HealthyNCT07351201
Effect of Head and Neck Positioning on Lung Sliding in Healthy Volunteers
A study testing Head-of-Bed Elevation in people with Healthy, run by Ankara Etlik City Hospital at 1 site in Turkey (Türkiye).
Trial summary
The goal of this clinical study is to learn how different head-of-bed positions affect lung movement during breathing in healthy adults. Researchers want to understand whether raising the head of the bed changes how the lungs move, which may help guide patient positioning in emergency and intensive care settings. Read more about this study
- Who is it for?
- Ages 18 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Head-of-Bed Elevation
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 31 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 20 Jan 2026to 20 Feb 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy adult volunteers aged eighteen to sixty years.
- No history of acute or chronic respiratory disease.
- Body mass index between eighteen point five and twenty-nine point nine kilograms per square meter.
- Ability to understand the study procedures and provide written informed consent.
- No skin lesions or wounds at the chest wall that would interfere with lung ultrasound examination.
Who cannot join
- History of respiratory system diseases, including asthma, chronic obstructive pulmonary disease, bronchiectasis, pneumonia, or tuberculosis.
- Presence of chest wall deformities (such as kyphoscoliosis or pectus deformities) or history of thoracic surgery.
- Inability to tolerate position changes during the study, including development of dizziness, syncope, or shortness of breath.
- Pregnancy or breastfeeding.
- Known significant cardiac, neurological, or metabolic disease.
- Known allergy to ultrasound gel or latex.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Ankara Etlik City Hospital
Ankara, Yenimahalle, 06170
About this study
Official title: The Effect of Head and Neck Positioning on Lung Sliding: A Bedside Comparison at 0°, 20°, and 40° in Healthy Volunteer
The goal of this clinical study is to learn how different head-of-bed positions affect lung movement during breathing in healthy adults. Researchers want to understand whether raising the head of the bed changes how the lungs move, which may help guide patient positioning in emergency and intensive care settings.
The main questions this study aims to answer are:
Read more
Does lung movement change when the head of the bed is positioned at zero, twenty, or forty degrees?
Are there differences in lung movement between the right and left lungs?
Are there differences between the upper (apical) and lower (basal) parts of the lungs?
Participants will be healthy adult volunteers between eighteen and sixty years of age. Each participant will lie on a bed in three different positions: flat, with the head raised to twenty degrees, and with the head raised to forty degrees.
During each position, researchers will use bedside lung ultrasound, a painless and non-invasive imaging method, to measure lung movement at four areas of the chest. No medications, injections, or invasive procedures will be used.
This study may help health care providers better understand how body position affects breathing and support safer and more effective positioning of patients with breathing problems.
Read the detailed description
This is a prospective, low-risk, non-drug interventional clinical study designed to evaluate the effect of head-of-bed elevation on lung sliding movement in healthy adult volunteers. Lung sliding is a dynamic ultrasound finding that reflects the movement between the visceral and parietal pleura during respiration and provides information about lung aeration and respiratory mechanics.
The primary objective of the study is to quantitatively assess changes in lung sliding amplitude across three standardized head-of-bed positions: zero degrees (supine), twenty degrees, and forty degrees. Measurements will be obtained using bedside lung ultrasonography at four predefined anatomical locations: right apical, right basal, left apical, and left basal lung regions.
Secondary objectives include evaluating potential differences in lung sliding between the right and left lungs, comparing apical and basal lung regions, and assessing whether positional changes have region-specific effects on lung movement.
The study population will consist of thirty-one healthy adult volunteers aged eighteen to sixty years. Individuals with known respiratory disease, significant cardiopulmonary conditions, pregnancy, prior thoracic surgery, or inability to tolerate position changes will be excluded. All participants will provide written informed consent prior to enrollment.
Each participant will undergo lung ultrasound measurements in all three positions in a repeated-measures design. Lung sliding will be recorded using high-frequency linear ultrasound probes. Quantitative assessment will be performed using M-mode imaging, measuring pleural line displacement in millimeters. Mean values will be calculated for each position and anatomical region.
