Third Molar ImpactionNCT07351279
The Effect of Platelet Rich Fibrin On Sensitivity and Periodontal Pockets Distal to Second Molar After Surgical Extraction of Impacted Third Molar
A study testing Platelet rich fibrin in people with Third Molar Impaction and Surgical Extraction of Impacted Third Molars, run by University of Health Sciences Lahore at 1 site in Pakistan.
Trial summary
Surgical extraction of impacted third molar is the most common surgical procedure performed in oral and maxillofacial surgery. The immediate post operative complications after 3rd molar surgery are pain, swelling and trismus while delayed post operative complications are mostly seen on the distal surface of second… Read more about this study
- Who is it for?
- Ages 18 to 40 years
- Conditions the study is for
- Third Molar Impaction, Surgical Extraction of Impacted Third Molars
- What is being tested?
- Platelet rich fibrin
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 56 participants
- Where
- 1 sitePakistan
- Study dates
- Feb 2026to Feb 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Impacted third molar (as per Operational Definition) with fully erupted second molars bilaterally.
- Impacted Third molar with Class 2 and Level B according to Pell and Gregory's classification (Annexure B) with mesioangular or horizontal angulation of impaction
- Periodontal pocket depth > 4mm and Clinical attachment loss > 1mm at distal side of second molar
- Age 18-40 years, both genders.
- Patients who give informed consent.
Who cannot join
- Any Systemic Disease i.e. Uncontrolled Diabetes mellitus, Uncontrolled hypertension, Ischemic heart disease, bleeding disorders, Autoimmune diseases or immunocompromised patients
- Decayed or recommended for extraction second molars on either side.
- Allergic to Amoxicillin to standardize Antibiotic therapy protocol.
- Untreated periodontal condition.
- Inability to follow up.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site
Allama Iqbal Medical College/ Jinnah Hospital
Lahore, Punjab Province, 54000
Allama Iqbal Medical College (AIMC), +92-42-99231480 ext. +92-42-9923144, Info@aimc.edu.pk
About this study
Official title: " The Effect of Platelet Rich Fibrin On Sensitivity and Periodontal Pockets Distal to Second Molar After Surgical Extraction of Impacted Third Molar "
Surgical extraction of impacted third molar is the most common surgical procedure performed in oral and maxillofacial surgery. The immediate post operative complications after 3rd molar surgery are pain, swelling and trismus while delayed post operative complications are mostly seen on the distal surface of second molar due to distal bone loss which include prolonged sensitivity due to increased periodontal pocket depth, gingival recession and root exposure.
When PRF clot is given in wound, it causes alterations of the cellular ratios in the wound blood clot, leading to replacement of blood cells with Platelets and growth factors stimulating all phases of healing which will improve the immidiate and delayed post operative complications The purpose of present study is to compare the clinical outcomes in the treatment of senstivity and periodontal pockets at the distal aspect of second molar following surgical extraction of impacted third molar using PRF or Blood clot alone.
Read the detailed description
Impacted third molars distal to second molar are the cause of distal attachment loss leading to degradation of the interdental bone. This causes formation of periodontal pocket which leads to pericoronitis and further infection. If there is minimum or no distance between second and third molar, the loss of interdental bone leads to periodonto-pathogenic bacterial aggression. Partially impacted third molars are the active source of bacterial entry into the distal area of the second molar because of food retention and poor oral hygiene.
PRF is the second generation autologous platelet concentrate that is obtained from patient's own blood in simple and cost effective manner. PRF contains platelets, cytokines, leucocytes and circulating stem cells that are embedded in a heterogeneous fibrin matrix. These unique elements in PRF make it a good biomaterial that improves healing. The slow release of cytokines-vascular endothelial growth factor, transforming growth factor, Epidermal growth factor and platelet-derived growth factor-are the main components which play an important role in neo-angiogenesis and tissue repair which makes this particular material useful.
