Peri ImplantitisNCT07365722
Comparison of Two Non-surgical Procedure to Manage Gum Disease Around Implants.
A study testing Non-Surgical Periodontal treatment (NSPT) and Minimally-invasive non-surgical therapy of peri-implantitis in people with Peri Implantitis, run by King's College London.
Trial summary
Research Question: Can a minimally invasive, non-surgical treatment approach (MINST) be more effective than the current standard non-surgical method in treating peri-implantitis, a common inflammatory condition affecting dental implants? Background: Dental implants are widely used to replace missing teeth. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Peri Implantitis
- What is being tested?
- Non-Surgical Periodontal treatment (NSPT) and Minimally-invasive non-surgical therapy of peri-implantitis
- Type of treatment
- Pill or oral medicine, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- No sites listed yet
- Study dates
- 1 Feb 2026to 7 Feb 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Diagnosis of peri-implantitis (any implant surface/any amount of keratinized gingiva)
- PPD>6mm at least in one implant surface
- Bone levels ≥3mm apical of the most coronal portion of the intra-osseous part of the implant.
- Implant surface deemed accessible by the treating clinician, without the need to remove the prosthetic suprastructure
- Full-mouth plaque score <30%
- Full-mouth bleeding score <30%
Who cannot join
- A course of antibiotics within the past 3 months
- Pregnant/lactating women
- Relevant medical history as evaluated by the examining clinician which may have the potential to affect periodontal surgical treatment (e.g., uncontrolled diabetes HbA1c≥7).
- Individuals on long-standing (2 or above years) supportive peri-implant care (SPIC)
- Previous non-surgical or surgical therapy of the affected implant within 12 months
- Current smoking or vaping (defined as any smoking or vaping within 12 months)
- Implant considered hopeless according to the treating clinician (e.g. mobility, circumferential bone loss >80%, implant outside the bone envelope)
- Case needing adjunctive antibiotic therapy, according to the treating clinician
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Minimally-Invasive Non-Surgical Therapy Of Peri-implantitis: A Multicenter Randomized Controlled Trial
Research Question:
Can a minimally invasive, non-surgical treatment approach (MINST) be more effective than the current standard non-surgical method in treating peri-implantitis, a common inflammatory condition affecting dental implants?
Read more
Background:
Dental implants are widely used to replace missing teeth. While they are usually successful, some patients develop a condition called peri-implantitis, an infection that causes inflammation and bone loss around the implant. This can eventually lead to implant failure if not treated properly. Currently, non-surgical treatments are used to clean the area and reduce inflammation. However, these methods often fall short of fully resolving the issue, and many patients require further treatment or even surgery.
A newer approach called MINST (Minimally-Invasive Non-Surgical Therapy) has shown promising results for treating gum disease around natural teeth. This method focuses on precision cleaning with minimal trauma to the surrounding tissues, reducing pain and improving healing. While MINST works well for gum disease, its effectiveness for treating peri-implantitis has not yet been tested.
Purpose of the Study:
This clinical trial will compare the effectiveness of MINST with the standard non-surgical treatment currently used for peri-implantitis.
The aim is to determine whether MINST can better treat the disease, improve healing, and reduce discomfort for patients.
Hypotheses:
Alternate Hypothesis (What we expect to find): MINST will result in better outcomes, specifically, fewer deep pockets around the implant, less bleeding, and fewer signs of infection, compared to the standard treatment.
Null Hypothesis: There will be no significant difference between the outcomes of the two treatment approaches.
Study Design:
Type of Study: A randomized controlled trial (RCT) involving 106 patients. Duration: Patients will be followed for 12 months after treatment. Locations: Multiple dental centers participating in the trial. Method: Half of the participants will receive MINST; the other half will receive the standard treatment. Neither patients nor outcome assessors will know which treatment was used (single-masked). What Will Be Measured? Primary Goal: To see how many patients show healing (defined as smaller pockets, little or no bleeding, and no pus) 12 months after treatment.
