Alzheimer DiseasePYL-AIPNCT07361601
Implementation of AIP Services for Older Adults With AD
An observational study of Alzheimer Disease and Mild Cognitive Impairment, run by Northwestern University at 1 site in United States.
Trial summary
This study will longitudinally follow a cohort of older adults to better understand how decisions about aging in place or transitioning to long-term care-and the implementation of those decisions-are influenced by age-related changes (e.g., cognition, health literacy, chronic conditions) and social supports (e.g.… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Alzheimer Disease, Mild Cognitive Impairment
- How many people
- 0 participants
- Where
- 1 siteUnited States
- Study dates
- 2 Jul 2026to 31 Dec 2031
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The study population consists of a cohort of older adults who are currently enrolled in the longitudinal study, R01AG058777. Older adults as well as their caregivers, where appropriate, are being followed over time to assess decision-making and planning related to aging in place and potential transitions to long-term care. The cohort includes individuals with varying levels of cognitive function, health status, chronic conditions, and social support, as well as diverse living environments (e.g., rural and urban settings, different types of housing). Participants will continue to be followed prospectively.
Who may be able to join
- Active participant in the 'Decision Making and Implementation of Aging-in-Place/Long Term Care Plans among Older Adults' [R01AG058777] study;
- Age 65 years or older (older adult); age 18 years or older (caregiver)
- Speak English; and
- Pass UBACC (University of California, San Diego Brief Assessment of Capacity to Consent) cognitive assessment
- Age 18 years or older;
- Speak English;
- Currently assist enrolled, older adult study participant with activities such as managing their health, and/or household activities (i.e., taking them to the doctor, housekeeping, meal prep, medication reminders); and
- Pass UBACC (University of California, San Diego Brief Assessment of Capacity to Consent) cognitive assessment
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Implementation of Aging in Place Services for Older Adults With Alzheimer's Disease
This study will longitudinally follow a cohort of older adults to better understand how decisions about aging in place or transitioning to long-term care-and the implementation of those decisions-are influenced by age-related changes (e.g., cognition, health literacy, chronic conditions) and social supports (e.g., caregivers).
Read the detailed description
Participants currently enrolled in the National Institute on Aging (NIA)-funded study Decision Making and Implementation of Aging-in-Place/Long-Term Care Plans Among Older Adults (R01AG058777) will continue to be followed for an additional 42 months.
This study will examine how decision-making and planning related to aging in place change over time and how these processes are influenced by age-related changes (e.g., cognition, multiple chronic conditions), social influences (e.g., adult children, spouses, friends), and environmental factors (e.g., rural vs. urban residence, housing type). The study will also assess whether aging-in-place planning translates into timely implementation of services and whether implemented plans are concordant with the goals and preferences of older adults and their surrogate or caregiver decision makers.
In addition, the study will examine how age-related changes, social influences, and environmental factors interact to affect planning and implementation of aging-in-place and long-term care decisions over time.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment
- Keywords
- Aging in place, Long term care planning
- Medical subject headings
- Alzheimer Disease, Cognitive Dysfunction
What is being measured
The primary outcome is the main question the study is designed to answer.
Rate of participant long term care planning for Alzheimer's Dementia/Memory Loss
Participants are asked "If you developed Alzheimer's or memory loss and could no longer live independently in your home, have you decided what your living preferences (e.g. stay in own home, retirement/long term care community) would be?" Decision-making is measured as a binary ('yes', 'no') outcome at each time-point. Will report % of participants who indicated "YES", that they have decided on their living preferences. Frequencies given for 108 month timepoint per primary outcome analysis.
Measured: Assessed every 6 months, 108 months reported
Secondary outcomes (9)
Rate of participant planning for in-home care in the event of Alzheimer's Disease/Memory Loss
Participants are asked "Have you already decided what your preferences would be if you developed Alzheimer's Disease or memory loss and needed caregiver help in your home?". Responses recorded as binary. Will report % of participants who indicated "YES", that they have decided on their caregiver preferences. Frequencies given for 108 month timepoint per primary outcome analysis.
Measured: Assessed every 6 months, 108 months reported
Rate of participant planning for memory care in the event of Alzheimer's Disease/Memory Loss
Participants are asked "Have you decided what your long-term care preferences (e.g. where you would prefer to go if you needed to be in a nursing home or memory care), would be if you ever developed Alzheimer's Disease or memory loss? " Here, participants were specifically asked about "memory care" vs other types of care options. Responses recorded as binary. Will report % of participants who indicated "YES", that they have a plan for that scenario. All statistical analyses for this outcome will reflect data at the 108 month assessment.
