Caries ActiveNCT07344038
Bioceramic Putty Versus MTA in Pulpotomized Primary Teeth to be Covered With 3D Printed Resin Crowns Versus Stainless Steel Crown
A study testing Endo-sequence bioceramic putty pulpotomy, Bio MTA+ pulpotomy and Stainless Steel Crowns (SSCs) in people with Caries Active, run by Alexandria University at 1 site in Egypt.
Trial summary
children aged 5 to 7 years with deep carious second primary molars that require vital pulp therapy will be treated using either MTA or bioceramic putty, then will be fully covered using either stainless steel crowns or 3D printed resin crowns. Read more about this study
- Who is it for?
- Ages 5 to 7 years
- Conditions the study is for
- Caries Active
- What is being tested?
- Endo-sequence bioceramic putty pulpotomy, Bio MTA+ pulpotomy and Stainless Steel Crowns (SSCs)
- Type of treatment
- Injection or infusion, Medical device, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteEgypt
- Study dates
- 20 Jan 2026to 15 Apr 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 5 to 7 years
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- Children aged from 5 to 7 years. 2. Medically healthy children (ASA I) (Appendix I) 3. Positive or definitely positive behavior (Frankl's rating scale scores III or IV) (Appendix II) 4. Parents/legal guardians who provide written informed consent Tooth inclusion criteria(8, 14, 31)
- Deep carious second primary molars with:
- Vital pulp confirmed by absence of clinical and/or radiographic signs of necorosis or infection.
- Signs of reversible pulpitis. 10
- Require full coverage restorations
- Cooperative children (Frankl 3 or 4 behavior rating scale)
Who cannot join
- History of spontaneous pain. 2. Tooth mobility. 3. Excessive bleeding from radicular stumps after coronal pulp amputation. 4. Radiographic evidence of pathological root resorption, inter-radicular bone loss, periapical pathology, or canal calcifications. 5. Previous dental treatment of the involved molar. 6. Children with special healthcare needs.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
yousr nader pediatric dentist specialist, doctorate contact
Egypt1 site, 1 recruiting
- Recruiting
Faculty of Dentistry, Alexandria University, Egypt
Alexandria
About this study
Official title: Effectiveness of Bioceramic Calcium Silicate-based Pulpotomy Medicament on Primary Molars Restored With 3d Printed Resin Crowns (a Randomized Controlled Clinical Trial)
children aged 5 to 7 years with deep carious second primary molars that require vital pulp therapy will be treated using either MTA or bioceramic putty, then will be fully covered using either stainless steel crowns or 3D printed resin crowns.
Read the detailed description
removal of caries from second primary molars reaching the pulp, pulpotomy will be done by controlling the bleeding after that pulp chamber will be covered with either MTA or endosequence bioceramic putty.
resin modified glass ionomer will be placed, crown preparation will be done to receive full coverage either stainless steel crowns or 3D printed resin crowns
- Conditions
- Caries Active
- Being tested
- Endo-sequence bioceramic putty pulpotomy, Bio MTA+ pulpotomy, Stainless Steel Crowns (SSCs), 3D-Printed Resin Crowns
- Keywords
- MTA, bioceramic putty, 3D printed resin crowns, stainless steel crowns
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Endo-sequence bioceramic putty pulpotomyProcedure or surgery
- Profound local anesthesia and rubber dam isolation will be applied.
- Carious tissue will be completely removed using diamond burs until pulp exposure and deroofing.
- Coronal pulp will be removed with a sharp excavator.
- Hemostasis will be achieved with a saline-moistened cotton pellet for 5 minutes.
- Bioceramic putty applied directly from the manufacturer's syringe, then adapted gently with a moist cotton pellet.
Bio MTA+ pulpotomyProcedure or surgery
- Profound local anesthesia and rubber dam isolation will be applied.
- Carious tissue will be completely removed using diamond burs until pulp exposure and deroofing.
- Coronal pulp will be removed with a sharp excavator.
- Hemostasis will be achieved with a saline-moistened cotton pellet for 5 minutes.
- The MTA powder will be mixed with the liquid to a putty consistency and applied with an amalgam carrier.
Stainless Steel Crowns (SSCs)Device
- Occlusal reduction of 1.0-1.5 mm using a flame-shaped diamond bur.
