AzTrials
AzTrials

Moderate to Severe Chronic Obstructive Pulmonary DiseasePhase 2/3COPDNCT07363694

A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease

A Phase 2/3 study testing PF-07275315 dose 1, PF-07275315-dose 2 and PF-07275315-dose 3 in people with Moderate to Severe Chronic Obstructive Pulmonary Disease, run by Pfizer at 189 sites in 18 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

The purpose of this clinical trial is to learn about the effects and safety of the study medicine PF-07275315 for the potential treatment of COPD. COPD is a condition that makes it difficult to breathe, which negatively impacts the quality of life and functioning of people who are affected. Read more about this study

Who is it for?
Ages 35 to 80 years
What is being tested?
PF-07275315 dose 1, PF-07275315-dose 2 and PF-07275315-dose 3
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
1,156 participants
Where
189 sitesin 18 countries
Study dates
11 Feb 2026to 16 Jan 2031
Phase
Phase 2/3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 35 to 80 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Diagnosis of chronic obstructive pulmonary disease (COPD) for at least 12 months (based on Global Initiative for Chronic Obstructive Lung Disease [GOLD] definition).
  • Spirometry values (post-bronchodilator forced expiratory volume in 1 second [FEV1]/forced vital capacity [FVC] less than [<] 70 percent (%) and post-bronchodilator FEV1 % predicted <70%, but greater than equal to 30%).
  • Continuous treatment with standard of care triple therapy of LABA + LAMA + ICS for ≥ 6 months prior to Screening Visit 1 and at a stable dose for ≥3 months
  • Documented history of at least 2 moderate or severe ECOPD within the last 12 months prior to Screening.

Who cannot join

  • Significant pulmonary disease other than COPD.
  • Requirement for continuous chronic treatment with oxygen at >4.0 liters / minute by nasal cannula or equivalent.
  • Hypoxemia with a resting SpO2 <88% while breathing ambient air (or on the participant's usual level of oxygen supplementation).
  • Clinically significant cardiovascular disease, acute and/or severe left heart failure, or heart failure partial ejection fraction, and/or cor pulmonale.

Trial locations and contacts

189 sites in 18 countries. Contact the study team or a site near you to ask about taking part.

Pfizer CT.gov Call Center contact

1-800-718-1021

ClinicalTrials.gov_Inquiries@pfizer.com

189 sites in 18 countries

United States66 sites, 66 recruiting

  • Paul A. Shapero, MD, PA

    Bangor, Maine, 04401

    Not yet recruiting

  • University of Alabama at Birmingham Lung Health Center

    Birmingham, Alabama, 35233

    Recruiting

  • South Texas Medical Research Institute, Inc., DBA TTS Research

    Boerne, Texas, 78006

    Recruiting

  • Ten20 Clinical Research

    Carrollton, Texas, 75010

    Recruiting

  • Northwell Health Physician Partners at Chappaqua

    Chappaqua, New York, 10514

    Not yet recruiting

  • Bogan Sleep Consultants, LLC

    Columbia, South Carolina, 29201

    Recruiting

  • Horizon Clinical Research Group

    Cypress, Texas, 77429

    Recruiting

  • Alina Clinical Trials, LLC.

    Dallas, Texas, 75209

    Recruiting

  • Baylor Scott & White Advanced Lung Disease Specialists

    Dallas, Texas, 75246

    Recruiting

  • Baylor University Medical Center (Research Office)

    Dallas, Texas, 75246

    Recruiting

  • Baylor University Medical Center

    Dallas, Texas, 75246

    Recruiting

  • Revival Research Institute, LLC

    Dearborn, Michigan, 48126

    Recruiting

  • SEC Clinical Research

    Dothan, Alabama, 36305

    Recruiting

  • Clinical Research Associates of Central PA, LLC

    DuBois, Pennsylvania, 15801

    Recruiting

  • Cpcc-Research Llc

    East Point, Georgia, 30344

    Recruiting

  • Exordia Medical Research Inc.

