Diabetes Mellitus, Type 1Interdiab 1NCT07365176
High-intensity Interval Exercise Compared With Continuous Moderate Exercise on Glycemia in Postabsorptive vs. Postprandial State in Adults With Type 1 Diabetes
A study testing High-intensity interval exercise performed in postprandial phase, High-intensity interval exercise performed in postabsorptive phase and Moderate-intensity continuous exercise performed in postprandial phase in people with Diabetes Mellitus, Type 1, run by Universite du Littoral Cote d'Opale at 1 site in France.
Trial summary
This randomized crossover trial examined whether exercise modality (high-intensity interval exercise vs. moderate-intensity continuous exercise) and timing relative to meals (postprandial vs. postabsorptive) influence glycemic responses in physically active adults with type 1 diabetes. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Diabetes Mellitus, Type 1
- What is being tested?
- High-intensity interval exercise performed in postprandial phase, High-intensity interval exercise performed in postabsorptive phase and Moderate-intensity continuous exercise performed in postprandial phase
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 21 participants
- Where
- 1 siteFrance
- Study dates
- 8 Feb 2023to 9 May 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Between 18 and 60 years of age
- Regular practice of physical activity (at least 2 training sessions/week for at least 3 months)
- Diagnosis of type 1 diabetes for >1 year
- No change in insulin delivery method (i.e., multiple daily injections [MDI], continuous subcutaneous insulin infusion [CSII] in open or closed loop) over the previous 3 months
- Use of a continuous glucose monitoring (CGM) device in daily life
Who cannot join
- Diabetes-related complications except for background retinopathy
Trial locations and contacts
1 site in 1 country.
France1 site
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS - ULR 7369)
Loos, 59120
About this study
Official title: The Protective Role of High-intensity Interval Exercise Compared With Continuous Moderate Exercise on Glycemia Decrease is More Relevant in Postabsorptive vs. Postprandial State in Adults With Type 1 Diabetes
This randomized crossover trial examined whether exercise modality (high-intensity interval exercise vs. moderate-intensity continuous exercise) and timing relative to meals (postprandial vs. postabsorptive) influence glycemic responses in physically active adults with type 1 diabetes. Participants completed four cycling sessions matched for total mechanical load, and glucose levels were monitored during exercise and for 24 hours afterward while accounting for dietary intake and insulin administration. The study hypothesized that glycemic responses differ according to both exercise type and prandial state.
Read the detailed description
Participants were tested at the laboratory during one inclusion visit followed by 4 intervention visits separated by at least 48 hours and 4 weeks maximum. During the inclusion visit, participants completed the YMCA submaximal cycle-ergometer (Excalibur Sport, Lode B.V.) test to estimate maximal aerobic power (MAP), which was then used to determine subsequent exercise workloads. The test started at 25 W (50 rpm), with increasing power outputs derived from the first-stage heart-rate response. The 3-min stages continued until steady-state heart rate achieved 85% of maximal heart rate minus 10 bpm, with a 1-min extension if heart rate varied by >5 beats·min-¹ between minutes 2 and 3. Participants completed questionnaires about physical activity levels, barriers to physical activity, quality-of-life and hypoglycemia awareness. The next four experimental visits in randomized order consisted of the two aerobic exercises (i.e. high-intensity interval exercise, HIIE and moderate-intensity continuous exercise, CONT), each performed under two different prandial conditions, postprandial (PP) and postabsorptive (PA) state. A triaxial accelerometer (ActiGraph, wGT3X-BT, 30 Hz, epoch set at 60 sec) was worn on the hip from wake-up until bedtime for the day before, during and after each experimental visit. Participants were also asked to record the time, type and amount of food consumed, with the option of photographing meals, as well as in case of multiple daily injection doses/timing of insulin (rapid- and long-acting), the 24 hours before, during and after each visit. Exercises were performed on a cycle ergometer (Excalibur Sport, Lode B.V.) and were matched for total mechanical load and total duration. Both exercises began with a 3-min warm-up at 20% of MAP and ended with a 2-min active recovery at 20% of MAP. The HIIE protocol consisted of ten 1-min intervals at 100% of MAP, each interspersed with 1-min of passive recovery. The CONT protocol consisted of continuous exercise at 50% of MAP for 20 minutes. For the postprandial state, exercise began 1.5 hours after the start of lunch and the corresponding meal-related bolus/rapid-acting insulin, (i.e., in the early afternoon). For the postabsorptive state, exercise began 5 hours after the start of lunch, (i.e., in the late afternoon). Participants were instructed to follow their habitual pre-exercise routine and to replicate, as closely as possible, the same lunch and dinner on the days of the experimental visits. The measurements included: oxygen uptake, heart rate, rate of perceived exertion, muscle vasoreactivity during exercise; capillary glycaemia and lactataemia at several time points during exercise; continuous glucose monitoring data from the personal (used in daily life) device of the participants.