Secondary Goals:
Patient-reported outcomes, including pain levels and quality of life Changes in pocket depth and tissue attachment Bacterial changes Time taken for treatment appointments Why Is This Important? If MINST proves to be more effective and comfortable for patients, it could change how peri-implantitis is managed in the future- potentially reducing the need for surgery, improving patient experience, and helping more people keep their dental implants for longer.
Read the detailed description
Study Overview (Design) This is a research study being carried out at several dental clinics to test two different types of non-surgical treatments for periimplantitis- a condition where the tissues around a dental implant become infected and inflamed. The goal is to see which treatment works better over a period of 12 months. Study Schedule Participants will be followed for 1 year after their treatment, with several check-up visits to monitor progress and collect information.
Who Can Take Part? Inclusion (Who can join?) People with peri-implantitis, a condition affecting the gums and bone around a dental implant.
At least one area around the implant with deep pockets (>6mm) and some bone loss.
Page 8 of 23 Project ID: 51376 Implants must be accessible for cleaning without removing the crown or prosthetic.
Good general mouth hygiene (low plaque and bleeding scores). Exclusion (Who cannot join?) People who recently took antibiotics. Pregnant or breastfeeding women. Those with certain medical conditions (e.g., uncontrolled diabetes). People who already had treatment for this condition recently. Smokers or people who vape. Implants that are severely damaged or considered untreatable. Recruiting Patients Patients referred to specialist periodontal clinics will be checked to see if they qualify. If they do, they'll be informed about the study and can decide whether to participate. If they agree, they will attend a baseline appointment where their current oral health will be recorded. Randomisation (Choosing Treatment Groups)
Participants will be randomly assigned to one of two treatment groups:
Standard non-surgical treatment Minimally invasive non-surgical treatment (MINST) The method of choosing who goes into which group is like flipping a coin-but controlled by a secure computer system to ensure fairness. Blinding/Masking (Avoiding Bias) The dentist doing the treatment will know which method is being used (they have to, to apply the treatment correctly).
But the person who checks the results (examiner) and the person analyzing the data (statistician) won't know who received which treatment. This helps make the study results more reliable. Patients will know which treatment they received. Treatment and Follow-up Visits
Participants will attend up to 7 visits over 12 months:
Visit 1 (Day 0 - Baseline) Consent to take part Full dental and medical check Photos taken Oral hygiene advice Visit 2 (Treatment)
One of the two types of cleaning will be performed:
Standard: Cleaning using ultrasonic tools and curettes. MINST: Cleaning using finer tools and magnification for a more gentle and precise approach.
Visit 3 (1 Month) Follow-up with oral hygiene support Check for pain or discomfort Short cleaning if needed Visit 4 (3 Months) - Optional Check-up with hygiene instructions Visit 5 (6 Months) Page 9 of 23 Project ID: 51376 Full periodontal check Cleaning and photos Visit 6 (9 Months) - Optional Same as 6-month visit Visit 7 (12 Months) Final check-up with full periodontal exam and photos Study completed Rescue Treatment (If Needed)
If the implant doesn't improve or worsens during the study, the patient may receive additional treatment, which could include:
Extra cleaning Surgery In serious cases, implant removal These situations will be documented and analyzed. Clinical Measurements
At various visits, the study team will:
Measure gum pocket depths around teeth and implants. Record bleeding, gum recession, plaque, and other oral health signs. Use a standard dental probe for measurements at six points around each implant and tooth.
Photographs Photos and sometimes videos will be taken to monitor changes over time. These will be stored securely and anonymised to protect patient privacy. PROMs (Patient-Reported Outcomes) Patients will fill in questionnaires at several time points (baseline, 4, 8, and 12 months) to report how their mouth condition affects their daily life. One is a general oral health quality-of-life questionnaire (OHIP-14), and another is implant-specific.
Repeatability (Calibration) To make sure the measurements are accurate and consistent, all examiners will go through training and calibration exercises before the study starts. X-rays Previous X-rays (taken within the last 3 months) will be used to confirm the bone loss around the implant. No new X-rays will be taken solely for the study. End of Study The study ends one year after the last patient finishes their follow-up. After that, patients can choose to be monitored annually for up to 4 more years.