    Fall River, Massachusetts, 02723

    Recruiting

  • AA Medical Research Center

    Flint, Michigan, 48504

    Recruiting

  • New York Presbyterian Queens

    Flushing, New York, 11355

    Recruiting

  • Clinical Trials Center of Middle Tennessee, LLC

    Franklin, Tennessee, 37067

    Recruiting

  • Velocity Clinical Research, Gaffney

    Gaffney, South Carolina, 29340

    Recruiting

  • Finlay Medical Research

    Greenacres City, Florida, 33467

    Recruiting

  • ASHA Clinical Research - Munster, LLC

    Hammond, Indiana, 46324

    Recruiting

  • Henderson Clinical Trials

    Henderson, Nevada, 89052

    Recruiting

  • Premier Research Center, LLC

    Hendersonville, Tennessee, 37075

    Recruiting

  • Greater Heights & Memorial Pulmonary and Sleep

    Houston, Texas, 77008

    Recruiting

  • Houston Pulmonary Sleep and Allergy Associates

    Houston, Texas, 77065

    Recruiting

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160

    Recruiting

  • Clinical Research Specialists LLC

    Kissimmee, Florida, 34746

    Recruiting

  • IMAX Clinical Trials

    La Palma, California, 90623

    Recruiting

  • Advanced Pulmonary Research Institute

    Loxahatchee Groves, Florida, 33470

    Recruiting

  • Methodist Hospital Southlake

    Merrillville, Indiana, 46410

    Recruiting

  • Reed Medical Research

    Miami, Florida, 33176

    Recruiting

  • Pulmonary Associates of Mobile, P.C.

    Mobile, Alabama, 36608

    Recruiting

  • Northern Westchester Hospital

    Mount Kisco, New York, 10549

    Not yet recruiting

  • NewportNativeMD, Inc.

    Newport Beach, California, 92663

    Recruiting

  • Infinity Medical Research

    North Dartmouth, Massachusetts, 02747

    Recruiting

  • California Medical Research Associates

    Northridge, California, 91324

    Recruiting

  • Renstar Medical Research

    Ocala, Florida, 34470

    Recruiting

  • HCA Florida Ocala Imaging Center

    Ocala, Florida, 34471

    Recruiting

  • Ocala Lung and Critical Care Associates

    Ocala, Florida, 34471

    Recruiting

  • Renstar Medical Research

    Ocala, Florida, 34471

    Recruiting

  • Temple University Hospital

    Philadelphia, Pennsylvania, 19140

    Not yet recruiting

  • Pulmonary Associates, PA

    Phoenix, Arizona, 85027

    Recruiting

  • Temple Health Oaks

    Phoenixville, Pennsylvania, 19460

    Not yet recruiting

  • Health Concepts

    Rapid City, South Dakota, 57702

    Recruiting

  • Centricity Research Rincon Pulmonology

    Rincon, Georgia, 31326

    Recruiting

  • Clinical Research of Rock Hill

    Rock Hill, South Carolina, 29732

    Recruiting

  • Institute of HealthCare Assessment d/b/a Apex Clinical Research

    San Diego, California, 92120

    Recruiting

  • Sherman Clinical Research

    Sherman, Texas, 75090

    Recruiting

  • Revive Research Institute, Inc.

    Southfield, Michigan, 48075

    Recruiting

  • Velocity Clinical Research, Spartanburg

    Spartanburg, South Carolina, 29303

    Recruiting

  • Washington University School of Medicine

    St Louis, Missouri, 63108

    Recruiting

  • Barnes-Jewish Hospital Investigational Drug Service

    St Louis, Missouri, 63110

    Recruiting

  • Barnes-Jewish Hospital

    St Louis, Missouri, 63110

    Recruiting

  • Washington University School of Medicine

    St Louis, Missouri, 63110

    Recruiting

  • Washington University School-Cardiovascular Imaging and Clinical Research Core Laboratory

    St Louis, Missouri, 63110

    Recruiting

  • Coastal Medical Research Institute, LLC

    St. Petersburg, Florida, 33704

    Recruiting

  • Coastal Pulmonary and Critical Care, P.L.C

    St. Petersburg, Florida, 33704

    Recruiting

  • Clinical Research Trials of Florida, Inc.

    Tampa, Florida, 33607

    Recruiting

  • Toledo Institute of Clinical Research Inc.

