Mental HealthNCT07351240
The Acupuncture Treatment Effect in Patients With Schizophrenia
A study testing Acupuncture in people with Mental Health, run by Calo Psychiatric Center at 1 site in Taiwan.
Trial summary
Among various psychiatric disorders, this study focuses specifically on patients with schizophrenia. The aim of this study is to evaluate the therapeutic effects of acupuncture on antipsychotic medication-related side effects and psychiatric symptoms in patients with schizophrenia. Read more about this study
- Who is it for?
- Ages 20 to 65 years
- Conditions the study is for
- Mental Health
- What is being tested?
- Acupuncture
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 siteTaiwan
- Study dates
- 16 Dec 2025to 30 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Diagnosis of schizophrenia according to DSM-5 criteria for at least six months
- Personal and Social Performance Scale score ≥ 50
Who cannot join
- Severe medical illnesses (e.g., cancer, chronic liver disease, renal failure)
- History of stroke or other causes of hemiplegia
- Severe dermatological disease or limb edema
- High risk of violence or suicide
- Alcohol or substance abuse or dependence
- Severe cognitive impairment
Show all 10Show fewer
- Pregnancy or breastfeeding
- Severe hepatic, renal, cardiac, pulmonary, or hematological disease
- Major infectious diseases (e.g., HIV infection)
- Refusal to provide informed consent
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Quality of Life of Acupuncture Treatment Effect in Patients With Schizophrenia
Among various psychiatric disorders, this study focuses specifically on patients with schizophrenia. The aim of this study is to evaluate the therapeutic effects of acupuncture on antipsychotic medication-related side effects and psychiatric symptoms in patients with schizophrenia. This is a single-blind randomized study. Participants will be randomly assigned to one of two groups: Neiguan and Shenmen. Both the Neiguan and Shenmen groups will receive acupuncture treatment twice weekly, with each session lasting 30 minutes, for a total of four consecutive weeks. Assessments will be conducted prior to acupuncture intervention and after each acupuncture session. All assessment data will be collected and analyzed using statistical methods including descriptive statistics, chi-square tests, and t-tests. Generalized Estimating Equations (GEE-I) and multiple linear regression analyses will be applied to examine differences in psychological health, quality of life, and happiness before and after acupuncture intervention. It is anticipated that acupuncture will reduce antipsychotic-related side effects, improve psychiatric symptoms in patients with schizophrenia, and subsequently enhance patients' quality of life and happiness.
- Conditions
- Mental Health
- Being tested
- Acupuncture
- Keywords
- schizophrenia patients, acupuncture, antipsychotic side effects, psychiatric symptoms
- Medical subject headings
- Psychological Well-Being
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AcupunctureOther
Both the Neiguan and Shenmen groups will receive acupuncture treatment twice weekly, with each session lasting 30 minutes, for a total of four consecutive weeks. Assessments will be conducted prior to acupuncture intervention and after each acupuncture session.
| Study group | Role | What they receive |
|---|---|---|
| The Effects of Acupuncture on quality of life in schizophrenia | Experimental | It is anticipated that acupuncture will reduce antipsychotic-related side effects, improve psychiatric symptoms in patients with schizophrenia, and subsequently enhance patients' quality of life and happiness. Receives: Other: Acupuncture |
What is being measured
The primary outcome is the main question the study is designed to answer.