- Conditions
- Diabetes Mellitus, Type 1
- Being tested
- High-intensity interval exercise performed in postprandial phase, High-intensity interval exercise performed in postabsorptive phase, Moderate-intensity continuous exercise performed in postprandial phase, Moderate-intensity continuous exercise performed in postabsorptive phase
- Keywords
- Blood glucose, Exercise, Hypoglycemia
- Medical subject headings
- Diabetes Mellitus, Type 1, Motor Activity, Hypoglycemia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High-intensity interval exercise performed in postprandial phaseOther
Exercises were performed on a cycle ergometer (Excalibur Sport, Lode B.V.). Exercise began with a 3-min warm-up at 20% of maximum aerobic power (MAP) and ended with a 2-min active recovery at 20% of MAP. The high-intensity interval exercise protocol consisted of ten 1-min intervals at 100% of MAP, each interspersed with 1-min of passive recovery. For the postprandial state, exercise began 1.5 hours after the start of lunch and the corresponding meal-related bolus/rapid-acting insulin (i.e., in the early afternoon).
High-intensity interval exercise performed in postabsorptive phaseOther
Exercises were performed on a cycle ergometer (Excalibur Sport, Lode B.V.). Exercise began with a 3-min warm-up at 20% of maximum aerobic power (MAP) and ended with a 2-min active recovery at 20% of MAP. The high-intensity interval exercise protocol consisted of ten 1-min intervals at 100% of MAP, each interspersed with 1-min of passive recovery. For the postabsorptive state, exercise began 5 hours after the start of lunch (i.e., in the late afternoon).
Moderate-intensity continuous exercise performed in postprandial phaseOther
Exercises were performed on a cycle ergometer (Excalibur Sport, Lode B.V.). Exercise began with a 3-min warm-up at 20% of maximum aerobic power (MAP) and ended with a 2-min active recovery at 20% of MAP. The moderate-intensity continuous exercise protocol consisted of continuous exercise at 50% of MAP for 20 minutes. For the postprandial state, exercise began 1.5 hours after the start of lunch and the corresponding meal-related bolus/rapid-acting insulin (i.e., in the early afternoon).
Moderate-intensity continuous exercise performed in postabsorptive phaseOther
Exercises were performed on a cycle ergometer (Excalibur Sport, Lode B.V.). Exercise began with a 3-min warm-up at 20% of MAP and ended with a 2-min active recovery at 20% of maximum aerobic power (MAP). The CONT protocol consisted of continuous exercise at 50% of MAP for 20 minutes. For the postabsorptive state, exercise began 5 hours after the start of lunch (i.e., in the late afternoon).
