HPV Vaccination RatesNCT07351604
Effectiveness of Large Language Model-Based Chatbot Among Female University Stdents in Improving HPV Vaccine Awareness, Intention and Vaccination Rates
A study testing Scientific videos and Vaccine chatbot in people with HPV Vaccination Rates and HPV Vaccine Awareness, run by Xiamen University.
Trial summary
This is an interventional study targeting female university students. The primary objective of the study is to evaluate the effectiveness of a vaccine chatbot in improving HPV vaccination rates. The secondary objectives are to evaluate the effectiveness in improving vaccine awareness and vaccination intention. Read more about this study
- Who is it for?
- Ages 15 years and olderHealthy volunteers can take part
- Conditions the study is for
- HPV Vaccination Rates, HPV Vaccine Awareness, HPV Vaccination Intention
- What is being tested?
- Scientific videos and Vaccine chatbot
- Type of treatment
- Vaccines, Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 18,000 participants
- Where
- No sites listed yet
- Study dates
- 1 Apr 2026to 31 Dec 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 15 years and older
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- Female university students.
- Possess an electronic device with QR code scanning capability.
- Female university students have no contraindications to HPV vaccination.
- No mental disorders or visual/reading impairments; able to cooperate with and implement the corresponding intervention activities.
- Have provided informed consent and are willing to participate in the study.
Who cannot join
- -
About this study
Official title: A Study on the Effectiveness of Large Language Model-Based Chatbot Interventions Among Female University Stdents in Improving HPV Vaccine Awareness, Intention and Vaccination Rates
This is an interventional study targeting female university students. The primary objective of the study is to evaluate the effectiveness of a vaccine chatbot in improving HPV vaccination rates. The secondary objectives are to evaluate the effectiveness in improving vaccine awareness and vaccination intention. All participants will be enrolled and randomly assigned to four groups: (1) vaccine chatbot plus scientific videos, (2) vaccine chatbot only, (3) scientific videos only, and (4) a control group (no intervention). The chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions. The scientific videos will cover content related to HPV vaccine safety, efficacy, and other relevant information. The study will compare changes in HPV vaccine awareness, vaccination intention, and vaccination behavior between the intervention groups and the control group after the intervention to evaluate whether the three intervention strategies enhance HPV vaccine awareness, vaccination intention, and vaccination uptake.
- Being tested
- Scientific videos, Vaccine chatbot
- Keywords
- HPV vaccine, chatbot, Large language model, AI, HPV vaccination
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Scientific videosDevice
Provide scientific videos related to HPV vaccine
Vaccine chatbotDevice
Provide vaccine chatbot to answer HPV vaccine questions
| Study group | Role | What they receive |
|---|---|---|
| Vaccine chatbot + Watching scientific videos group | Experimental | The chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions. Scientific videos cover content related to HPV vaccine safety, efficacy, and other relevant information. Receives: Device: Scientific videos; Device: Vaccine chatbot |
| Watching scientific videos group | Experimental | Scientific videos cover content related to HPV vaccine safety, efficacy, and other relevant information. Receives: Device: Scientific videos |
| Vaccine chatbot group | Experimental | The chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions. Receives: Device: Vaccine chatbot |
| Control group | No intervention | No intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
HPV vaccination rates for female university students in all groups before and after the intervention
Whether female university students get vaccinated against HPV or have an appointment for vaccination, measured by self-report and validated by vaccination information system
Measured: Baseline and two months
Secondary outcomes (2)
HPV vaccine awareness for eligible female university students in all groups before and after the intervention
A questionnaire consisting of 11 questions related to HPV vaccines will be used to investigate the awareness of HPV vaccines.Total knowledge score is calculated based on the number of questions answered correctly by the participants and the higher scores mean a better outcome.