- Conditions
- Peri Implantitis
- Being tested
- Non-Surgical Periodontal treatment (NSPT), Minimally-invasive non-surgical therapy of peri-implantitis
- Keywords
- peri implantitis
- Medical subject headings
- Peri-Implantitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Non-Surgical Periodontal treatment (NSPT)Procedure or surgery
Control group will receive one session of non-surgical debridement as described previously (Liñares et al., 2019) by an experienced periodontist. Non-surgical treatment under local anaesthesia consisting of supra- and submucosal mechanical debridement using ultrasonic stainless steel scaling inserts(EMS® , Electro Medical Systems) will be performed in one treatment session with no time restrictions. After that, a stainless steel Columbia 4R/4L curette (LM Instruments Oy) will be used to remove granulation tissue and minor mucosal curettage.
Minimally-invasive non-surgical therapy of peri-implantitisProcedure or surgery
Half of the study participants (tests) will be randomised to receive minimally-invasive non-surgical periodontal treatment (MINST). All treatment will be carried out by the same therapist in each centre, including oral hygiene. The protocol for MINST is as follows: participants will receive local anaesthesia, then thorough debridement of the implant surface will be completed to the depth of the periodontal and peri-implant pockets following this protocol:
- In agreement with (Mehta et al., 2024) exclusive use of piezo-electric/ultrasonic devices with specific non-diamond thin and delicate tips (PS, PL1, PL2 from EMS, Nyon, Switzerland; Siroperio 1, 2, 3 and 7 from Sirona, Salzburg, Austria; Woodpecker P3 tip, Guilin Woodpecker, Guilin, China; Satelec 10Z from Acteon, UK, depending on what was available in the different study centres)
- using at least x3 magnification loupes
- aiming to obtain a stable blood clot in the pocke
| Study group | Role | What they receive |
|---|---|---|
| Non Surgical Periodontal Therapy- Group | Active comparator | Control group will receive one session of non-surgical debridement as described previously (Liñares et al., 2019) by an experienced periodontist. Non-surgical treatment under local anaesthesia consisting of supra- and submucosal mechanical debridement using ultrasonic stainless steel scaling inserts(EMS® , Electro Medical Systems) will be performed in one treatment session with no time restrictions. After that, a stainless steel Columbia 4R/4L curette (LM Instruments Oy) will be used to remove granulation tissue and minor mucosal curettage. Receives: Procedure: Non-Surgical Periodontal treatment (NSPT) |
| Minimally-invasive non-surgical therapy of peri-implantitis- Group | Experimental | Minimally-invasive non-surgical therapy of peri-implantitis
Half of the study participants (tests) will be randomised to receive minimally-invasive non-surgical periodontal treatment (MINST). All treatment will be carried out by the same therapist in each centre, including oral hygiene. The protocol for MINST is as follows: participants will receive local anaesthesia, then thorough debridement of the implant surface will be completed to the depth of the periodontal and peri-implant pockets following this protocol:
* In agreement with (Mehta et al., 2024) exclusive use of piezo-electric/ultrasonic devices with specific non-diamond thin and delicate tips (PS, PL1, PL2 from EMS, Nyon, Switzerland; Siroperio 1, 2, 3 and 7 from Sirona, Salzburg, Austria; Woodpecker P3 tip, Guilin Woodpecker, Guilin, China; Satelec 10Z from Acteon, UK, depending on what was available in the different study centres)
* using at least x3 magnification loupes
* aiming to obtain a stable blood clot in the pock Receives: Procedure: Minimally-invasive non-surgical therapy of peri-implantitis |
What is being measured
The primary outcome is the main question the study is designed to answer.
