Liver Transplant RecipientsNCT07365098
Liver Transplant Recipients and 30-Second Lie-to-Sit Test
An observational study of Liver Transplant Recipients, run by Inonu University at 1 site in Turkey (Türkiye).
Trial summary
The aim of this study is to assess functional capacity in liver transplant recipients using the 30-second lie-to-sit test and to examine the relationships between functional capacity and variables such as muscle strength, upper and lower extremity function, exercise capacity, and perceived exertion. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Liver Transplant Recipients
- What is being tested?
- 30-second lie-to-sit test, Modified Borg Scale and waist circumference
- How many people
- 34 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 8 Nov 2025to 20 Dec 2026
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: liver transplant recipients
Who may be able to join
- Adults aged 18-65 years
- Diagnosed with end-stage liver disease and listed for liver transplantation
- Ability to speak, understand, and write in Turkish
- No mental disorders
- Voluntary participation with informed consent
Who cannot join
- Pulmonary, neurological, or cardiac diseases that may interfere with adherence to the assessment protocol
- Difficulty complying with the assessment program
- Musculoskeletal problems
- History of regular physical activity
- Multiple organ failure
- Cognitive impairment
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Inonu Unıversity
Malatya
About this study
Official title: Assessment of Functional Capacity in Liver Transplant Recipients Using the 30-Second Lie-to-Sit Test
The aim of this study is to assess functional capacity in liver transplant recipients using the 30-second lie-to-sit test and to examine the relationships between functional capacity and variables such as muscle strength, upper and lower extremity function, exercise capacity, and perceived exertion.
Read the detailed description
Participants' demographic and clinical characteristics, including age, gender, BMI, waist circumference, and relevant clinical data, will be recorded. Functional capacity will also be assessed using the 30-second sit-to-stand test, the 2-minute walk test, and upper and lower extremity functional scales (UEFI-15, AEFÖ), with perceived exertion measured using the Modified Borg Scale. Muscle strength will be measured isometrically with a dynamometer for the quadriceps, deltoid, trunk flexor/extensor muscles, and handgrip. The obtained data will provide a comprehensive evaluation of muscle strength and functional status, contributing to individualized rehabilitation planning.
- Conditions
- Liver Transplant Recipients
- Being tested
- 30-second lie-to-sit test, Modified Borg Scale, waist circumference, 30-second sit-to-stand test, Quadriceps muscle strength
- Keywords
- liver, functional capacity, liver transplant recipients, 30 second lie-to-sit test
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
30-second lie-to-sit testOther
In this test, participants will be asked to start from a supine position with their head and arms supported and move to a sitting position as quickly as possible.
They will be allowed to use one hand and, if necessary, a thin cushion to help them sit up. The number of repetitions performed within 30 seconds will be recorded.
Modified Borg ScaleOther
Following the 30-second lie-to-sit test, the modified Borg scale will be used to assess participants' perceived exertion levels.This scale is a standard tool that allows individuals to subjectively assess their level of exertion during physical activity or exercise, rated from 0 (no exertion) to 10 (maximum exertion).
waist circumferenceOther
Waist circumference will be measured in centimeters at the narrowest point between the lowest rib and the upper border of the pelvis while the participant is standing, and the value will be recorded.
30-second sit-to-stand testOther
The 30-second sit-to-stand test will be used to assess participants' lower extremity muscle strength and functional capacity. In this test, the participant sits with their back against a chair, feet flat on the floor, and arms crossed over the chest, and stands up and sits down as many times as possible within 30 seconds. Hands should not touch the chair during the test, and only full, complete repetitions are counted. The total number of repetitions at the end of the test will be recorded.
Quadriceps muscle strengthOther
Quadriceps muscle strength will be measured isometrically using a hand-held dynamometer. The participant will be seated with the knees flexed at 90°. The dynamometer will be placed on the front of the leg at ankle level, and the participant will be asked to lift the leg with maximal effort. Three measurements will be taken for each leg, and the average value will be recorded.
Deltoid muscle strengthOther
Isometric strength of the deltoid muscle will be assessed using a hand-held dynamometer. The participant will be seated with the shoulder positioned at 90° abduction and the elbow slightly flexed. The dynamometer will be placed on the lateral side of the upper arm at elbow level, and the participant will perform maximum-effort shoulder abduction. Three measurements will be taken for each extremity, and the average value will be recorded.
Trunk flexion strengthOther
The isometric trunk flexion strength test will be performed with the participant positioned supine, with the knees extented or the hips flexed at 30°. The dynamometer will be placed below the suprasternal notch of the sternum. The participant will place their hands on the opposite acromions and perform isometric trunk flexion.