Platelet-Rich Fibrin (PRF), has potential to enhance soft and hard tissue healing However, the evidence surrounding its effectiveness in reduction of sensitivity and periodontal pockets remains inconclusive. Previous studies evaluating the use of PRF have reported contradictory results. While some have demonstrated a significant reduction in periodontal pocket depth and improved healing when PRF is applied to the extraction socket, others have found little to no difference when compared to surgical extraction without PRF placement. This inconsistency highlights the need for further investigation to clarify PRF's role in postoperative outcomes, particularly in relation to periodontal health distal to the second molar. In addition, many of the available studies on PRF in third molar extraction are limited by small sample sizes which reduces the statistical power and generalizability of their findings. Contradiction in their results are most probably due to small sample size Therefore study with larger sample size is required to validate previous results and offer more conclusive evidence Furthermore, there is a notable lack of research focusing on postoperative tooth sensitivity, which is a common patient complaint following third molar extraction. Existing literature has predominantly emphasized parameters such as pain, swelling, and periodontal pocket depth, while the effect of PRF on sensitivity remains largely unexplored. This represents a significant gap in research and patient-centered outcomes.
By assessing periodontal pocket depth, clinical attachment loss and sensitivity distal to the second molar with larger sample size, this study aims to offer a more integrated evaluation of PRF's effectiveness in third molar surgery
- Being tested
- Platelet rich fibrin
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Platelet rich fibrinOther
Also called PRF
After surgical extraction of impacted mandibular 3rd molar PRF will be placed in extraction socket
| Study group | Role | What they receive |
|---|---|---|
| Case Group | Experimental | PRF placement in extraction socket Receives: Other: Platelet rich fibrin |
| Control Group | No intervention | Surgical extraction without using PRF |
What is being measured
The primary outcome is the main question the study is designed to answer.
Periodontal Pocket Depth
Periodontal pocket depth will be measured as a distance between gingival margin and base of the periodontal pocket in millimeters by Williams periodontal probe .
Measured: From Enrollment to end of treatment at 03 months
Senstivity
Response of patient elicited by painful stimulus i.e Tactile stimulus which is characteristically of short duration will be measured by Tactile method i.e. scratching the distal surface of second molar at cemento-enamel junction with dental explorer on Numeric scale with values from 0 to 10, 0 being the least/no sensitivity and 10 being the worst
Measured: from Enrollment to end of treatment at 03 months
Clinical attachment loss
Clinical attachment loss will be measured as a distance between cemento-enamel junction of second molar to the base of periodontal pocket in millimeters by williams periodontal probe
Measured: From Enrollment to end of treatment at 03 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Jan 2026
- Study startFeb 2026 (estimated)
- Primary completionJul 2027 (estimated)
- Study completionFeb 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (11)Papers the sponsor has linked to this study.
- Other trials for Third Molar ImpactionStudies of the same condition, open and under way.
- More trials run by University of Health Sciences LahoreThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Split mouth randomized, Controlled clinical trial
- Masking
- None (open label)
- Enrolment
- 56 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Health Sciences Lahore
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Muhammad Umar Hayat, University of Health Sciences Lahore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07351279
- Sponsor's protocol ID
- ERB167/2/02-07-2024/S1 ERB
- Status last verified
- Jan 2026
- First submitted
- 11 Jan 2026
- Last updated
- 20 Jan 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Tadić, A., Bajkin, B., Mijatov, I., Mirnić, J., Vukoje, K., Sokač, M. And Vukelić, D., 2023. Influence of L-PRF topical application on bone tissue healing after surgical extraction of impacted mandibular third molars: A randomized split-mouth clinical study. Applied Sciences, 13, 4823.
Sybil D, Sawai M, Faisal M, Singh S, Jain V. Platelet-Rich Fibrin for Hard- and Soft-Tissue Healing in Mandibular Third Molar Extraction Socket. Ann Maxillofac Surg. 2020 Jan-Jun;10(1):102-107. doi: 10.4103/ams.ams_228_19. Epub 2020 Jun 8.
PubMed 32855924Swetha Bhat, B., Periasamy, S. And Arun, M., 2021. Incidence of residual periodontal defects distal to second molar due to a mesioangular mandibular impacted third molar. International Journal of Dentistry and Oral Science, 8(7), pp. 3119-3123.
Roy, I.D., Saxena, V., Babu, B.K.N. and Perumal, S.J., 2021. Efficacy of platelet-rich fibrin on pain, edema, and healing in mandibular third molar surgery: A split-mouth randomized study. Journal of Dental Defence Section, 15, pp. 21-30.
Rocha MOC, Cruz AACF, Santos DO, Douglas-DE-Oliveira DW, Flecha OD, Goncalves PF. Sensitivity and specificity of assessment scales of dentin hypersensitivity - an accuracy study. Braz Oral Res. 2020 May 8;34:e043. doi: 10.1590/1807-3107bor-2020.vol34.0043.