    Toledo, Ohio, 43617

    Recruiting

  • Oakland Medical Research

    Troy, Michigan, 48085

    Recruiting

  • Layrek Clinical Research

    Tulsa, Oklahoma, 74133

    Recruiting

  • Salem Chest Specialists

    Winston-Salem, North Carolina, 27103

    Recruiting

  • Southeastern Research Center

    Winston-Salem, North Carolina, 27103

    Recruiting

  • Clinical Site Partners, LLC dba Flourish Research

    Winter Park, Florida, 32789

    Recruiting

  • Southern Clinical Research, LLC

    Zachary, Louisiana, 70791

    Recruiting

Other trials in United States

China22 sites, 22 recruiting

  • China-Japan Friendship Hospital

    Beijing, Beijing Municipality, 100029

    Recruiting

  • The First Hospital of Changsha

    Changsha, Hunan, 410005

    Recruiting

  • The Second Xiangya Hospital of Central South University

    Changsha, Hunan, 410011

    Recruiting

  • Chengdu Fifth People's Hospital

    Chengdu, Sichuan, 611130

    Recruiting

  • The People's Hospital of Chizhou

    Chizhou, Anhui, 247000

    Recruiting

  • Chongqing Red Cross Hospital (Jiangbei District People's Hospital)

    Chongqing, Chongqing Municipality, 400000

    Recruiting

  • Fuyang People's Hospital

    Fuyang, Anhui, 236000

    Recruiting

  • The Third Affiliated Hospital of Guangzhou Medical University

    Guangzhou, Guangdong, 510150

    Recruiting

  • Anhui Chest Hospital

    Hefei, Anhui, 230022

    Recruiting

  • Inner Mongolia People's Hospital

    Hohhot, Inner Mongolia, 010017

    Recruiting

  • The Affiliated Hospital of Inner Mongolia Medical University

    Hohhot, Inner Mongolia, 010050

    Recruiting

  • Huizhou Central People's Hospital

    Huizhou, Guangdong, 516001

    Recruiting

  • Jinan Central Hospital

    Jinan, Shandong, 250013

    Recruiting

  • Taizhou Hospital of Zhejiang Province

    Linhai, Zhejiang, 317000

    Recruiting

  • Jiangxi Provincial People's Hospital

    Nanchang, Jiangxi, 330038

    Recruiting

  • Zhongda Hospital Southeast University

    Nanjing, Jiangsu, 210009

    Recruiting

  • Ruijin Hospital Shanghai Jiaotong University School of Medicine

    Shanghai, Shanghai Municipality, 200025

    Recruiting

  • Shanghai Tongji Hospital

    Shanghai, Shanghai Municipality, 200065

    Recruiting

  • The Central Hospital of Wuhan

    Wuhan, Hubei, 430024

    Recruiting

  • The First People's Hospital of Xinxiang

    Xinxiang, Henan, 453000

    Recruiting

  • The Affiliated Hospital of Xuzhou Medical College

    Xuzhou, Jiangsu, 221006

    Recruiting

  • Yangzhou University-Affiliated Hospital

    Yangzhou, Jiangsu, 225012

    Recruiting

Other trials in China

Bulgaria10 sites, 10 recruiting

  • MHAT "Sveta Ekaterina" Dimitrovgrad

    Dimitrovgrad, 6400

    Recruiting

  • Medical Center Pulmo - 2018 EOOD

    Haskovo, Haskovo, 6300

    Recruiting

  • Specialized Hospital for Active Treatment of Lung Diseases - Sv. Panteleymon EOOD

    Pernik, Pernik, 2300

    Recruiting

  • Medical Center Fama Medical

    Plovdiv

    Recruiting

  • SHATPPD Dr. Dimitar Gramatikov - Ruse EOOD

    Rousse, Ruse, 7002

    Recruiting

  • MHAT Knyaginya Klementina - Sofia EAD

    Sofia, Sofia, 1233

    Recruiting

  • Medical Center Hera EOOD

    Sofia, Sofia (stolitsa), 1510

    Recruiting

  • Fifth MHAT EAD

    Sofia, 1233

    Recruiting

  • Medical Center New Rehabilitation Center EOOD

    Stara Zagora, Stara Zagora, 6001

    Recruiting

  • Specialized Hospital for Active Treatment of Pneumo-Phthisiatric Diseases Dr. Treiman

