On-pump Cardiac Surgery - Prevention - Intervention - Experimental Group - Control Group - Incidence - ComplicationsDVTNCT07347652
This Research Proposal Focuses on Evaluating the Effectiveness of a Nursing Care Protocol in Preventing Deep Vein Thrombosis (DVT) in Patients Undergoing On-pump Cardiac Surgery. The Study Will Include an Intervention Group That Receives the Nursing Protocol and a Control Group That Receives Routine
A study testing IPC devices facilitate venous return by simulating the physiological effects of muscle contraction, reducing venous stasis. in people with On-pump Cardiac Surgery - Prevention - Intervention - Experimental Group - Control Group - Incidence - Complications and DVT - Deep Vein Thrombosis, run by Near East University, Turkey at 1 site in Cyprus.
Trial summary
The primary focus of this research proposal is to examine the efficacy of a nursing care protocol in preventing the occurrence of deep vein thrombosis (DVT) in patients undergoing on-pump cardiac surgery. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- On-pump Cardiac Surgery - Prevention - Intervention - Experimental Group - Control Group - Incidence - Complications, DVT - Deep Vein Thrombosis, DVT Prophylaxis
- What is being tested?
- IPC devices facilitate venous return by simulating the physiological effects of muscle contraction, reducing venous stasis.
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 67 participants
- Where
- 1 siteCyprus
- Study dates
- 14 Jun 2024to 1 Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Patients will be eligible for participation in the study if they meet all of the following criteria:
- Adult patients aged 18 years or older.
- Patients scheduled to undergo elective or urgent on-pump cardiac surgery using cardiopulmonary bypass (e.g., coronary artery bypass grafting, valve replacement or repair, or combined procedures).
- Both male and female patients.
- Patients admitted to the participating cardiac surgery unit during the study period.
- Patients with no evidence of preoperative deep vein thrombosis (DVT) or pulmonary embolism (PE) as confirmed by clinical assessment and/or Doppler ultrasonography when indicated.
Show all 9Show fewer
- Patients who are hemodynamically stable postoperatively and eligible to receive mechanical and/or pharmacological thromboprophylaxis.
- Patients able to understand the study procedures and provide written informed consent (or consent obtained from a legal representative when applicable).
- Patients expected to survive for at least three months postoperatively, allowing completion of the follow-up period.
Who cannot join
- Patients will be excluded from the study if they meet any of the following criteria:
- History of deep vein thrombosis (DVT) or pulmonary embolism (PE) within the previous six months.
- Known congenital or acquired coagulation disorders, including but not limited to hemophilia, thrombophilia, or antiphospholipid syndrome.
- Patients receiving long-term therapeutic anticoagulation (e.g., warfarin, direct oral anticoagulants) for other medical indications prior to surgery.
- Contraindications to pharmacological thromboprophylaxis, such as:
- Active bleeding
Show all 17Show fewer
- Severe thrombocytopenia (platelet count <50,000/µL)
- History of heparin-induced thrombocytopenia (HIT)
- Contraindications to mechanical prophylaxis, including:
- Severe peripheral arterial disease
- Skin ulcers, infections, or recent lower-limb surgery preventing device application
- Patients undergoing off-pump cardiac surgery or minimally invasive cardiac procedures not requiring cardiopulmonary bypass.
- Emergency surgery requiring immediate intervention where preoperative assessment and consent cannot be obtained.
- Pregnant or postpartum women.
- Patients with severe renal or hepatic failure that may interfere with anticoagulant metabolism or increase bleeding risk.
- Patients with documented malignancy under active treatment associated with a markedly elevated thrombotic risk.
- Patients unwilling or unable to comply with the study protocol or follow-up schedule.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Development of a Nursing Care Protocol for the Prevention of Deep Vein Thrombosis and Its Impact on Patient Outcomes Following Cardiac Surgery
The primary focus of this research proposal is to examine the efficacy of a nursing care protocol in preventing the occurrence of deep vein thrombosis (DVT) in patients undergoing on-pump cardiac surgery. The investigation will encompass an experimental group that will be subjected to a specific intervention, alongside a control group that will adhere to conventional care procedures. The central objective is to exhibit a statistically significant decrease in the incidence of DVT within the experimental group in comparison to the control group. The secondary outcomes involve assessing the severity of DVT instances and the development of associated complications.