| Study group | Role | What they receive |
|---|---|---|
| A/B/C/D | Experimental | A= High-intensity interval exercise in postabsorptive phase B= High-intensity interval exercise in postprandial phase C= Moderate-intensity continuous exercise in postabsorptive phase D= Moderate-intensity continuous exercise in postprandial phase Receives: Other: High-intensity interval exercise performed in postprandial phase; Other: High-intensity interval exercise performed in postabsorptive phase; Other: Moderate-intensity continuous exercise performed in postprandial phase; Other: Moderate-intensity continuous exercise performed in postabsorptive phase |
| B/C/D/A | Experimental | A= High-intensity interval exercise in postabsorptive phase B= High-intensity interval exercise in postprandial phase C= Moderate-intensity continuous exercise in postabsorptive phase D= Moderate-intensity continuous exercise in postprandial phase Receives: Other: High-intensity interval exercise performed in postprandial phase; Other: High-intensity interval exercise performed in postabsorptive phase; Other: Moderate-intensity continuous exercise performed in postprandial phase; Other: Moderate-intensity continuous exercise performed in postabsorptive phase |
| C/D/A/B | Experimental | A= High-intensity interval exercise in postabsorptive phase B= High-intensity interval exercise in postprandial phase C= Moderate-intensity continuous exercise in postabsorptive phase D= Moderate-intensity continuous exercise in postprandial phase Receives: Other: High-intensity interval exercise performed in postprandial phase; Other: High-intensity interval exercise performed in postabsorptive phase; Other: Moderate-intensity continuous exercise performed in postprandial phase; Other: Moderate-intensity continuous exercise performed in postabsorptive phase |
| D/A/B/C | Experimental | A= High-intensity interval exercise in postabsorptive phase B= High-intensity interval exercise in postprandial phase C= Moderate-intensity continuous exercise in postabsorptive phase D= Moderate-intensity continuous exercise in postprandial phase Receives: Other: High-intensity interval exercise performed in postprandial phase; Other: High-intensity interval exercise performed in postabsorptive phase; Other: Moderate-intensity continuous exercise performed in postprandial phase; Other: Moderate-intensity continuous exercise performed in postabsorptive phase |
What is being measured
The primary outcome is the main question the study is designed to answer.
Capillary glycemia
Blood glucose meter
Measured: At rest before exercise, then at 10 and 20 min of exercise, at 2 min of active recovery post-exercise, and at 10 min of passive recovery post-exercise.
Secondary outcomes (7)
Interstitial glucose
Continuous Glucose Monitoring system used by the participant in daily life
Measured: The 24 hours before and the 24 hours after each visit
Capillary blood lactate
Measured using the Lactate Scout device.
Measured: At rest before exercise, then at 10 and 20 min of exercise, at 2 min of active recovery post-exercise, and at 10 min of passive recovery post-exercise.
Oxygen consumption
Measured with a mask and a Vynthus CPX, Vyaire Medical
Measured: During a 5-min rest before exercise, a 3-min warm-up, 20-min of exercise, a 2-min active recovery post-exercise, and a 10-min passive recovery post-exercise.
Rate of Perveived Exertion
Rate of Perveived Exertion from the Borg Scale (6 to 20 scale)
Measured: At rest before the exercise, and then at 5-min, 10-min, 15-min and 20-min of exercise, at 2-min active recovery post-exercise and at 5 and 10-min passive recovery post-exercise.
Variation of muscle blood volume.
Measured with Near infrared spectroscopy (Artinis, PortaLite)
Measured: During a 5-min rest before exercise, a 3-min warm-up, 20-min of exercise, a 2-min active recovery post-exercise, and a 5-min passive recovery post-exercise.
Heart rate
Measured with Polar V800.
Measured: During a 5-min rest before exercise, a 3-min warm-up, 20-min of exercise, a 2-min active recovery post-exercise, and a 10-min passive recovery post-exercise.
Perceived pleasure
Physical activity enjoyment scale (PACES) 18 items rated on a 7-point Likert scale.
Measured: At the end of 10-min passive recovery post-exercise.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Jan 2026
- Study start8 Feb 2023
- Primary completion17 Jan 2025
- Study completion9 May 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Diabetes Mellitus, Type 1Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 21 participants (actual)
Sponsor and investigators
- Lead sponsor
- Universite du Littoral Cote d'Opale
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Herve DEVANNE, PhD, Universite du Littoral Cote d'Opale
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07365176
- Sponsor's protocol ID
- IRB00012476-2023-08-02-225
- Acronym
- Interdiab 1
- Status last verified
- Jan 2026
- First submitted
- 28 Dec 2025
- Last updated
- 26 Jan 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The investigators will share on http://recherche.data.gouv.fr all anonymized data presented in the publication of the results
Publications
Melin A, Lespagnol E, Combes A, Berthoin S, Rabasa-Lhoret R, Savina Y, Tagougui S, Bautin N, Baudoux F, Descatoire A, Vambergue A, Heyman E. The protective effect of high-intensity interval exercise compared with continuous moderate exercise on glycaemic decline is more pronounced in the postabsorptive vs postprandial state in adults with type 1 diabetes: a randomised crossover trial. Diabetologia. 2026 Sep;69(9):2408-2420. doi: 10.1007/s00125-026-06760-z. Epub 2026 Jun 9.
