Muscle DamageNCT07356193
Serum CPK and Creatinine Changes During Plyometric Training in Collegiate Athletes
A study testing Lower Body Plyometric Training in people with Muscle Damage and Plyometric Exercises, run by Batterjee Medical College at 1 site in Saudi Arabia.
Trial summary
This retrospective study evaluated the effects of an eight-week lower body plyometric training program on serum creatine phosphokinase (CPK) and creatinine levels in male collegiate volleyball players. Sixty two players were divided into experimental and control groups. Read more about this study
- Who is it for?
- Ages 18 to 20 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Muscle Damage, Plyometric Exercises, Creatine Kinase
- What is being tested?
- Lower Body Plyometric Training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 62 participants
- Where
- 1 siteSaudi Arabia
- Study dates
- 13 Feb 2022to 28 Dec 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 20 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- male collegiate volleyball players
- Age: 18-20 years
- No prior plyometric training
Who cannot join
- History of kidney disease
- Current musculoskeletal injury
- neuromuscular impairments
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Lower Body Plyometric Training on Serum Creatine Phosphokinase and Creatinine Levels in Male Collegiate Volleyball Players
This retrospective study evaluated the effects of an eight-week lower body plyometric training program on serum creatine phosphokinase (CPK) and creatinine levels in male collegiate volleyball players. Sixty two players were divided into experimental and control groups. CPK and creatinine were measured at baseline and multiple time points during training. The study assessed whether plyometric training produced harmful biochemical changes or signs of rhabdomyolysis.
Read the detailed description
This study evaluated the physiological effects and safety of an eight-week lower body plyometric training program in male collegiate volleyball players, focusing on changes in serum creatine phosphokinase (CPK) and creatinine levels. Sixty two healthy athletes were randomly assigned to either a plyometric training group or a control group. The experimental group performed progressive lower body plyometric exercises twice weekly for eight weeks, while the control group continued regular volleyball training.
Serum CPK and creatinine were assessed at baseline and multiple time points throughout the intervention. CPK levels in the training group increased significantly early in the program, peaking on Day 4 and remaining elevated until Week 2, before returning to baseline by Week 8. Importantly, all values remained within normal clinical ranges, and no signs of rhabdomyolysis or overtraining were observed. Serum creatinine levels showed no significant changes, indicating preserved renal function. No biomarker changes were detected in the control group.
These findings indicate that an eight-week, progressively designed plyometric training program is safe and well tolerated in male collegiate volleyball players.
- Being tested
- Lower Body Plyometric Training, control group
- Keywords
- Plyometric Training, Volleyball Players, Creatine Phosphokinase, Serum Creatinine
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Lower Body Plyometric TrainingBehavioural
Training twice weekly for eight weeks, including low-, moderate-, and high-intensity plyometric exercises (squat jumps, box jumps, tuck jumps, split squat jumps, lateral hurdle jumps, zigzag jumps, single-leg tuck jumps, and depth jumps).
control groupOther
Routine volleyball training only; no plyometric exercises.
| Study group | Role | What they receive |
|---|---|---|
| Lower Body Plyometric Training | Experimental | Not described Receives: Behavioral: Lower Body Plyometric Training; Other: control group |
| Control Group | Active comparator | Not described Receives: Other: control group |
What is being measured
The primary outcome is the main question the study is designed to answer.
Serum Creatine Phosphokinase (CPK) Levels
Change in serum CPK measured using the CK-NAC optimized IFCC method.
Measured: Baseline; Day 2; Day 4; Week 1; Week 2; Week 4; Week 6; Week 8
Secondary outcomes (1)
Serum Creatinine Levels
Measured using modified Jaffe's method.
Measured: Baseline; Day 2; Day 4; Week 1; Week 2; Week 4; Week 6; Week 8
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Jan 2026
- Study start13 Feb 2022
- Primary completion10 Aug 2022
- Study completion28 Dec 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Muscle DamageStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 62 participants (actual)
Sponsor and investigators
- Lead sponsor
- Batterjee Medical College
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mohamed A. Abdel Ghafar, Batterjee Medical College
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07356193
- Sponsor's protocol ID
- BMC-CPK-Study-2023
- Status last verified
- Jan 2026
- First submitted
- 11 Jan 2026
- Last updated
- 22 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: IPD will not be shared because participant consent did not include permission for data sharing and the dataset contains sensitive physiological information.
