Colorectal Cancer PreventionPOGNCT07361575
Study Comparing the Quality of Colon Cleanliness With Prepackaged LRD (Low-residue Diet) vs. Guided (POG).
A study testing Colonoscopy, Questionnaires and Pre-colonoscopy diet according to the investigator's oral instructions in people with Colorectal Cancer Prevention and Colorectal Cancer (Diagnosis), run by Clinique Paris-Bercy at 1 site in France.
Trial summary
Low-residue diet (LRD) in patient improves the quality of the colon cleanliness and thus the adenoma detection rate (ADR). This is a key criterion in colonoscopy screening for colorectal cancer (CRC). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Colorectal Cancer Prevention, Colorectal Cancer (Diagnosis), Colorectal Adenocarcinoma
- What is being tested?
- Colonoscopy, Questionnaires and Pre-colonoscopy diet according to the investigator's oral instructions
- Type of treatment
- Pill or oral medicine, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 230 participants
- Where
- 1 siteFrance
- Study dates
- 30 Jan 2026to 30 Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patient of one of the investigators for total colonoscopy (no prior colonic surgery);
- Patient aged 18 years or older;
- Patient classified as ASA 1, ASA 2, or ASA 3;
- Not participating in any other current clinical trial;
- Free, informed, and signed consent;
- Patient affiliated with or a beneficiary of a social security scheme, according to Article L.1124-1 of the French Public Health Code;
Who cannot join
- Patient taking major psychotropic medications;
- Patient with uncontrolled diabetes;
- Patient with coagulation abnormalities preventing polypectomy: PT <50%, Platelets <50,000/mm³, current effective anticoagulation therapy (clopidogrel, prasugrel, or ticagrelor);
- Patient referred for removal of a known polyp;
- Chronic inflammatory bowel disease;
- Known colonic stenosis;
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- Diverticulitis of less than 6 weeks duration;
- Pregnant, parturient, or breastfeeding woman;
- Patient deprived of liberty by administrative or judicial order, or under guardianship or limited legal protection;
- Patient unable to understand the objectives and constraints of the study.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site
Clinique Paris Bercy
Charenton-le-Pont, 94220
David KARSENTI, Dr, 0033143967850, karsenti.paris@gmail.com
About this study
Official title: A Single-blind, Randomized Study Comparing the Quality of Colon Cleanliness With Prepackaged LRD (Low-residue Diet) vs. Guided (POG).
Low-residue diet (LRD) in patient improves the quality of the colon cleanliness and thus the adenoma detection rate (ADR). This is a key criterion in colonoscopy screening for colorectal cancer (CRC). The benefit of an LRD lasting more than 24 hours before colonoscopy has not been demonstrated compared to a 24-hour LRD.
Few studies have evaluated the benefit of a prepackaged 24-hour LRD compared to simply receiving oral and written LRD instructions during a consultation.
The aim of the study is to evaluate the usefulness of a prepackaged LRD (Colobox®) compared to simple LRD instructions on colon cleanliness (Boston score) in patients examined by endoscopy.
- Being tested
- Colonoscopy, Questionnaires, Pre-colonoscopy diet according to the investigator's oral instructions, Pre-colonoscopy diet by following a special preparation, Colobox.
- Medical subject headings
- Colorectal Neoplasms, Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ColonoscopyProcedure or surgery
Colonoscopy performed and Boston score evaluated
QuestionnairesOther
LRD satisfaction questionnaire LRD compliance questionnaire
Pre-colonoscopy diet according to the investigator's oral instructionsOther
24 hours before the colonoscopy, The patients follow a special diet, either by themselves according to the investigator's oral instructions
Pre-colonoscopy diet by following a special preparation, Colobox.Other
24 hours before the colonoscopy, The patients follow a special diet, by following a special preparation, Colobox.
| Study group | Role | What they receive |
|---|---|---|
| Patient with LRD prepared 24 hours before colonoscopy | Experimental | The LRD prepared is Colobox Receives: Procedure: Colonoscopy; Other: Questionnaires; Other: Pre-colonoscopy diet by following a special preparation, Colobox. |
| Patients with not prepared LRD, 24 hours before colonoscopy | Active comparator | The LRD is only explained orally and in writing to the patient Receives: Procedure: Colonoscopy; Other: Questionnaires; Other: Pre-colonoscopy diet according to the investigator's oral instructions |
What is being measured
The primary outcome is the main question the study is designed to answer.
Boston Score
A 9-point system, helps them see how clean a patient's large intestine is during a colonoscopy. This scale divides the large intestine into three parts: right, middle, and left.
Each part can score from :
BBPS = 0 (per segment) : unprepared colon segment with mucosa not seen because of solid stool that cannot be cleared.