No investigational drugs, medical devices, or invasive procedures will be used. The only intervention is controlled head-of-bed positioning. The study is considered minimal risk. Potential discomfort related to short-term position changes, such as mild dizziness or transient shortness of breath, will be monitored, and measurements will be discontinued if symptoms occur.
Data will be analyzed using repeated measures statistical methods to compare lung sliding values across positions and regions. The findings are expected to improve understanding of the positional sensitivity of lung ultrasound measurements and may contribute to evidence-based recommendations for patient positioning in emergency and critical care settings.
- Conditions
- Healthy
- Being tested
- Head-of-Bed Elevation
- Keywords
- Ultrasonography, Lung, Pleura, Respiratory Mechanics, Patient Positioning
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Head-of-Bed ElevationProcedure or surgery
Controlled positioning of the participant with the head of the bed at zero, twenty, and forty degrees. At each position, lung sliding movement will be assessed using bedside lung ultrasound with a high-frequency linear probe.
| Study group | Role | What they receive |
|---|---|---|
| Head-of-Bed Position Assessment (0°, 20°, 40°) | Other | Participants in this single-arm study will undergo lung ultrasound assessments during a single study visit. Each participant will be positioned sequentially at three different head-of-bed angles: zero degrees (supine), twenty degrees, and forty degrees. At each position, lung sliding movement will be evaluated using bedside lung ultrasonography with a high-frequency linear probe.
Measurements will be obtained from four predefined anatomical regions: right apical, right basal, left apical, and left basal lung areas. Lung sliding will be quantitatively assessed using M-mode imaging by measuring pleural line displacement. Receives: Procedure: Head-of-Bed Elevation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Lung Sliding Amplitude Across Different Head-of-Bed Positions
Lung sliding amplitude will be quantitatively measured using bedside lung ultrasonography in healthy adult participants. Measurements will be obtained at four predefined anatomical regions (right apical, right basal, left apical, and left basal lung areas) while participants are positioned sequentially at three head-of-bed angles: zero degrees, twenty degrees, and forty degrees. Lung sliding amplitude will be assessed using M-mode imaging by measuring pleural line displacement in millimeters. Mean values for each position will be calculated and compared to evaluate the effect of head-of-bed elevation on lung sliding movement.
Measured: Periprocedural (during a single study visit)
Secondary outcomes (1)
Difference in Lung Sliding Amplitude Between Right and Left Lungs
Lung sliding amplitude values obtained from the right and left lungs will be compared to assess side-related differences in lung movement. Measurements will be performed at both apical and basal regions of each lung using bedside lung ultrasonography while participants are positioned at three different head-of-bed angles (zero, twenty, and forty degrees). This analysis will evaluate whether lung sliding differs between the right and left lungs under different positional conditions.
Measured: Periprocedural (during a single study visit)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Jan 2026
- Study start20 Jan 2026
- Primary completion20 Feb 2026
- Study completion20 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for HealthyStudies of the same condition, open and under way.
- More trials run by Ankara Etlik City HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 31 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ankara Etlik City Hospital
- Sponsor type
- Other government
- Responsible party
- Principal investigator, İLKER ŞİRİN, Ankara Etlik City Hospital
- Investigators
- İLKER ŞİRİN, Principal investigator, Ankara Etlik City Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07351201
- Sponsor's protocol ID
- AEŞH-EK-2025-305
- Status last verified
- Feb 2026
- First submitted
- 10 Jan 2026
- Last updated
- 2 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared because this study involves a small sample of healthy volunteers and collects detailed physiological measurements that could increase the risk of re-identification, even after de-identification. The study protocol and informed consent do not include provisions for public sharing of individual-level data. Only aggregated and anonymized results will be reported.
Publications
Briganti DN, Choi CE, Nguyen J, Lanks CW. Determinants of point-of-care ultrasound lung sliding amplitude in mechanically ventilated patients. Ultrasound J. 2023 May 23;15(1):25. doi: 10.1186/s13089-023-00326-5.
PubMed 37219721Sirin I, Erdem AB, Uysal SB, Gedikaslan S. The Effect of Tidal Volumes of Mechanically Ventilated Patients on Lung Sliding Amplitude in Point-Of-Care Lung Ultrasound. J Clin Ultrasound. 2025 Jun;53(5):989-996. doi: 10.1002/jcu.23968. Epub 2025 Mar 17.