- Interproximal slicing to enable passive crown placement.
- Crown size selection based on best fit.
- Cementation using RMGIC.
- Excess cement will be removed.
3D-Printed Resin CrownsDevice
- Tooth preparation: 1 mm axial reduction with a chamfer finish line using tapered diamond stone with round end (Mani TR-12) for buccal, lingual, mesial, and distal walls.
- One and half - 2 mm occlusal reduction.
- Digital impressions using IOS scanning, including occlusion and antagonist.
- 3D printed resin crowns will be designed using the Exocad software (Exocad Rigeka 3.1) to have a uniform thickness on all surfaces (average 1 mm), including occlusal, buccal, lingual, and proximal surfaces. After reviewing each design, it will be exported as a high-resolution STL file (standard tessellation language) to be outsourced and 3D printed.
- BEGO DLP printer will be utilized to print the crowns using VarseoSmile Trinique resin via digital light processing (DLP) technique.
- After printing, the platform will be removed from the 3D printer and placed on a paper towel with the printed crowns facing upward.
- The printed crowns will be separated from the platform and rinsed tw
| Study group | Role | What they receive |
|---|---|---|
| Endo-sequence bioceramic putty pulpotomy | Experimental | Not described Receives: Procedure: Endo-sequence bioceramic putty pulpotomy |
| Bio MTA+ | Active comparator | Not described Receives: Procedure: Bio MTA+ pulpotomy |
| 3D-printed ceramic-filled hybrid resin crowns | Experimental | Not described Receives: Device: 3D-Printed Resin Crowns |
| Stainless steel crowns | Active comparator | Not described Receives: Device: Stainless Steel Crowns (SSCs) |
What is being measured
The primary outcome is the main question the study is designed to answer.
clinical success of pulpotomy at 1 week
Clinical success: Absence of pain, sensitivity to percussion, swelling, or fistula.
Measured: clinical success at 1 week
clinical success of pulpotomy at 6 months
Absence of pain, sensitivity to percussion, swelling, or fistula.
Measured: clinical success at 6 months
clinical success of pulpotomy at 12 months
Absence of pain, sensitivity to percussion, swelling, or fistula.
Measured: clinical success at 12 months
radiographic success of pulpotomy at 1 week
No periodontal ligament space widening, resorption, or periapical/furcal radiolucency.
Measured: radiographic success at 1 week
radiographic success of pulpotomy at 6 months
No periodontal ligament space widening, resorption, or periapical/furcal radiolucency.
Measured: radiographic success at 6 months
radiographic success of pulpotomy at 12 months
No periodontal ligament space widening, resorption, or periapical/furcal radiolucency.
Measured: radiographic success at 12 months
Crown evaluation at 6 months using Modified United States Public Health Service
Resistance to dislodgment Alpha: Snap-fit retention Bravo: Partial retention Charlie: No retention Crown - high in occlusion Alpha: Ideal, with the crown being in harmony with occlusion.
Bravo: Clinically acceptable, with the crown occluding slightly high or low in occlusion. Charlie: Clinically unacceptable, with the crown needing to be replaced. Retention of crown after cementation Alpha: Intact Bravo: Chipped/loss of material Charlie: Complete loss of crown Occlusal wear of crown Alpha: Occlusal surface intact. Bravo: Wear of occlusal surface without tooth surface exposure. Charlie: Wear of occlusal surface with tooth surface exposure. Wear of opposing crown or tooth Alpha: Clinically ideal, with no evidence of wear.
Bravo: Clinically acceptable, with mild wear of the opposing tooth. Charlie: Clinically unacceptable, with severe wear of the opposing tooth. Marginal integrity and discoloration Alpha: Clinically ideal, with no evidence of gap along the gingival crown margin. Bravo: C
Measured: at 6 months
crown evaluation at 12 months using Modified United States Public Health Service
Resistance to dislodgment Alpha: Snap-fit retention Bravo: Partial retention Charlie: No retention Crown - high in occlusion Alpha: Ideal, with the crown being in harmony with occlusion.