PubMed 32401933Malhotra A, Kapur I, Das D, Sharma A, Gupta M, Kumar M. Comparative evaluation of bone regeneration with platelet-rich fibrin in mandibular third molar extraction socket: A randomized split-mouth study. Natl J Maxillofac Surg. 2020 Jul-Dec;11(2):241-247. doi: 10.4103/njms.NJMS_50_19. Epub 2020 Dec 16.
PubMed 33897188Lam, C.P., Nguyen, T.B.N. and Nguyen, T.B.L., 2023. Effect of platelet-rich fibrin on soft tissue, periodontal pocket healing, and alveolar bone height after third molar surgery: A randomized clinical trial. Scholars Journal of Dental Sciences, 10(7), pp. 121-127.
Gasparro R, Sammartino G, Mariniello M, di Lauro AE, Spagnuolo G, Marenzi G. Treatment of periodontal pockets at the distal aspect of mandibular second molar after surgical removal of impacted third molar and application of L-PRF: a split-mouth randomized clinical trial. Quintessence Int. 2020;51(3):204-211. doi: 10.3290/j.qi.a43947.
PubMed 32020130Castro AB, Meschi N, Temmerman A, Pinto N, Lambrechts P, Teughels W, Quirynen M. Regenerative potential of leucocyte- and platelet-rich fibrin. Part A: intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysis. J Clin Periodontol. 2017 Jan;44(1):67-82. doi: 10.1111/jcpe.12643. Epub 2016 Nov 24.
PubMed 27783851Bhujbal, R., Veerabhadrappa, S.K., Yadav, S., Chappi, M. And Patil, V., 2020. Evaluation of platelet-rich fibrin and platelet-rich plasma in impacted mandibular third molar extraction socket healing and bone regeneration: A split-mouth comparative study. European Journal of General Dentistry, 9, pp. 96-102.
Abad CE, Sanz-Sanchez I, Serrano V, Sanz Esporrin J, Sanz-Martin I, Sanz M. Efficacy of the application of leukocyte and platelet-rich fibrin (L-PRF) on alveolar ridge preservation. A randomized controlled clinical trial. Clin Implant Dent Relat Res. 2023 Jun;25(3):592-604. doi: 10.1111/cid.13208. Epub 2023 Apr 23.
PubMed 37088697
Study at a glance
From the registry record, last updated by the sponsor on 20 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- " The Effect of Platelet Rich Fibrin On Sensitivity and Periodontal Pockets Distal to Second Molar After Surgical Extraction of Impacted Third Molar "
- ClinicalTrials.gov ID
- NCT07351279
- Acronym / sponsor ID
- ERB167/2/02-07-2024/S1 ERB
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 56 participants (estimated)
- Lead sponsor
- University of Health Sciences LahoreUniversity, hospital or other
- Study start
- Feb 2026 (estimated)
- Primary completion
- Jul 2027 (estimated)
- Study completion
- Feb 2028 (estimated)
- First posted
- 20 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Surgical extraction of impacted third molar is the most common surgical procedure performed in oral and maxillofacial surgery. The immediate post operative complications after 3rd molar surgery are pain, swelling and trismus while delayed post operative complications are mostly seen on the distal surface of second molar due to distal bone loss which include prolonged sensitivity due to increased periodontal pocket depth, gingival recession and root exposure.
When PRF clot is given in wound, it causes alterations of the cellular ratios in the wound blood clot, leading to replacement of blood cells with Platelets and growth factors stimulating all phases of healing which will improve the immidiate and delayed post operative complications The purpose of present study is to compare the clinical outcomes in the treatment of senstivity and periodontal pockets at the distal aspect of second molar following surgical extraction of impacted third molar using PRF or Blood clot alone.
Detailed description
Impacted third molars distal to second molar are the cause of distal attachment loss leading to degradation of the interdental bone. This causes formation of periodontal pocket which leads to pericoronitis and further infection. If there is minimum or no distance between second and third molar, the loss of interdental bone leads to periodonto-pathogenic bacterial aggression. Partially impacted third molars are the active source of bacterial entry into the distal area of the second molar because of food retention and poor oral hygiene.
