Total Knee ReplacementNCT07361770
Comparative Effect of Instrument Assisted Soft Tissue Mobilization and Cross Fiber Massage in Patients With Total Knee Replacement.
A study testing Instrument-assisted soft tissue mobilization and Cross Fibre Massage in people with Total Knee Replacement, run by Rashid Latif Medical College at 1 site in Pakistan.
Trial summary
Comparative effect of Instrument Assisted Soft Tissue Mobilization and Cross Fiber Massage in patients with Total Knee Replacement Read more about this study
- Who is it for?
- Ages 40 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Total Knee Replacement
- What is being tested?
- Instrument-assisted soft tissue mobilization and Cross Fibre Massage
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 sitePakistan
- Study dates
- 15 Aug 2024to 8 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Both male and female of Age 40-60
- Radiological diagnosis
- Advanced degenerative OA knee, undergoing a primary TKR
- Pain intensity >3
Who cannot join
- Rheumatoid Arthritis patients
- Septic Arthritis and other inflammatory arthritis patients
- Secondary or traumatic O.A
- Congenital bony deformities
- Flexion contracture, patellar dislocation
- Fracture or pervious osteotomy
- Neurological dysfunction
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Arif Memorial Teaching Hospital
Lahore, Punjab Province, 54000
About this study
Comparative effect of Instrument Assisted Soft Tissue Mobilization and Cross Fiber Massage in patients with Total Knee Replacement
Read the detailed description
Total knee replacement (TKR) is an elective procedure in which the knee joint is resurfaced with a metal or plastic implant intended to restore function, provide pain relief, and improve quality of life.IASTM helps to remove the scarring and decrease the pain caused by muscular tightness. The therapeutic benefits of the application of IASTM occur in a short period, including improvement in range of motion, reduction of pain, decreasing hypertonia.Cross fiber massage, is a form of massage technique that focuses on the body's deep tissues. The massage is deep and should be delivered in transverse direction to the particular tissue affected, as opposed to superficial massage applied longitudinally parallel to the vessels, which promotes circulation and fluid return.
- Conditions
- Total Knee Replacement
- Being tested
- Instrument-assisted soft tissue mobilization, Cross Fibre Massage
- Keywords
- Instrument Assisted Soft Tissue Mobilization, Cross Fibre Massage, Pain, Range of motion, Total Knee Replacement
- Medical subject headings
- Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Instrument-assisted soft tissue mobilizationOther
Each treatment session was of 15-20 minutes for all muscles, with the help of IASTM device assisted by friction-free oil or gel. The general principle is a six-step technique comprising examination, warm-up, IASTM, stretching, strengthening and icing. Data was collected by an independent assessor at baseline and after 4 weeks
Cross Fibre MassageOther
The massage is deep and must be applied transversely to the specific tissue involved unlike the superficial massage given in the longitudinal direction parallel to the vessels which enhances circulation and return of fluid. The therapist's fingers and patient's skin must move as one, otherwise moving subcutaneous fascia against muscle or ligament could lead to blister formation or subcutaneous bruising.
Data was collected by an independent assessor at baseline and after 4 weeks.
| Study group | Role | What they receive |
|---|---|---|
| Instrument Assisted Soft Tissue Mobilization | Experimental | The Graston Technique of Soft-Tissue Therapy (GT), also known as instrument-assisted soft tissue mobilization (IASTM), is used by chiropractors, physicians, and therapists to manage pain and range-of-motion limitations caused by scar tissue and musculoskeletal injuries. The GT treats tissue injuries and pain by separating scar tissue and producing heat, which increases blood flow to the areas affected by pain or trauma. Receives: Other: Instrument-assisted soft tissue mobilization |
| Cross Fibre Massage | Active comparator | Deep tissue massage is a type of massage that focuses on the muscular tissue's most profound levels. In tight regions, therapists utilize a combination of gentle strokes and deep pressure with their fingers, palms, and forearms. Either following or by going over the muscle fibers. It is used for back pain Reduce high blood pressure, Relieve pain and stiffness Speed up the healing of muscle strains and sprains Chronic constipation. Receives: Other: Cross Fibre Massage |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain Intensity
Visual Analogue Scale (VAS) is a widely used tool to measure pain intensity. The visual analog scale (VAS) for pain is a straight line with one end meaning no pain and the other end meaning the worst pain imaginable. It was used to assess pain.
Measured: Baseline and 4th week
Secondary outcomes (1)
Range Of Motion
An inclinometer app is a tool that helps measure and track changes in joint mobility, flexibility, and range of motion. It provide objective, reliable degree measurements of knee range of motion and joint position sense error. These measurements are then compared against established normal ranges or the patient's own previous results to track progress.
Measured: Baseline and 4th week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Jan 2026
- Study start15 Aug 2024
- Primary completion25 Dec 2024
- Study completion8 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Total Knee ReplacementStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Group A: IASTM Patients received IASTM with baseline treatment. Group B: Cross Fiber Massage Patients received Cross fiber massage with baseline treatment.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Rashid Latif Medical College
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Kainat Zahara, Rashid Latif Medical College
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07361770
- Sponsor's protocol ID
- IRB/2024/168
- Status last verified
- Jan 2026
- First submitted
- 15 Jan 2026
- Last updated
- 23 Jan 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The data will be available on reasonable request from corresponding author.
Publications
Bhosale P, Kolke Pt S. Effectiveness of instrument assisted soft tissue mobilization (IASTM) and muscle energy technique (MET) on post-operative elbow stiffness: a randomized clinical trial. J Man Manip Ther. 2023 Oct;31(5):340-348. doi: 10.1080/10669817.2022.2122372. Epub 2022 Sep 28.