PubMed 42262529
Study at a glance
From the registry record, last updated by the sponsor on 26 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Protective Role of High-intensity Interval Exercise Compared With Continuous Moderate Exercise on Glycemia Decrease is More Relevant in Postabsorptive vs. Postprandial State in Adults With Type 1 Diabetes
- ClinicalTrials.gov ID
- NCT07365176
- Acronym / sponsor ID
- Interdiab 1 / IRB00012476-2023-08-02-225
- Conditions
- Diabetes Mellitus, Type 1
- Keywords
- Blood glucose, Exercise, Hypoglycemia
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 21 participants (actual)
- Lead sponsor
- Universite du Littoral Cote d'OpaleUniversity, hospital or other
- Study start
- 8 Feb 2023 (actual)
- Primary completion
- 17 Jan 2025 (actual)
- Study completion
- 9 May 2025 (actual)
- First posted
- 26 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized crossover trial examined whether exercise modality (high-intensity interval exercise vs. moderate-intensity continuous exercise) and timing relative to meals (postprandial vs. postabsorptive) influence glycemic responses in physically active adults with type 1 diabetes. Participants completed four cycling sessions matched for total mechanical load, and glucose levels were monitored during exercise and for 24 hours afterward while accounting for dietary intake and insulin administration. The study hypothesized that glycemic responses differ according to both exercise type and prandial state.
Detailed description
Participants were tested at the laboratory during one inclusion visit followed by 4 intervention visits separated by at least 48 hours and 4 weeks maximum. During the inclusion visit, participants completed the YMCA submaximal cycle-ergometer (Excalibur Sport, Lode B.V.) test to estimate maximal aerobic power (MAP), which was then used to determine subsequent exercise workloads. The test started at 25 W (50 rpm), with increasing power outputs derived from the first-stage heart-rate response. The 3-min stages continued until steady-state heart rate achieved 85% of maximal heart rate minus 10 bpm, with a 1-min extension if heart rate varied by >5 beats·min-¹ between minutes 2 and 3. Participants completed questionnaires about physical activity levels, barriers to physical activity, quality-of-life and hypoglycemia awareness. The next four experimental visits in randomized order consisted of the two aerobic exercises (i.e. high-intensity interval exercise, HIIE and moderate-intensity continuous exercise, CONT), each performed under two different prandial conditions, postprandial (PP) and postabsorptive (PA) state. A triaxial accelerometer (ActiGraph, wGT3X-BT, 30 Hz, epoch set at 60 sec) was worn on the hip from wake-up until bedtime for the day before, during and after each experimental visit. Participants were also asked to record the time, type and amount of food consumed, with the option of photographing meals, as well as in case of multiple daily injection doses/timing of insulin (rapid- and long-acting), the 24 hours before, during and after each visit. Exercises were performed on a cycle ergometer (Excalibur Sport, Lode B.V.) and were matched for total mechanical load and total duration. Both exercises began with a 3-min warm-up at 20% of MAP and ended with a 2-min active recovery at 20% of MAP. The HIIE protocol consisted of ten 1-min intervals at 100% of MAP, each interspersed with 1-min of passive recovery. The CONT protocol consisted of continuous exercise at 50% of MAP for 20 minutes. For the postprandial state, exercise began 1.5 hours after the start of lunch and the corresponding meal-related bolus/rapid-acting insulin, (i.e., in the early afternoon). For the postabsorptive state, exercise began 5 hours after the start of lunch, (i.e., in the late afternoon). Participants were instructed to follow their habitual pre-exercise routine and to replicate, as closely as possible, the same lunch and dinner on the days of the experimental visits. The measurements included: oxygen uptake, heart rate, rate of perceived exertion, muscle vasoreactivity during exercise; capillary glycaemia and lactataemia at several time points during exercise; continuous glucose monitoring data from the personal (used in daily life) device of the participants.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| A/B/C/D | Experimental | Other: High-intensity interval exercise performed in postprandial phase, Other: High-intensity interval exercise performed in postabsorptive phase, Other: Moderate-intensity continuous exercise performed in postprandial phase, Other: Moderate-intensity continuous exercise performed in postabsorptive phaseA= High-intensity interval exercise in postabsorptive phase B= High-intensity interval exercise in postprandial phase C= Moderate-intensity continuous exercise in postabsorptive phase D= Moderate-intensity continuous exercise in postprandial phase |