Measured: Assessed every 6 months, 108 months reported
Rate of participant planning for a hospitalization requiring rehabilitation outside the home
Participants are asked "Have you already decided what your preferences would be if you were hospitalized and needed post-hospitalization rehabilitation outside of the home? " Responses recorded as binary. Will report % of participants who reported positively ("Yes") that they had a plan for the scenario. Frequencies given for 108 month timepoint per primary outcome analysis.
Measured: Assessed every 6 months, 108 months reported
Rate of participant planning for a hospitalization requiring in-home care
Participants are asked "Have you already decided what your preferences would be if you were hospitalized and needed caregiver help in your home?" Responses recorded as binary. Will report % of participants who reported positively ("Yes") that they had a plan for the scenario. All statistical analyses for this outcome will reflect data at the 108 month assessment.
Measured: Assessed every 6 months, 108 months reported
Rate of participant decision-making contemplation: Alzheimer's Dementia/Memory Loss (ADML)
Participants are asked a panel of statements about contemplation for decision-making in the event of Alzheimer's Dementia/Memory Loss (ADML). Participants are shown a statement and asked to gauge how frequently they contemplated the possibility of the given scenario, ranging from "Never" to "A Lot". Frequencies given for 108 month timepoint per primary outcome analysis. Each statement is prefixed by "How much have you thought about..."
Measured: Assessed every 6 months, 108 months reported
Rate of participant decision-making contemplation: Hospitalization
Participants were asked a panel of statements about contemplation for decision-making in the event of Hospitalization. Participants are shown a statement and asked to gauge how frequently they contemplated the possibility of the given scenario, ranging from "Never" to "A lot". Frequencies given for 108 month timepoint per primary outcome analysis. Each statement is prefixed by "How much have you thought about..."
Measured: Assessed every 6 months, 108 months reported
Participant utilization of long-term care services (RUI)
Participant utilization of long-term care services such as in-home caregivers as measured by the Resource Use Inventory (RUI). Frequencies provided for "yes" responses to individual items on the inventory. This outcome measure collected as part of the LitCog assessment battery. Frequencies reflect all available data at the 72 month assessment.
Measured: 72-month timepoint
Previous health experiences: Self and others
Participants are asked a panel of non-validated questions about their previous health experiences and their experiences with others. Frequencies reflect all available data at the 72 month assessment.
Measured: 72-month timepoint
Event and Goal Concordance
Participants report on any hospitalizations, recent memory loss, and changes in lifestyle due to hospitalization and memory loss. Responses are binary (yes/no), with a N/A and "unsure/don't know" option. Questions are non-validated. Frequencies given for 108 month timepoint per primary outcome analysis.
Measured: Assessed every 6 months, 108 months reported
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Jan 2026
- Study start2 Jul 2026
- Primary completion31 Mar 2030 (estimated)
- Study completion31 Dec 2031 (estimated)
Why it stopped: Not a clinical trial so retiring ClinicalTrials.gov record
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alzheimer DiseaseStudies of the same condition, open and under way.
- More trials run by Northwestern UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 0 participants (actual)
Sponsor and investigators
- Lead sponsor
- Northwestern University
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute on Aging (NIA)
- Responsible party
- Sponsor
- Investigators
- Lee A Lindquist, MD MPH MBA, Principal investigator, Northwestern University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07361601
- Sponsor's protocol ID
- R01AG091323-01
- Acronym
- PYL-AIP
- Status last verified
- Sep 2026
- First submitted
- 21 Jan 2026
- Last updated
- 14 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: There is no plan to make IPD and related data dictionaries available.