Measured: Baseline and two weeks
HPV vaccination intention for eligible female university students in all groups before and after the intervention
Female university students' willingness to vaccinate themselves, measured using a five-point Likert scale from "not willing at all" to "strongly willing"
Measured: Baseline and two weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Jan 2026
- Study start1 Apr 2026 (estimated)
- Primary completion31 Dec 2027 (estimated)
- Study completion31 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HPV Vaccination RatesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 18,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Xiamen University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jun Zhang, Xiamen University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07351604
- Sponsor's protocol ID
- HPV-AI-001
- Status last verified
- Mar 2026
- First submitted
- 25 Dec 2025
- Last updated
- 31 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 31 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Study on the Effectiveness of Large Language Model-Based Chatbot Interventions Among Female University Stdents in Improving HPV Vaccine Awareness, Intention and Vaccination Rates
- ClinicalTrials.gov ID
- NCT07351604
- Acronym / sponsor ID
- HPV-AI-001
- Keywords
- HPV vaccine, chatbot, Large language model, AI, HPV vaccination
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 18,000 participants (estimated)
- Lead sponsor
- Xiamen UniversityUniversity, hospital or other
- Study start
- 1 Apr 2026 (estimated)
- Primary completion
- 31 Dec 2027 (estimated)
- Study completion
- 31 Dec 2027 (estimated)
- First posted
- 20 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is an interventional study targeting female university students. The primary objective of the study is to evaluate the effectiveness of a vaccine chatbot in improving HPV vaccination rates. The secondary objectives are to evaluate the effectiveness in improving vaccine awareness and vaccination intention. All participants will be enrolled and randomly assigned to four groups: (1) vaccine chatbot plus scientific videos, (2) vaccine chatbot only, (3) scientific videos only, and (4) a control group (no intervention). The chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions. The scientific videos will cover content related to HPV vaccine safety, efficacy, and other relevant information. The study will compare changes in HPV vaccine awareness, vaccination intention, and vaccination behavior between the intervention groups and the control group after the intervention to evaluate whether the three intervention strategies enhance HPV vaccine awareness, vaccination intention, and vaccination uptake.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Vaccine chatbot + Watching scientific videos group | Experimental | Device: Scientific videos, Device: Vaccine chatbotThe chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions. Scientific videos cover content related to HPV vaccine safety, efficacy, and other relevant information. |
| Watching scientific videos group | Experimental | Device: Scientific videosScientific videos cover content related to HPV vaccine safety, efficacy, and other relevant information. |
| Vaccine chatbot group | Experimental | Device: Vaccine chatbotThe chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions. |
| Control group | No intervention | –No intervention |
Who may qualify
- Ages
- 15 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (5 listed)
- Female university students.
- Possess an electronic device with QR code scanning capability.
- Female university students have no contraindications to HPV vaccination.
- No mental disorders or visual/reading impairments; able to cooperate with and implement the corresponding intervention activities.
- Have provided informed consent and are willing to participate in the study.
Key exclusion criteria (1 listed)
- -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Scientific videosProvide scientific videos related to HPV vaccine | Device | Vaccine chatbot + Watching scientific videos group, Watching scientific videos group |
| Vaccine chatbotProvide vaccine chatbot to answer HPV vaccine questions | Device | Vaccine chatbot + Watching scientific videos group, Vaccine chatbot group |
Primary outcome
HPV vaccination rates for female university students in all groups before and after the intervention
Time frame: Baseline and two months
Whether female university students get vaccinated against HPV or have an appointment for vaccination, measured by self-report and validated by vaccination information system
2 secondary outcomes
HPV vaccine awareness for eligible female university students in all groups before and after the intervention
Time frame: Baseline and two weeks
HPV vaccination intention for eligible female university students in all groups before and after the intervention
Time frame: Baseline and two weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Mar 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A study testing Scientific videos and Vaccine chatbot in people with HPV Vaccination Rates and HPV Vaccine Awareness, run by Xiamen University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 31 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
HPV vaccination rates for female university students in all groups before and after the intervention (time frame: Baseline and two months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Mar 2026; AzTrials last refreshed its copy on 6 Nov 2026.