The proposed research strategy entails delineating the criteria for selecting participants, outlining methodologies for gathering data, and detailing statistical approaches for analysis. The amassed data will undergo scrutiny through suitable statistical examinations, including chi-square tests, t-tests, or Mann-Whitney U tests, as well as logistic regression analysis. The process of data analysis will involve descriptive statistics, comparative assessments, regression analysis, and subgroup scrutiny. The interpretation of outcomes will be contextualized within the framework of the research objectives and pre-existing scientific knowledge.
The ultimate objective of this study is to enhance the existing understanding of DVT prevention, provide clinically grounded recommendations supported by evidence, and elevate the quality and safety of patient care.
Read the detailed description
General Information Regarding the Thesis Topic Deep vein thrombosis (DVT) stands as a frequent complication encountered among patients undergoing on-pump cardiac surgery. A variety of interventions and protocols have been explored to forestall DVT, encompassing strategies like pharmacological prophylaxis, intermittent pneumatic leg compression, active toe movement, and supplementary measures. The objective of this survey of recent literature is to present the most current research related to nursing care protocols' impact on DVT prevention within the context of on-pump cardiac surgery patients.
undertook a thorough systematic examination, culminating in the determination that the combined utilization of intermittent pneumatic leg compression and pharmacological prophylaxis constitutes an efficacious approach for averting venous thromboembolism, encompassing DVT. Their conclusions resoundingly advocate for the integration of this dual strategy into a nursing care protocol to forestall DVT in on-pump cardiac surgery patients.
undertook a distinct systematic review with a focus on venous thromboembolic events in adults undergoing extracorporeal membrane oxygenation (ECMO) support. While the review did not exclusively center on on-pump cardiac surgery patients, it does offer valuable insights for managing individuals undergoing cardiac procedures. The review underlines the significance of acknowledging thromboembolic events in patients relying on ECMO support, and it underscores the importance of enacting appropriate prophylactic strategies to stave off DVT.
conducted a systematic review and meta-analysis specifically focusing on hip and knee arthroplasty. Despite the different study population, their findings regarding the use of aspirin as thromboprophylaxis may have implications for on-pump cardiac surgery patients. The review emphasizes the potential of aspirin as a pharmacological intervention for preventing DVT.
In a prospective randomized study, investigated the impact of active toe movement (AToM) on both calf pump function and the occurrence of DVT in patients with acute foot and ankle trauma who were treated with a cast. Although the study did not specifically target individuals undergoing on-pump cardiac surgery, it illuminates the potential advantages of integrating AToM into nursing care strategies to enhance venous return and thwart DVT. The outcomes suggest that incorporating AToM into nursing care protocols for on-pump cardiac surgery patients could hold promising benefits.
In a distinct analysis conducted by Zheng, the authors delved into the advancements in nursing care for elderly patients who experienced postoperative hip fractures and associated DVT in China. Despite the differing study populations, this review offers insightful perspectives on nursing care protocols and optimal approaches to prevent DVT. These insights might hold relevance for on-pump cardiac surgery patients, particularly concerning nursing interventions and tactics to prevent DVT.
specifically examined the risk of DVT in neurosurgery but also discussed prophylaxis protocols and best clinical practices. Although the context varies, the review emphasizes the significance of implementing appropriate prophylaxis protocols to prevent DVT. The insights from this review can be applied to on-pump cardiac surgery patients to guide nursing care protocols.
executed a comprehensive systematic review and meta-analysis to assess the supplementary application of intermittent pneumatic compression in hospitalized patients who were concurrently receiving pharmacologic prophylaxis for venous thromboprophylaxis. The outcomes indicate that the addition of intermittent pneumatic compression has the potential to amplify the effectiveness of pharmacologic prophylaxis. This investigation advocates for the integration of complementary interventions into nursing care protocols for the prevention of DVT in on-pump cardiac surgery patients.
