8 weeks after intervention
- Conditions
- Non Specific Low Back Pain
- Being tested
- back strengthening exercise, OKC Exercise, CKC Exercise, CKC and OKC Exercise
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
back strengthening exerciseOther
strengthening exercise to lumbar extensors
OKC ExerciseOther
knee extensor OKC exercise added to the lumbar strengthening exercise
CKC ExerciseOther
knee extensor CKC exercise added to the lumbar strengthening exercise
CKC and OKC ExerciseOther
knee extensor OKC and CKC exercise added to the lumbar strengthening exercise
| Study group | Role | What they receive |
|---|---|---|
| control group | Active comparator | lumbar strengthening Receives: Other: back strengthening exercise |
| Treatment Group I | Experimental | lumbar strengthening exercise and knee CKC exercise Receives: Other: OKC Exercise |
| Treatment Group II | Experimental | lumbar strengthening exercise and knee CKC exercise Receives: Other: CKC Exercise |
| Treatment Group III | Experimental | lumbar strengthening exercise and knee OKC and CKC exercise Receives: Other: CKC and OKC Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mean change in the Lumbar lordosis Cobb angle in degrees measured by X-ray
Measured: 8 weeks
Secondary outcomes (4)
Mean change of LBP intensity from the baseline measured by Numeric Pain Rating Scale
Minimum Value: 0, which represents "no pain". Maximum Value: 10, which represents "worst imaginable pain," "worst possible pain," or "most intense pain imaginable Higher scores indicate a worse outcome
Measured: 8 weeks
Mean change in the quality of Life score as measured by the Oswestry Disability Index
Minimum Value: 0%, which represents the highest possible level of functioning and independence (no disability).
Maximum Value: 100%, which represents the lowest possible level of functioning and total dependence
Measured: 8 weeks
Mean change in the muscle strength measured by the Hand-held dynamometer
A higher score indicate improvement
Measured: 8 weeks
Mean change in the posture control measured by the stare exursion test
Higher scores mean a better outcome
Measured: 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Jan 2026
- Study start1 Feb 2026 (estimated)
- Primary completion1 Apr 2026 (estimated)
- Study completion1 Jun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Non Specific Low Back PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Care provider, Outcomes assessor
- Enrolment
- 128 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Lincoln University College
- Sponsor type
- University, hospital or other
- Collaborators
- Cairo University, Taif University
- Responsible party
- Principal investigator, ALHUMAYANI ABDULLAH FALEHA, Lincoln University College
- Investigators
- ABDULLAH F ALHUMAYANI, Principal investigator, LUC Malaysia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07337213
- Sponsor's protocol ID
- LUC/RADMIN/SP/05/903
- Status last verified
- Jan 2026
- First submitted
- 9 Dec 2025
- Last updated
- 13 Jan 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Knee Extensor-Focused Biomechanical Intervention for Pain, Posture, and Disability in Non-Specific Low Back Pain: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07337213
- Acronym / sponsor ID
- LUC/RADMIN/SP/05/903
- Conditions
- Non Specific Low Back Pain
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 128 participants (estimated)
- Lead sponsor
- Lincoln University CollegeUniversity, hospital or other
- Collaborators
- Cairo University, Taif University
- Study start
- 1 Feb 2026 (estimated)
- Primary completion
- 1 Apr 2026 (estimated)
- Study completion
- 1 Jun 2026 (estimated)
- First posted
- 13 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn if knee extensor training with different protocols works to treat LBP in adults.. The main questions it aims to answer are:
What are the comparative effects of open and closed kinetic chain knee extensor strengthening exercises versus lumbar stabilization exercises on lumbar curvature, postural control, and disability in individuals with non-specific low back pain? 1.4.2. How does open kinetic chain knee extensor strengthening affect pain, functional capacity, and lumbar spine stability compared to closed kinetic chain exercises in individuals with non-specific low back pain? 1.4.3 What is the effect of open kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability compared to conventional lumbar muscle exercises in individuals with non-specific low back pain? 1.4.4 What is the effect of closed kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability compared to conventional lumbar muscle exercises in individuals with non-specific low back pain? 1.4.5 What is the effect of open kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain? 1.4.6 What is the effect of close kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain? 1.4.7 What is the effect of conventional lumbar extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain Researchers will compare three different exercise protocols to a control group (will not receive exercise) to see if knee extensor training has an effect on problems associated with LBP.
Participants will:
- Exercise three times per week for 8 weeks
- Be assessed before, 4 weeks after, and 8 weeks after intervention
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, care provider, outcomes assessor)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| control group | Active comparator | Other: back strengthening exerciselumbar strengthening |
| Treatment Group I | Experimental | Other: OKC Exerciselumbar strengthening exercise and knee CKC exercise |
| Treatment Group II | Experimental | Other: CKC Exerciselumbar strengthening exercise and knee CKC exercise |
| Treatment Group III | Experimental | Other: CKC and OKC Exerciselumbar strengthening exercise and knee OKC and CKC exercise |
Who may qualify
- Ages
- 40 to 60 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Males aged 40 to 60 years, II. nonsmokers, III. with normal body mass index IV. of Saudi nationality, V. office workers, VI. suffering from chronic NLBP for 12 weeks or more with a moderate disability according to the Oswestry Disability Index (score of 21 - 40%) moderate activity level according to the Arabic version of the International Physical Activity Questionnaire short form .
Key exclusion criteria (2 listed)
- Previous spinal surgery, fracture, deformity, or disease. II. Neurological deficit and Lower limb deformity or fracture, or disease. III. Mental or psychological illness. The Arabic version of the Self-Reporting Questionnaire (SRQ-20) developed by the World Health Organization (WHO) to screen for common mental disorders such as depression and anxiety, uses a cut-off score to distinguish between individuals with and without significant psychological distress. A score of 7 or below is generally considered "normal", indicating no significant psychological distress (Al-Subaie et al., 1998).
- Systematic chronic illnesses such as hypertension, cardiac and respiratory disorders, and diabetes mellitus.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| back strengthening exercisestrengthening exercise to lumbar extensors | Other | control group |
| OKC Exerciseknee extensor OKC exercise added to the lumbar strengthening exercise | Other | Treatment Group I |
| CKC Exerciseknee extensor CKC exercise added to the lumbar strengthening exercise | Other | Treatment Group II |
| CKC and OKC Exerciseknee extensor OKC and CKC exercise added to the lumbar strengthening exercise | Other | Treatment Group III |
Primary outcome
Mean change in the Lumbar lordosis Cobb angle in degrees measured by X-ray
Time frame: 8 weeks
4 secondary outcomes
Mean change of LBP intensity from the baseline measured by Numeric Pain Rating Scale
Time frame: 8 weeks
Mean change in the quality of Life score as measured by the Oswestry Disability Index
Time frame: 8 weeks
Mean change in the muscle strength measured by the Hand-held dynamometer
Time frame: 8 weeks
Mean change in the posture control measured by the stare exursion test
Time frame: 8 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Jan 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
ABDULLAH F ALHUMAYANI principal investigator
LUC Malaysia
Questions about this trial
What is this clinical trial studying?
A study testing back strengthening exercise, OKC Exercise and CKC Exercise in people with Non Specific Low Back Pain, run by Lincoln University College.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 13 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Lamiaa K Elsayyad, Assistant professor (+201095366120, dr.elsayyadlamiaa@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mean change in the Lumbar lordosis Cobb angle in degrees measured by X-ray (time frame: 8 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Jan 2026.