PubMed 36171728
Study at a glance
From the registry record, last updated by the sponsor on 23 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Effect of Instrument Assisted Soft Tissue Mobilization and Cross Fiber Massage in Patients With Total Knee Replacement.
- ClinicalTrials.gov ID
- NCT07361770
- Acronym / sponsor ID
- IRB/2024/168
- Conditions
- Total Knee Replacement
- Keywords
- Instrument Assisted Soft Tissue Mobilization, Cross Fibre Massage, Pain, Range of motion, Total Knee Replacement
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Rashid Latif Medical CollegeUniversity, hospital or other
- Study start
- 15 Aug 2024 (actual)
- Primary completion
- 25 Dec 2024 (actual)
- Study completion
- 8 Jan 2026 (actual)
- First posted
- 23 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Comparative effect of Instrument Assisted Soft Tissue Mobilization and Cross Fiber Massage in patients with Total Knee Replacement
Detailed description
Total knee replacement (TKR) is an elective procedure in which the knee joint is resurfaced with a metal or plastic implant intended to restore function, provide pain relief, and improve quality of life.IASTM helps to remove the scarring and decrease the pain caused by muscular tightness. The therapeutic benefits of the application of IASTM occur in a short period, including improvement in range of motion, reduction of pain, decreasing hypertonia.Cross fiber massage, is a form of massage technique that focuses on the body's deep tissues. The massage is deep and should be delivered in transverse direction to the particular tissue affected, as opposed to superficial massage applied longitudinally parallel to the vessels, which promotes circulation and fluid return.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Group A: IASTM Patients received IASTM with baseline treatment. Group B: Cross Fiber Massage Patients received Cross fiber massage with baseline treatment.
| Arm | Type | Receives |
|---|---|---|
| Instrument Assisted Soft Tissue Mobilization | Experimental | Other: Instrument-assisted soft tissue mobilizationThe Graston Technique of Soft-Tissue Therapy (GT), also known as instrument-assisted soft tissue mobilization (IASTM), is used by chiropractors, physicians, and therapists to manage pain and range-of-motion limitations caused by scar tissue and musculoskeletal injuries. The GT treats tissue injuries and pain by separating scar tissue and producing heat, which increases blood flow to the areas affected by pain or trauma. |
| Cross Fibre Massage | Active comparator | Other: Cross Fibre MassageDeep tissue massage is a type of massage that focuses on the muscular tissue's most profound levels. In tight regions, therapists utilize a combination of gentle strokes and deep pressure with their fingers, palms, and forearms. Either following or by going over the muscle fibers. It is used for back pain Reduce high blood pressure, Relieve pain and stiffness Speed up the healing of muscle strains and sprains Chronic constipation. |
Who may qualify
- Ages
- 40 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Both male and female of Age 40-60
- Radiological diagnosis
- Advanced degenerative OA knee, undergoing a primary TKR
- Pain intensity >3
Key exclusion criteria (7 listed)
- Rheumatoid Arthritis patients
- Septic Arthritis and other inflammatory arthritis patients
- Secondary or traumatic O.A
- Congenital bony deformities
- Flexion contracture, patellar dislocation
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Instrument-assisted soft tissue mobilizationEach treatment session was of 15-20 minutes for all muscles, with the help of IASTM device assisted by friction-free oil or gel. The general principle is a six-step technique comprising examination, warm-up, IASTM, stretching, strengthening and icing. Data was collected by an independent assessor at baseline and after 4 weeks | Other | Instrument Assisted Soft Tissue Mobilization |
| Cross Fibre MassageThe massage is deep and must be applied transversely to the specific tissue involved unlike the superficial massage given in the longitudinal direction parallel to the vessels which enhances circulation and return of fluid. The therapist's fingers and patient's skin must move as one, otherwise moving subcutaneous fascia against muscle or ligament could lead to blister formation or subcutaneous bruising. Data was collected by an independent assessor at baseline and after 4 weeks. | Other | Cross Fibre Massage |
Primary outcome
Pain Intensity
Time frame: Baseline and 4th week
Visual Analogue Scale (VAS) is a widely used tool to measure pain intensity. The visual analog scale (VAS) for pain is a straight line with one end meaning no pain and the other end meaning the worst pain imaginable. It was used to assess pain.
1 secondary outcome
Range Of Motion
Time frame: Baseline and 4th week
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jan 2026.
- Results publication: PubMed 36171728Bhosale P, Kolke Pt S. Effectiveness of instrument assisted soft tissue mobilization (IASTM) and muscle energy technique (MET) on post-operative elbow stiffness: a randomized clinical trial. J Man Manip Ther. 2023 Oct;31(5):340-348. doi: 10.1080/10669817.2022.2122372. Epub 2022 Sep 28.
- Individual participant dataSharing planned: Yes. The data will be available on reasonable request from corresponding author.
Related trials for Total Knee Replacement
RecruitingPhase 3
REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults
Venous Thromboembolism (VTE)
Recruiting
SII Levels Following iPACK Block With Adductor Canal Block in Knee Arthroplasty
Knee Osteoarthritis
Enrolling by invitationObservational study
Persona SoluTion PPS Femur PMCF
Rhematoid Arthritis, Osteo Arthritis of the Knee
Recruiting
ACB and iPACK Blocks With Intravenous Dexamethasone and Perineural Dexmedetomidine in Total Knee Arthroplasty
Knee Osteoarthritis
RecruitingPhase 3
REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants
Symptomatic Venous Thromboembolism (VTE)
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Instrument-assisted soft tissue mobilization and Cross Fibre Massage in people with Total Knee Replacement, run by Rashid Latif Medical College at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain Intensity (time frame: Baseline and 4th week). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07361770, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jan 2026.