In a randomized controlled trial carried out , the influence of a foot pump on the incidence of DVT subsequent to total knee arthroplasty in patients undergoing treatment with edoxaban was examined. Despite the different patient demographic addressed in the study, the results underscore the prospective advantages of incorporating foot pumps as an adjunctive measure for DVT prevention. Incorporating foot pumps into nursing care protocols for on-pump cardiac surgery patients could potentially yield benefits.
conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of tranexamic acid in high-risk non-cardiac surgical cases necessitating transfusion. Although the study's primary focus does not directly encompass on-pump cardiac surgery patients, the conclusions extend to a broader spectrum of surgical cases. The review indicates that tranexamic acid can effectively curtail bleeding and mitigate the likelihood of transfusions during high-risk surgical procedures. Considering the plausible ramifications of bleeding and subsequent immobility on DVT development, these findings may hold significance for nursing care protocols aimed at averting DVT in on-pump cardiac surgery patients.
executed a randomized placebo-controlled study with the intention of exploring the potential of dexmedetomidine in diminishing occurrences of atrial fibrillation and delirium subsequent to cardiac surgery. While the study focuses on distinct outcomes, it yields insights pertinent to perioperative management and interventions in cardiac surgery cases. The ramifications of atrial fibrillation and delirium on patient mobility and the risk of DVT underscore the potential value of integrating strategies to manage these complications within nursing care protocols, indirectly contributing to DVT prevention.
In their investigation, delved into the impacts of basic exercise, with or without physiotherapy, in staving off DVT in postmenopausal women undergoing coronary artery bypass graft surgery. Despite the divergence in patient demographics from on-pump cardiac surgery cases, the findings underscore the significance of exercise and physiotherapy in DVT prevention. Recognizing the potential advantages of exercise and early mobilization in curtailing DVT risk, integrating these approaches into nursing care protocols for on-pump cardiac surgery patients holds potential value.
A systematic review and meta-analysis undertaken by took a specific focus on the incidence of venous thromboembolism (VTE) and the pros and cons of thromboprophylaxis following cardiac surgery. The review furnishes invaluable perspectives regarding the overarching VTE risk and the effectiveness of thromboprophylaxis strategies. The outcomes underline the importance of well-suited thromboprophylaxis in deterring DVT in cardiac surgery patients, thereby offering informative guidance for nursing care protocols.
executed a study that specifically investigated the influence of a nursing care protocol on the incidence of DVT among critically ill neurological patients. Despite the distinct patient demographic addressed, the outcomes underscore the potential advantages of nursing care protocols in mitigating DVT occurrences. The study imparts insights into the function of nursing interventions and protocols in diminishing DVT risk, which could hold relevance for on-pump cardiac surgery patients.
In an endeavor led by Sachdeva, a systematic review and meta-analysis were conducted regarding the application of graduated compression stockings for the prevention of DVT. The review scrutinizes the efficacy of graduated compression stockings as a preventive measure. While the scope extends beyond on-pump cardiac surgery patients, the findings contribute to the comprehension of compression stockings as an intervention for DVT prevention. Incorporating the utilization of graduated compression stockings into nursing care protocols for on-pump cardiac surgery patients may offer advantages.
performed a study specifically concentrating on DVT and pulmonary embolism in patients undergoing cardiac surgery. The study explores the occurrence and risk factors associated with DVT and pulmonary embolism in this specific patient population. The findings highlight the importance of identifying and addressing risk factors to prevent DVT in cardiac surgical patients, which can be valuable in shaping nursing care protocols.
conducted a systematic review that examined the pros and cons of prophylactic measures for DVT and pulmonary embolus in plastic surgery. Although the study had a different focus on a distinct surgical population, the results provide valuable insights into the potential benefits and risks linked to prophylaxis strategies. Understanding the risks associated with prophylactic measures can contribute to the development of nursing care protocols for preventing DVT in on-pump cardiac surgery patients.
