ShockNCT07362628
US Guidance for Radial Arterial Puncture in Shock
A study testing Ultrasound-guided radial arterial puncture for arterial blood gas sampling and Conventional radial artery puncture for arterial blood gas sampling in people with Shock and Shock Circulatory, run by Ismail Erkan Aydin at 1 site in Turkey (Türkiye).
Trial summary
Doctors in the emergency department often need to take blood samples from an artery to understand how well a patient is breathing and how the body is responding to serious illness. This is usually done by inserting a needle into an artery at the wrist. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Shock, Shock Circulatory
- What is being tested?
- Ultrasound-guided radial arterial puncture for arterial blood gas sampling and Conventional radial artery puncture for arterial blood gas sampling
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Oct 2024to 31 Mar 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients aged 18 years and older
- Patients diagnosed with shock
- Patients with an indication for arterial blood gas analysis due to respiratory or metabolic disorders
- Patients who provided written informed consent, either personally or through their legal representatives.
Who cannot join
- Patients who declined to participate
- Patients presenting with cardiac arrest
- Patients with a positive Allen test
- Patients with a history of coagulopathy
- Patients with evidence of infection at the puncture site
- Patients with evidence of trauma at the puncture site
- Patients with an arteriovenous fistula at the puncture site
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Alanya Alaaddin Keykubat University Hospital
Alanya, Antalya, 07400
About this study
Official title: Ultrasound Guidance Versus Conventional Technique for Radial Arterial Puncture in Patients With Shock in the Emergency Department: A Randomized Controlled Trial
Doctors in the emergency department often need to take blood samples from an artery to understand how well a patient is breathing and how the body is responding to serious illness. This is usually done by inserting a needle into an artery at the wrist. In patients with shock, this procedure can be difficult because blood pressure is low and the pulse may be hard to feel.
In this study, two different methods for obtaining arterial blood samples were compared in adult patients presenting to the emergency department with shock. In one group, the radial artery puncture was performed with ultrasound guidance, allowing direct visualization of the artery. In the other group, the procedure was carried out using the conventional palpation technique based on manual detection of the pulse.
Read more
Patients were randomly assigned to one of the two techniques. The study assessed the success of the procedure on the first attempt, the total number of attempts required, the time needed to obtain a successful sample, and whether puncture of the femoral artery was required when radial access could not be achieved.
The aim of the study was to evaluate whether the use of ultrasound improves the efficiency and success of radial artery blood sampling in patients with shock treated in the emergency department.
- Conditions
- Shock, Shock Circulatory
- Being tested
- Ultrasound-guided radial arterial puncture for arterial blood gas sampling, Conventional radial artery puncture for arterial blood gas sampling
- Keywords
- Arterial blood gas, Emergency department, Radial artery puncture, Shock, Ultrasound
- Medical subject headings
- Shock, Emergencies
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ultrasound-guided radial arterial puncture for arterial blood gas samplingProcedure or surgery
Radial artery puncture for arterial blood gas sampling performed under real-time ultrasound guidance. The artery is visualized on the screen and the needle is advanced under direct visualization until arterial blood flow is obtained.
Conventional radial artery puncture for arterial blood gas samplingProcedure or surgery
Radial artery puncture for arterial blood gas sampling performed using the conventional palpation technique. The artery is identified by manual palpation and the needle is advanced until arterial blood flow is obtained.
| Study group | Role | What they receive |
|---|---|---|
| Ultrasound-Guided Radial Artery Puncture | Experimental | Participants undergo radial artery puncture for arterial blood gas sampling using real-time ultrasound guidance. Receives: Procedure: Ultrasound-guided radial arterial puncture for arterial blood gas sampling |
| Conventional Palpation-Guided Radial Artery Puncture | Experimental | Participants undergo radial artery puncture for arterial blood gas sampling using the conventional palpation technique, which represents the standard practice. Receives: Procedure: Conventional radial artery puncture for arterial blood gas sampling |
What is being measured
The primary outcome is the main question the study is designed to answer.