Bravo: Clinically acceptable, with the crown occluding slightly high or low in occlusion. Charlie: Clinically unacceptable, with the crown needing to be replaced. Retention of crown after cementation Alpha: Intact Bravo: Chipped/loss of material Charlie: Complete loss of crown Occlusal wear of crown Alpha: Occlusal surface intact. Bravo: Wear of occlusal surface without tooth surface exposure. Charlie: Wear of occlusal surface with tooth surface exposure. Wear of opposing crown or tooth Alpha: Clinically ideal, with no evidence of wear.
Bravo: Clinically acceptable, with mild wear of the opposing tooth. Charlie: Clinically unacceptable, with severe wear of the opposing tooth. Marginal integrity and discoloration Alpha: Clinically ideal, with no evidence of gap along the gingival crown margin. Bravo: C
Measured: at 12 months
Secondary outcomes (5)
Parental satisfaction Assessed immediately after treatment using a 5-point Likert scale concerning appearance, color, size, durability, and overall satisfaction
1 Very dissatisfied 2 Dissatisfied 3 Neutrally satisfied 4 Satisfied 5 Very satisfied
Measured: immediately after treatment
Parental satisfaction Assessed after 1 week using a 5-point Likert scale concerning appearance, color, size, durability, and overall satisfaction
1 Very dissatisfied 2 Dissatisfied 3 Neutrally satisfied 4 Satisfied 5 Very satisfied
Measured: parental satisfaction after 1 week
parental satisfaction assessed after 6 months using a 5-point Likert scale concerning appearance, color, size, durability, and overall satisfaction
1 Very dissatisfied 2 Dissatisfied 3 Neutrally satisfied 4 Satisfied 5 Very satisfied
Measured: parental satisfaction after 6 months
parental satisfaction assessed after 12 months using a 5-point Likert scale concerning appearance, color, size, durability, and overall satisfaction
1 Very dissatisfied 2 Dissatisfied 3 Neutrally satisfied 4 Satisfied 5 Very satisfied
Measured: parental satisfaction after 12 months
Child satisfaction Measured immediately post-cementation using a Smiley Face Likert scale in child-friendly language.
Child Satisfaction (Smiley Face Likert Scale) awful not very good good really good fantastic
Measured: immediately after crown cementation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Jan 2026
- Study start20 Jan 2026 (estimated)
- Primary completion15 Feb 2026 (estimated)
- Study completion15 Apr 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Caries ActiveStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Alexandria University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yousr Nader, Alexandria University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07344038
- Sponsor's protocol ID
- 1155-10/2025
- Status last verified
- Jan 2026
- First submitted
- 14 Jan 2026
- Last updated
- 15 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
Publications
American Academy of Pediatric Dentistry. Pulp therapy for primary and immature permanent teeth Chicago (IL): American Academy of Pediatric Dentistry; 2023. 2. Abdelwahab DH KN, Badran AS, Darwish D, Abd El Geleel OM. Oneyear radiographic and clinical performance of bioactive materials in primary molar pulpotomy: A randomized controlled trial. J Dent 2024;143:104864. 3. Wang Z. Bioceramic materials in endodontics. Endod Topics 2015;32:3- 30. 4. Mahgoub N, Alqadasi B, Aldhorae K, Assiry A, Altawili ZM, Tao H. Comparison between iRoot BP Plus (EndoSequence Root Repair Material) and Mineral Trioxide Aggregate as Pulp-capping Agents: A Systematic Review. J Int Soc Prev Community Dent 2019;9:542-52. 5. Moazzami F, Sahebi S, Shirzadi S, Azadeh N. Comparative in vitro Assessment of Tooth Color Change under the Influence of Nano Fast Cement and MTA. J Dent (Shiraz) 2021;22:48-52. 6. Ayoub KM, Nagy MM, Aly RM, El Deen GN, El-Batouty K. Effect of Bio MTA plus & ProRoot MTA pulp capping materials on the regenerative properties of human dental pulp stem cells. Sci Rep 2025;15:4749. 7. Voicu G, Didilescu AC, Stoian AB, Dumitriu C, Greabu M, Andrei M. Mineralogical and Microstructural Characteristics of Two Dental Pulp Capping Materials. Materials (Basel) 2019;12:1772. 25 8. Kiranmayi T, Vemagiri CT, Rayala C, Chandrappa V, Bathula H, Challagulla A. In vivo comparison of bioceramic putty and mineral trioxide aggregate as pulpotomy medicament in primary molars. A 12- month follow-up randomized clinical trial. Dent Res J (Isfahan) 2022;19:84. 9. Alqahtani AS, Alsuhaibani NN, Sulimany AM, Bawazir OA. NeoPUTTY(®) Versus NeoMTA 2(®) as a Pulpotomy Medicament for Primary Molars: A Randomized Clinical Trial. Pediatr Dent 2023;45:240-4. 10. Arvelaiz C, Fernandes A, Graterol V, Gomez K, Gomez-Sosa JF, Caviedes-Bucheli J, et al. In Vitro Comparison of MTA and BC RRMFast Set Putty as Retrograde Filling Materials. Eur Endod J 2022;7:203- 9. 11. Motwani N, Ikhar A, Nikhade P, Chandak M, Rathi