Probing Pocket depth
measure in mm of distance between gingival margin and bottom of the periodontal pocket
Measured: 12 months
Secondary outcomes (2)
Bleeding on probing
presence or absence of bleeding after probing the periodontal pocket
Measured: 12 months
suppuration
presence or absence of suppuration after probing the periodontal pocket
Measured: 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Jan 2026
- Study start1 Feb 2026 (estimated)
- Primary completion31 Jan 2028 (estimated)
- Study completion7 Feb 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Peri ImplantitisStudies of the same condition, open and under way.
- More trials run by King's College LondonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- King's College London
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07365722
- Sponsor's protocol ID
- 51376
- Status last verified
- Dec 2025
- First submitted
- 5 Jan 2026
- Last updated
- 26 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: upon requested to the authors
Study at a glance
From the registry record, last updated by the sponsor on 26 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Minimally-Invasive Non-Surgical Therapy Of Peri-implantitis: A Multicenter Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07365722
- Acronym / sponsor ID
- 51376
- Conditions
- Peri Implantitis
- Keywords
- peri implantitis
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- King's College LondonUniversity, hospital or other
- Study start
- 1 Feb 2026 (estimated)
- Primary completion
- 31 Jan 2028 (estimated)
- Study completion
- 7 Feb 2028 (estimated)
- First posted
- 26 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Research Question:
Can a minimally invasive, non-surgical treatment approach (MINST) be more effective than the current standard non-surgical method in treating peri-implantitis, a common inflammatory condition affecting dental implants?
Background:
Dental implants are widely used to replace missing teeth. While they are usually successful, some patients develop a condition called peri-implantitis, an infection that causes inflammation and bone loss around the implant. This can eventually lead to implant failure if not treated properly. Currently, non-surgical treatments are used to clean the area and reduce inflammation. However, these methods often fall short of fully resolving the issue, and many patients require further treatment or even surgery.
A newer approach called MINST (Minimally-Invasive Non-Surgical Therapy) has shown promising results for treating gum disease around natural teeth. This method focuses on precision cleaning with minimal trauma to the surrounding tissues, reducing pain and improving healing. While MINST works well for gum disease, its effectiveness for treating peri-implantitis has not yet been tested.
Purpose of the Study:
This clinical trial will compare the effectiveness of MINST with the standard non-surgical treatment currently used for peri-implantitis.
The aim is to determine whether MINST can better treat the disease, improve healing, and reduce discomfort for patients.
Hypotheses:
Alternate Hypothesis (What we expect to find): MINST will result in better outcomes, specifically, fewer deep pockets around the implant, less bleeding, and fewer signs of infection, compared to the standard treatment.
Null Hypothesis: There will be no significant difference between the outcomes of the two treatment approaches.
Study Design:
Type of Study: A randomized controlled trial (RCT) involving 106 patients. Duration: Patients will be followed for 12 months after treatment. Locations: Multiple dental centers participating in the trial. Method: Half of the participants will receive MINST; the other half will receive the standard treatment. Neither patients nor outcome assessors will know which treatment was used (single-masked). What Will Be Measured? Primary Goal: To see how many patients show healing (defined as smaller pockets, little or no bleeding, and no pus) 12 months after treatment.
Secondary Goals:
Patient-reported outcomes, including pain levels and quality of life Changes in pocket depth and tissue attachment Bacterial changes Time taken for treatment appointments Why Is This Important? If MINST proves to be more effective and comfortable for patients, it could change how peri-implantitis is managed in the future- potentially reducing the need for surgery, improving patient experience, and helping more people keep their dental implants for longer.
Detailed description
Study Overview (Design) This is a research study being carried out at several dental clinics to test two different types of non-surgical treatments for periimplantitis- a condition where the tissues around a dental implant become infected and inflamed. The goal is to see which treatment works better over a period of 12 months. Study Schedule Participants will be followed for 1 year after their treatment, with several check-up visits to monitor progress and collect information.
Who Can Take Part? Inclusion (Who can join?) People with peri-implantitis, a condition affecting the gums and bone around a dental implant.
At least one area around the implant with deep pockets (>6mm) and some bone loss.
Page 8 of 23 Project ID: 51376 Implants must be accessible for cleaning without removing the crown or prosthetic.
