Post Operative Pain ControlNCT07360028
Efficacy of Ultrasound Guided Erector Spinae Plane Block Versus Ultrasound Guided Serratus Anterior Plane Block for Postoperative Pain Control Following Video-assisted Thoracoscopic Surgeries (VATS): Randomized Control Trial
A study testing Erector Spinae (ESP) Block with Bupivacaine (Marcaine®) and Serratus anterior plane block (SAP) in people with Post Operative Pain Control, run by Ain Shams University at 1 site in Egypt.
Trial summary
The aim of the study is to compare the analgesic efficacy of Erector spinae plane block versus Serratus anterior plane block in patients undergoing video-assisted thoracoscopic surgeries. Read more about this study
- Who is it for?
- Ages 25 to 70 years
- Conditions the study is for
- Post Operative Pain Control
- What is being tested?
- Erector Spinae (ESP) Block with Bupivacaine (Marcaine®) and Serratus anterior plane block (SAP)
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Dec 2025to 30 Dec 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 25 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients with American Society of Anesthesiology physical status ASA I, II and III.
- Patients aged between 25 and 70 years.
- patients undergoing video-assisted thoracoscopic surgeries (VATS), including pleurectomy, bullectomy, sympathectomy, esophagectomy, decortication, lobectomy, and pneumonectomy.
Who cannot join
- Patients below age of 25 or above age of 70.
- Patient refusal.
- Allergy to local anesthetic drugs.
- Bleeding or coagulation disorder.
- Psychiatric disorders.
- Infection at the needle entry site.
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- Renal impairment (creatinine >1.5 ).
- Hepatic impairment (Child B or C).
- Patients with known Cortisol related diseases such as Cushing's Syndrome or Addison's Disease.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Ain-Shams University Hospitals
Cairo, Abbassia-Egypt
EMAN ZAGHLOUL MADY, MSc, 00201013177848, Emanzaghloul@med.asu.edu.eg
About this study
The aim of the study is to compare the analgesic efficacy of Erector spinae plane block versus Serratus anterior plane block in patients undergoing video-assisted thoracoscopic surgeries.
Read the detailed description
The aim of the study is to compare the analgesic efficacy of Erector spinae plane block versus Serratus anterior plane block in patients undergoing video-assisted thoracoscopic surgeries.
Preoperative: - On the day before surgery, all patients will be evaluated, detailed medical and surgical history will be taken also physical and systemic examinations will be done.
The following investigations will be done including complete blood count, liver enzymes, prothrombin time, partial thromboplastin time, International normalized ratio (INR) , kidney functions, serum electrolytes and ECG.
All patients will be informed about the visual analogue scale (VAS) on a scale from 0 to 10 where 0 represents no pain and 10 represents the worst imaginable pain.
In the pre-Anesthetic room:
- baseline hemodynamics will be recorded including heart rate (HR) and mean arterial blood pressure (MAP) and An intravenous access will be inserted.
- In the operating theatre, full monitors will be applied. Intraoperative: -
- Fentanyl (1 μg/kg), propofol (2 mg/kg) and atracurium(0.5 mg/kg) will be given IV for general anesthesia induction.
- Intubation will be done using a double-lumen endobronchial tube size 37 Fr in females and 39 Fr in males, tidal volume will be 6-8 ml/kg in case of both lungs ventilation and 4-6ml/kg during singe lung ventilation.
Anesthesia will continue using isoflurane 2 vol. %, 50% O2 and 50% air.
- Moreover, three milligrams of Granisetron will be given as prophylactic against nausea and vomiting post-operatively.
- During operation, 6 mL/kg/h of Ringer's solution will be administered.
- At the end of surgery, the patient will be positioned laterally.
- All blocks will be done using ultrasound-guidance (Mindray ultrasound) using high frequency linear probe (10-12 MHZ) by the same experienced senior doctors.
Group A : (25 patients) patients will receive Erector Spinae Plane Block using 20 mL of 0.25% bupivacaine.
Group B: (25 patients) patients will recieve Serratus Aneterior Plane Block using 20 mL of 0.25% bupivacaine.
- Conditions
- Post Operative Pain Control
- Being tested
- Erector Spinae (ESP) Block with Bupivacaine (Marcaine®), Serratus anterior plane block (SAP)
- Keywords
- post operative pain control
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)Procedure or surgery
Ultrasound Guided Erector Spinae Plane block using 20 mL of 0.25% bupivacaine.
Serratus anterior plane block (SAP)Procedure or surgery
Ultrasound Guided Serratus Anterior Plane Block using 20 mL of 0.25% bupivacaine.
| Study group | Role | What they receive |
|---|---|---|
| Erectror Spinae Plane Block | Active comparator | Ultrasound Guided block using 20 mL of 0.25% bupivacaine. Receives: Procedure: Erector Spinae (ESP) Block with Bupivacaine (Marcaine®) |
| Serratus Anterior Plane Block | Active comparator | Ultrasound Guided block using 20 mL of 0.25% bupivacaine. Receives: Procedure: Serratus anterior plane block (SAP) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Visual analogue scale for Assessing postoperative pain control
Assessing The difference in postoperative pain control between both groups as determined by assessing the visual analogue scale
Measured: after ICU admission at 2, 4, 8, 16, 24 hours post operative.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jan 2026
- Study start1 Dec 2025
- Primary completion30 Dec 2027 (estimated)
- Study completion30 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Post Operative Pain ControlStudies of the same condition, open and under way.