Study at a glance
From the registry record, last updated by the sponsor on 15 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effectiveness of Bioceramic Calcium Silicate-based Pulpotomy Medicament on Primary Molars Restored With 3d Printed Resin Crowns (a Randomized Controlled Clinical Trial)
- ClinicalTrials.gov ID
- NCT07344038
- Acronym / sponsor ID
- 1155-10/2025
- Conditions
- Caries Active
- Keywords
- MTA, bioceramic putty, 3D printed resin crowns, stainless steel crowns
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Alexandria UniversityUniversity, hospital or other
- Study start
- 20 Jan 2026 (estimated)
- Primary completion
- 15 Feb 2026 (estimated)
- Study completion
- 15 Apr 2027 (estimated)
- First posted
- 15 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
children aged 5 to 7 years with deep carious second primary molars that require vital pulp therapy will be treated using either MTA or bioceramic putty, then will be fully covered using either stainless steel crowns or 3D printed resin crowns.
Detailed description
removal of caries from second primary molars reaching the pulp, pulpotomy will be done by controlling the bleeding after that pulp chamber will be covered with either MTA or endosequence bioceramic putty.
resin modified glass ionomer will be placed, crown preparation will be done to receive full coverage either stainless steel crowns or 3D printed resin crowns
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Endo-sequence bioceramic putty pulpotomy | Experimental | Procedure: Endo-sequence bioceramic putty pulpotomy |
| Bio MTA+ | Active comparator | Procedure: Bio MTA+ pulpotomy |
| 3D-printed ceramic-filled hybrid resin crowns | Experimental | Device: 3D-Printed Resin Crowns |
| Stainless steel crowns | Active comparator | Device: Stainless Steel Crowns (SSCs) |
Who may qualify
- Ages
- 5 to 7 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (6 listed)
- Children aged from 5 to 7 years. 2. Medically healthy children (ASA I) (Appendix I) 3. Positive or definitely positive behavior (Frankl's rating scale scores III or IV) (Appendix II) 4. Parents/legal guardians who provide written informed consent Tooth inclusion criteria(8, 14, 31)
Key exclusion criteria (1 listed)
- History of spontaneous pain. 2. Tooth mobility. 3. Excessive bleeding from radicular stumps after coronal pulp amputation. 4. Radiographic evidence of pathological root resorption, inter-radicular bone loss, periapical pathology, or canal calcifications. 5. Previous dental treatment of the involved molar. 6. Children with special healthcare needs.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Endo-sequence bioceramic putty pulpotomy* Profound local anesthesia and rubber dam isolation will be applied. * Carious tissue will be completely removed using diamond burs until pulp exposure and deroofing. * Coronal pulp will be removed with a sharp excavator. * Hemostasis will be achieved with a saline-moistened cotton pellet for 5 minutes. * Bioceramic putty applied directly from the manufacturer's syringe, then adapted gently with a moist cotton pellet. | Procedure or surgery | Endo-sequence bioceramic putty pulpotomy |
| Bio MTA+ pulpotomy* Profound local anesthesia and rubber dam isolation will be applied. * Carious tissue will be completely removed using diamond burs until pulp exposure and deroofing. * Coronal pulp will be removed with a sharp excavator. * Hemostasis will be achieved with a saline-moistened cotton pellet for 5 minutes. * The MTA powder will be mixed with the liquid to a putty consistency and applied with an amalgam carrier. | Procedure or surgery | Bio MTA+ |
| Stainless Steel Crowns (SSCs)* Occlusal reduction of 1.0-1.5 mm using a flame-shaped diamond bur. * Interproximal slicing to enable passive crown placement. * Crown size selection based on best fit. * Cementation using RMGIC. * Excess cement will be removed. | Device | Stainless steel crowns |