Good general mouth hygiene (low plaque and bleeding scores). Exclusion (Who cannot join?) People who recently took antibiotics. Pregnant or breastfeeding women. Those with certain medical conditions (e.g., uncontrolled diabetes). People who already had treatment for this condition recently. Smokers or people who vape. Implants that are severely damaged or considered untreatable. Recruiting Patients Patients referred to specialist periodontal clinics will be checked to see if they qualify. If they do, they'll be informed about the study and can decide whether to participate. If they agree, they will attend a baseline appointment where their current oral health will be recorded. Randomisation (Choosing Treatment Groups)
Participants will be randomly assigned to one of two treatment groups:
Standard non-surgical treatment Minimally invasive non-surgical treatment (MINST) The method of choosing who goes into which group is like flipping a coin-but controlled by a secure computer system to ensure fairness. Blinding/Masking (Avoiding Bias) The dentist doing the treatment will know which method is being used (they have to, to apply the treatment correctly).
But the person who checks the results (examiner) and the person analyzing the data (statistician) won't know who received which treatment. This helps make the study results more reliable. Patients will know which treatment they received. Treatment and Follow-up Visits
Participants will attend up to 7 visits over 12 months:
Visit 1 (Day 0 - Baseline) Consent to take part Full dental and medical check Photos taken Oral hygiene advice Visit 2 (Treatment)
One of the two types of cleaning will be performed:
Standard: Cleaning using ultrasonic tools and curettes. MINST: Cleaning using finer tools and magnification for a more gentle and precise approach.
Visit 3 (1 Month) Follow-up with oral hygiene support Check for pain or discomfort Short cleaning if needed Visit 4 (3 Months) - Optional Check-up with hygiene instructions Visit 5 (6 Months) Page 9 of 23 Project ID: 51376 Full periodontal check Cleaning and photos Visit 6 (9 Months) - Optional Same as 6-month visit Visit 7 (12 Months) Final check-up with full periodontal exam and photos Study completed Rescue Treatment (If Needed)
If the implant doesn't improve or worsens during the study, the patient may receive additional treatment, which could include:
Extra cleaning Surgery In serious cases, implant removal These situations will be documented and analyzed. Clinical Measurements
At various visits, the study team will:
Measure gum pocket depths around teeth and implants. Record bleeding, gum recession, plaque, and other oral health signs. Use a standard dental probe for measurements at six points around each implant and tooth.
Photographs Photos and sometimes videos will be taken to monitor changes over time. These will be stored securely and anonymised to protect patient privacy. PROMs (Patient-Reported Outcomes) Patients will fill in questionnaires at several time points (baseline, 4, 8, and 12 months) to report how their mouth condition affects their daily life. One is a general oral health quality-of-life questionnaire (OHIP-14), and another is implant-specific.
Repeatability (Calibration) To make sure the measurements are accurate and consistent, all examiners will go through training and calibration exercises before the study starts. X-rays Previous X-rays (taken within the last 3 months) will be used to confirm the bone loss around the implant. No new X-rays will be taken solely for the study. End of Study The study ends one year after the last patient finishes their follow-up. After that, patients can choose to be monitored annually for up to 4 more years.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Non Surgical Periodontal Therapy- Group | Active comparator | Procedure: Non-Surgical Periodontal treatment (NSPT)Control group will receive one session of non-surgical debridement as described previously (Liñares et al., 2019) by an experienced periodontist. Non-surgical treatment under local anaesthesia consisting of supra- and submucosal mechanical debridement using ultrasonic stainless steel scaling inserts(EMS® , Electro Medical Systems) will be performed in one treatment session with no time restrictions. After that, a stainless steel Columbia 4R/4L curette (LM Instruments Oy) will be used to remove granulation tissue and minor mucosal curettage. |
| Minimally-invasive non-surgical therapy of peri-implantitis- Group | Experimental | Procedure: Minimally-invasive non-surgical therapy of peri-implantitisMinimally-invasive non-surgical therapy of peri-implantitis Half of the study participants (tests) will be randomised to receive minimally-invasive non-surgical periodontal treatment (MINST). All treatment will be carried out by the same therapist in each centre, including oral hygiene. The protocol for MINST is as follows: participants will receive local anaesthesia, then thorough debridement of the implant surface will be completed to the depth of the periodontal and peri-implant pockets following this protocol: * In agreement with (Mehta et al., 2024) exclusive use of piezo-electric/ultrasonic devices with specific non-diamond thin and delicate tips (PS, PL1, PL2 from EMS, Nyon, Switzerland; Siroperio 1, 2, 3 and 7 from Sirona, Salzburg, Austria; Woodpecker P3 tip, Guilin Woodpecker, Guilin, China; Satelec 10Z from Acteon, UK, depending on what was available in the different study centres) * using at least x3 magnification loupes * aiming to obtain a stable blood clot in the pock |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (6 listed)
- Diagnosis of peri-implantitis (any implant surface/any amount of keratinized gingiva)
- PPD>6mm at least in one implant surface
- Bone levels ≥3mm apical of the most coronal portion of the intra-osseous part of the implant.