First-Attempt Success of Radial Artery Puncture
In the ultrasound-guided group, a stopwatch was started when the ultrasound transducer made contact with the skin over the radial artery. The artery was visualized on the screen, and the needle was advanced under real-time ultrasound guidance until arterial blood flow was obtained. The stopwatch was stopped when arterial blood flow was observed in the syringe, and the procedure was considered successful. Each new puncture attempt was recorded as a separate attempt.
In the conventional palpation group, a stopwatch was started when the physician made skin contact after identifying the radial artery by palpation. The needle was advanced into the radial artery until arterial blood flow was obtained. The stopwatch was stopped when arterial blood flow was observed in the syringe, and the procedure was considered successful. Each new puncture attempt was recorded as a separate attempt.
Measured: During procedure
Secondary outcomes (1)
The Number of Attempts
Secondary outcomes included the number of attempts until successful puncture, time to successful puncture, and the need for a rescue femoral artery puncture.
Measured: During procedure
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Jan 2026
- Study start1 Oct 2024
- Primary completion31 Mar 2025
- Study completion31 Mar 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for ShockStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This is a single-center, prospective, randomized controlled trial. Patients were randomized in a 1:1 ratio into two groups using an online randomization tool. In the US group, arterial blood gas sampling was performed via radial artery puncture under real-time US guidance. In the non-US group, arterial blood gas sampling was performed using the conventional palpation technique.
- Masking
- None (open label)
- Enrolment
- 100 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ismail Erkan Aydin
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Ismail Erkan Aydin, Alanya Alaaddin Keykubat University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07362628
- Sponsor's protocol ID
- September 11, 2024 ID: 20-09
- Status last verified
- Jan 2026
- First submitted
- 9 Jan 2026
- Last updated
- 23 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified individual participant data related to the primary and secondary outcomes will be shared upon reasonable request to the corresponding author.
Publications
Ersahin DA, Aydin IE, Ersahin T, Kozaci N. Ultrasound guidance versus conventional technique for radial arterial puncture in patients with shock in the emergency department: a randomized controlled trial. BMC Emerg Med. 2026 Mar 19;26(1):123. doi: 10.1186/s12873-026-01538-3.
PubMed 41857503
Study at a glance
From the registry record, last updated by the sponsor on 23 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Ultrasound Guidance Versus Conventional Technique for Radial Arterial Puncture in Patients With Shock in the Emergency Department: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07362628
- Acronym / sponsor ID
- September 11, 2024 ID: 20-09
- Conditions
- Shock, Shock Circulatory
- Keywords
- Arterial blood gas, Emergency department, Radial artery puncture, Shock, Ultrasound
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 100 participants (actual)
- Lead sponsor
- Ismail Erkan AydinUniversity, hospital or other
- Study start
- 1 Oct 2024 (actual)
- Primary completion
- 31 Mar 2025 (actual)
- Study completion
- 31 Mar 2025 (actual)
- First posted
- 23 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Doctors in the emergency department often need to take blood samples from an artery to understand how well a patient is breathing and how the body is responding to serious illness. This is usually done by inserting a needle into an artery at the wrist. In patients with shock, this procedure can be difficult because blood pressure is low and the pulse may be hard to feel.
In this study, two different methods for obtaining arterial blood samples were compared in adult patients presenting to the emergency department with shock. In one group, the radial artery puncture was performed with ultrasound guidance, allowing direct visualization of the artery. In the other group, the procedure was carried out using the conventional palpation technique based on manual detection of the pulse.
Patients were randomly assigned to one of the two techniques. The study assessed the success of the procedure on the first attempt, the total number of attempts required, the time needed to obtain a successful sample, and whether puncture of the femoral artery was required when radial access could not be achieved.