    Veliko Tarnovo, Veliko Tarnovo, 5000

    Recruiting

Other trials in Bulgaria

Japan10 sites, 10 recruiting

  • Fujieda Municipal General Hospital

    Fujieda, Shizuoka, 426-8677

    Recruiting

  • Nishifukuoka Hospital

    Fukuoka, Fukuoka, 819-8555

    Recruiting

  • National Hospital Organization Okinawa Hospital

    Ginowan, Okinawa, 901-2214

    Recruiting

  • Tokyo Medical University Hachioji Medical Center

    Hachiōji, Tokyo, 1930998

    Recruiting

  • Hiroshima Prefectural Hospital

    Hiroshima, Hiroshima, 734-8530

    Recruiting

  • Aso Iizuka Hospital

    Iizuka-shi, Fukuoka, 820-8505

    Recruiting

  • Kure Kyosai Hospital

    Kure, Hiroshima, 737-8505

    Recruiting

  • Koujunkai Daido Clinic

    Nagoya, Aichi-ken, 457-8511

    Recruiting

  • NHO Kinki Chuo Chest Medical Center

    Sakai, Osaka, 591-8555

    Recruiting

  • Yamaguchi University Hospital

    Ube, Yamaguchi, 755-8505

    Recruiting

Other trials in Japan

India9 sites, 9 recruiting

  • KLES Dr. Prabhakar Kore Hospital and Medical Research Centre

    Belagavi, Karnataka, 590010

    Recruiting

  • Hindusthan Hospital

    Coimbatore, Tamil Nadu, 641028

    Recruiting

  • Shri Guru Ram Rai Institute of Medical & Health Sciences & Shri Mahant lndiresh Hospital

    Dehradun, Uttarakhand, 248001

    Recruiting

  • Kamineni Hospitals Private Limited

    Hyderabad, Telangana, 500068

    Recruiting

  • Maharaja Agrasen Superspeciality Hospital

    Jaipur, Rajasthan, 302039

    Recruiting

  • Nil Ratan Sircar Medical College and Hospital

    Kolkata, West Bengal, 700014

    Recruiting

  • All India Institute of Medical Sciences

    New Delhi, National Capital Territory of Delhi, 110029

    Recruiting

  • Sir Ganga Ram Hospital

    New Delhi, National Capital Territory of Delhi, 110060

    Recruiting

  • Bhaktivedanta Hospital and Research Institute

    Thane, Maharashtra, 401107

    Recruiting

Other trials in India

United Kingdom8 sites, 8 recruiting

  • Bradford Royal Infirmary

    Bradford, BRADFORD, BD9 6RJ

    Recruiting

  • Ashford and St Peter's Hospital NHS Foundation Trust

    Chertsey, KT16 0PZ

    Recruiting

  • Glasgow Royal Infirmary

    Glasgow, CITY of Glasgow, G31 2ER

    Recruiting

  • The Glenfield Hospital

    Leicester, LEICESTERSHIRE, LE3 9QP

    Recruiting

  • Guy's & St Thomas' NHS Foundation Trust

    London, London, CITY of, SE1 9RT

    Not yet recruiting

  • Queen Anne Street Medical Centre

    London, W1T 6AH

    Recruiting

  • Wythenshawe Hospital

    Manchester, MANCHESTER, M23 9LT

    Recruiting

  • North Tyneside General Hospital

    North Shields, NE29 8NH

    Not yet recruiting

Other trials in United Kingdom

Poland7 sites, 7 recruiting

  • Centrum Medyczne Pratia Katowice

    Katowice, 40-081

    Recruiting

  • Pro Familia Altera Sp. z o.o.

    Katowice, 40-648

    Recruiting

  • Diamond Clinic Sp. z o.o.

    Krakow, 31-559

    Recruiting

  • Ostrowieckie Centrum Medyczne spółka cywilna Anna Olech-Cudzik, Krzysztof Cudzik

    Ostrowiec Świętokrzyski, Świętokrzyskie Voivodeship, 27-400

    Recruiting

  • Centermed Sp. z o.o.