PRF is the second generation autologous platelet concentrate that is obtained from patient's own blood in simple and cost effective manner. PRF contains platelets, cytokines, leucocytes and circulating stem cells that are embedded in a heterogeneous fibrin matrix. These unique elements in PRF make it a good biomaterial that improves healing. The slow release of cytokines-vascular endothelial growth factor, transforming growth factor, Epidermal growth factor and platelet-derived growth factor-are the main components which play an important role in neo-angiogenesis and tissue repair which makes this particular material useful.
Platelet-Rich Fibrin (PRF), has potential to enhance soft and hard tissue healing However, the evidence surrounding its effectiveness in reduction of sensitivity and periodontal pockets remains inconclusive. Previous studies evaluating the use of PRF have reported contradictory results. While some have demonstrated a significant reduction in periodontal pocket depth and improved healing when PRF is applied to the extraction socket, others have found little to no difference when compared to surgical extraction without PRF placement. This inconsistency highlights the need for further investigation to clarify PRF's role in postoperative outcomes, particularly in relation to periodontal health distal to the second molar. In addition, many of the available studies on PRF in third molar extraction are limited by small sample sizes which reduces the statistical power and generalizability of their findings. Contradiction in their results are most probably due to small sample size Therefore study with larger sample size is required to validate previous results and offer more conclusive evidence Furthermore, there is a notable lack of research focusing on postoperative tooth sensitivity, which is a common patient complaint following third molar extraction. Existing literature has predominantly emphasized parameters such as pain, swelling, and periodontal pocket depth, while the effect of PRF on sensitivity remains largely unexplored. This represents a significant gap in research and patient-centered outcomes.
By assessing periodontal pocket depth, clinical attachment loss and sensitivity distal to the second molar with larger sample size, this study aims to offer a more integrated evaluation of PRF's effectiveness in third molar surgery
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Split mouth randomized, Controlled clinical trial
| Arm | Type | Receives |
|---|---|---|
| Case Group | Experimental | Other: Platelet rich fibrinPRF placement in extraction socket |
| Control Group | No intervention | –Surgical extraction without using PRF |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Impacted third molar (as per Operational Definition) with fully erupted second molars bilaterally.
- Impacted Third molar with Class 2 and Level B according to Pell and Gregory's classification (Annexure B) with mesioangular or horizontal angulation of impaction
- Periodontal pocket depth > 4mm and Clinical attachment loss > 1mm at distal side of second molar
- Age 18-40 years, both genders.
- Patients who give informed consent.
Key exclusion criteria (5 listed)
- Any Systemic Disease i.e. Uncontrolled Diabetes mellitus, Uncontrolled hypertension, Ischemic heart disease, bleeding disorders, Autoimmune diseases or immunocompromised patients
- Decayed or recommended for extraction second molars on either side.
- Allergic to Amoxicillin to standardize Antibiotic therapy protocol.
- Untreated periodontal condition.
- Inability to follow up.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Platelet rich fibrinAlso: PRFAfter surgical extraction of impacted mandibular 3rd molar PRF will be placed in extraction socket | Other | Case Group |
Primary outcome
Periodontal Pocket Depth
Time frame: From Enrollment to end of treatment at 03 months
Periodontal pocket depth will be measured as a distance between gingival margin and base of the periodontal pocket in millimeters by Williams periodontal probe .
Senstivity
Time frame: from Enrollment to end of treatment at 03 months
Response of patient elicited by painful stimulus i.e Tactile stimulus which is characteristically of short duration will be measured by Tactile method i.e. scratching the distal surface of second molar at cemento-enamel junction with dental explorer on Numeric scale with values from 0 to 10, 0 being the least/no sensitivity and 10 being the worst
Clinical attachment loss
Time frame: From Enrollment to end of treatment at 03 months
Clinical attachment loss will be measured as a distance between cemento-enamel junction of second molar to the base of periodontal pocket in millimeters by williams periodontal probe
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Jan 2026.
- BackgroundTadić, A., Bajkin, B., Mijatov, I., Mirnić, J., Vukoje, K., Sokač, M. And Vukelić, D., 2023. Influence of L-PRF topical application on bone tissue healing after surgical extraction of impacted mandibular third molars: A randomized split-mouth clinical study. Applied Sciences, 13, 4823.