Hamilton Anxiety Scale
assess the anxiety state
Measured: 15 minutes
Hamilton Depression Scale
assess the depression state
Measured: 15-20 minutes
Short Version of the Udvalg for Kliniske Undersøgelser Side Effect Rating Scale
assess the psychiatric symptoms
Measured: 5-10 minutes
Secondary outcomes (1)
Happiness Scale
assess the happiness state
Measured: 5 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Jan 2026
- Study start16 Dec 2025
- Primary completion31 Jul 2026
- Study completion30 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Mental HealthStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Calo Psychiatric Center
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07351240
- Sponsor's protocol ID
- 114-051
- Status last verified
- Jan 2026
- First submitted
- 12 Jan 2026
- Last updated
- 3 Nov 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Quality of Life of Acupuncture Treatment Effect in Patients With Schizophrenia
- ClinicalTrials.gov ID
- NCT07351240
- Acronym / sponsor ID
- 114-051
- Conditions
- Mental Health
- Keywords
- schizophrenia patients, acupuncture, antipsychotic side effects, psychiatric symptoms
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Calo Psychiatric CenterUniversity, hospital or other
- Study start
- 16 Dec 2025 (actual)
- Primary completion
- 31 Jul 2026 (actual)
- Study completion
- 30 Dec 2026 (estimated)
- First posted
- 20 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Among various psychiatric disorders, this study focuses specifically on patients with schizophrenia. The aim of this study is to evaluate the therapeutic effects of acupuncture on antipsychotic medication-related side effects and psychiatric symptoms in patients with schizophrenia. This is a single-blind randomized study. Participants will be randomly assigned to one of two groups: Neiguan and Shenmen. Both the Neiguan and Shenmen groups will receive acupuncture treatment twice weekly, with each session lasting 30 minutes, for a total of four consecutive weeks. Assessments will be conducted prior to acupuncture intervention and after each acupuncture session. All assessment data will be collected and analyzed using statistical methods including descriptive statistics, chi-square tests, and t-tests. Generalized Estimating Equations (GEE-I) and multiple linear regression analyses will be applied to examine differences in psychological health, quality of life, and happiness before and after acupuncture intervention. It is anticipated that acupuncture will reduce antipsychotic-related side effects, improve psychiatric symptoms in patients with schizophrenia, and subsequently enhance patients' quality of life and happiness.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| The Effects of Acupuncture on quality of life in schizophrenia | Experimental | Other: AcupunctureIt is anticipated that acupuncture will reduce antipsychotic-related side effects, improve psychiatric symptoms in patients with schizophrenia, and subsequently enhance patients' quality of life and happiness. |
Who may qualify
- Ages
- 20 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Diagnosis of schizophrenia according to DSM-5 criteria for at least six months
- Personal and Social Performance Scale score ≥ 50
Key exclusion criteria (10 listed)
- Severe medical illnesses (e.g., cancer, chronic liver disease, renal failure)
- History of stroke or other causes of hemiplegia
- Severe dermatological disease or limb edema
- High risk of violence or suicide
- Alcohol or substance abuse or dependence
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AcupunctureBoth the Neiguan and Shenmen groups will receive acupuncture treatment twice weekly, with each session lasting 30 minutes, for a total of four consecutive weeks. Assessments will be conducted prior to acupuncture intervention and after each acupuncture session. | Other | The Effects of Acupuncture on quality of life in schizophrenia |
Primary outcome
Hamilton Anxiety Scale
Time frame: 15 minutes
assess the anxiety state
Hamilton Depression Scale
Time frame: 15-20 minutes
assess the depression state
Short Version of the Udvalg for Kliniske Undersøgelser Side Effect Rating Scale
Time frame: 5-10 minutes
assess the psychiatric symptoms
1 secondary outcome
Happiness Scale
Time frame: 5 minutes
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Nov 2026.
- Individual participant dataSharing planned: No
Related trials for Mental Health
Not yet recruiting
Effect of Stress Ball Use During Femoral Arterial Sheath Removal After Coronary Angiography
Femoral Arterial Sheath Removal, Stress Ball
Not yet recruiting
Preventive and Personalized Digital Emotion Regulation Skills Intervention to Reduce Depression and Anxiety in Youths With Adverse Childhood Experiences
Adverse Childhood Experience, Depression / Major Depressive Disorder
Recruiting
Effect of a Brief Daily Digital Meditation on Well-Being in US Young Adults (BEGIN II)
Mental Health and General Well-being
Recruiting
NightWare and Cardiovascular Health in Women With PTSD
Post Traumatic Stress Disorder, Cardiovascular Diseases
Active, not recruiting
Intervention to Address Disparate Mental Health Consequences of COVID-19 Pandemic on Latinx and African Newcomers
Mental Health Issue, Mental Health Disorder
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Acupuncture in people with Mental Health, run by Calo Psychiatric Center at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 3 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Hamilton Anxiety Scale (time frame: 15 minutes). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Nov 2026.