carried out a systematic review on patient preferences and adherence to the proper usage of graduated compression stockings for DVT prevention in surgical patients. While the review does not specifically target cardiac surgery patients, it offers valuable information concerning patient preferences and adherence to compression stockings. Taking patient preferences into consideration and promoting adherence to preventive measures can enhance the effectiveness of nursing care protocols for DVT prevention.
conducted a systematic review and meta-analysis specifically focusing on tranexamic acid in cardiac surgery. Although the study focuses on a different outcome (bleeding control), it provides insights into the use of tranexamic acid, which may indirectly impact DVT prevention. Considering the potential influence of bleeding on DVT occurrence, incorporating strategies for bleeding control into nursing care protocols may indirectly contribute to DVT prevention in on-pump cardiac surgery patients.
- Conditions
- On-pump Cardiac Surgery - Prevention - Intervention - Experimental Group - Control Group - Incidence - Complications, DVT - Deep Vein Thrombosis, DVT Prophylaxis, DVT Prevention, Cardiac On-pump Surgery, Nursing Care Protocol
- Being tested
- IPC devices facilitate venous return by simulating the physiological effects of muscle contraction, reducing venous stasis.
- Keywords
- DVT, NCP, CPS
- Medical subject headings
- Venous Thrombosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
IPC devices facilitate venous return by simulating the physiological effects of muscle contraction, reducing venous stasis.Device
Also called Anticoagulant therapy reduces the likelihood of clot formation in high-risk individuals by inhibiting thrombus development., Early identification of at-risk patients enables proactive preventive strategies, reducing the likelihood of complications., Ambulation stimulates circulation and prevents venous stasis, a primary risk factor for DVT., Proper hydration reduces blood viscosity, which helps prevent thrombosis.
Padua Prediction Score is a clinical tool that has been validated and created to identify hospitalized medical patients who are at risk of developing Venous Thromboembolism (VTE).
Caprini's Risk Assessment Model (RAM) is one of the preferred risk scoring systems for assessing VTE chances for surgery patients. Joseph A. Caprini introduced it, which combines the hereditary and environmental risk factors, with a total of more than 40 different variables used in the assessment such as age, body mass index, past occurrence of VTE, varicose veins, presence of cancer, hormone therapy, and the length of immobility. The resulting score then puts patients into risk categories of very low with 0 points, low with 1-2 points, moderate with 3-4 pts., and high with ≥5 points
| Study group | Role | What they receive |
|---|---|---|
| Nursing Care Protocol The nursing care protocol designed for this study is a structured, evidence-ba | Experimental | Nursing Care Protocol The nursing care protocol designed for this study is a structured, evidence-based guideline specifically tailored for on-pump cardiac surgery patients. It differs from existing DVT prevention protocols by integrating four core components: individualized risk stratification (using Padua and Caprini scores), combined pharmacological and mechanical prophylaxis, an early mobilization regimen adapted to post-cardiac surgery tolerance, and a structured patient education component. Unlike generic thromboprophylaxis guidelines, this protocol standardizes nursing-led interventions and monitoring across preoperative, intraoperative, and postoperative stages.
Follow-Up Schedule and Time-Points
Follow-Up Time-Points:
* Day 0 (Start of prophylaxis / Baseline)
* Day 3 (Early in-hospital monitoring)
* Day 7 (or just before discharge)
* Week 2 (Outpatient follow-up)
* Month 3 (Long-term follow-up) Receives: Device: IPC devices facilitate venous return by simulating the physiological effects of muscle contraction, reducing venous stasis. |
What is being measured
The primary outcome is the main question the study is designed to answer.