- Background: PubMed 32855924Sybil D, Sawai M, Faisal M, Singh S, Jain V. Platelet-Rich Fibrin for Hard- and Soft-Tissue Healing in Mandibular Third Molar Extraction Socket. Ann Maxillofac Surg. 2020 Jan-Jun;10(1):102-107. doi: 10.4103/ams.ams_228_19. Epub 2020 Jun 8.
- BackgroundSwetha Bhat, B., Periasamy, S. And Arun, M., 2021. Incidence of residual periodontal defects distal to second molar due to a mesioangular mandibular impacted third molar. International Journal of Dentistry and Oral Science, 8(7), pp. 3119-3123.
- BackgroundRoy, I.D., Saxena, V., Babu, B.K.N. and Perumal, S.J., 2021. Efficacy of platelet-rich fibrin on pain, edema, and healing in mandibular third molar surgery: A split-mouth randomized study. Journal of Dental Defence Section, 15, pp. 21-30.
- Background: PubMed 32401933Rocha MOC, Cruz AACF, Santos DO, Douglas-DE-Oliveira DW, Flecha OD, Goncalves PF. Sensitivity and specificity of assessment scales of dentin hypersensitivity - an accuracy study. Braz Oral Res. 2020 May 8;34:e043. doi: 10.1590/1807-3107bor-2020.vol34.0043.
- Background: PubMed 33897188Malhotra A, Kapur I, Das D, Sharma A, Gupta M, Kumar M. Comparative evaluation of bone regeneration with platelet-rich fibrin in mandibular third molar extraction socket: A randomized split-mouth study. Natl J Maxillofac Surg. 2020 Jul-Dec;11(2):241-247. doi: 10.4103/njms.NJMS_50_19. Epub 2020 Dec 16.
- BackgroundLam, C.P., Nguyen, T.B.N. and Nguyen, T.B.L., 2023. Effect of platelet-rich fibrin on soft tissue, periodontal pocket healing, and alveolar bone height after third molar surgery: A randomized clinical trial. Scholars Journal of Dental Sciences, 10(7), pp. 121-127.
- Background: PubMed 32020130Gasparro R, Sammartino G, Mariniello M, di Lauro AE, Spagnuolo G, Marenzi G. Treatment of periodontal pockets at the distal aspect of mandibular second molar after surgical removal of impacted third molar and application of L-PRF: a split-mouth randomized clinical trial. Quintessence Int. 2020;51(3):204-211. doi: 10.3290/j.qi.a43947.
- Background: PubMed 27783851Castro AB, Meschi N, Temmerman A, Pinto N, Lambrechts P, Teughels W, Quirynen M. Regenerative potential of leucocyte- and platelet-rich fibrin. Part A: intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysis. J Clin Periodontol. 2017 Jan;44(1):67-82. doi: 10.1111/jcpe.12643. Epub 2016 Nov 24.
- BackgroundBhujbal, R., Veerabhadrappa, S.K., Yadav, S., Chappi, M. And Patil, V., 2020. Evaluation of platelet-rich fibrin and platelet-rich plasma in impacted mandibular third molar extraction socket healing and bone regeneration: A split-mouth comparative study. European Journal of General Dentistry, 9, pp. 96-102.
- Background: PubMed 37088697Abad CE, Sanz-Sanchez I, Serrano V, Sanz Esporrin J, Sanz-Martin I, Sanz M. Efficacy of the application of leukocyte and platelet-rich fibrin (L-PRF) on alveolar ridge preservation. A randomized controlled clinical trial. Clin Implant Dent Relat Res. 2023 Jun;25(3):592-604. doi: 10.1111/cid.13208. Epub 2023 Apr 23.
Related trials for Third Molar Impaction
RecruitingObservational study
Oral Specimen and Data Acquisition Study of Subjects Requiring Third Molar Removal
Stomatognatic, Tooth Diseases
Active, not recruiting
Clinical and Radiographic Evaluation of Local Application of Melatonin on Postoperative Outcomes After Surgical Removal of Impacted Mandibular Third Molar
Impact Molar
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Platelet rich fibrin in people with Third Molar Impaction and Surgical Extraction of Impacted Third Molars, run by University of Health Sciences Lahore at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 20 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact MHayat (+923420690087, uhayat722@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Periodontal Pocket Depth (time frame: From Enrollment to end of treatment at 03 months). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07351279, which also lists 11 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Jan 2026.