The aim of the study was to evaluate whether the use of ultrasound improves the efficiency and success of radial artery blood sampling in patients with shock treated in the emergency department.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- This is a single-center, prospective, randomized controlled trial. Patients were randomized in a 1:1 ratio into two groups using an online randomization tool. In the US group, arterial blood gas sampling was performed via radial artery puncture under real-time US guidance. In the non-US group, arterial blood gas sampling was performed using the conventional palpation technique.
| Arm | Type | Receives |
|---|---|---|
| Ultrasound-Guided Radial Artery Puncture | Experimental | Procedure: Ultrasound-guided radial arterial puncture for arterial blood gas samplingParticipants undergo radial artery puncture for arterial blood gas sampling using real-time ultrasound guidance. |
| Conventional Palpation-Guided Radial Artery Puncture | Experimental | Procedure: Conventional radial artery puncture for arterial blood gas samplingParticipants undergo radial artery puncture for arterial blood gas sampling using the conventional palpation technique, which represents the standard practice. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Patients aged 18 years and older
- Patients diagnosed with shock
- Patients with an indication for arterial blood gas analysis due to respiratory or metabolic disorders
- Patients who provided written informed consent, either personally or through their legal representatives.
Key exclusion criteria (7 listed)
- Patients who declined to participate
- Patients presenting with cardiac arrest
- Patients with a positive Allen test
- Patients with a history of coagulopathy
- Patients with evidence of infection at the puncture site
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ultrasound-guided radial arterial puncture for arterial blood gas samplingRadial artery puncture for arterial blood gas sampling performed under real-time ultrasound guidance. The artery is visualized on the screen and the needle is advanced under direct visualization until arterial blood flow is obtained. | Procedure or surgery | Ultrasound-Guided Radial Artery Puncture |
| Conventional radial artery puncture for arterial blood gas samplingRadial artery puncture for arterial blood gas sampling performed using the conventional palpation technique. The artery is identified by manual palpation and the needle is advanced until arterial blood flow is obtained. | Procedure or surgery | Conventional Palpation-Guided Radial Artery Puncture |
Primary outcome
First-Attempt Success of Radial Artery Puncture
Time frame: During procedure
In the ultrasound-guided group, a stopwatch was started when the ultrasound transducer made contact with the skin over the radial artery. The artery was visualized on the screen, and the needle was advanced under real-time ultrasound guidance until arterial blood flow was obtained. The stopwatch was stopped when arterial blood flow was observed in the syringe, and the procedure was considered successful. Each new puncture attempt was recorded as a separate attempt. In the conventional palpation group, a stopwatch was started when the physician made skin contact after identifying the radial artery by palpation. The needle was advanced into the radial artery until arterial blood flow was obtained. The stopwatch was stopped when arterial blood flow was observed in the syringe, and the procedure was considered successful. Each new puncture attempt was recorded as a separate attempt.
1 secondary outcome
The Number of Attempts
Time frame: During procedure
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jan 2026.
- Derived from this study: PubMed 41857503Ersahin DA, Aydin IE, Ersahin T, Kozaci N. Ultrasound guidance versus conventional technique for radial arterial puncture in patients with shock in the emergency department: a randomized controlled trial. BMC Emerg Med. 2026 Mar 19;26(1):123. doi: 10.1186/s12873-026-01538-3.
- Individual participant dataSharing planned: Yes. De-identified individual participant data related to the primary and secondary outcomes will be shared upon reasonable request to the corresponding author.
Related trials for Shock
Active, not recruiting
CT for Personalized Mechanical Ventilation
Ventilator-Induced Lung Injury, Sepsis Syndrome
Active, not recruitingPhase 4
Thymosin Alpha 1 and IgM Levels in Sepsis
Sepsis, Septic Shock
Not yet recruiting
Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial
Acute-on-Chronic Liver Failure (ACLF)
RecruitingObservational study
Hemophagocytic Lymphohistiocytosis (HLH) Evaluation and Research of Clinical, ImmUnoLogic and TranscriptomE Study
Lymphohistiocytosis, Hemophagocytic, Secondary Hemophagocytic Lymphohistiocytosis
Active, not recruitingPhase 3
The Danish Out-of-Hospital Cardiac Arrest Study
Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Ultrasound-guided radial arterial puncture for arterial blood gas sampling and Conventional radial artery puncture for arterial blood gas sampling in people with Shock and Shock Circulatory, run by Ismail Erkan Aydin at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
First-Attempt Success of Radial Artery Puncture (time frame: During procedure). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07362628, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jan 2026.