The primary endpoint is the incidence of symptomatic or confirmed deep-vein thrombosis (DVT) and/or pulmonary embolism (PE) within the 3-month follow-up period. Secondary endpoints include: adherence to the prophylaxis protocol, occurrence of prophylaxis
Measured: three months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Jan 2026
- Study start14 Jun 2024
- Primary completion20 Dec 2025
- Study completion1 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for On-pump Cardiac Surgery - Prevention - Intervention - Experimental Group - Control Group - Incidence - ComplicationsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Experimental Group,Justification: The experimental group will receive a specific intervention aimed at preventing deep vein thrombosis (DVT) in on-pump cardiac surgery patients. * Sample Selection: Participants will be selected from a specific hospital or clinical setting based on predetermined inclusion and exclusion criteria. * Source of Sample: Patients admitted to the participating hospital or clinical setting for on-pump cardiac surgery.Control Group,Justification: The control group will serve as a comparison to evaluate the effectiveness of the intervention by comparing the occurrence of DVT in this group.
- Masking
- None (open label)
- Enrolment
- 67 participants (actual)
Sponsor and investigators
- Lead sponsor
- Near East University, Turkey
- Sponsor type
- University, hospital or other
- Collaborators
- Al-Ahli Hospital, Hebron
- Responsible party
- Principal investigator, Abdallah Ibraheem Abdallah Halahla, Near East University, Turkey
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07347652
- Sponsor's protocol ID
- NEU\2025\138-2044
- Acronym
- DVT
- Status last verified
- Oct 2026
- First submitted
- 29 Dec 2025
- Last updated
- 4 Nov 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Development of a Nursing Care Protocol for the Prevention of Deep Vein Thrombosis and Its Impact on Patient Outcomes Following Cardiac Surgery
- ClinicalTrials.gov ID
- NCT07347652
- Acronym / sponsor ID
- DVT / NEU\2025\138-2044
- Conditions
- On-pump Cardiac Surgery - Prevention - Intervention - Experimental Group - Control Group - Incidence - Complications, DVT - Deep Vein Thrombosis, DVT Prophylaxis, DVT Prevention, Cardiac On-pump Surgery, Nursing Care Protocol
- Keywords
- DVT, NCP, CPS
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 67 participants (actual)
- Lead sponsor
- Near East University, TurkeyUniversity, hospital or other
- Collaborators
- Al-Ahli Hospital, Hebron
- Study start
- 14 Jun 2024 (actual)
- Primary completion
- 20 Dec 2025 (actual)
- Study completion
- 1 Nov 2026 (estimated)
- First posted
- 16 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The primary focus of this research proposal is to examine the efficacy of a nursing care protocol in preventing the occurrence of deep vein thrombosis (DVT) in patients undergoing on-pump cardiac surgery. The investigation will encompass an experimental group that will be subjected to a specific intervention, alongside a control group that will adhere to conventional care procedures. The central objective is to exhibit a statistically significant decrease in the incidence of DVT within the experimental group in comparison to the control group. The secondary outcomes involve assessing the severity of DVT instances and the development of associated complications.
The proposed research strategy entails delineating the criteria for selecting participants, outlining methodologies for gathering data, and detailing statistical approaches for analysis. The amassed data will undergo scrutiny through suitable statistical examinations, including chi-square tests, t-tests, or Mann-Whitney U tests, as well as logistic regression analysis. The process of data analysis will involve descriptive statistics, comparative assessments, regression analysis, and subgroup scrutiny. The interpretation of outcomes will be contextualized within the framework of the research objectives and pre-existing scientific knowledge.
The ultimate objective of this study is to enhance the existing understanding of DVT prevention, provide clinically grounded recommendations supported by evidence, and elevate the quality and safety of patient care.
Detailed description
General Information Regarding the Thesis Topic Deep vein thrombosis (DVT) stands as a frequent complication encountered among patients undergoing on-pump cardiac surgery. A variety of interventions and protocols have been explored to forestall DVT, encompassing strategies like pharmacological prophylaxis, intermittent pneumatic leg compression, active toe movement, and supplementary measures. The objective of this survey of recent literature is to present the most current research related to nursing care protocols' impact on DVT prevention within the context of on-pump cardiac surgery patients.