BPPS=3 (per segment) : entire mucosa of the colon segment seen well, with no residual staining, small fragments of stool, or opaque liquid.
Measured: 1 day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Jan 2026
- Study start30 Jan 2026 (estimated)
- Primary completion15 Nov 2026 (estimated)
- Study completion30 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Colorectal Cancer PreventionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Care provider
- Enrolment
- 230 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Clinique Paris-Bercy
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07361575
- Sponsor's protocol ID
- POG
- Acronym
- POG
- Status last verified
- Feb 2026
- First submitted
- 3 Dec 2025
- Last updated
- 17 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Single-blind, Randomized Study Comparing the Quality of Colon Cleanliness With Prepackaged LRD (Low-residue Diet) vs. Guided (POG).
- ClinicalTrials.gov ID
- NCT07361575
- Acronym / sponsor ID
- POG / POG
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 230 participants (estimated)
- Lead sponsor
- Clinique Paris-BercyUniversity, hospital or other
- Study start
- 30 Jan 2026 (estimated)
- Primary completion
- 15 Nov 2026 (estimated)
- Study completion
- 30 Nov 2026 (estimated)
- First posted
- 23 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Low-residue diet (LRD) in patient improves the quality of the colon cleanliness and thus the adenoma detection rate (ADR). This is a key criterion in colonoscopy screening for colorectal cancer (CRC). The benefit of an LRD lasting more than 24 hours before colonoscopy has not been demonstrated compared to a 24-hour LRD.
Few studies have evaluated the benefit of a prepackaged 24-hour LRD compared to simply receiving oral and written LRD instructions during a consultation.
The aim of the study is to evaluate the usefulness of a prepackaged LRD (Colobox®) compared to simple LRD instructions on colon cleanliness (Boston score) in patients examined by endoscopy.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (care provider)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Patient with LRD prepared 24 hours before colonoscopy | Experimental | Procedure: Colonoscopy, Other: Questionnaires, Other: Pre-colonoscopy diet by following a special preparation, Colobox.The LRD prepared is Colobox |
| Patients with not prepared LRD, 24 hours before colonoscopy | Active comparator | Procedure: Colonoscopy, Other: Questionnaires, Other: Pre-colonoscopy diet according to the investigator's oral instructionsThe LRD is only explained orally and in writing to the patient |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Patient of one of the investigators for total colonoscopy (no prior colonic surgery);
- Patient aged 18 years or older;
- Patient classified as ASA 1, ASA 2, or ASA 3;
- Not participating in any other current clinical trial;
- Free, informed, and signed consent;
Key exclusion criteria (10 listed)
- Patient taking major psychotropic medications;
- Patient with uncontrolled diabetes;
- Patient with coagulation abnormalities preventing polypectomy: PT <50%, Platelets <50,000/mm³, current effective anticoagulation therapy (clopidogrel, prasugrel, or ticagrelor);
- Patient referred for removal of a known polyp;
- Chronic inflammatory bowel disease;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ColonoscopyColonoscopy performed and Boston score evaluated | Procedure or surgery | Patient with LRD prepared 24 hours before colonoscopy, Patients with not prepared LRD, 24 hours before colonoscopy |
| QuestionnairesLRD satisfaction questionnaire LRD compliance questionnaire | Other | Patient with LRD prepared 24 hours before colonoscopy, Patients with not prepared LRD, 24 hours before colonoscopy |
| Pre-colonoscopy diet according to the investigator's oral instructions24 hours before the colonoscopy, The patients follow a special diet, either by themselves according to the investigator's oral instructions | Other | Patients with not prepared LRD, 24 hours before colonoscopy |
| Pre-colonoscopy diet by following a special preparation, Colobox.24 hours before the colonoscopy, The patients follow a special diet, by following a special preparation, Colobox. | Other | Patient with LRD prepared 24 hours before colonoscopy |
Primary outcome
Boston Score
Time frame: 1 day
A 9-point system, helps them see how clean a patient's large intestine is during a colonoscopy. This scale divides the large intestine into three parts: right, middle, and left. Each part can score from : BBPS = 0 (per segment) : unprepared colon segment with mucosa not seen because of solid stool that cannot be cleared. BPPS=3 (per segment) : entire mucosa of the colon segment seen well, with no residual staining, small fragments of stool, or opaque liquid.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Colonoscopy, Questionnaires and Pre-colonoscopy diet according to the investigator's oral instructions in people with Colorectal Cancer Prevention and Colorectal Cancer (Diagnosis), run by Clinique Paris-Bercy at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 17 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Coralie DE CLERCK (0033143967823, c.declerck@clinique-bercy.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Boston Score (time frame: 1 day). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Feb 2026.