Study at a glance
From the registry record, last updated by the sponsor on 22 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Lower Body Plyometric Training on Serum Creatine Phosphokinase and Creatinine Levels in Male Collegiate Volleyball Players
- ClinicalTrials.gov ID
- NCT07356193
- Acronym / sponsor ID
- BMC-CPK-Study-2023
- Keywords
- Plyometric Training, Volleyball Players, Creatine Phosphokinase, Serum Creatinine
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 62 participants (actual)
- Lead sponsor
- Batterjee Medical CollegeUniversity, hospital or other
- Study start
- 13 Feb 2022 (actual)
- Primary completion
- 10 Aug 2022 (actual)
- Study completion
- 28 Dec 2022 (actual)
- First posted
- 21 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This retrospective study evaluated the effects of an eight-week lower body plyometric training program on serum creatine phosphokinase (CPK) and creatinine levels in male collegiate volleyball players. Sixty two players were divided into experimental and control groups. CPK and creatinine were measured at baseline and multiple time points during training. The study assessed whether plyometric training produced harmful biochemical changes or signs of rhabdomyolysis.
Detailed description
This study evaluated the physiological effects and safety of an eight-week lower body plyometric training program in male collegiate volleyball players, focusing on changes in serum creatine phosphokinase (CPK) and creatinine levels. Sixty two healthy athletes were randomly assigned to either a plyometric training group or a control group. The experimental group performed progressive lower body plyometric exercises twice weekly for eight weeks, while the control group continued regular volleyball training.
Serum CPK and creatinine were assessed at baseline and multiple time points throughout the intervention. CPK levels in the training group increased significantly early in the program, peaking on Day 4 and remaining elevated until Week 2, before returning to baseline by Week 8. Importantly, all values remained within normal clinical ranges, and no signs of rhabdomyolysis or overtraining were observed. Serum creatinine levels showed no significant changes, indicating preserved renal function. No biomarker changes were detected in the control group.
These findings indicate that an eight-week, progressively designed plyometric training program is safe and well tolerated in male collegiate volleyball players.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Lower Body Plyometric Training | Experimental | Behavioral: Lower Body Plyometric Training, Other: control group |
| Control Group | Active comparator | Other: control group |
Who may qualify
- Ages
- 18 to 20 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- male collegiate volleyball players
- Age: 18-20 years
- No prior plyometric training
Key exclusion criteria (3 listed)
- History of kidney disease
- Current musculoskeletal injury
- neuromuscular impairments
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Lower Body Plyometric TrainingTraining twice weekly for eight weeks, including low-, moderate-, and high-intensity plyometric exercises (squat jumps, box jumps, tuck jumps, split squat jumps, lateral hurdle jumps, zigzag jumps, single-leg tuck jumps, and depth jumps). | Behavioural | Lower Body Plyometric Training |
| control groupRoutine volleyball training only; no plyometric exercises. | Other | Control Group, Lower Body Plyometric Training |
Primary outcome
Serum Creatine Phosphokinase (CPK) Levels
Time frame: Baseline; Day 2; Day 4; Week 1; Week 2; Week 4; Week 6; Week 8
Change in serum CPK measured using the CK-NAC optimized IFCC method.
1 secondary outcome
Serum Creatinine Levels
Time frame: Baseline; Day 2; Day 4; Week 1; Week 2; Week 4; Week 6; Week 8
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Jan 2026.
- Individual participant dataSharing planned: No. IPD will not be shared because participant consent did not include permission for data sharing and the dataset contains sensitive physiological information.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Lower Body Plyometric Training in people with Muscle Damage and Plyometric Exercises, run by Batterjee Medical College at 1 site in Saudi Arabia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Saudi Arabia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Serum Creatine Phosphokinase (CPK) Levels (time frame: Baseline; Day 2; Day 4; Week 1; Week 2; Week 4; Week 6; Week 8). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jan 2026.