undertook a thorough systematic examination, culminating in the determination that the combined utilization of intermittent pneumatic leg compression and pharmacological prophylaxis constitutes an efficacious approach for averting venous thromboembolism, encompassing DVT. Their conclusions resoundingly advocate for the integration of this dual strategy into a nursing care protocol to forestall DVT in on-pump cardiac surgery patients.
undertook a distinct systematic review with a focus on venous thromboembolic events in adults undergoing extracorporeal membrane oxygenation (ECMO) support. While the review did not exclusively center on on-pump cardiac surgery patients, it does offer valuable insights for managing individuals undergoing cardiac procedures. The review underlines the significance of acknowledging thromboembolic events in patients relying on ECMO support, and it underscores the importance of enacting appropriate prophylactic strategies to stave off DVT.
conducted a systematic review and meta-analysis specifically focusing on hip and knee arthroplasty. Despite the different study population, their findings regarding the use of aspirin as thromboprophylaxis may have implications for on-pump cardiac surgery patients. The review emphasizes the potential of aspirin as a pharmacological intervention for preventing DVT.
In a prospective randomized study, investigated the impact of active toe movement (AToM) on both calf pump function and the occurrence of DVT in patients with acute foot and ankle trauma who were treated with a cast. Although the study did not specifically target individuals undergoing on-pump cardiac surgery, it illuminates the potential advantages of integrating AToM into nursing care strategies to enhance venous return and thwart DVT. The outcomes suggest that incorporating AToM into nursing care protocols for on-pump cardiac surgery patients could hold promising benefits.
In a distinct analysis conducted by Zheng, the authors delved into the advancements in nursing care for elderly patients who experienced postoperative hip fractures and associated DVT in China. Despite the differing study populations, this review offers insightful perspectives on nursing care protocols and optimal approaches to prevent DVT. These insights might hold relevance for on-pump cardiac surgery patients, particularly concerning nursing interventions and tactics to prevent DVT.
specifically examined the risk of DVT in neurosurgery but also discussed prophylaxis protocols and best clinical practices. Although the context varies, the review emphasizes the significance of implementing appropriate prophylaxis protocols to prevent DVT. The insights from this review can be applied to on-pump cardiac surgery patients to guide nursing care protocols.
executed a comprehensive systematic review and meta-analysis to assess the supplementary application of intermittent pneumatic compression in hospitalized patients who were concurrently receiving pharmacologic prophylaxis for venous thromboprophylaxis. The outcomes indicate that the addition of intermittent pneumatic compression has the potential to amplify the effectiveness of pharmacologic prophylaxis. This investigation advocates for the integration of complementary interventions into nursing care protocols for the prevention of DVT in on-pump cardiac surgery patients.
In a randomized controlled trial carried out , the influence of a foot pump on the incidence of DVT subsequent to total knee arthroplasty in patients undergoing treatment with edoxaban was examined. Despite the different patient demographic addressed in the study, the results underscore the prospective advantages of incorporating foot pumps as an adjunctive measure for DVT prevention. Incorporating foot pumps into nursing care protocols for on-pump cardiac surgery patients could potentially yield benefits.
conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of tranexamic acid in high-risk non-cardiac surgical cases necessitating transfusion. Although the study's primary focus does not directly encompass on-pump cardiac surgery patients, the conclusions extend to a broader spectrum of surgical cases. The review indicates that tranexamic acid can effectively curtail bleeding and mitigate the likelihood of transfusions during high-risk surgical procedures. Considering the plausible ramifications of bleeding and subsequent immobility on DVT development, these findings may hold significance for nursing care protocols aimed at averting DVT in on-pump cardiac surgery patients.
executed a randomized placebo-controlled study with the intention of exploring the potential of dexmedetomidine in diminishing occurrences of atrial fibrillation and delirium subsequent to cardiac surgery. While the study focuses on distinct outcomes, it yields insights pertinent to perioperative management and interventions in cardiac surgery cases. The ramifications of atrial fibrillation and delirium on patient mobility and the risk of DVT underscore the potential value of integrating strategies to manage these complications within nursing care protocols, indirectly contributing to DVT prevention.