| B/C/D/A | Experimental | Other: High-intensity interval exercise performed in postprandial phase, Other: High-intensity interval exercise performed in postabsorptive phase, Other: Moderate-intensity continuous exercise performed in postprandial phase, Other: Moderate-intensity continuous exercise performed in postabsorptive phaseA= High-intensity interval exercise in postabsorptive phase B= High-intensity interval exercise in postprandial phase C= Moderate-intensity continuous exercise in postabsorptive phase D= Moderate-intensity continuous exercise in postprandial phase |
| C/D/A/B | Experimental | Other: High-intensity interval exercise performed in postprandial phase, Other: High-intensity interval exercise performed in postabsorptive phase, Other: Moderate-intensity continuous exercise performed in postprandial phase, Other: Moderate-intensity continuous exercise performed in postabsorptive phaseA= High-intensity interval exercise in postabsorptive phase B= High-intensity interval exercise in postprandial phase C= Moderate-intensity continuous exercise in postabsorptive phase D= Moderate-intensity continuous exercise in postprandial phase |
| D/A/B/C | Experimental | Other: High-intensity interval exercise performed in postprandial phase, Other: High-intensity interval exercise performed in postabsorptive phase, Other: Moderate-intensity continuous exercise performed in postprandial phase, Other: Moderate-intensity continuous exercise performed in postabsorptive phaseA= High-intensity interval exercise in postabsorptive phase B= High-intensity interval exercise in postprandial phase C= Moderate-intensity continuous exercise in postabsorptive phase D= Moderate-intensity continuous exercise in postprandial phase |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Between 18 and 60 years of age
- Regular practice of physical activity (at least 2 training sessions/week for at least 3 months)
- Diagnosis of type 1 diabetes for >1 year
- No change in insulin delivery method (i.e., multiple daily injections [MDI], continuous subcutaneous insulin infusion [CSII] in open or closed loop) over the previous 3 months
- Use of a continuous glucose monitoring (CGM) device in daily life
Key exclusion criteria (1 listed)
- Diabetes-related complications except for background retinopathy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High-intensity interval exercise performed in postprandial phaseExercises were performed on a cycle ergometer (Excalibur Sport, Lode B.V.). Exercise began with a 3-min warm-up at 20% of maximum aerobic power (MAP) and ended with a 2-min active recovery at 20% of MAP. The high-intensity interval exercise protocol consisted of ten 1-min intervals at 100% of MAP, each interspersed with 1-min of passive recovery. For the postprandial state, exercise began 1.5 hours after the start of lunch and the corresponding meal-related bolus/rapid-acting insulin (i.e., in the early afternoon). | Other | A/B/C/D, B/C/D/A, C/D/A/B, D/A/B/C |
| High-intensity interval exercise performed in postabsorptive phaseExercises were performed on a cycle ergometer (Excalibur Sport, Lode B.V.). Exercise began with a 3-min warm-up at 20% of maximum aerobic power (MAP) and ended with a 2-min active recovery at 20% of MAP. The high-intensity interval exercise protocol consisted of ten 1-min intervals at 100% of MAP, each interspersed with 1-min of passive recovery. For the postabsorptive state, exercise began 5 hours after the start of lunch (i.e., in the late afternoon). | Other | A/B/C/D, B/C/D/A, C/D/A/B, D/A/B/C |
| Moderate-intensity continuous exercise performed in postprandial phaseExercises were performed on a cycle ergometer (Excalibur Sport, Lode B.V.). Exercise began with a 3-min warm-up at 20% of maximum aerobic power (MAP) and ended with a 2-min active recovery at 20% of MAP. The moderate-intensity continuous exercise protocol consisted of continuous exercise at 50% of MAP for 20 minutes. For the postprandial state, exercise began 1.5 hours after the start of lunch and the corresponding meal-related bolus/rapid-acting insulin (i.e., in the early afternoon). | Other | A/B/C/D, B/C/D/A, C/D/A/B, D/A/B/C |
| Moderate-intensity continuous exercise performed in postabsorptive phaseExercises were performed on a cycle ergometer (Excalibur Sport, Lode B.V.). Exercise began with a 3-min warm-up at 20% of MAP and ended with a 2-min active recovery at 20% of maximum aerobic power (MAP). The CONT protocol consisted of continuous exercise at 50% of MAP for 20 minutes. For the postabsorptive state, exercise began 5 hours after the start of lunch (i.e., in the late afternoon). | Other | A/B/C/D, B/C/D/A, C/D/A/B, D/A/B/C |
Primary outcome
Capillary glycemia
Time frame: At rest before exercise, then at 10 and 20 min of exercise, at 2 min of active recovery post-exercise, and at 10 min of passive recovery post-exercise.