    Tarnów, 33-100

    Not yet recruiting

  • ETG Warszawa

    Warsaw, 02-677

    Recruiting

  • DOBROSTAN - Gabinety Lekarskie

    Wroclaw, 53-301

    Recruiting

Other trials in Poland

Taiwan7 sites, 7 recruiting

  • National Taiwan University Hospital - Hsinchu branch

    Hsinchu, 302

    Recruiting

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, Kaohsiung, 807

    Recruiting

  • Far Eastern Memorial Hospital

    New Taipei City, 220

    Recruiting

  • Taichung Veterans General Hospital

    Taichung, TAICHUNG, 407219

    Recruiting

  • China Medical University Hospital

    Taichung, 40447

    Recruiting

  • National Taiwan University Hospital

    Taipei, 10002

    Recruiting

  • Chang Gung Medical Foundation-Linkou Branch

    Taoyuan, TAOYUAN, 333

    Recruiting

Other trials in Taiwan

Argentina6 sites, 6 recruiting

  • IDIM - Instituto de Investigaciones Metabólicas

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1012AAR

    Recruiting

  • Centro Médico Dra. De Salvo - Fundación Respirar

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1426ABP

    Recruiting

  • Instituto Médico DAMIC

    Córdoba, Córdoba Province, X5003DCE

    Recruiting

  • Centro de Investigaciones Médicas Mar del Plata

    Mar del Plata, Buenos Aires, 7600

    Recruiting

  • Instituto de Salud Respiratoria - (INSARES)

    Mendoza, Mendoza Province, 5500

    Recruiting

  • Fundación Grupo Colaborativo Rosario Investigación y Prevención Médica

    Rosario, Santa Fe Province, 2000

    Recruiting

Other trials in Argentina

Czechia6 sites, 6 recruiting

  • MUDr.I. Cierna Peterova s.r.o.

    Brandýs nad Labem-Stará Boleslav, 250 01

    Recruiting

  • MEDITRIAL s.r.o.

    Jindřichův Hradec, 377 01

    Recruiting

  • Oblastni nemocnice Mlada Boleslav, a.s., nemocnice Stredoceskeho kraje

    Mladá Boleslav, 293 01

    Recruiting

  • Ordinace chorob plicnich s.r.o.

    Prague, 11000

    Recruiting

  • MEDICON a.s.

    Prague, 140 00

    Recruiting

  • Pneumologie Varnsdorf s.r.o.

    Varnsdorf, Ústí nad Labem Region, 407 47

    Not yet recruiting

Other trials in Czechia

Germany6 sites, 6 recruiting

  • KPPK Studienzentrum GmbH

    Bendorf, Rhineland-Palatinate, 56170

    Recruiting

  • Clinical Studies Pankow

    Berlin, 13187

    Not yet recruiting

  • Klifeck GmbH

    Delitzsch, 04509

    Not yet recruiting

  • Medizentrum Essen Borbeck

    Essen, North Rhine-Westphalia, 45355

    Not yet recruiting

  • IKF Pneumologie GmbH & Co KG; Institut für klinische Forschung

    Frankfurt, 60596

    Recruiting

  • Pneumologisch Onkologisch Internistisches Studienzentrum (POIS) Sachsen GmbH

    Leipzig, 04347

    Not yet recruiting

Other trials in Germany

Hungary5 sites, 5 recruiting

  • Koch Róbert Kórház és Rendelőintézet

    Edelény, Borsod-Abauj Zemplen county, 3780

    Not yet recruiting

  • Erzsebet Gondozohaz

    Gödöllő, Pest County, 2100

    Recruiting

  • Szalay János Rendelőintézet

    Hajdúnánás, Hajdú-Bihar, 4080

    Recruiting

  • Omnimodus Elixír Kft.