Trunk extension strengthOther
The isometric trunk extension strength, the participant will be positioned prone while lying down. The dynamometer will be placed at the T4 level, and the participant will be asked to perform maximum isometric trunk extension. In each test position, participants will first perform a submaximal trial, followed by three correct repetitions, and the average value will be recorded.
Handgrip strengthOther
Handgrip strength will be assessed using a hand dynamometer. Participants will be seated with their shoulders adducted at the sides, elbows flexed at 90°, forearms in a neutral position, and wrists positioned at 0-30° extension and 0-15° ulnar deviation. Three trials will be performed for each hand, with a 30-second rest between trials. For analysis, the average of three measurements for both hands will be recorded.
2-minute walk testOther
The 2-minute walk test will be used to assess participants' exercise capacity and physical performance. During the test, participants will walk at a self-selected, safe pace for two minutes, and the distance covered in meters will be recorded.
Upper Extremity Functional Index-15 (UEFI-15)Other
This questionnaire consists of 15 items that assess difficulties in using the upper extremities for activities of daily living. Each item is scored from 0 (cannot do) to 4 (no difficulty). The raw score ranges from 0 to 59 and is converted to a final score ranging from 0 to 100. A higher final score indicates better upper extremity function, providing a comprehensive assessment of functional capacity.
Lower Extremity Functional Scale (LEFS)Other
This questionnaire is important for assessing lower extremity functional capacity and examining activity limitations in various lower extremity disorders. It consists of 20 items, each scored from 0 (extreme difficulty or unable to perform the activity) to 4 (no difficulty). Intermediate values are defined as 1 (quite difficult), 2 (moderately difficult), and 3 (somewhat difficult). The total score ranges from 0 to 80, with higher scores indicating better functional level.
What is being measured
The primary outcome is the main question the study is designed to answer.
30-second lie-to-sit test
In this test, participants will be asked to start from a supine position with their head and arms supported and move to a sitting position as quickly as possible. They will be allowed to use one hand and, if necessary, a thin cushion to help them sit up. The number of repetitions performed within 30 seconds will be recorded.
Measured: 24 hours
Secondary outcomes (11)
Waist Circumference
Waist circumference will be measured in centimeters at the narrowest point between the lowest rib and the upper border of the pelvis while the participant is standing, and the value will be recorded.
Measured: 24 hours
Modified Borg Scale
Following the 30-second lie-to-sit test, the modified Borg scale will be used to assess participants' perceived exertion levels.This scale is a standard tool that allows individuals to subjectively assess their level of exertion during physical activity or exercise, rated from 0 (no exertion) to 10 (maximum exertion).
Measured: 24 hours
30-second sit-to-stand test
The 30-second sit-to-stand test will be used to assess participants' lower extremity muscle strength and functional capacity. In this test, the participant sits with their back against a chair, feet flat on the floor, and arms crossed over the chest, and stands up and sits down as many times as possible within 30 seconds. Hands should not touch the chair during the test, and only full, complete repetitions are counted. The total number of repetitions at the end of the test will be recorded.
Measured: 24 hours
Quadriceps muscle strength
Quadriceps muscle strength will be measured isometrically using a hand-held dynamometer. The participant will be seated with the knees flexed at 90°. The dynamometer will be placed on the front of the leg at ankle level, and the participant will be asked to lift the leg with maximal effort. Three measurements will be taken for each leg, and the average value will be recorded.
Measured: 24 hours
Deltoid muscle strength
Isometric strength of the deltoid muscle will be assessed using a hand-held dynamometer. The participant will be seated with the shoulder positioned at 90° abduction and the elbow slightly flexed. The dynamometer will be placed on the lateral side of the upper arm at elbow level, and the participant will perform maximum-effort shoulder abduction. Three measurements will be taken for each extremity, and the average value will be recorded.
Measured: 24 hours
Trunk flexion strength
The isometric trunk flexion strength test will be performed with the participant positioned supine, with the knees extented or the hips flexed at 30°. The dynamometer will be placed below the suprasternal notch of the sternum. The participant will place their hands on the opposite acromions and perform isometric trunk flexion.
Measured: 24 hours
Trunk extension strength
The isometric trunk extension strength, the participant will be positioned prone while lying down. The dynamometer will be placed at the T4 level, and the participant will be asked to perform maximum isometric trunk extension. In each test position, participants will first perform a submaximal trial, followed by three correct repetitions, and the average value will be recorded.