- Implant surface deemed accessible by the treating clinician, without the need to remove the prosthetic suprastructure
- Full-mouth plaque score <30%
Key exclusion criteria (8 listed)
- A course of antibiotics within the past 3 months
- Pregnant/lactating women
- Relevant medical history as evaluated by the examining clinician which may have the potential to affect periodontal surgical treatment (e.g., uncontrolled diabetes HbA1c≥7).
- Individuals on long-standing (2 or above years) supportive peri-implant care (SPIC)
- Previous non-surgical or surgical therapy of the affected implant within 12 months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Non-Surgical Periodontal treatment (NSPT)Control group will receive one session of non-surgical debridement as described previously (Liñares et al., 2019) by an experienced periodontist. Non-surgical treatment under local anaesthesia consisting of supra- and submucosal mechanical debridement using ultrasonic stainless steel scaling inserts(EMS® , Electro Medical Systems) will be performed in one treatment session with no time restrictions. After that, a stainless steel Columbia 4R/4L curette (LM Instruments Oy) will be used to remove granulation tissue and minor mucosal curettage. | Procedure or surgery | Non Surgical Periodontal Therapy- Group |
| Minimally-invasive non-surgical therapy of peri-implantitisHalf of the study participants (tests) will be randomised to receive minimally-invasive non-surgical periodontal treatment (MINST). All treatment will be carried out by the same therapist in each centre, including oral hygiene. The protocol for MINST is as follows: participants will receive local anaesthesia, then thorough debridement of the implant surface will be completed to the depth of the periodontal and peri-implant pockets following this protocol: * In agreement with (Mehta et al., 2024) exclusive use of piezo-electric/ultrasonic devices with specific non-diamond thin and delicate tips (PS, PL1, PL2 from EMS, Nyon, Switzerland; Siroperio 1, 2, 3 and 7 from Sirona, Salzburg, Austria; Woodpecker P3 tip, Guilin Woodpecker, Guilin, China; Satelec 10Z from Acteon, UK, depending on what was available in the different study centres) * using at least x3 magnification loupes * aiming to obtain a stable blood clot in the pocke | Procedure or surgery | Minimally-invasive non-surgical therapy of peri-implantitis- Group |
Primary outcome
Probing Pocket depth
Time frame: 12 months
measure in mm of distance between gingival margin and bottom of the periodontal pocket
2 secondary outcomes
Bleeding on probing
Time frame: 12 months
suppuration
Time frame: 12 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Jan 2026.
- Individual participant dataSharing planned: Yes. upon requested to the authors
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Non-Surgical Periodontal treatment (NSPT) and Minimally-invasive non-surgical therapy of peri-implantitis in people with Peri Implantitis, run by King's College London.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 26 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Luigi Nibali, Chief Investigator (86824 ext. 020, luigi.nibali@kcl.ac.uk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Probing Pocket depth (time frame: 12 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Jan 2026; AzTrials last refreshed its copy on 8 Nov 2026.