    Mosonmagyaróvár, Győr-Moson-Sopron, 9200

    Not yet recruiting

  • Da Vinci Magánklinika

    Pécs, 7635

    Not yet recruiting

Other trials in Hungary

Italy5 sites, 5 recruiting

  • Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII

    Bergamo, BERGAMO, 24127

    Not yet recruiting

  • Azienda Ospedaliero Universitaria di Ferrara -Arcispedale Sant' Anna

    Cona, FERRARA, 44124

    Not yet recruiting

  • San Paolo Hospital, ASST Santi Paolo e Carlo

    Milan, Milan, 20142

    Recruiting

  • Azienda Arcispedale Santa Maria Nuova _Usl Di Reggio Emilia/Irccs

    Reggio Emilia, Emilia-Romagna, 42123

    Recruiting

  • Azienda Ospedaliero-Universitaria Policlinico Umberto I

    Roma, ROME, 00161

    Not yet recruiting

Other trials in Italy

South Korea5 sites, 5 recruiting

  • Jeonbuk National University Hospital

    Jeonju, Jeonbuk-do, 54907

    Recruiting

  • Korea University Anam Hospital

    Seoul, Seoul-teukbyeolsi [seoul], 02841

    Recruiting

  • The Catholic University of Korea, Eunpyeong St. Mary's Hospital

    Seoul, 03312

    Recruiting

  • Konkuk University Medical Center

    Seoul, 05030

    Recruiting

  • The Catholic Univ. of Korea Seoul St. Mary's Hospital

    Seoul, 06591

    Recruiting

Other trials in South Korea

Spain5 sites, 5 recruiting

  • Hospital Universitario Virgen de las Nieves (HUVN) - Hospital Materno Infantil

    Granada, Andalusia, 18014

    Recruiting

  • Hospital Universitario Virgen de la Victoria

    Málaga, MÁLAGA, 29010

    Recruiting

  • Hospital de Merida

    Mérida, BADAJOZ, 06800

    Recruiting

  • Hospital Universitario Miguel Servet

    Zaragoza, Aragon, 50009

    Not yet recruiting

  • Hospital Universitario Miguel Servet

    Zaragoza, 50009

    Not yet recruiting

Other trials in Spain

Australia4 sites, 4 recruiting

  • Monash Health

    Clayton, Victoria, 3168

    Not yet recruiting

  • Mater Misericordiae Limited

    South Brisbane, Queensland, 4101

    Not yet recruiting

  • TrialsWest - Spearwood

    Spearwood, Western Australia, 6163

    Recruiting

  • Westmead Hospital

    Westmead, New South Wales, 2145

    Not yet recruiting

Other trials in Australia

Canada4 sites, 4 recruiting

  • Institut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval (IUCPQ-UL)

    Québec, Quebec, G1V 4G5

    Recruiting

  • Synergy Respiratory Care

    Sherwood Park, Alberta, T8H 0N2

    Recruiting

  • C.I.C. Mauricie inc.

    Trois-Rivières, Quebec, G8T 7A1

    Not yet recruiting

  • Dr. Syed Anees Medicine Professional Corporation

    Windsor, Ontario, N8X 1T3

    Recruiting

Other trials in Canada

France4 sites, 4 recruiting

  • Centre Hospitalier Annecy Genevois

    Epagny Metz-Tessy, 74370

    Not yet recruiting

  • Hôpital de la Croix Rousse

    Lyon, 69004

    Not yet recruiting

  • Hôpital Arnaud de Villeneuve - CHU Montpellier

    Montpellier, HÉRAULT, 34090

    Not yet recruiting

  • Hopitaux Universitaires Paris Centre-Hopital Cochin

    Paris, PARIS, 75679

    Not yet recruiting

Other trials in France

About this study

Official title: AN INTERVENTIONAL PHASE 2/3, RANDOMIZED, DOUBLE-BLIND, THIRD PARTY-UNBLINDED, PLACEBO-CONTROLLED, PARALLEL-GROUP STUDY TO INVESTIGATE EFFICACY AND SAFETY OF PF-07275315 IN ADULT PARTICIPANTS WITH MODERATE-TO-SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

The purpose of this clinical trial is to learn about the effects and safety of the study medicine PF-07275315 for the potential treatment of COPD. COPD is a condition that makes it difficult to breathe, which negatively impacts the quality of life and functioning of people who are affected.

This study is seeking participants who:

Read more
  • Are 35 to 80 years old
  • Have had moderate-to-severe COPD for at least 12 months
  • Have a documented history of at least 2 moderate or severe exacerbations within the last 12 months
  • Have been continuously taking their regular maintenance treatment(s) for COPD over at least 6 months at a stable dose for 3 months

All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied.

PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 24 weeks for the Phase 2 part and 52 weeks for the Phase 3 part. We will compare the results of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective.

Participants who will be involved in the Phase 2 part of the study for about 40 weeks. During this time, they will have 11 visits at the study clinic.

Participants who will be involved in the Phase 3 part of the study for about 68 weeks. During this time, they will have 18 visits at the study clinic.

Being tested
PF-07275315 dose 1, PF-07275315-dose 2, Placebo, PF-07275315-dose 3
Keywords
COPD
Medical subject headings
Pulmonary Disease, Chronic Obstructive

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • PF-07275315 dose 1Drug

    SC injection dose 1

  • PF-07275315-dose 2Drug

    SC injection dose 2

  • PlaceboDrug

    SC injection matched

  • PF-07275315-dose 3Drug

    SC injection dose 3

Study groups in NCT07363694
Study groupRoleWhat they receive
Phase 3 Treatment Arm AExperimentalNot described
Receives: Drug: PF-07275315-dose 3
Phase 2 Treatment Arm BExperimentalNot described
Receives: Drug: PF-07275315-dose 2
Phase 2 Treatment Arm AExperimentalNot described
Receives: Drug: PF-07275315 dose 1
Phase 3 Treatment Arm BPlacebo comparatorNot described
Receives: Drug: Placebo
Phase 2 Treatment Arm CPlacebo comparatorNot described
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Phase 2 part: Change from baseline in pre-bronchodilator Forced Expiratory Volume in 1 Second (FEV1) at Week 24

    FEV1 is the maximal volume of air exhaled in the first second of a forced expiration from a position of full inspiration. FEV1 is obtained from spirometry.

