Pediatric CancerNCT07345598
Central Venous Catheter Care Training for Pediatric Oncology Nurses
A study testing CVC Care Training in people with Pediatric Cancer and Pediatric Oncology, run by Fenerbahce University at 1 site in Turkey (Türkiye).
Trial summary
The knowledge level of nurses regarding care techniques plays a crucial role in the prevention of central venous catheter-related infections. This study was designed to evaluate the effect of training on central venous catheter care (CVCC), provided to nurses caring for pediatric oncology patients, on their knowledge… Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Pediatric Cancer, Pediatric Oncology, Central Venous Catheter
- What is being tested?
- CVC Care Training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 10 Feb 2025to 26 Jun 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- Provided care to a pediatric oncology patient at least once
- Performed a procedure via a central venous catheter on a pediatric oncology patient
- Voluntarily signed the informed consent form
Who cannot join
- Not having previously performed a procedure via a central venous catheter
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Acıbadem Maslak Hospital - Pediatric Oncology Unit
Istanbul
About this study
Official title: Training in Central Venous Catheter Care: Effects on Knowledge and Infection Prevention Behaviors of Pediatric Oncology Nurses
The knowledge level of nurses regarding care techniques plays a crucial role in the prevention of central venous catheter-related infections. This study was designed to evaluate the effect of training on central venous catheter care (CVCC), provided to nurses caring for pediatric oncology patients, on their knowledge level and infection prevention behaviors. The study aims to determine the effectiveness of an educational program intended to enhance nurses' knowledge and practical skills in preventing CVC-related infections, thereby contributing to evidence-based practices that improve patient safety.
Read the detailed description
Quasi-experimental, single-group pre-test/post-test desing. Central catheters are frequently used in hematology and oncology clinics. They are invasive devices employed in hospitalized patients for fluid therapy, drug administration, blood transfusions, total parenteral nutrition, and hemodynamic monitoring. In addition to enabling the effective continuation of treatment, they provide patients with a more comfortable therapeutic experience.
Proper maintenance of catheters is crucial for treatment continuity. Despite their medical advantages, central venous catheters (CVCs) are associated with complications such as infection, hemorrhage, and thrombosis. When central venous catheterization and catheter care are performed by inexperienced personnel or teams, the risk of catheter colonization and infection increases. Furthermore, if the catheter remains in place for more than five days, the risk of infection is eight times higher in groups using gauze dressings and microporous tape.
CVC-related infection is a significant cause of morbidity and mortality in immunocompromised children and adults, with infection-related mortality estimated between 12% and 25%. Recent studies have demonstrated that standardization of aseptic techniques and the provision of regular training reduce the risk of infection, while catheter insertion and maintenance by inexperienced personnel increase the likelihood of colonization or infection.
Nurses are key personnel both during central venous catheter insertion and in ensuring catheter care is maintained with aseptic technique . Regular training of healthcare professionals responsible for catheter insertion and care, ensuring compliance with hand hygiene, and adopting maximum barrier precautions during insertion (use of sterile gloves, gown, sterile drape covering the insertion site, mask, and cap) are recommended. In addition, the use of >0.5% chlorhexidine-alcohol combinations for skin antisepsis, routine use of chlorhexidine/antiseptic-impregnated catheters, and chlorhexidine-impregnated dressings are advised.
There are various nursing care practices aimed at preventing CVC-associated infections. It has been recommended that healthcare professionals conduct high-level evidence clinical studies to evaluate the effectiveness of these practices on infection, develop clinical protocols that may serve as guidelines for CVC care, and monitor these protocols regularly. Many healthcare institutions provide not only initial training for newly employed staff but also refresher training for existing personnel. Since aseptic techniques are complex, nurses need to complement their education with practical training to strengthen their knowledge and skills. CVC-associated infections remain an important risk factor; however, with properly planned training, nurses' knowledge of current guidelines and their compliance with them should be periodically evaluated . Educational programs provided to nurses should be didactic, evidence-based, and structured with appropriate content and timing.
Nursing is an applied profession that requires meaningful integration of theoretical knowledge and practical skills. Therefore, this single-group pre-test/post-test study was designed to evaluate the effect of theoretical and practical training on central venous catheter care on nurses knowledge levels and infection prevention behaviors.