PubMed 40098375
Study at a glance
From the registry record, last updated by the sponsor on 2 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Head and Neck Positioning on Lung Sliding: A Bedside Comparison at 0°, 20°, and 40° in Healthy Volunteer
- ClinicalTrials.gov ID
- NCT07351201
- Acronym / sponsor ID
- AEŞH-EK-2025-305
- Conditions
- Healthy
- Keywords
- Ultrasonography, Lung, Pleura, Respiratory Mechanics, Patient Positioning
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 31 participants (actual)
- Lead sponsor
- Ankara Etlik City HospitalOther government
- Study start
- 20 Jan 2026 (actual)
- Primary completion
- 20 Feb 2026 (actual)
- Study completion
- 20 Feb 2026 (actual)
- First posted
- 20 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical study is to learn how different head-of-bed positions affect lung movement during breathing in healthy adults. Researchers want to understand whether raising the head of the bed changes how the lungs move, which may help guide patient positioning in emergency and intensive care settings.
The main questions this study aims to answer are:
Does lung movement change when the head of the bed is positioned at zero, twenty, or forty degrees?
Are there differences in lung movement between the right and left lungs?
Are there differences between the upper (apical) and lower (basal) parts of the lungs?
Participants will be healthy adult volunteers between eighteen and sixty years of age. Each participant will lie on a bed in three different positions: flat, with the head raised to twenty degrees, and with the head raised to forty degrees.
During each position, researchers will use bedside lung ultrasound, a painless and non-invasive imaging method, to measure lung movement at four areas of the chest. No medications, injections, or invasive procedures will be used.
This study may help health care providers better understand how body position affects breathing and support safer and more effective positioning of patients with breathing problems.
Detailed description
This is a prospective, low-risk, non-drug interventional clinical study designed to evaluate the effect of head-of-bed elevation on lung sliding movement in healthy adult volunteers. Lung sliding is a dynamic ultrasound finding that reflects the movement between the visceral and parietal pleura during respiration and provides information about lung aeration and respiratory mechanics.
The primary objective of the study is to quantitatively assess changes in lung sliding amplitude across three standardized head-of-bed positions: zero degrees (supine), twenty degrees, and forty degrees. Measurements will be obtained using bedside lung ultrasonography at four predefined anatomical locations: right apical, right basal, left apical, and left basal lung regions.
Secondary objectives include evaluating potential differences in lung sliding between the right and left lungs, comparing apical and basal lung regions, and assessing whether positional changes have region-specific effects on lung movement.
The study population will consist of thirty-one healthy adult volunteers aged eighteen to sixty years. Individuals with known respiratory disease, significant cardiopulmonary conditions, pregnancy, prior thoracic surgery, or inability to tolerate position changes will be excluded. All participants will provide written informed consent prior to enrollment.
Each participant will undergo lung ultrasound measurements in all three positions in a repeated-measures design. Lung sliding will be recorded using high-frequency linear ultrasound probes. Quantitative assessment will be performed using M-mode imaging, measuring pleural line displacement in millimeters. Mean values will be calculated for each position and anatomical region.
No investigational drugs, medical devices, or invasive procedures will be used. The only intervention is controlled head-of-bed positioning. The study is considered minimal risk. Potential discomfort related to short-term position changes, such as mild dizziness or transient shortness of breath, will be monitored, and measurements will be discontinued if symptoms occur.
Data will be analyzed using repeated measures statistical methods to compare lung sliding values across positions and regions. The findings are expected to improve understanding of the positional sensitivity of lung ultrasound measurements and may contribute to evidence-based recommendations for patient positioning in emergency and critical care settings.
Study design
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Head-of-Bed Position Assessment (0°, 20°, 40°) | Other | Procedure: Head-of-Bed ElevationParticipants in this single-arm study will undergo lung ultrasound assessments during a single study visit. Each participant will be positioned sequentially at three different head-of-bed angles: zero degrees (supine), twenty degrees, and forty degrees. At each position, lung sliding movement will be evaluated using bedside lung ultrasonography with a high-frequency linear probe. Measurements will be obtained from four predefined anatomical regions: right apical, right basal, left apical, and left basal lung areas. Lung sliding will be quantitatively assessed using M-mode imaging by measuring pleural line displacement. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Healthy adult volunteers aged eighteen to sixty years.