Study at a glance
From the registry record, last updated by the sponsor on 14 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Implementation of Aging in Place Services for Older Adults With Alzheimer's Disease
- ClinicalTrials.gov ID
- NCT07361601
- Acronym / sponsor ID
- PYL-AIP / R01AG091323-01
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment
- Keywords
- Aging in place, Long term care planning
- Study type
- Observational
- Recruitment status
- WithdrawnReason stopped: Not a clinical trial so retiring ClinicalTrials.gov record
- Enrolment
- 0 participants (actual)
- Lead sponsor
- Northwestern UniversityUniversity, hospital or other
- Collaborators
- National Institute on Aging (NIA)
- Study start
- 2 Jul 2026 (actual)
- Primary completion
- 31 Mar 2030 (estimated)
- Study completion
- 31 Dec 2031 (estimated)
- First posted
- 23 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will longitudinally follow a cohort of older adults to better understand how decisions about aging in place or transitioning to long-term care-and the implementation of those decisions-are influenced by age-related changes (e.g., cognition, health literacy, chronic conditions) and social supports (e.g., caregivers).
Detailed description
Participants currently enrolled in the National Institute on Aging (NIA)-funded study Decision Making and Implementation of Aging-in-Place/Long-Term Care Plans Among Older Adults (R01AG058777) will continue to be followed for an additional 42 months.
This study will examine how decision-making and planning related to aging in place change over time and how these processes are influenced by age-related changes (e.g., cognition, multiple chronic conditions), social influences (e.g., adult children, spouses, friends), and environmental factors (e.g., rural vs. urban residence, housing type). The study will also assess whether aging-in-place planning translates into timely implementation of services and whether implemented plans are concordant with the goals and preferences of older adults and their surrogate or caregiver decision makers.
In addition, the study will examine how age-related changes, social influences, and environmental factors interact to affect planning and implementation of aging-in-place and long-term care decisions over time.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The study population consists of a cohort of older adults who are currently enrolled in the longitudinal study, R01AG058777. Older adults as well as their caregivers, where appropriate, are being followed over time to assess decision-making and planning related to aging in place and potential transitions to long-term care. The cohort includes individuals with varying levels of cognitive function, health status, chronic conditions, and social support, as well as diverse living environments (e.g., rural and urban settings, different types of housing). Participants will continue to be followed prospectively.
Key inclusion criteria (8 listed)
- Active participant in the 'Decision Making and Implementation of Aging-in-Place/Long Term Care Plans among Older Adults' [R01AG058777] study;
- Age 65 years or older (older adult); age 18 years or older (caregiver)
- Speak English; and
- Pass UBACC (University of California, San Diego Brief Assessment of Capacity to Consent) cognitive assessment
- Age 18 years or older;
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Rate of participant long term care planning for Alzheimer's Dementia/Memory Loss
Time frame: Assessed every 6 months, 108 months reported
Participants are asked "If you developed Alzheimer's or memory loss and could no longer live independently in your home, have you decided what your living preferences (e.g. stay in own home, retirement/long term care community) would be?" Decision-making is measured as a binary ('yes', 'no') outcome at each time-point. Will report % of participants who indicated "YES", that they have decided on their living preferences. Frequencies given for 108 month timepoint per primary outcome analysis.
9 secondary outcomes
Rate of participant planning for in-home care in the event of Alzheimer's Disease/Memory Loss
Time frame: Assessed every 6 months, 108 months reported
Rate of participant planning for memory care in the event of Alzheimer's Disease/Memory Loss
Time frame: Assessed every 6 months, 108 months reported
Rate of participant planning for a hospitalization requiring rehabilitation outside the home
Time frame: Assessed every 6 months, 108 months reported
Rate of participant planning for a hospitalization requiring in-home care
Time frame: Assessed every 6 months, 108 months reported
Rate of participant decision-making contemplation: Alzheimer's Dementia/Memory Loss (ADML)
Time frame: Assessed every 6 months, 108 months reported
Rate of participant decision-making contemplation: Hospitalization
Time frame: Assessed every 6 months, 108 months reported
Participant utilization of long-term care services (RUI)
Time frame: 72-month timepoint
Previous health experiences: Self and others
Time frame: 72-month timepoint
Event and Goal Concordance
Time frame: Assessed every 6 months, 108 months reported
Results and safety
The study was withdrawn before enrolling participants, so there are no results.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Sep 2026.
- Individual participant dataSharing planned: No. There is no plan to make IPD and related data dictionaries available.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Lee A Lindquist, MD MPH MBA principal investigator
Northwestern University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Alzheimer Disease and Mild Cognitive Impairment, run by Northwestern University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: withdrawn, as of the sponsor's last update on 14 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was withdrawn before enrolling participants, so there are no results.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Rate of participant long term care planning for Alzheimer's Dementia/Memory Loss (time frame: Assessed every 6 months, 108 months reported). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Sep 2026.