- Conditions
- Pediatric Cancer, Pediatric Oncology, Central Venous Catheter, Central Venous Catheter Placement, Central Venous Catheter Exit Site Infection
- Being tested
- CVC Care Training
- Keywords
- Pediatric Nursing, Central venous catheter placement, Central Venous Catheter Exit Site Infection, Nurse training, hand hygiene, knowledge, infection prevention, clinical education, quasi-experimental study
- Medical subject headings
- Neoplasms
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
CVC Care TrainingOther
The intervention consists of an educational training program including a PowerPoint presentation, training video, and hands-on practice with a mannequin. Data collection tools include the Sociodemographic Information Form, the Evidence-Based Guidelines Knowledge Test, and the Nurses' Observation Questionnaire on Infection Control and Prevention.
| Study group | Role | What they receive |
|---|---|---|
| Training Group | Experimental | Participants in this arm will receive the central venous catheter care training program, including theoretical education, video demonstration, and hansd-on practice. Receives: Other: CVC Care Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Knowledge Level of Nurses
Knowledge level will be measured using the Evidence-Based Guidelines Knowledge Assessment Test for the Prevention of Central Venous Catheter-Related Infections. The test consists of 10 questions, with each correct answer scored as 1 and incorrect or unanswered items scored as 0. Total scores range from 0 to 10, with higher scores indicating greater knowledge. Nurses will complete the test before and immediately after the training.
Measured: At baseline (pre-training) and on the same day immediately after completion of the training
Secondary outcomes (1)
Post-Training Observation of Infection Prevention Behaviors
Nurses will be observed in their clinical practice environment after completing the training program. Observations will be conducted by the principal investigator and an independent observer using the Nurses' Infection Control and Prevention Observation Questionnaire. The questionnaire consists of 19 items, with total scores ranging from 19 to 95. Lower scores indicate better infection prevention behaviors. A greater decrease in the total score from pre-training to post-training indicates a greater effect of the educational intervention.
Measured: At 4 weeks after completion of the training program
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Jan 2026
- Study start10 Feb 2025
- Primary completion26 Jun 2025
- Study completion26 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pediatric CancerStudies of the same condition, open and under way.
- More trials run by Fenerbahce UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- All participants will receive central venous catheter care training follewed by evaluation of knowledge and infection prevention behaviors.
- Masking
- None (open label)
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Fenerbahce University
- Sponsor type
- University, hospital or other
- Collaborators
- Acibadem Maslak Hospital
- Responsible party
- Principal investigator, Emine I Yıldız, Fenerbahce University
- Investigators
- Yagmur Sancı, Assistant Professor, Study director, Fenerbahce University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07345598
- Sponsor's protocol ID
- FBU-YILDIZ-001
- Status last verified
- Sep 2026
- First submitted
- 12 Sep 2025
- Last updated
- 10 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified individual participant data (IPD) will be available from the corresponding author upon reasonable request for academic and scientific research purposes.
Study at a glance
From the registry record, last updated by the sponsor on 10 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Training in Central Venous Catheter Care: Effects on Knowledge and Infection Prevention Behaviors of Pediatric Oncology Nurses
- ClinicalTrials.gov ID
- NCT07345598
- Acronym / sponsor ID
- FBU-YILDIZ-001
- Conditions
- Pediatric Cancer, Pediatric Oncology, Central Venous Catheter, Central Venous Catheter Placement, Central Venous Catheter Exit Site Infection
- Keywords
- Pediatric Nursing, Central venous catheter placement, Central Venous Catheter Exit Site Infection, Nurse training, hand hygiene, knowledge, infection prevention, clinical education
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Fenerbahce UniversityUniversity, hospital or other
- Collaborators
- Acibadem Maslak Hospital
- Study start
- 10 Feb 2025 (actual)
- Primary completion
- 26 Jun 2025 (actual)
- Study completion
- 26 Jun 2025 (actual)
- First posted
- 15 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The knowledge level of nurses regarding care techniques plays a crucial role in the prevention of central venous catheter-related infections. This study was designed to evaluate the effect of training on central venous catheter care (CVCC), provided to nurses caring for pediatric oncology patients, on their knowledge level and infection prevention behaviors. The study aims to determine the effectiveness of an educational program intended to enhance nurses' knowledge and practical skills in preventing CVC-related infections, thereby contributing to evidence-based practices that improve patient safety.
Detailed description
Quasi-experimental, single-group pre-test/post-test desing. Central catheters are frequently used in hematology and oncology clinics. They are invasive devices employed in hospitalized patients for fluid therapy, drug administration, blood transfusions, total parenteral nutrition, and hemodynamic monitoring. In addition to enabling the effective continuation of treatment, they provide patients with a more comfortable therapeutic experience.