| 3D-Printed Resin Crowns* Tooth preparation: 1 mm axial reduction with a chamfer finish line using tapered diamond stone with round end (Mani TR-12) for buccal, lingual, mesial, and distal walls. * One and half - 2 mm occlusal reduction. * Digital impressions using IOS scanning, including occlusion and antagonist. * 3D printed resin crowns will be designed using the Exocad software (Exocad Rigeka 3.1) to have a uniform thickness on all surfaces (average 1 mm), including occlusal, buccal, lingual, and proximal surfaces. After reviewing each design, it will be exported as a high-resolution STL file (standard tessellation language) to be outsourced and 3D printed. * BEGO DLP printer will be utilized to print the crowns using VarseoSmile Trinique resin via digital light processing (DLP) technique. * After printing, the platform will be removed from the 3D printer and placed on a paper towel with the printed crowns facing upward. * The printed crowns will be separated from the platform and rinsed tw | Device | 3D-printed ceramic-filled hybrid resin crowns |
Primary outcome
clinical success of pulpotomy at 1 week
Time frame: clinical success at 1 week
Clinical success: Absence of pain, sensitivity to percussion, swelling, or fistula.
clinical success of pulpotomy at 6 months
Time frame: clinical success at 6 months
Absence of pain, sensitivity to percussion, swelling, or fistula.
clinical success of pulpotomy at 12 months
Time frame: clinical success at 12 months
Absence of pain, sensitivity to percussion, swelling, or fistula.
radiographic success of pulpotomy at 1 week
Time frame: radiographic success at 1 week
No periodontal ligament space widening, resorption, or periapical/furcal radiolucency.
radiographic success of pulpotomy at 6 months
Time frame: radiographic success at 6 months
No periodontal ligament space widening, resorption, or periapical/furcal radiolucency.
radiographic success of pulpotomy at 12 months
Time frame: radiographic success at 12 months
No periodontal ligament space widening, resorption, or periapical/furcal radiolucency.
Crown evaluation at 6 months using Modified United States Public Health Service
Time frame: at 6 months
Resistance to dislodgment Alpha: Snap-fit retention Bravo: Partial retention Charlie: No retention Crown - high in occlusion Alpha: Ideal, with the crown being in harmony with occlusion. Bravo: Clinically acceptable, with the crown occluding slightly high or low in occlusion. Charlie: Clinically unacceptable, with the crown needing to be replaced. Retention of crown after cementation Alpha: Intact Bravo: Chipped/loss of material Charlie: Complete loss of crown Occlusal wear of crown Alpha: Occlusal surface intact. Bravo: Wear of occlusal surface without tooth surface exposure. Charlie: Wear of occlusal surface with tooth surface exposure. Wear of opposing crown or tooth Alpha: Clinically ideal, with no evidence of wear. Bravo: Clinically acceptable, with mild wear of the opposing tooth. Charlie: Clinically unacceptable, with severe wear of the opposing tooth. Marginal integrity and discoloration Alpha: Clinically ideal, with no evidence of gap along the gingival crown margin. Bravo: C
crown evaluation at 12 months using Modified United States Public Health Service
Time frame: at 12 months
Resistance to dislodgment Alpha: Snap-fit retention Bravo: Partial retention Charlie: No retention Crown - high in occlusion Alpha: Ideal, with the crown being in harmony with occlusion. Bravo: Clinically acceptable, with the crown occluding slightly high or low in occlusion. Charlie: Clinically unacceptable, with the crown needing to be replaced. Retention of crown after cementation Alpha: Intact Bravo: Chipped/loss of material Charlie: Complete loss of crown Occlusal wear of crown Alpha: Occlusal surface intact. Bravo: Wear of occlusal surface without tooth surface exposure. Charlie: Wear of occlusal surface with tooth surface exposure. Wear of opposing crown or tooth Alpha: Clinically ideal, with no evidence of wear. Bravo: Clinically acceptable, with mild wear of the opposing tooth. Charlie: Clinically unacceptable, with severe wear of the opposing tooth. Marginal integrity and discoloration Alpha: Clinically ideal, with no evidence of gap along the gingival crown margin. Bravo: C
5 secondary outcomes
Parental satisfaction Assessed immediately after treatment using a 5-point Likert scale concerning appearance, color, size, durability, and overall satisfaction
Time frame: immediately after treatment
Parental satisfaction Assessed after 1 week using a 5-point Likert scale concerning appearance, color, size, durability, and overall satisfaction
Time frame: parental satisfaction after 1 week
parental satisfaction assessed after 6 months using a 5-point Likert scale concerning appearance, color, size, durability, and overall satisfaction
Time frame: parental satisfaction after 6 months
parental satisfaction assessed after 12 months using a 5-point Likert scale concerning appearance, color, size, durability, and overall satisfaction
Time frame: parental satisfaction after 12 months
Child satisfaction Measured immediately post-cementation using a Smiley Face Likert scale in child-friendly language.