In their investigation, delved into the impacts of basic exercise, with or without physiotherapy, in staving off DVT in postmenopausal women undergoing coronary artery bypass graft surgery. Despite the divergence in patient demographics from on-pump cardiac surgery cases, the findings underscore the significance of exercise and physiotherapy in DVT prevention. Recognizing the potential advantages of exercise and early mobilization in curtailing DVT risk, integrating these approaches into nursing care protocols for on-pump cardiac surgery patients holds potential value.
A systematic review and meta-analysis undertaken by took a specific focus on the incidence of venous thromboembolism (VTE) and the pros and cons of thromboprophylaxis following cardiac surgery. The review furnishes invaluable perspectives regarding the overarching VTE risk and the effectiveness of thromboprophylaxis strategies. The outcomes underline the importance of well-suited thromboprophylaxis in deterring DVT in cardiac surgery patients, thereby offering informative guidance for nursing care protocols.
executed a study that specifically investigated the influence of a nursing care protocol on the incidence of DVT among critically ill neurological patients. Despite the distinct patient demographic addressed, the outcomes underscore the potential advantages of nursing care protocols in mitigating DVT occurrences. The study imparts insights into the function of nursing interventions and protocols in diminishing DVT risk, which could hold relevance for on-pump cardiac surgery patients.
In an endeavor led by Sachdeva, a systematic review and meta-analysis were conducted regarding the application of graduated compression stockings for the prevention of DVT. The review scrutinizes the efficacy of graduated compression stockings as a preventive measure. While the scope extends beyond on-pump cardiac surgery patients, the findings contribute to the comprehension of compression stockings as an intervention for DVT prevention. Incorporating the utilization of graduated compression stockings into nursing care protocols for on-pump cardiac surgery patients may offer advantages.
performed a study specifically concentrating on DVT and pulmonary embolism in patients undergoing cardiac surgery. The study explores the occurrence and risk factors associated with DVT and pulmonary embolism in this specific patient population. The findings highlight the importance of identifying and addressing risk factors to prevent DVT in cardiac surgical patients, which can be valuable in shaping nursing care protocols.
conducted a systematic review that examined the pros and cons of prophylactic measures for DVT and pulmonary embolus in plastic surgery. Although the study had a different focus on a distinct surgical population, the results provide valuable insights into the potential benefits and risks linked to prophylaxis strategies. Understanding the risks associated with prophylactic measures can contribute to the development of nursing care protocols for preventing DVT in on-pump cardiac surgery patients.
carried out a systematic review on patient preferences and adherence to the proper usage of graduated compression stockings for DVT prevention in surgical patients. While the review does not specifically target cardiac surgery patients, it offers valuable information concerning patient preferences and adherence to compression stockings. Taking patient preferences into consideration and promoting adherence to preventive measures can enhance the effectiveness of nursing care protocols for DVT prevention.
conducted a systematic review and meta-analysis specifically focusing on tranexamic acid in cardiac surgery. Although the study focuses on a different outcome (bleeding control), it provides insights into the use of tranexamic acid, which may indirectly impact DVT prevention. Considering the potential influence of bleeding on DVT occurrence, incorporating strategies for bleeding control into nursing care protocols may indirectly contribute to DVT prevention in on-pump cardiac surgery patients.
Study design
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Experimental Group,Justification: The experimental group will receive a specific intervention aimed at preventing deep vein thrombosis (DVT) in on-pump cardiac surgery patients. * Sample Selection: Participants will be selected from a specific hospital or clinical setting based on predetermined inclusion and exclusion criteria. * Source of Sample: Patients admitted to the participating hospital or clinical setting for on-pump cardiac surgery.Control Group,Justification: The control group will serve as a comparison to evaluate the effectiveness of the intervention by comparing the occurrence of DVT in this group.
