Kidney StonesNCT07349992
Retrograde Intrarenal Surgery (RIRS) With High-Power Laser and Flexible, Navigable Suction Access Sheath (FANS) vs Mini-Percutaneous Nephrolithotomy (miniPCNL) for 2-3 cm Renal Stones
A study testing Retrograde Intrarenal Surgery and Mini Percutaneous Nephrolithotomy in people with Kidney Stones and Nephrolithiasis, run by Necmettin Erbakan University at 1 site in Turkey (Türkiye).
Trial summary
This prospective cohort study aims to compare the safety and efficacy of retrograde intrarenal surgery combined with a high-power Holmium:YAG laser and flexible navigable suction access sheath versus mini-percutaneous nephrolithotomy in patients with 2-3 cm renal stones. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Kidney Stones, Nephrolithiasis
- What is being tested?
- Retrograde Intrarenal Surgery and Mini Percutaneous Nephrolithotomy
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jun 2022to 1 Jun 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age ≥18 years
- Kidney stones measuring 2-3 cm
- Suitable for Retrograde Intrarenal Surgery (RIRS) or Mini-Percutaneous Nephrolithotomy (MiniPCNL)
- Provided written informed consent
Who cannot join
- Pregnancy
- Renal transplantation
- Congenital renal anomalies
- Uncorrectable coagulopathy
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Necmettin Erbakan University Medical Faculty
Konya, Konya
About this study
Official title: Flexible Ureterorenoscopy With High-Power Holmium: YAG Laser and Flexible, Navigable Suction Access Sheath vs Mini-Percutaneous Nephrolithotomy in 2-3 cm Kidney Stones Treatment: A Prospective Cohort Study
This prospective cohort study aims to compare the safety and efficacy of retrograde intrarenal surgery combined with a high-power Holmium:YAG laser and flexible navigable suction access sheath versus mini-percutaneous nephrolithotomy in patients with 2-3 cm renal stones.
- Conditions
- Kidney Stones, Nephrolithiasis
- Being tested
- Retrograde Intrarenal Surgery, Mini Percutaneous Nephrolithotomy
- Medical subject headings
- Kidney Calculi, Nephrolithiasis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Retrograde Intrarenal SurgeryProcedure or surgery
We performed retrograde intrarenal surgery combined with a high-power Holmium:YAG laser and flexible navigable suction access sheath in patients with 2-3 cm renal stones.
Mini Percutaneous NephrolithotomyProcedure or surgery
We performed mini-percutaneous nephrolithotomy in patients with 2-3 cm renal stones.
| Study group | Role | What they receive |
|---|---|---|
| Retrograde Intrarenal Surgery (RIRS) Group | Experimental | Intervention: Procedure-Retrograde Intrarenal Surgery Receives: Procedure: Retrograde Intrarenal Surgery |
| Mini-Percutaneous Nephrolithotomy (MiniPCNL) Group | Experimental | Intervention: Procedure- Mini Percutaneous Nephrolithotomy Receives: Procedure: Mini Percutaneous Nephrolithotomy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Stone-Free Rate
Measured: 1 month
Secondary outcomes (3)
Hemoglobin change
Measured: postoperative first day
Fluoroscopy time
Measured: Perioperative
Complications
Measured: up to 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Jan 2026
- Study start1 Jun 2022
- Primary completion1 Jun 2024
- Study completion1 Jun 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Kidney StonesStudies of the same condition, open and under way.
- More trials run by Necmettin Erbakan UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Necmettin Erbakan University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Muzaffer Tansel Kilinc, Necmettin Erbakan University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07349992
- Sponsor's protocol ID
- RIRS-MiniPCNL-2022
- Status last verified
- Jan 2026
- First submitted
- 8 Jan 2026
- Last updated
- 20 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Publications
Kilinc MT, Goger YE, Cavdar OF, Taskapu HH, Ozkent MS. Comparative outcomes of flexible ureterorenoscopy with high-power holmium: YAG laser and flexible, navigable suction access sheath vs mini-percutaneous nephrolithotomy in 2-3 cm kidney stones treatment: a prospective cohort study. BMC Urol. 2026 Jul 11. doi: 10.1186/s12894-026-02250-x. Online ahead of print.
PubMed 42436463
Study at a glance
From the registry record, last updated by the sponsor on 20 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Flexible Ureterorenoscopy With High-Power Holmium: YAG Laser and Flexible, Navigable Suction Access Sheath vs Mini-Percutaneous Nephrolithotomy in 2-3 cm Kidney Stones Treatment: A Prospective Cohort Study
- ClinicalTrials.gov ID
- NCT07349992
- Acronym / sponsor ID
- RIRS-MiniPCNL-2022
- Conditions
- Kidney Stones, Nephrolithiasis
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Necmettin Erbakan UniversityUniversity, hospital or other
- Study start
- 1 Jun 2022 (actual)
- Primary completion
- 1 Jun 2024 (actual)
- Study completion
- 1 Jun 2024 (actual)
- First posted
- 20 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective cohort study aims to compare the safety and efficacy of retrograde intrarenal surgery combined with a high-power Holmium:YAG laser and flexible navigable suction access sheath versus mini-percutaneous nephrolithotomy in patients with 2-3 cm renal stones.
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Retrograde Intrarenal Surgery (RIRS) Group | Experimental | Procedure: Retrograde Intrarenal SurgeryIntervention: Procedure-Retrograde Intrarenal Surgery |
| Mini-Percutaneous Nephrolithotomy (MiniPCNL) Group | Experimental | Procedure: Mini Percutaneous NephrolithotomyIntervention: Procedure- Mini Percutaneous Nephrolithotomy |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age ≥18 years
- Kidney stones measuring 2-3 cm
- Suitable for Retrograde Intrarenal Surgery (RIRS) or Mini-Percutaneous Nephrolithotomy (MiniPCNL)
- Provided written informed consent
Key exclusion criteria (4 listed)
- Pregnancy
- Renal transplantation
- Congenital renal anomalies
- Uncorrectable coagulopathy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Retrograde Intrarenal SurgeryWe performed retrograde intrarenal surgery combined with a high-power Holmium:YAG laser and flexible navigable suction access sheath in patients with 2-3 cm renal stones. | Procedure or surgery | Retrograde Intrarenal Surgery (RIRS) Group |
| Mini Percutaneous NephrolithotomyWe performed mini-percutaneous nephrolithotomy in patients with 2-3 cm renal stones. | Procedure or surgery | Mini-Percutaneous Nephrolithotomy (MiniPCNL) Group |
Primary outcome
Stone-Free Rate
Time frame: 1 month
3 secondary outcomes
Hemoglobin change
Time frame: postoperative first day
Fluoroscopy time
Time frame: Perioperative
Complications
Time frame: up to 4 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Jan 2026.
- Derived from this study: PubMed 42436463Kilinc MT, Goger YE, Cavdar OF, Taskapu HH, Ozkent MS. Comparative outcomes of flexible ureterorenoscopy with high-power holmium: YAG laser and flexible, navigable suction access sheath vs mini-percutaneous nephrolithotomy in 2-3 cm kidney stones treatment: a prospective cohort study. BMC Urol. 2026 Jul 11. doi: 10.1186/s12894-026-02250-x. Online ahead of print.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Retrograde Intrarenal Surgery and Mini Percutaneous Nephrolithotomy in people with Kidney Stones and Nephrolithiasis, run by Necmettin Erbakan University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Stone-Free Rate (time frame: 1 month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07349992, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Jan 2026.