Proper maintenance of catheters is crucial for treatment continuity. Despite their medical advantages, central venous catheters (CVCs) are associated with complications such as infection, hemorrhage, and thrombosis. When central venous catheterization and catheter care are performed by inexperienced personnel or teams, the risk of catheter colonization and infection increases. Furthermore, if the catheter remains in place for more than five days, the risk of infection is eight times higher in groups using gauze dressings and microporous tape.
CVC-related infection is a significant cause of morbidity and mortality in immunocompromised children and adults, with infection-related mortality estimated between 12% and 25%. Recent studies have demonstrated that standardization of aseptic techniques and the provision of regular training reduce the risk of infection, while catheter insertion and maintenance by inexperienced personnel increase the likelihood of colonization or infection.
Nurses are key personnel both during central venous catheter insertion and in ensuring catheter care is maintained with aseptic technique . Regular training of healthcare professionals responsible for catheter insertion and care, ensuring compliance with hand hygiene, and adopting maximum barrier precautions during insertion (use of sterile gloves, gown, sterile drape covering the insertion site, mask, and cap) are recommended. In addition, the use of >0.5% chlorhexidine-alcohol combinations for skin antisepsis, routine use of chlorhexidine/antiseptic-impregnated catheters, and chlorhexidine-impregnated dressings are advised.
There are various nursing care practices aimed at preventing CVC-associated infections. It has been recommended that healthcare professionals conduct high-level evidence clinical studies to evaluate the effectiveness of these practices on infection, develop clinical protocols that may serve as guidelines for CVC care, and monitor these protocols regularly. Many healthcare institutions provide not only initial training for newly employed staff but also refresher training for existing personnel. Since aseptic techniques are complex, nurses need to complement their education with practical training to strengthen their knowledge and skills. CVC-associated infections remain an important risk factor; however, with properly planned training, nurses' knowledge of current guidelines and their compliance with them should be periodically evaluated . Educational programs provided to nurses should be didactic, evidence-based, and structured with appropriate content and timing.
Nursing is an applied profession that requires meaningful integration of theoretical knowledge and practical skills. Therefore, this single-group pre-test/post-test study was designed to evaluate the effect of theoretical and practical training on central venous catheter care on nurses knowledge levels and infection prevention behaviors.
Study design
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- All participants will receive central venous catheter care training follewed by evaluation of knowledge and infection prevention behaviors.
| Arm | Type | Receives |
|---|---|---|
| Training Group | Experimental | Other: CVC Care TrainingParticipants in this arm will receive the central venous catheter care training program, including theoretical education, video demonstration, and hansd-on practice. |
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (3 listed)
- Provided care to a pediatric oncology patient at least once
- Performed a procedure via a central venous catheter on a pediatric oncology patient
- Voluntarily signed the informed consent form
Key exclusion criteria (1 listed)
- Not having previously performed a procedure via a central venous catheter
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| CVC Care TrainingThe intervention consists of an educational training program including a PowerPoint presentation, training video, and hands-on practice with a mannequin. Data collection tools include the Sociodemographic Information Form, the Evidence-Based Guidelines Knowledge Test, and the Nurses' Observation Questionnaire on Infection Control and Prevention. | Other | Training Group |
Primary outcome
Change in Knowledge Level of Nurses
Time frame: At baseline (pre-training) and on the same day immediately after completion of the training
Knowledge level will be measured using the Evidence-Based Guidelines Knowledge Assessment Test for the Prevention of Central Venous Catheter-Related Infections. The test consists of 10 questions, with each correct answer scored as 1 and incorrect or unanswered items scored as 0. Total scores range from 0 to 10, with higher scores indicating greater knowledge. Nurses will complete the test before and immediately after the training.
1 secondary outcome
Post-Training Observation of Infection Prevention Behaviors
Time frame: At 4 weeks after completion of the training program
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Sep 2026.
- Individual participant dataSharing planned: Yes. De-identified individual participant data (IPD) will be available from the corresponding author upon reasonable request for academic and scientific research purposes.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Yagmur Sancı, Assistant Professor study director
Fenerbahce University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing CVC Care Training in people with Pediatric Cancer and Pediatric Oncology, run by Fenerbahce University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Knowledge Level of Nurses (time frame: At baseline (pre-training) and on the same day immediately after completion of the training). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Sep 2026.