| Arm | Type | Receives |
|---|---|---|
| Nursing Care Protocol The nursing care protocol designed for this study is a structured, evidence-ba | Experimental | Device: IPC devices facilitate venous return by simulating the physiological effects of muscle contraction, reducing venous stasis.Nursing Care Protocol The nursing care protocol designed for this study is a structured, evidence-based guideline specifically tailored for on-pump cardiac surgery patients. It differs from existing DVT prevention protocols by integrating four core components: individualized risk stratification (using Padua and Caprini scores), combined pharmacological and mechanical prophylaxis, an early mobilization regimen adapted to post-cardiac surgery tolerance, and a structured patient education component. Unlike generic thromboprophylaxis guidelines, this protocol standardizes nursing-led interventions and monitoring across preoperative, intraoperative, and postoperative stages. Follow-Up Schedule and Time-Points Follow-Up Time-Points: * Day 0 (Start of prophylaxis / Baseline) * Day 3 (Early in-hospital monitoring) * Day 7 (or just before discharge) * Week 2 (Outpatient follow-up) * Month 3 (Long-term follow-up) |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (9 listed)
- Patients will be eligible for participation in the study if they meet all of the following criteria:
- Adult patients aged 18 years or older.
- Patients scheduled to undergo elective or urgent on-pump cardiac surgery using cardiopulmonary bypass (e.g., coronary artery bypass grafting, valve replacement or repair, or combined procedures).
- Both male and female patients.
- Patients admitted to the participating cardiac surgery unit during the study period.
Key exclusion criteria (17 listed)
- History of deep vein thrombosis (DVT) or pulmonary embolism (PE) within the previous six months.
- Known congenital or acquired coagulation disorders, including but not limited to hemophilia, thrombophilia, or antiphospholipid syndrome.
- Patients receiving long-term therapeutic anticoagulation (e.g., warfarin, direct oral anticoagulants) for other medical indications prior to surgery.
- Contraindications to pharmacological thromboprophylaxis, such as:
- Contraindications to mechanical prophylaxis, including:
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| IPC devices facilitate venous return by simulating the physiological effects of muscle contraction, reducing venous stasis.Also: Anticoagulant therapy reduces the likelihood of clot formation in high-risk individuals by inhibiting thrombus development., Early identification of at-risk patients enables proactive preventive strategies, reducing the likelihood of complications., Ambulation stimulates circulation and prevents venous stasis, a primary risk factor for DVT., Proper hydration reduces blood viscosity, which helps prevent thrombosis.Padua Prediction Score is a clinical tool that has been validated and created to identify hospitalized medical patients who are at risk of developing Venous Thromboembolism (VTE). Caprini's Risk Assessment Model (RAM) is one of the preferred risk scoring systems for assessing VTE chances for surgery patients. Joseph A. Caprini introduced it, which combines the hereditary and environmental risk factors, with a total of more than 40 different variables used in the assessment such as age, body mass index, past occurrence of VTE, varicose veins, presence of cancer, hormone therapy, and the length of immobility. The resulting score then puts patients into risk categories of very low with 0 points, low with 1-2 points, moderate with 3-4 pts., and high with ≥5 points | Device | Nursing Care Protocol The nursing care protocol designed for this study is a structured, evidence-ba |
Primary outcome
The primary endpoint is the incidence of symptomatic or confirmed deep-vein thrombosis (DVT) and/or pulmonary embolism (PE) within the 3-month follow-up period. Secondary endpoints include: adherence to the prophylaxis protocol, occurrence of prophylaxis
Time frame: three months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Nov 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing IPC devices facilitate venous return by simulating the physiological effects of muscle contraction, reducing venous stasis. in people with On-pump Cardiac Surgery - Prevention - Intervention - Experimental Group - Control Group - Incidence - Complications and DVT - Deep Vein Thrombosis, run by Near East University, Turkey at 1 site in Cyprus.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 17 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 4 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Cyprus. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The primary endpoint is the incidence of symptomatic or confirmed deep-vein thrombosis (DVT) and/or pulmonary embolism (PE) within the 3-month follow-up period. Secondary endpoints include: adherence to the prophylaxis protocol, occurrence of prophylaxis (time frame: three months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Nov 2026; AzTrials last refreshed its copy on 6 Nov 2026.