    Measured: Baseline to Week 24

  2. Phase 3 part: Annualized rate of moderate or severe ECOPD

    Exacerbation of Chronic Obstructive Pulmonary Disease (ECOPD) are sudden worsening of respiratory symptoms that significantly worsen lung function and quality of life.

    Measured: Baseline to Week 52

Secondary outcomes (15)

  1. Phase 2: Annualized rate of moderate or severe ECOPD.

    Measured: Baseline to Week 24

  2. Phase 2: Change from baseline in pre-BD FEV1 up to Week 24.

    Measured: Baseline to Week 24

  3. Phase 2: Change from baseline in trough, pre- and post-BD FEV1 up to Week 24

    Measured: Baseline to Week 24

  4. Phase 2: Change from baseline in trough, pre- and post-BD FVC and FEV1/FVC ratio, % predicted FEV1, % predicted FVC up to Week 24.

    Measured: Baseline to Week 24

  5. Phase 2: Change from baseline in trough FEV1 responsiveness to BD up to Week 24.

    Measured: Baseline to Week 24

  6. Phase 2: Incidence and severity of TEAEs throughout Phase 2 part of the study.

    Measured: Baseline to Week 24

  7. Phase 2: Incidence of treatment-emergent adverse events and serious adverse events leading to discontinuation.

    Measured: Baseline to Week 24

  8. Phase 2: Incidence of clinical abnormalities in clinical laboratory values, ECG measurements, and vital signs.

    Measured: Baseline to Week 24

  9. Phase 3: change from baseline in pre- and post-BD FEV1 at Week 12 and Week 52.

    Measured: Baseline to Week 52

  10. Phase 3: Percentage of participants with ≥4 points improvement from baseline in Saint George's Respiratory Questionnaire (SGRQ) score at Week 52.

    Measured: Baseline to Week 52

  11. Phase 3: Percentage of participants with ≥2 points improvement from baseline in the COPD Assessment Test (CAT) total score at Week 52.

    Measured: Baseline to Week 52

  12. Phase 3: Percentage of participants with ≥2 points improvement from baseline in E-RS:COPD total score at Week 52.

    Measured: Baseline to Week 52

  13. Phase 3: Annualized rate of severe ECOPD.

    Measured: Baseline to Week 52

  14. Phase 2: Change from baseline of clinical abnormalities in clinical laboratory values, ECG measurements, and vital signs.

    Measured: Baseline to Week 24

  15. Phase 3: Annualized rate of exacerbations requiring emergency department visit and/or hospitalization.

    Measured: Baseline to Week 52

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted23 Jan 2026
  2. Study start11 Feb 2026
  3. Primary completion24 Oct 2030 (estimated)
  4. Study completion16 Jan 2031 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 2/3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
1,156 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07363694
Sponsor's protocol ID
C4531031
Other IDs
2024-518587-12-00
Acronym
COPD
Status last verified
Oct 2026
First submitted
22 Jan 2026
Last updated
22 Oct 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical\_trials/trial\_data\_and\_results/data\_requests.

Questions about this trial

What is this clinical trial studying?

A Phase 2/3 study testing PF-07275315 dose 1, PF-07275315-dose 2 and PF-07275315-dose 3 in people with Moderate to Severe Chronic Obstructive Pulmonary Disease, run by Pfizer at 189 sites in 18 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 22 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 189 sites in United States, China, Bulgaria, Japan, India and 13 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this combined phase mean?

Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Pfizer CT.gov Call Center (1-800-718-1021, ClinicalTrials.gov_Inquiries@pfizer.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Phase 2 part: Change from baseline in pre-bronchodilator Forced Expiratory Volume in 1 Second (FEV1) at Week 24 (time frame: Baseline to Week 24). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07363694.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Oct 2026.

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