Measured: 24 hours
Handgrip strength
Handgrip strength will be assessed using a hand dynamometer. Participants will be seated with their shoulders adducted at the sides, elbows flexed at 90°, forearms in a neutral position, and wrists positioned at 0-30° extension and 0-15° ulnar deviation. Three trials will be performed for each hand, with a 30-second rest between trials. For analysis, the average of three measurements for both hands will be recorded.
Measured: 24 hours
2-minute Walk Test
The 2-minute walk test will be used to assess participants' exercise capacity and physical performance. During the test, participants will walk at a self-selected, safe pace for two minutes, and the distance covered in meters will be recorded.
Measured: 24 hours
Upper Extremity Functional Index-15 (UEFI-15)
This questionnaire consists of 15 items that assess difficulties in using the upper extremities for activities of daily living. Each item is scored from 0 (cannot do) to 4 (no difficulty). The raw score ranges from 0 to 59 and is converted to a final score ranging from 0 to 100. A higher final score indicates better upper extremity function, providing a comprehensive assessment of functional capacity.
Measured: 24 hours
Lower Extremity Functional Scale (LEFS)
This questionnaire is important for assessing lower extremity functional capacity and examining activity limitations in various lower extremity disorders. It consists of 20 items, each scored from 0 (extreme difficulty or unable to perform the activity) to 4 (no difficulty). Intermediate values are defined as 1 (quite difficult), 2 (moderately difficult), and 3 (somewhat difficult). The total score ranges from 0 to 80, with higher scores indicating better functional level.
Measured: 24 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Jan 2026
- Study start8 Nov 2025
- Primary completion20 Oct 2026 (estimated)
- Study completion20 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Liver Transplant RecipientsStudies of the same condition, open and under way.
- More trials run by Inonu UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 34 participants (estimated)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Inonu University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, BÜŞRA CANDİRİ, Inonu University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07365098
- Sponsor's protocol ID
- 2025/8550
- Status last verified
- Nov 2025
- First submitted
- 15 Jan 2026
- Last updated
- 26 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 26 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Assessment of Functional Capacity in Liver Transplant Recipients Using the 30-Second Lie-to-Sit Test
- ClinicalTrials.gov ID
- NCT07365098
- Acronym / sponsor ID
- 2025/8550
- Conditions
- Liver Transplant Recipients
- Keywords
- liver, functional capacity, liver transplant recipients, 30 second lie-to-sit test
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 34 participants (estimated)
- Lead sponsor
- Inonu UniversityUniversity, hospital or other
- Study start
- 8 Nov 2025 (actual)
- Primary completion
- 20 Oct 2026 (estimated)
- Study completion
- 20 Dec 2026 (estimated)
- First posted
- 26 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to assess functional capacity in liver transplant recipients using the 30-second lie-to-sit test and to examine the relationships between functional capacity and variables such as muscle strength, upper and lower extremity function, exercise capacity, and perceived exertion.
Detailed description
Participants' demographic and clinical characteristics, including age, gender, BMI, waist circumference, and relevant clinical data, will be recorded. Functional capacity will also be assessed using the 30-second sit-to-stand test, the 2-minute walk test, and upper and lower extremity functional scales (UEFI-15, AEFÖ), with perceived exertion measured using the Modified Borg Scale. Muscle strength will be measured isometrically with a dynamometer for the quadriceps, deltoid, trunk flexor/extensor muscles, and handgrip. The obtained data will provide a comprehensive evaluation of muscle strength and functional status, contributing to individualized rehabilitation planning.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
- Target follow-up
- 1 Day
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- liver transplant recipients
Key inclusion criteria (5 listed)
- Adults aged 18-65 years
- Diagnosed with end-stage liver disease and listed for liver transplantation
- Ability to speak, understand, and write in Turkish
- No mental disorders
- Voluntary participation with informed consent
Key exclusion criteria (6 listed)
- Pulmonary, neurological, or cardiac diseases that may interfere with adherence to the assessment protocol
- Difficulty complying with the assessment program
- Musculoskeletal problems
- History of regular physical activity
- Multiple organ failure
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| 30-second lie-to-sit testIn this test, participants will be asked to start from a supine position with their head and arms supported and move to a sitting position as quickly as possible. They will be allowed to use one hand and, if necessary, a thin cushion to help them sit up. The number of repetitions performed within 30 seconds will be recorded. | Other | – |
| Modified Borg ScaleFollowing the 30-second lie-to-sit test, the modified Borg scale will be used to assess participants' perceived exertion levels.This scale is a standard tool that allows individuals to subjectively assess their level of exertion during physical activity or exercise, rated from 0 (no exertion) to 10 (maximum exertion). | Other | – |