Time frame: immediately after crown cementation
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Jan 2026.
- BackgroundAmerican Academy of Pediatric Dentistry. Pulp therapy for primary and immature permanent teeth Chicago (IL): American Academy of Pediatric Dentistry; 2023. 2. Abdelwahab DH KN, Badran AS, Darwish D, Abd El Geleel OM. Oneyear radiographic and clinical performance of bioactive materials in primary molar pulpotomy: A randomized controlled trial. J Dent 2024;143:104864. 3. Wang Z. Bioceramic materials in endodontics. Endod Topics 2015;32:3- 30. 4. Mahgoub N, Alqadasi B, Aldhorae K, Assiry A, Altawili ZM, Tao H. Comparison between iRoot BP Plus (EndoSequence Root Repair Material) and Mineral Trioxide Aggregate as Pulp-capping Agents: A Systematic Review. J Int Soc Prev Community Dent 2019;9:542-52. 5. Moazzami F, Sahebi S, Shirzadi S, Azadeh N. Comparative in vitro Assessment of Tooth Color Change under the Influence of Nano Fast Cement and MTA. J Dent (Shiraz) 2021;22:48-52. 6. Ayoub KM, Nagy MM, Aly RM, El Deen GN, El-Batouty K. Effect of Bio MTA plus & ProRoot MTA pulp capping materials on the regenerative properties of human dental pulp stem cells. Sci Rep 2025;15:4749. 7. Voicu G, Didilescu AC, Stoian AB, Dumitriu C, Greabu M, Andrei M. Mineralogical and Microstructural Characteristics of Two Dental Pulp Capping Materials. Materials (Basel) 2019;12:1772. 25 8. Kiranmayi T, Vemagiri CT, Rayala C, Chandrappa V, Bathula H, Challagulla A. In vivo comparison of bioceramic putty and mineral trioxide aggregate as pulpotomy medicament in primary molars. A 12- month follow-up randomized clinical trial. Dent Res J (Isfahan) 2022;19:84. 9. Alqahtani AS, Alsuhaibani NN, Sulimany AM, Bawazir OA. NeoPUTTY(®) Versus NeoMTA 2(®) as a Pulpotomy Medicament for Primary Molars: A Randomized Clinical Trial. Pediatr Dent 2023;45:240-4. 10. Arvelaiz C, Fernandes A, Graterol V, Gomez K, Gomez-Sosa JF, Caviedes-Bucheli J, et al. In Vitro Comparison of MTA and BC RRMFast Set Putty as Retrograde Filling Materials. Eur Endod J 2022;7:203- 9. 11. Motwani N, Ikhar A, Nikhade P, Chandak M, Rathi
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
yousr nader pediatric dentist specialist, doctorate contact
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Endo-sequence bioceramic putty pulpotomy, Bio MTA+ pulpotomy and Stainless Steel Crowns (SSCs) in people with Caries Active, run by Alexandria University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 15 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact yousr nader pediatric dentist specialist, doctorate (yousr.nader@gmail.com, yousr.nader@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
clinical success of pulpotomy at 1 week (time frame: clinical success at 1 week). The study lists 8 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07344038, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Jan 2026.