Blood glucose meter
7 secondary outcomes
Interstitial glucose
Time frame: The 24 hours before and the 24 hours after each visit
Capillary blood lactate
Time frame: At rest before exercise, then at 10 and 20 min of exercise, at 2 min of active recovery post-exercise, and at 10 min of passive recovery post-exercise.
Oxygen consumption
Time frame: During a 5-min rest before exercise, a 3-min warm-up, 20-min of exercise, a 2-min active recovery post-exercise, and a 10-min passive recovery post-exercise.
Rate of Perveived Exertion
Time frame: At rest before the exercise, and then at 5-min, 10-min, 15-min and 20-min of exercise, at 2-min active recovery post-exercise and at 5 and 10-min passive recovery post-exercise.
Variation of muscle blood volume.
Time frame: During a 5-min rest before exercise, a 3-min warm-up, 20-min of exercise, a 2-min active recovery post-exercise, and a 5-min passive recovery post-exercise.
Heart rate
Time frame: During a 5-min rest before exercise, a 3-min warm-up, 20-min of exercise, a 2-min active recovery post-exercise, and a 10-min passive recovery post-exercise.
Perceived pleasure
Time frame: At the end of 10-min passive recovery post-exercise.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Jan 2026.
- Derived from this study: PubMed 42262529Melin A, Lespagnol E, Combes A, Berthoin S, Rabasa-Lhoret R, Savina Y, Tagougui S, Bautin N, Baudoux F, Descatoire A, Vambergue A, Heyman E. The protective effect of high-intensity interval exercise compared with continuous moderate exercise on glycaemic decline is more pronounced in the postabsorptive vs postprandial state in adults with type 1 diabetes: a randomised crossover trial. Diabetologia. 2026 Sep;69(9):2408-2420. doi: 10.1007/s00125-026-06760-z. Epub 2026 Jun 9.
- Individual participant dataSharing planned: Yes. The investigators will share on http://recherche.data.gouv.fr all anonymized data presented in the publication of the results
Related trials for Diabetes Mellitus, Type 1
Active, not recruitingPhase 3
Clinical Application of Stem Cell Educator Therapy in Type 1 Diabetes
Type 1 Diabetes
RecruitingObservational study
Study of High Density Lipoprotein Function in Type 1 Diabetic Patients With Nephropathy
Type 1 Diabetes
Active, not recruitingPhase 1/2
A First-In-Human Study of ARO-INHBE in Adults With Obesity With and Without Type 2 Diabetes Mellitus
Obesity
RecruitingPhase 3
A Study to Evaluate Effect of AZD6234 in Adult Participants With Obesity or Overweight With Weight-related Comorbidity Without Type 2 Diabetes Mellitus
Obesity or Overweight
Not yet recruitingPhase 1/2
Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas
Sarcoma, Osteoid Sarcoma
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High-intensity interval exercise performed in postprandial phase, High-intensity interval exercise performed in postabsorptive phase and Moderate-intensity continuous exercise performed in postprandial phase in people with Diabetes Mellitus, Type 1, run by Universite du Littoral Cote d'Opale at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 26 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Capillary glycemia (time frame: At rest before exercise, then at 10 and 20 min of exercise, at 2 min of active recovery post-exercise, and at 10 min of passive recovery post-exercise.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07365176, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Jan 2026.