- More trials run by Ain Shams UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Care provider
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ain Shams University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07360028
- Sponsor's protocol ID
- FMASU MD 307/2025
- Status last verified
- Jan 2026
- First submitted
- 14 Jan 2026
- Last updated
- 22 Jan 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Efficacy of Ultrasound Guided Erector Spinae Plane Block Versus Ultrasound Guided Serratus Anterior Plane Block for Postoperative Pain Control Following Video-assisted Thoracoscopic Surgeries (VATS): Randomized Control Trial
- ClinicalTrials.gov ID
- NCT07360028
- Acronym / sponsor ID
- FMASU MD 307/2025
- Conditions
- Post Operative Pain Control
- Keywords
- post operative pain control
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Ain Shams UniversityUniversity, hospital or other
- Study start
- 1 Dec 2025 (actual)
- Primary completion
- 30 Dec 2027 (estimated)
- Study completion
- 30 Dec 2027 (estimated)
- First posted
- 22 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of the study is to compare the analgesic efficacy of Erector spinae plane block versus Serratus anterior plane block in patients undergoing video-assisted thoracoscopic surgeries.
Detailed description
The aim of the study is to compare the analgesic efficacy of Erector spinae plane block versus Serratus anterior plane block in patients undergoing video-assisted thoracoscopic surgeries.
Preoperative: - On the day before surgery, all patients will be evaluated, detailed medical and surgical history will be taken also physical and systemic examinations will be done.
The following investigations will be done including complete blood count, liver enzymes, prothrombin time, partial thromboplastin time, International normalized ratio (INR) , kidney functions, serum electrolytes and ECG.
All patients will be informed about the visual analogue scale (VAS) on a scale from 0 to 10 where 0 represents no pain and 10 represents the worst imaginable pain.
In the pre-Anesthetic room:
- baseline hemodynamics will be recorded including heart rate (HR) and mean arterial blood pressure (MAP) and An intravenous access will be inserted.
- In the operating theatre, full monitors will be applied. Intraoperative: -
- Fentanyl (1 μg/kg), propofol (2 mg/kg) and atracurium(0.5 mg/kg) will be given IV for general anesthesia induction.
- Intubation will be done using a double-lumen endobronchial tube size 37 Fr in females and 39 Fr in males, tidal volume will be 6-8 ml/kg in case of both lungs ventilation and 4-6ml/kg during singe lung ventilation.
Anesthesia will continue using isoflurane 2 vol. %, 50% O2 and 50% air.
- Moreover, three milligrams of Granisetron will be given as prophylactic against nausea and vomiting post-operatively.
- During operation, 6 mL/kg/h of Ringer's solution will be administered.
- At the end of surgery, the patient will be positioned laterally.
- All blocks will be done using ultrasound-guidance (Mindray ultrasound) using high frequency linear probe (10-12 MHZ) by the same experienced senior doctors.
Group A : (25 patients) patients will receive Erector Spinae Plane Block using 20 mL of 0.25% bupivacaine.
Group B: (25 patients) patients will recieve Serratus Aneterior Plane Block using 20 mL of 0.25% bupivacaine.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, care provider)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Erectror Spinae Plane Block | Active comparator | Procedure: Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)Ultrasound Guided block using 20 mL of 0.25% bupivacaine. |
| Serratus Anterior Plane Block | Active comparator | Procedure: Serratus anterior plane block (SAP)Ultrasound Guided block using 20 mL of 0.25% bupivacaine. |
Who may qualify
- Ages
- 25 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Patients with American Society of Anesthesiology physical status ASA I, II and III.
- Patients aged between 25 and 70 years.
- patients undergoing video-assisted thoracoscopic surgeries (VATS), including pleurectomy, bullectomy, sympathectomy, esophagectomy, decortication, lobectomy, and pneumonectomy.
Key exclusion criteria (9 listed)
- Patients below age of 25 or above age of 70.
- Patient refusal.
- Allergy to local anesthetic drugs.
- Bleeding or coagulation disorder.
- Psychiatric disorders.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)Ultrasound Guided Erector Spinae Plane block using 20 mL of 0.25% bupivacaine. | Procedure or surgery | Erectror Spinae Plane Block |
| Serratus anterior plane block (SAP)Ultrasound Guided Serratus Anterior Plane Block using 20 mL of 0.25% bupivacaine. | Procedure or surgery | Serratus Anterior Plane Block |
Primary outcome
Visual analogue scale for Assessing postoperative pain control
Time frame: after ICU admission at 2, 4, 8, 16, 24 hours post operative.
Assessing The difference in postoperative pain control between both groups as determined by assessing the visual analogue scale
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Jan 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Erector Spinae (ESP) Block with Bupivacaine (Marcaine®) and Serratus anterior plane block (SAP) in people with Post Operative Pain Control, run by Ain Shams University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 22 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact EMAN ZAGHLOUL MADY, MSc (00201013177848, Emanzaghloul@med.asu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Visual analogue scale for Assessing postoperative pain control (time frame: after ICU admission at 2, 4, 8, 16, 24 hours post operative.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jan 2026.