Family History of Pancreas CancerPARTNERNCT07358208
Prospective Familial Registry for Pancreas Research
An observational study of Family History of Pancreas Cancer, run by Mayo Clinic at 1 site in United States.
Trial summary
The purpose of this research is to develop a resource registry of individuals currently without pancreatic cancer but are members of a kindred with two or more blood-related family members with pancreas cancer. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Family History of Pancreas Cancer
- How many people
- 3,000 participants
- Where
- 1 siteUnited States
- Study dates
- 5 Jan 2026to Nov 2040
- How long will I take part?
- 25 Years
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: US citizens who meet eligibility requirements
Who may be able to join
- An individual who was previously enrolled in Mayo Clinic IRB # 1197-00, 354-06, 355-06, or 19-010791
- Is age 18 years or older.
- Has a valid United States mailing address.
- Has at least two blood-related relatives who have had pancreas cancer or has a blood-relative with pancreatic cancer and that relative carries a known germline mutation in APC, ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, STK11, TP53 or mutations in other genes known to be associated with pancreatic cancer.
Who cannot join
- An individual who is a prison inmate
- An individual who is not compos mentis (of sound mind, memory, and understanding), and not able to give consent.
- Has personal history of pancreas cancer.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Prospective Familial Cohort for Pancreas Research
The purpose of this research is to develop a resource registry of individuals currently without pancreatic cancer but are members of a kindred with two or more blood-related family members with pancreas cancer.
Read the detailed description
If you agree to be in the study, you will be asked to fill out a questionnaire once every two years. The questionnaire will ask you questions about your health and family history. The investigator may ask you to donate a one-time blood specimen of approximately 3½ tablespoons, which can be done at your local doctor's office. The investigator may ask you if you are willing to provide the names and addresses of other family members who may be eligible to participate in the study. No visits to Mayo Clinic are required for your participation.
- Conditions
- Family History of Pancreas Cancer
- Keywords
- Family history of pancreas cancer
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Family history of pancreas cancer | Prospective cohort of individuals who do not have pancreas cancer but are members of a kindred with two or more blood-related family members with pancreas cancer, or with at least one blood-related family member with pancreas cancer and one relative who carries a variant in a gene known to be associated with pancreatic cancer. |
What is being measured
The primary outcome is the main question the study is designed to answer.
To establish a prospective cohort of individuals from pancreas cancer families
To establish and actively follow a resource registry of individuals currently without pancreatic cancer but are members of a kindred with two or more blood-related family members with pancreas cancer.
Measured: 25 years
Change in health
Participants will be asked to complete a health questionnaire every 2 years to ascertain new cancer diagnosis in the subject and in first-degree relatives.
Measured: 25 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jan 2026
- Study start5 Jan 2026
- Primary completionNov 2040 (estimated)
- Study completionNov 2040 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Family History of Pancreas CancerStudies of the same condition, open and under way.
- More trials run by Mayo ClinicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 3,000 participants (estimated)
- Target duration
- 25 Years
Sponsor and investigators
- Lead sponsor
- Mayo Clinic
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Samuel Antwi, Ph.D., Principal investigator, Mayo Clinic
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07358208
- Sponsor's protocol ID
- 25-002416
- Acronym
- PARTNER
- Status last verified
- Jan 2026
- First submitted
- 5 Jan 2026
- Last updated
- 22 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Prospective Familial Cohort for Pancreas Research
- ClinicalTrials.gov ID
- NCT07358208
- Acronym / sponsor ID
- PARTNER / 25-002416
- Conditions
- Family History of Pancreas Cancer
- Keywords
- Family history of pancreas cancer
- Study type
- Observational
- Recruitment status
- Enrolling by invitation
- Enrolment
- 3,000 participants (estimated)
- Lead sponsor
- Mayo ClinicUniversity, hospital or other
- Study start
- 5 Jan 2026 (actual)
- Primary completion
- Nov 2040 (estimated)
- Study completion
- Nov 2040 (estimated)
- First posted
- 22 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this research is to develop a resource registry of individuals currently without pancreatic cancer but are members of a kindred with two or more blood-related family members with pancreas cancer.
Detailed description
If you agree to be in the study, you will be asked to fill out a questionnaire once every two years. The questionnaire will ask you questions about your health and family history. The investigator may ask you to donate a one-time blood specimen of approximately 3½ tablespoons, which can be done at your local doctor's office. The investigator may ask you if you are willing to provide the names and addresses of other family members who may be eligible to participate in the study. No visits to Mayo Clinic are required for your participation.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 25 Years
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Family history of pancreas cancer | – | –Prospective cohort of individuals who do not have pancreas cancer but are members of a kindred with two or more blood-related family members with pancreas cancer, or with at least one blood-related family member with pancreas cancer and one relative who carries a variant in a gene known to be associated with pancreatic cancer. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- US citizens who meet eligibility requirements
Key inclusion criteria (4 listed)
- An individual who was previously enrolled in Mayo Clinic IRB # 1197-00, 354-06, 355-06, or 19-010791
- Is age 18 years or older.
- Has a valid United States mailing address.
- Has at least two blood-related relatives who have had pancreas cancer or has a blood-relative with pancreatic cancer and that relative carries a known germline mutation in APC, ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, STK11, TP53 or mutations in other genes known to be associated with pancreatic cancer.
Key exclusion criteria (3 listed)
- An individual who is a prison inmate
- An individual who is not compos mentis (of sound mind, memory, and understanding), and not able to give consent.
- Has personal history of pancreas cancer.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
To establish a prospective cohort of individuals from pancreas cancer families
Time frame: 25 years
To establish and actively follow a resource registry of individuals currently without pancreatic cancer but are members of a kindred with two or more blood-related family members with pancreas cancer.
Change in health
Time frame: 25 years
Participants will be asked to complete a health questionnaire every 2 years to ascertain new cancer diagnosis in the subject and in first-degree relatives.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Jan 2026.
- Mayo Clinic Clinical TrialsLink provided by the sponsor.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Samuel Antwi, Ph.D. principal investigator
Mayo Clinic
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Family History of Pancreas Cancer, run by Mayo Clinic at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 22 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
To establish a prospective cohort of individuals from pancreas cancer families (time frame: 25 years). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jan 2026.