- No history of acute or chronic respiratory disease.
- Body mass index between eighteen point five and twenty-nine point nine kilograms per square meter.
- Ability to understand the study procedures and provide written informed consent.
- No skin lesions or wounds at the chest wall that would interfere with lung ultrasound examination.
Key exclusion criteria (6 listed)
- History of respiratory system diseases, including asthma, chronic obstructive pulmonary disease, bronchiectasis, pneumonia, or tuberculosis.
- Presence of chest wall deformities (such as kyphoscoliosis or pectus deformities) or history of thoracic surgery.
- Inability to tolerate position changes during the study, including development of dizziness, syncope, or shortness of breath.
- Pregnancy or breastfeeding.
- Known significant cardiac, neurological, or metabolic disease.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Head-of-Bed ElevationControlled positioning of the participant with the head of the bed at zero, twenty, and forty degrees. At each position, lung sliding movement will be assessed using bedside lung ultrasound with a high-frequency linear probe. | Procedure or surgery | Head-of-Bed Position Assessment (0°, 20°, 40°) |
Primary outcome
Change in Lung Sliding Amplitude Across Different Head-of-Bed Positions
Time frame: Periprocedural (during a single study visit)
Lung sliding amplitude will be quantitatively measured using bedside lung ultrasonography in healthy adult participants. Measurements will be obtained at four predefined anatomical regions (right apical, right basal, left apical, and left basal lung areas) while participants are positioned sequentially at three head-of-bed angles: zero degrees, twenty degrees, and forty degrees. Lung sliding amplitude will be assessed using M-mode imaging by measuring pleural line displacement in millimeters. Mean values for each position will be calculated and compared to evaluate the effect of head-of-bed elevation on lung sliding movement.
1 secondary outcome
Difference in Lung Sliding Amplitude Between Right and Left Lungs
Time frame: Periprocedural (during a single study visit)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Mar 2026.
- Background: PubMed 37219721Briganti DN, Choi CE, Nguyen J, Lanks CW. Determinants of point-of-care ultrasound lung sliding amplitude in mechanically ventilated patients. Ultrasound J. 2023 May 23;15(1):25. doi: 10.1186/s13089-023-00326-5.
- Background: PubMed 40098375Sirin I, Erdem AB, Uysal SB, Gedikaslan S. The Effect of Tidal Volumes of Mechanically Ventilated Patients on Lung Sliding Amplitude in Point-Of-Care Lung Ultrasound. J Clin Ultrasound. 2025 Jun;53(5):989-996. doi: 10.1002/jcu.23968. Epub 2025 Mar 17.
- Individual participant dataSharing planned: No. Individual participant data will not be shared because this study involves a small sample of healthy volunteers and collects detailed physiological measurements that could increase the risk of re-identification, even after de-identification. The study protocol and informed consent do not include provisions for public sharing of individual-level data. Only aggregated and anonymized results will be reported.
Related trials for Healthy
Recruiting
THE EFFECTS OF GAME-BASED EXERCISE PROGRAMS
Physical Activity, Body Image
Not yet recruitingPhase 1
A Phase I Study of GLR2053 Tablets in Chinese Healthy Adult Participants
Atopic Dermatitis
Recruiting
Colon-delivered Riboflavin and Gut Microbiota Composition
Microbiome Dysbiosis, Gut Health
Not yet recruiting
Neuroergonomic Analysis of a Brain-Computer Interface Device (BCI)
Healthy Volunteers - Male and Female
RecruitingPhase 1
First-in-Human Trial to Assess REGN20423 in Healthy Adult Participants and Adult Participants With Atopic Dermatitis
Healthy Volunteer, Atopic Dermatitis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
İLKER ŞİRİN principal investigator
Ankara Etlik City Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Head-of-Bed Elevation in people with Healthy, run by Ankara Etlik City Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Lung Sliding Amplitude Across Different Head-of-Bed Positions (time frame: Periprocedural (during a single study visit)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07351201, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Mar 2026.