| waist circumferenceWaist circumference will be measured in centimeters at the narrowest point between the lowest rib and the upper border of the pelvis while the participant is standing, and the value will be recorded. | Other | – |
| 30-second sit-to-stand testThe 30-second sit-to-stand test will be used to assess participants' lower extremity muscle strength and functional capacity. In this test, the participant sits with their back against a chair, feet flat on the floor, and arms crossed over the chest, and stands up and sits down as many times as possible within 30 seconds. Hands should not touch the chair during the test, and only full, complete repetitions are counted. The total number of repetitions at the end of the test will be recorded. | Other | – |
| Quadriceps muscle strengthQuadriceps muscle strength will be measured isometrically using a hand-held dynamometer. The participant will be seated with the knees flexed at 90°. The dynamometer will be placed on the front of the leg at ankle level, and the participant will be asked to lift the leg with maximal effort. Three measurements will be taken for each leg, and the average value will be recorded. | Other | – |
| Deltoid muscle strengthIsometric strength of the deltoid muscle will be assessed using a hand-held dynamometer. The participant will be seated with the shoulder positioned at 90° abduction and the elbow slightly flexed. The dynamometer will be placed on the lateral side of the upper arm at elbow level, and the participant will perform maximum-effort shoulder abduction. Three measurements will be taken for each extremity, and the average value will be recorded. | Other | – |
| Trunk flexion strengthThe isometric trunk flexion strength test will be performed with the participant positioned supine, with the knees extented or the hips flexed at 30°. The dynamometer will be placed below the suprasternal notch of the sternum. The participant will place their hands on the opposite acromions and perform isometric trunk flexion. | Other | – |
| Trunk extension strengthThe isometric trunk extension strength, the participant will be positioned prone while lying down. The dynamometer will be placed at the T4 level, and the participant will be asked to perform maximum isometric trunk extension. In each test position, participants will first perform a submaximal trial, followed by three correct repetitions, and the average value will be recorded. | Other | – |
| Handgrip strengthHandgrip strength will be assessed using a hand dynamometer. Participants will be seated with their shoulders adducted at the sides, elbows flexed at 90°, forearms in a neutral position, and wrists positioned at 0-30° extension and 0-15° ulnar deviation. Three trials will be performed for each hand, with a 30-second rest between trials. For analysis, the average of three measurements for both hands will be recorded. | Other | – |
| 2-minute walk testThe 2-minute walk test will be used to assess participants' exercise capacity and physical performance. During the test, participants will walk at a self-selected, safe pace for two minutes, and the distance covered in meters will be recorded. | Other | – |
| Upper Extremity Functional Index-15 (UEFI-15)This questionnaire consists of 15 items that assess difficulties in using the upper extremities for activities of daily living. Each item is scored from 0 (cannot do) to 4 (no difficulty). The raw score ranges from 0 to 59 and is converted to a final score ranging from 0 to 100. A higher final score indicates better upper extremity function, providing a comprehensive assessment of functional capacity. | Other | – |
| Lower Extremity Functional Scale (LEFS)This questionnaire is important for assessing lower extremity functional capacity and examining activity limitations in various lower extremity disorders. It consists of 20 items, each scored from 0 (extreme difficulty or unable to perform the activity) to 4 (no difficulty). Intermediate values are defined as 1 (quite difficult), 2 (moderately difficult), and 3 (somewhat difficult). The total score ranges from 0 to 80, with higher scores indicating better functional level. | Other | – |
Primary outcome
30-second lie-to-sit test
Time frame: 24 hours
In this test, participants will be asked to start from a supine position with their head and arms supported and move to a sitting position as quickly as possible. They will be allowed to use one hand and, if necessary, a thin cushion to help them sit up. The number of repetitions performed within 30 seconds will be recorded.
11 secondary outcomes
Waist Circumference
Time frame: 24 hours
Modified Borg Scale
Time frame: 24 hours
30-second sit-to-stand test
Time frame: 24 hours
Quadriceps muscle strength
Time frame: 24 hours
Deltoid muscle strength
Time frame: 24 hours
Trunk flexion strength
Time frame: 24 hours
Trunk extension strength
Time frame: 24 hours
Handgrip strength
Time frame: 24 hours
2-minute Walk Test
Time frame: 24 hours
Upper Extremity Functional Index-15 (UEFI-15)
Time frame: 24 hours
Lower Extremity Functional Scale (LEFS)
Time frame: 24 hours
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Jan 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Liver Transplant Recipients, run by Inonu University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 26 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Büşra CANDİRİ (+905073780717, candiri_17@hotmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
30-second lie-to-sit test (time frame: 24 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Jan 2026.